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Volumn 19, Issue 3, 1996, Pages 425-444

Liposomal targeting and drug delivery: Kinetic consideration

Author keywords

Clearance; Drug delivery system; Intracellular targeting; Liposomes; Long circulating liposomes; Opsonin; Phagocytosis; Pharmacokinetics; Targeting

Indexed keywords

DRUG DOSAGE; DRUG INTERACTIONS; DRUG PRODUCTS; LIPIDS; PHARMACOKINETICS; TISSUE;

EID: 0030580954     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-409X(96)00012-9     Document Type: Review
Times cited : (79)

References (135)
  • 1
    • 0027533544 scopus 로고
    • Liposomes in drug delivery. Clinical, diagnostic and ophthalmic potential
    • [1] Gregoriadis, G. and Florence, A.T. (1993) Liposomes in drug delivery. Clinical, diagnostic and ophthalmic potential. Drugs 45, 15-28.
    • (1993) Drugs , vol.45 , pp. 15-28
    • Gregoriadis, G.1    Florence, A.T.2
  • 2
    • 0024468809 scopus 로고
    • Pharmacokinetics and tissue distribution of doxorubicin encapsulated in stable liposomes with long circulation times
    • [2] Gabizon, A., Shiota, R. and Papahadjopoulos, D. (1989) Pharmacokinetics and tissue distribution of doxorubicin encapsulated in stable liposomes with long circulation times. J. Natl. Cancer Inst. 81, 1484-1488.
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 1484-1488
    • Gabizon, A.1    Shiota, R.2    Papahadjopoulos, D.3
  • 3
    • 0026009755 scopus 로고
    • Separation of large unilamellar liposomes from blood components by a spin column procedure: Towards identifying plasma proteins which mediate liposome clearance in vivo
    • [3] Chonn, A. Semple, S.C. and Cullis, P.R. (1991) Separation of large unilamellar liposomes from blood components by a spin column procedure: towards identifying plasma proteins which mediate liposome clearance in vivo. Biochim. Biopys. Acta 1070, 215-222.
    • (1991) Biochim. Biopys. Acta , vol.1070 , pp. 215-222
    • Chonn, A.1    Semple, S.C.2    Cullis, P.R.3
  • 4
    • 0027537835 scopus 로고
    • Kinetic modelling of liposome degradation in blood circulation
    • [4] Harashima, H., Kume, Y., Yamane, C. and Kiwada, H. (1993) Kinetic modelling of liposome degradation in blood circulation. Biopharm. Drug Dispos. 14, 265-270.
    • (1993) Biopharm. Drug Dispos. , vol.14 , pp. 265-270
    • Harashima, H.1    Kume, Y.2    Yamane, C.3    Kiwada, H.4
  • 5
    • 84988097991 scopus 로고
    • Quantitative analysis of the stability of liposomes in blood in vivo
    • [5] Kume, Y., Yamane, C., Harashima, H. and Kiwada, H. (1991) Quantitative analysis of the stability of liposomes in blood in vivo. Xenobiot. Metab. Dispos. 6, 201-208.
    • (1991) Xenobiot. Metab. Dispos. , vol.6 , pp. 201-208
    • Kume, Y.1    Yamane, C.2    Harashima, H.3    Kiwada, H.4
  • 6
    • 0027362476 scopus 로고
    • Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (II) Biopharm
    • [6] Harashima, H., Midori, Y., Ohshima, S., Yachi, K., Kikuchi, Y. and Kiwada, H. (1993) Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (II) Biopharm. Drug Dispos. 14, 595-608.
    • (1993) Drug Dispos. , vol.14 , pp. 595-608
    • Harashima, H.1    Midori, Y.2    Ohshima, S.3    Yachi, K.4    Kikuchi, Y.5    Kiwada, H.6
  • 7
    • 0029000870 scopus 로고
    • Effect of the size and fluidity of liposomes on their accumulation in tumors: A presumption of their interaction with tumors
    • [7] Uchiyama, K., Nagayasu, A., Yamagiwa, Y. Nishida, T. Harashima, H. and Kiwada, H. (1993) Effect of the size and fluidity of liposomes on their accumulation in tumors: A presumption of their interaction with tumors. Int. J. Pharm. 121, 195-203.
    • (1993) Int. J. Pharm. , vol.121 , pp. 195-203
    • Uchiyama, K.1    Nagayasu, A.2    Yamagiwa, Y.3    Nishida, T.4    Harashima, H.5    Kiwada, H.6
  • 8
    • 84957794434 scopus 로고
    • Filtration, diffusion and molecular sieving through peripheral capillary membranes. A contribution to the pore theory of capillary permeability
    • [8] Pappenheimer, J.R., Renkin, E.M. and Borrero, L.M. (1951) Filtration, diffusion and molecular sieving through peripheral capillary membranes. A contribution to the pore theory of capillary permeability. Am. J. Physiol. 167, 13-46.
