Submicron oil-in-water emulsion formulations for mefloquine and halofantrine: Effect of electric-charge inducers on antimalarial activity in mice

Journal of Pharmacy and Pharmacology

Volumn 50, Issue 11, 1998, Pages 1221-1225

  Mbela, T K M ^a,c   Deharo, E ^b   Haemers, A ^c   Ludwig, A ^c  

^a UNIVERSITY OF KINSHASA   (Congo)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; DICETYL PHOSPHATE; HALOFANTRINE; MEFLOQUINE; OCTADECYLAMINE; OIL; OLEIC ACID; PHOSPHATIDYLSERINE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ELECTRICITY; EMULSION; MALE; MOUSE; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031790623     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1998.tb03337.x     Document Type: Article

References (20)

1. Aoki, H., Tottori, T., Sakurai, F., Fuji, K., Miyajima, K. (1997) Effects of positive charge density on the liposomal surface on disposition kinetics of liposomes in rats. Int. J. Pharm. 156: 163-174
2. Couvreur, P., Vauthier, C. (1991) Polyalkylcyanoacrylate nanoparticles as drug carrier: present state and perspectives. J. Contr. Rel. 17: 187-198
3. Harashima, H., Kiwada, H. (1996) Liposomal targeting and drug delivery: kinetic consideration. Adv. Drug Delivery Rev. 19: 425-444
4. Hines, J. W., Elkins, P. D., Cook, C. E., Sparacino, C. M. (1985) Paired-ion liquid chromatographic method for the analysis of a phenanthrenemethanol antimalarial in whole blood. J. Pharm. Sci. 74: 433-437
5. Humberstone, A. J., Cowman, A. F., Horton, J., Charman, W. N. (1998) Effect of altered serum lipid concentration on the IC50 of halofantrine against Plasmodium falciparum. J. Pharm. Sci. 87: 256-258
6. Kapetanovic, I. M., Digiovanni, J. D., Bartosevich, J., Melendez, V., Von Bredow, J., Heiffer, M. (1983) Analysis of the antimalarial mefloquine in blood and plasma using high-performance liquid chromatography. J. Chromatogr. 277: 200-215
7. Karbwang, J., Bangchang, K. N. (1994) Clinical pharmacokinetics of halofantrine. Clin. Pharmacokinet. 27: 104-119
8. Karbwang, J., White, N. J. (1990) Clinical pharmacokinetics of mefloquine. Clin. Pharmacokinet. 19: 264-279
9. Klang, S. H., Frucht-Pery, J., Hoffman, A., Benita, S. (1994) Physicochemical characterization and acute toxicity evaluation of a positively-charged submicron emulsion. J. Pharm. Pharmacol. 46: 986-993
10. Koster, V. S., Kuks, P. F. M., Lange, R., Talsma, H. (1996) Particle size in parenteral emulsions, what are the true limitations? Int. J. Pharm. 134: 235-238
11. Krishna, S., ter Kuile, F., Supanaranond, W. (1993) Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. Br. J. Clin. Pharmacol. 36: 585-591
12. Lundberg, B., Mortimer, B.-C., Redgrave, T. G. (1996) Submicron lipid emulsions containing amphiphatic polyethyleneglycol for use as drug carrier with prolonged circulation time. Int. J. Pharm. 134: 119-127
13. Mbela, N., Ludwig, A. (1995) Physical properties and stability-evaluation of submicron mefloquine emulsions. S.T.P. Pharma Sci. 5: 225-231
14. Mbela, N., Ludwig, A., Landau, I., Deharo, E., Haemers, A. (1994) Preparation, characterization and in-vivo activity of mefloquine submicron emulsions. Int. J. Pharm. 110: 189-196
15. Mbela, N., Verschueren, E., Ludwig, A. (1998) Influence of stearylamine and dicetylphosphate on the physical properties of submicron o/w emulsions. J. Pharm. Belg. 53: 81-86
16. Oussoren, C., Storm, G. (1998) Targeting to lymph nodes by subcutaneous administration of liposomes. Int. J. Pharm. 162: 39-44
17. Peters, W. (ed.) (1980) Chemotherapy and Drug Resistance in Malaria. Vol. 1, 2nd edn, Academic Press, London, pp 113-114
18. Storm, G., Belliot, S. O., Daemen, T., Lasic, D. D. (1995) Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system. Adv. Drug Delivery Rev. 17: 31-48
19. Uchegbu, I. F., Double, J. A., Turton, J. A., Florence, A. T. (1995) Distribution, metabolism and tumoricidal activity of doxorubicin administered in sorbitan monostearate (Span 60) niosomes in the mouse. Pharm. Res. 12: 1019-1024
20. Washington, C., Davis, S. S. (1987) Ageing effects in parenteral emulsions: the role of fatty acids. Int. J. Pharm. 39: 33-37