Cytogenetic and FISH analyses of pancreatic carcinoma reveal breaks in 18q11 with consistent loss of 18q12-qter and frequent gain of 18p

British Journal of Cancer

Volumn 77, Issue 11, 1998, Pages 1893-1899

  Hoglund M ^a   Gorunova, L ^a   Jonson, T ^a   Dawiskiba, S ^a   Andren Sandberg A ^a   Stenman, G ^b   Johansson, B ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Chromosome 18; Deletions; Pancreatic carcinoma

Indexed keywords

ADULT; AGED; ARTICLE; CENTROMERE; CHROMOSOME 18P; CHROMOSOME 18Q; CHROMOSOME ANALYSIS; CHROMOSOME BANDING PATTERN; CHROMOSOME BREAKAGE; CHROMOSOME LOSS; CHROMOSOME REARRANGEMENT; CLINICAL ARTICLE; DICENTRIC CHROMOSOME; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MALE; PANCREAS CARCINOMA; PRIORITY JOURNAL; RING CHROMOSOME; YEAST ARTIFICIAL CHROMOSOME;

EID: 0031802008     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.315     Document Type: Article

References (38)

1. Bardi G, Johansson B, Pandis N, Mandahl N, Bak-Jensen E, Andrén-Sandberg Å, Mitelman F and Heim S (1993) Karyotypic abnormalities in tumours of the pancreas. Br J Cancer 67: 1106-1112
2. Barrett MT, Schutte M, Kern SE and Reid BJ (1996) Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma. Cancer Res 56: 4351-4353
3. Bartsch D, Shevlin DW, Tung WS, Kisker O, Wells Jr SA and Goodfellow PJ (1995) Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas. Genes Chrom Cancer 14: 189-195
4. Bray-Ward P, Menninger J, Lieman J, Desai T, Mokady N, Banks A and Ward DC (1996) Integration of cytogenetic, genetic, and physical maps of the human genome by FISH mapping of CEPH YAC clones. Genomics 32: 1-14
5. Caldas C, Hahn SA, Da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ and Kern SE (1994) Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nature Genet 8: 27-32
6. Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui L-C, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL and Attisano L (1996) MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86: 543-552
7. Fazeli A, Dickinson SL, Hermiston ML, Tighe, RV, Steen RG, Small CG, Stoeckli E, Keino-Masu K, Masu M, Rayburn H, Simons J, Bronson RT, Gordon JI, Tessier-Lavigne, M and Weinberg RA (1997) Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386: 796-804
8. Fearon, ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW and Vogelstein B (1990) Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247: 49-56
9. Fukushige S, Waldman FM, Kimura M, Abe T, Furukawa T, Sunamura M, Kobari M and Horii A (1997) Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma. Genes Chrom Cancer 19: 161-169
10. Giacalone J, Li X, Lehrach H and Francke U (1996) High-density radiation hybrid map of human chromosome 18 and contig of 18p. Genomics 37: 9-18
11. Goggins M, Schutte M, Lu J, Moskaluk CA, Weinstein CL, Petersen GM, Yeo CJ, Jackson CE, Lynch HT, Hruban RH and Kern SE (1996) Germline BRCA2 mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 56: 5360-5364
12. Gorunova L, Johansson B, Dawiskiba S, Andrén-Sandberg Å, Jin Y, Mandahl N, Heim S and Mitelman F (1995) Massive cytogenetic heterogeneity in a pancreatic carcinoma: fifty-four karyotypically unrelated clones. Genes Chrom Cancer 14: 259-266
13. Gorunova L, Höglund M, Andrén-Sandberg Å, Dawiskiba S, Jin Y, Mitelman F and Johansson B (1998) Cytogenetic analysis of panreatic carcinomas: intratumor heterogeneity and nonrandom pattern of chromosome aberrations. Genes Chromosomes Cancer (in press)
14. Griffin CA, Hruban RH, Long PP, Morsberger LA, Douna-Issa, F and Yeo CJ (1994) Chromosome abnormalities in pancreatic adenocarcinoma. Genes Chromosom Cancer 9: 93-100
15. Griffin CA, Hruban RH, Morsberger LA, Ellingham T, Long PP, Jaffee EM, Hauda KM, Bohlander SK and Yeo CJ (1995) Consistent chromosome abnormalities in adenocarcinoma of the pancreas. Cancer Res 55: 2394-2399
16. Hahn SA, Seymour AB, Hoque ATMS, Schutte M, Da Costa LT, Redston MS, Caldas, C, Weinstein CL, Fischer A, Yeo CJ, Hruban RH and Kern SE (1995) Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res 55: 4670-4675