    • (1951) Am. J. Physiol. , vol.167 , pp. 13-46
    • Pappenheimer, J.R.1    Renkin, E.M.2    Borrero, L.M.3
  • 9
    • 0028147336 scopus 로고
    • Transport of macromolecules across microvascular walls: The two pore theory
    • [9] Rippe, B. and Haraldsson, B. (1994) Transport of macromolecules across microvascular walls: The two pore theory. Physiol. Rev. 74, 163-219.
    • (1994) Physiol. Rev. , vol.74 , pp. 163-219
    • Rippe, B.1    Haraldsson, B.2
  • 10
    • 0020374303 scopus 로고
    • Volume of distribution and transcapillary passage of small unilamellar vesicles
    • [10] Hwang, K.J., Luk, K.F.S. and Beaumier, P.L. (1982) Volume of distribution and transcapillary passage of small unilamellar vesicles. Life Sci. 31, 949-955.
    • (1982) Life Sci. , vol.31 , pp. 949-955
    • Hwang, K.J.1    Luk, K.F.S.2    Beaumier, P.L.3
  • 11
    • 0016612425 scopus 로고
    • The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs
    • [11] Juliano, R.L. and Stamp, D. (1975) The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs. Biochem. Biophys. Res. Commun. 63: 651-658.
    • (1975) Biochem. Biophys. Res. Commun. , vol.63 , pp. 651-658
    • Juliano, R.L.1    Stamp, D.2
  • 12
    • 0019330875 scopus 로고
    • The phospholipid component of small unilamellar liposomes controls the rate of clearance of entrapped solutes from the circulation
    • [12] Gregoriadis, G. and Senior, J. (1980) The phospholipid component of small unilamellar liposomes controls the rate of clearance of entrapped solutes from the circulation. FEBS Lett. 119, 43-46.
    • (1980) FEBS Lett. , vol.119 , pp. 43-46
    • Gregoriadis, G.1    Senior, J.2
  • 13
    • 0019929258 scopus 로고
    • Is half-life of circulating liposomes determined by changes in their permeability?
    • [13] Senir, J. and Gregoriadis, G. (1982) Is half-life of circulating liposomes determined by changes in their permeability? FEBS Lett. 145, 109-114.
    • (1982) FEBS Lett. , vol.145 , pp. 109-114
    • Senir, J.1    Gregoriadis, G.2
  • 14
    • 0019324697 scopus 로고
    • Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro
    • [14] Kirby, C., Larke, J. and Gregoriadis, G. (1980) Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro. Biochem J. 186, 591-598.
    • (1980) Biochem J. , vol.186 , pp. 591-598
    • Kirby, C.1    Larke, J.2    Gregoriadis, G.3
  • 15
    • 0019214736 scopus 로고
    • The effect of the cholesterol content of small unilamellar liposomes on the fate of their lipid components in vivo
    • [15] Kirby, C. and Gregoriadis, G. (1980) The effect of the cholesterol content of small unilamellar liposomes on the fate of their lipid components in vivo. Life Sci. 27, 2223-2230.
    • (1980) Life Sci. , vol.27 , pp. 2223-2230
    • Kirby, C.1    Gregoriadis, G.2
  • 16
    • 0017830215 scopus 로고
    • Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins
    • [16] Scherphof, G., Roerdink, F., Waite, M. and Parks, J. (1978) Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins. Biochim. Biophys. Acta 542, 296-307.
    • (1978) Biochim. Biophys. Acta , vol.542 , pp. 296-307
    • Scherphof, G.1    Roerdink, F.2    Waite, M.3    Parks, J.4
  • 17
    • 0027411971 scopus 로고
    • Complement defense mechanisms
    • [17] Tomlilnson, S. (1993) Complement defense mechanisms. Curr. Opin. Immunol. 5, 83-89.
    • (1993) Curr. Opin. Immunol. , vol.5 , pp. 83-89
    • Tomlilnson, S.1
  • 18
    • 0028224099 scopus 로고
    • Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes
    • [18] Harashima, H., Sakata, K., Funato, K. and Kiwada, H. (1994) Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes. Pharm. Res. 11, 402-406.
