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Hallek M, Bergsagel PL, Anderson KC: Multiple myeloma: Increasing evidence for a multistep transformation process. Blood 1998, 91:3-21. This review article discusses the critical steps thought to be involved in the malignant transformation of myeloma cells, including cytogenetic and molecular changes, role of the microenvironment and growth factors, and factors potentially leading to independent growth or inhibition of apoptosis.
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Lack of serologic association between human herpesvirus-8 infection and multiple myeloma and monoclonal gammopathies of undetermined significance
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Cigudosa JC, Rao PH, Calasanz MJ, Odero MD, Michaeli J, Jhanwar SC, Chaganti RSK: Characterization of nonrandom chromosomal gains and losses in multiple myeloma by comparative genomic hybridization. Blood 1998, 91:3007-3010.
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Perez-Simon JA, Garcia-Sanz R, Tabernero MD, Almeida J, Gonzalez M, Fernandez-Calvo J, et al.: Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. Blood 1998, 91:3366-3371.
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Seong C, Delasalle K, Hayes K, Weber D, Dimopoulos M, Swantkowski J, Huh Y, Glassman A, Champlin R, Alexanian R: Prognostic value of cytogenetics in multiple myeloma. Br J Haematol 1998, 101:189-194.
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A novel chromosomal translocation t(4;14) (p16.3;q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
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Richelda R, Ronchetti D, Baldini L, Cro L, Viggiano L, Marzella R, et al.: A novel chromosomal translocation t(4;14) (p16.3;q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene. Blood 1997, 90:4062-4070.
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Tricot G, Sawyer JR, Jagannath S, Desikan KR, Siegel D, Naucke S, et al.: Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants. J Clin Oncol 1997, 15:2659-2666. The absence of unfavorable cytogenetics, defined as abnormalities of 11q, partial or complete detection of 13, and the presence of any translocation, was the most important prognostic factor among 427 myeloma patients treated on a double autologous stem cell transplantation protocol. Duration of initial therapy and β2 microglobulin level were also important variables for outcome.
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Fonseca R, Witzig TE, Gertz MA, Kyle RA, Hoyer JD, Jalal SM, Greipp PR: Multiple myeloma and the translocation t(11;14)(q13;q32): A report on 13 cases. Br J Haematol 1998, 101:296-301.
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Hypodiploidy and 22q11 rearrangements at diagnosis are associated with poor prognosis in patients with multiple myeloma
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Calasanz MJ, Cigudosa JC, Odero MD, Garcia-Foncillas J, Marin J, Ardanaz MT, Rocha E, Gullon A: Hypodiploidy and 22q11 rearrangements at diagnosis are associated with poor prognosis in patients with multiple myeloma. Br J Haematol 1997, 98:418-425.
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Feinman R, Sawyer J, Hardin J, Tricot G: Cytogenetics and molecular genetics in multiple myeloma. Hematol Oncol Clin North Am. 1997, 11:1-25.
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Donor leukocyte infusions are effective in relapsed multiple myeloma after allogeneic bone marrow transplantation
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Lokhorst HM, Schattenberg A, Comelissen JJ, Thomas LLM, Verdonck LF: Donor leukocyte infusions are effective in relapsed multiple myeloma after allogeneic bone marrow transplantation. Blood 1997, 90:4206-4211. This group's initial report has been increased to 13 patients treated with donor lymphocyte infusion for relapse after allogeneic transplantation; 4 achieved a complete response and 3 a partial response. Acute graft-versus-host disease was seen in the majority and 2 aplastic deaths were observed.
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Toxicity and efficacy of defined doses of CD4+ donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant
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Alyea EP, Soiffer RJ, Canning C, Neuberg D, Schlossman R, Pickett C, et al.: Toxicity and efficacy of defined doses of CD4+ donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant. Blood 1998, 91:3671-3680. Among 40 patients with various hematologic disorders given donor CD4+ cells, five of six with myeloma responded. Graft-versus-host disease occurred in 32% with a mortality rate of 3%.
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Blood
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Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir
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Munshi NC, Govindarajan R, Drake R, Ding LM, lyer R, Saylors R, et al.: Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir. Blood 1997, 89:1334-1340.
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Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases
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Slavin S, Nagler A, Naparstek E, Kapelushnik Y, Aker M, Cividalli G, et al.: Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 1998, 91:756-763. Nonmyeloablative therapy with fludarabine, busulfan, and antithymocyte globulin was given before allogeneic blood stem cell transplantation in 26 patients with hematologic disorders, including myeloma. Partial or complete chimerism was seen in all. The early disease-free survival rate was encouraging despite the development of severe graft-versus-host disease in seven patients.
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Blood
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Kwak LW, Sternas LA, Jagannath S, Siegel D, Munshi NC, Barlogie B: T-cell responses elicited by immunization of multiple myeloma patients with idiotypic M-protein plus GM-CSF in remission after autologous transplantation (PSCT). Blood 1997, 90(Suppl 1):579a.
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Vescio R, Wu C, Rettig M, Stewart A, Ballester O, Noga S, et al.: The detection of KSHV is increased by mobilization chemotherapy and reduced in autografts by CD34-selection. Blood 1997, 90(suppl 1):565a.
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Cull GM, Timms JM, Haynes AP, Russell NH, Irving WL, Ball JK, Thomson BJ: Dendritic cells cultured from mononuclear cells and CD34 cells in myeloma do not harbor human herpesvirus 8. Br J Haematol 1998, 100:793-796.
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Tarte K, Olsen SJ, Lu ZY, Legouffe E, Rossi JF, Chang Y, Klein B: Clinicalgrade functional dendritic cells from patients with multiple myeloma are not infected with Kaposi's sarcoma-associated herpesvirus. Blood 1998, 91:1852-1857. Dendritic cells were cultured from apheresis products in 11 myeloma patients; only 1 patient was weakly positive for human herpesvirus-8 by polymerase chain reaction. This level of detection was believed to be due to background prevalence of infection.
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