17. Hahn SA, Schutte M, Hoque ATMS, Moskaluk CA, Da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH and Kern SE (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353
18. Höglund M, Gorunova L, Andrén-Sandberg Å, Dawiskiba S, Mitelman F and Johanson B (1998) Cytogenetic and fluorescence in situ hybridization analysis of chromosome 19 aberrations in pancreatic carcinomas: frequent loss of 19p13.3 and gain of 19q13.1-13.2. Genes Chrom Cancer 21: 8-16
19. Höhne MW, Halatsch M-E, Kahl GF and Weinel RJ (1992) Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Cancer Res 52: 2612-2619
20. Johansson B, Bardi G, Heim S, Mandahl N, Mertens F, Bakjensen E, Andrén-Sandberg Å and Mitelman F (1992) Nonrandom chromosomal rearrangements in pancreatic carcinomas. Cancer 69: 1674-1681
21. Lei J, Zou T-T, Shi Y-Q, Zhou X, Smolinski KN, Yin J, Souza RF, Appel R, Wang S, Cymes K, Chan O, Abraham JM, Harpaz N and Meltzer SJ (1996) Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. Oncogene 13: 2459-2462
22. Lengauer C, Green ED and Cremer T (1992) Fluorescence in situ hybridization of YAC clones after Alu-PCR amplification. Genomics 13: 826-828
23. Loganzo F, Dosik JS, Zhao Y, Vidal MJ, Nanus DM, Sudol M and Albino AP (1993) Elevated expression of protein tyrosine kinase c-Yes, but not c-Src, in human malignant melanoma. Oncogene 8: 2637-2644
24. Mahlamäki EH, Höglund M, Gorunova L, Karhu R, Dawiskiba S, Andrén-Sandberg Å, Kallioniemi O-P and Johansson B (1997) Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q and losses of 18q, 9p, and 15q in pancreatic cancer. Genes Chromo Cancer 20: 383-391
25. Mertens F, Johansson B, Höglund M and Mitelman F (1997) Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Res 37: 2765-2780
26. Nagatake M, Takagi Y, Osada H, Uchida K, Mitsudomi T, Saji S, Shimokata K, Takahashi T and Takahashi T (1996) Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers. Cancer Res 56: 2718-2720
27. Park J, Meisler AI and Cartwright CA (1993) c-Yes tyrosine kinase activity in human colon carcinoma. Oncogene 8: 2627-2635
28. Ruggeri B, Zhang S-Y, Caamano J, Dirado M, Flynn SD and Klein-Szanto AJP (1992) Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes. Oncogene 7: 1503-1511
29. Scarpa A, Capelli P, Mukai K, Zamboni G, Oda T, Iacono C and Hirohashi S (1993) Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol 142: 1534-1543
30. Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casero Jr, RA, Meltzer PS, Hahn SA and Kern SE (1996) DPC4 gene in various tumor types. Cancer Res 56: 2527-2530
31. Seymour AB, Hruban RH, Redston M, Caldas C, Powell SM, Kinzler KW, Yeo CJ and Kern SE (1994) Allelotype of pancreatic adenocarcinoma. Cancer Res 54: 2761-2764
32. Shridhar R, Shridhar V, Wang X, Paradee W, Dugan M, Sarkar, F, Wilke C, Glover TW, Vaitkevicius VK and Smith DI (1996) Frequent breakpoints in the 3p14.2 fragile site, FRA3B, in pancreatic tumors. Cancer Res 56: 4347-4350
33. Silverman, GA, Kuo W-L, Taillon-Miller P and Gray JW (1993) Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18. Genomics 15: 442-445
34. Simon B, Weinel R, Höhne M, Watz J, Schmidt J, Kortner G and Arnold R (1994) Frequent alterations of the tumor suppressor genes P53 and DCC in human pancreatic carcinoma. Gastroenterology 106: 1645-1651
35. Solinas-Toldo S, Wallrapp C, Müller-Pillasch F, Bentz M, Gress T and Lichter P (1996) Mapping of chromosomal imbalances in pancreatic carcinoma by comparative genomic hybridization. Cancer Res 56: 3803-3807
36. Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JKV, Markowitz S, Hamilton SR, Kern SE, Kinzler KW and Vogelstein B (1996) Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers. Nature Genet 13: 343-346
37. Uchida K, Nagatake M, Osada H, Yatabe Y, Kondo M, Mitsudomi T, Masuda A, Takahashi T and Takahashi T (1996) Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers. Cancer Res 56: 5583-5585
38. Voorter C, Joos S, Bringuier PP, Vallinga M, Poddighe P, Schalken J, Du Manoir S, Ramaekers F, Lichter P and Hopman A (1995) Detection of chromosomal imbalances in transitional cell carcinoma of the bladder by comparative genomic hybridization. Am J Pathol 146: 1341-1354