    • (1994) Pharm. Res. , vol.11 , pp. 402-406
    • Harashima, H.1    Sakata, K.2    Funato, K.3    Kiwada, H.4
  • 19
    • 0026052844 scopus 로고
    • The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes
    • [19] Chonn, A., Cullis, P.R. and Devine, D. (1991) The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. J. Immunol. 146, 4234-4241.
    • (1991) J. Immunol. , vol.146 , pp. 4234-4241
    • Chonn, A.1    Cullis, P.R.2    Devine, D.3
  • 20
    • 0026575128 scopus 로고
    • Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma
    • [20] Funato, K., Yoda, R. and Kiwada, H. (1992) Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma. Biochim. Biophys. Acta 1103, 198-204.
    • (1992) Biochim. Biophys. Acta , vol.1103 , pp. 198-204
    • Funato, K.1    Yoda, R.2    Kiwada, H.3
  • 21
    • 0028326452 scopus 로고
    • Liposome-complement interactions in rat serum: Implications for liposome survival studies
    • [21] Devine, D., Wong, K., Serrano, K.A., Chonn, A. and Cullis, P.R. (1994) Liposome-complement interactions in rat serum: implications for liposome survival studies. Biochim. Biophys. Acta 1191, 43-51.
    • (1994) Biochim. Biophys. Acta , vol.1191 , pp. 43-51
    • Devine, D.1    Wong, K.2    Serrano, K.A.3    Chonn, A.4    Cullis, P.R.5
  • 22
    • 0026778635 scopus 로고
    • Association of blood proteins with large unilamellar liposomes in vivo: Relation to circulation lifetimes
    • [22] Chonn, A., Semple, S.C. and Cullis, P.R. (1992) Association of blood proteins with large unilamellar liposomes in vivo: relation to circulation lifetimes. J. Biol. Chem. 267, 18759-18765.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18759-18765
    • Chonn, A.1    Semple, S.C.2    Cullis, P.R.3
  • 23
    • 0028327344 scopus 로고
    • Kinetic modelling of liposome degradation in serum: Effect of size and concentration of liposomes in vitro
    • [23] Harashima, H., Ochi, Y. and Kiwada, H. (1994) Kinetic modelling of liposome degradation in serum: Effect of size and concentration of liposomes in vitro. Biopharm. Drug Dispos. 15, 217-225.
    • (1994) Biopharm. Drug Dispos. , vol.15 , pp. 217-225
    • Harashima, H.1    Ochi, Y.2    Kiwada, H.3
  • 24
    • 0029590781 scopus 로고
    • Size dependent liposome degradation in blood: In vivo/in vitro correlation by kinetic modelling
    • [24] Harashima, H., Hiraiwa, T., Ochi, Y. and Kiwada, H. (1995) Size dependent liposome degradation in blood: In vivo/in vitro correlation by kinetic modelling. J. Drug Target. 9, 253-261.
    • (1995) J. Drug Target. , vol.9 , pp. 253-261
    • Harashima, H.1    Hiraiwa, T.2    Ochi, Y.3    Kiwada, H.4
  • 25
    • 0024470863 scopus 로고
    • Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice
    • [25] Mayer, L.D., Tai, L.C.K., Ko, D.S.C., Masin, D., Ginsberg, R.S., Cullis, P.R. and Bally, M.B. (1989) Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Res. 49, 5922-5930.
    • (1989) Cancer Res. , vol.49 , pp. 5922-5930
    • Mayer, L.D.1    Tai, L.C.K.2    Ko, D.S.C.3    Masin, D.4    Ginsberg, R.S.5    Cullis, P.R.6    Bally, M.B.7
  • 26
    • 0027433668 scopus 로고
    • Optimization of the retention properties of vincristine in liposomal systems
    • [26] Boman, N.L., Mayer, L.D. and Cullis, P.R. (1993) Optimization of the retention properties of vincristine in liposomal systems. Biochim. Biophys. Acta 1152, 253-258.
    • (1993) Biochim. Biophys. Acta , vol.1152 , pp. 253-258
    • Boman, N.L.1    Mayer, L.D.2    Cullis, P.R.3
  • 27
    • 0028306031 scopus 로고
    • Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors
    • [27] Boman, N.L., Masin, D., Mayer, L.D., Cullis, P.R. and Bally, M.B. (1994) Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors. Cancer Res. 54, 2830-2833.
    • (1994) Cancer Res. , vol.54 , pp. 2830-2833
    • Boman, N.L.1    Masin, D.2    Mayer, L.D.3    Cullis, P.R.4    Bally, M.B.5
  • 28
    • 0023806697 scopus 로고
    • Factors affecting the clearance kinetics and tissue distribution of liposomes, microspheres and emulsions
    • [28] Juliano, R.L. (1988) Factors affecting the clearance kinetics and tissue distribution of liposomes, microspheres and emulsions. Adv. Drug Deliv. Rev. 2, 31-54.
    • (1988) Adv. Drug Deliv. Rev. , vol.2 , pp. 31-54
    • Juliano, R.L.1
  • 29
    • 0022340897 scopus 로고
    • Receptor mediated endocytosis
    • [29] Wileman, T., Harding, C. and Stahl, P. (1985) Receptor mediated endocytosis. Biochem. J. 232, 1-14.
    • (1985) Biochem. J. , vol.232 , pp. 1-14
    • Wileman, T.1    Harding, C.2    Stahl, P.3
  • 30
    • 0026034434 scopus 로고
    • Complement receptors and phagocytosis
    • [30] Brown, E.J. (1991) Complement receptors and phagocytosis. Curr. Opin. Immunol. 3, 76-82.
    • (1991) Curr. Opin. Immunol. , vol.3 , pp. 76-82
    • Brown, E.J.1
  • 31
    • 0026541171 scopus 로고
    • Serum opsonins and liposomes: Their interaction and opsonophagocytosis
    • [31] Patel, H.M. (1992) Serum opsonins and liposomes: Their interaction and opsonophagocytosis. Crit. Rev. Ther. Drug Carr. Syst. 9, 39-90.
    • (1992) Crit. Rev. Ther. Drug Carr. Syst. , vol.9 , pp. 39-90
    • Patel, H.M.1
  • 32
    • 0026054526 scopus 로고
    • Uptake of liposomes by cultured mouse bone marrow macrophages: Influence of liposome composition and size
    • [32] Allen, T.M., Austin, G.A., Chonn, A., Lin, L. and Lee, K.C. (1991) Uptake of liposomes by cultured mouse bone marrow macrophages: influence of liposome composition and size. Biochim. Biophys. Acta 1061, 56-64.
    • (1991) Biochim. Biophys. Acta , vol.1061 , pp. 56-64
    • Allen, T.M.1    Austin, G.A.2    Chonn, A.3    Lin, L.4    Lee, K.C.5
  • 33
    • 0019951707 scopus 로고
    • Stability of small unilamellar liposomes in serum and clearance from the circulation: The effect of the phospholipid and cholesterol components
    • [33] Senior, J. and Gregoriadis, G. (1982) Stability of small unilamellar liposomes in serum and clearance from the circulation: The effect of the phospholipid and cholesterol components. Life Sci. 30, 2123-2136.
    • (1982) Life Sci. , vol.30 , pp. 2123-2136
    • Senior, J.1    Gregoriadis, G.2
  • 34
    • 0021042461 scopus 로고
    • Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen
    • [34] Patel, H.M., Tuzel, N.S. and Ryman, B.E. (1983) Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen. Biochim. Biophys. Acta 761, 142-151.
    • (1983) Biochim. Biophys. Acta , vol.761 , pp. 142-151
    • Patel, H.M.1    Tuzel, N.S.2    Ryman, B.E.3
  • 35
    • 0023917015 scopus 로고
    • 3H]methotrexate with thioglycollate elicited macrophages in-vitro
    • 3H]methotrexate with thioglycollate elicited macrophages in-vitro. J. Pharm. Pharmacol. 40, 171-175.
    • (1988) J. Pharm. Pharmacol. , vol.40 , pp. 171-175
    • Foong, W.C.1    Green, K.L.2
  • 36
    • 0023885873 scopus 로고
    • Tissue specific opsonins for phagocytic cells and their different affinity for cholestero-rich liposomes
    • [36] Moghimi, S.M. and Patel, H.M. (1988) Tissue specific opsonins for phagocytic cells and their different affinity for cholestero-rich liposomes. FEBS Lett. 233, 143-147.
    • (1988) FEBS Lett. , vol.233 , pp. 143-147
    • Moghimi, S.M.1    Patel, H.M.2
  • 37
    • 0024461102 scopus 로고
    • Serum opsonins and phagocytosis of saturated and unsaturated phospholipid liposomes
    • [37] Moghimi, S.M. and Patel, H.M. (1989) Serum opsonins and phagocytosis of saturated and unsaturated phospholipid liposomes. Biochim. Biophys. Acta 984, 384-387.
    • (1989) Biochim. Biophys. Acta , vol.984 , pp. 384-387
    • Moghimi, S.M.1    Patel, H.M.2
  • 38
    • 0020355291 scopus 로고
    • Differential uptake of liposomes varying in size and lipid composition by parenchymal and Kupffer cells of mouse liver
    • [38] Rahman, Y.E., Cerny, E.A., Patel, K.R., Lau, E.H. and Wright, B.J. (1982) Differential uptake of liposomes varying in size and lipid composition by parenchymal and Kupffer cells of mouse liver. Life Sci. 31, 2061-2071.
    • (1982) Life Sci. , vol.31 , pp. 2061-2071
    • Rahman, Y.E.1    Cerny, E.A.2    Patel, K.R.3    Lau, E.H.4    Wright, B.J.5
  • 39
    • 0023002524 scopus 로고
    • Intrahepatic distribution of small unilamellar liposomes as a function of liposomal lipid composition
    • [39] Spanjer, H.H., Galen, M., Roerdink, F.H., Regts, J. and Scherphof, G.L. (1986) Intrahepatic distribution of small unilamellar liposomes as a function of liposomal lipid composition. Biochim. Biophys. Acta 863, 224-230.
    • (1986) Biochim. Biophys. Acta , vol.863 , pp. 224-230
    • Spanjer, H.H.1    Galen, M.2    Roerdink, F.H.3    Regts, J.4    Scherphof, G.L.5
  • 40
    • 0016156147 scopus 로고
    • Control of the rate of hepatic uptake and catabolism of liposome-entrapped proteins injected into rats. Possible therapeutic applications
    • [40] Gregoriadis, G. and Neerunjun, D.E. (1975) Control of the rate of hepatic uptake and catabolism of liposome-entrapped proteins injected into rats. Possible therapeutic applications. Eur. J. Biochem. 47, 179-185.
    • (1975) Eur. J. Biochem. , vol.47 , pp. 179-185
    • Gregoriadis, G.1    Neerunjun, D.E.2
  • 41
    • 0019439249 scopus 로고
    • The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes
    • [41] Souhami, R., Patel, H.M. and Ryman, B.E. (1981) The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes. Biochim. Biophys. Acta 674, 354-371.
    • (1981) Biochim. Biophys. Acta , vol.674 , pp. 354-371
    • Souhami, R.1    Patel, H.M.2    Ryman, B.E.3
  • 42
    • 0020488877 scopus 로고
    • Interactions of liposomes with the reticuloendothelial system. II: Non-specific and receptor-mediated uptake of liposomes by mouse peritoneal macrophages
    • [42] Hsu, M.J. and Juliano, R.L. (1982) Interactions of liposomes with the reticuloendothelial system. II: Non-specific and receptor-mediated uptake of liposomes by mouse peritoneal macrophages. Biochim. Biophys. Acta 7211, 411-419.
    • (1982) Biochim. Biophys. Acta , vol.7211 , pp. 411-419
    • Hsu, M.J.1    Juliano, R.L.2
  • 43
    • 0019779784 scopus 로고
    • The involvement of parenchymal, Kupffer and endothelial liver cells in the hepatic uptake of intravenously injected liposomes. Effect of lanthanum and gadolinium salts
    • [43] Roerdink, F., Dijkstra, J., Hartman, G., Bolscher, B. and Scherphof, G. (1981) The involvement of parenchymal, Kupffer and endothelial liver cells in the hepatic uptake of intravenously injected liposomes. Effect of lanthanum and gadolinium salts. Biochim. Biophys. Acta 677, 79-89.
    • (1981) Biochim. Biophys. Acta , vol.677 , pp. 79-89
    • Roerdink, F.1    Dijkstra, J.2    Hartman, G.3    Bolscher, B.4    Scherphof, G.5
  • 44
    • 0020518842 scopus 로고
    • Effect of liposome size and drug release properties on pharmacokinetics of encapsulated drug in rats
    • [44] Allen, T.M. and Everest, J.M. (1983) Effect of liposome size and drug release properties on pharmacokinetics of encapsulated drug in rats. J. Pharmacol. Exp. Ther. 226, 539-544.
    • (1983) J. Pharmacol. Exp. Ther. , vol.226 , pp. 539-544
    • Allen, T.M.1    Everest, J.M.2
  • 45
    • 0021848043 scopus 로고
    • Tissue distribution of liposomes exhibiting lung half-lives in the circulation after intravenous injection
    • [45] Senior, J., Crawley, J.C. and Gregoriadis, G. (1985) Tissue distribution of liposomes exhibiting lung half-lives in the circulation after intravenous injection. Biochim. Biophys. Acta 839, 1-8.
    • (1985) Biochim. Biophys. Acta , vol.839 , pp. 1-8
    • Senior, J.1    Crawley, J.C.2    Gregoriadis, G.3
  • 46
    • 0020526895 scopus 로고
    • Effects of liposome size on the degradation of bovine brain sphingomyelin/cholesterol liposomes in the mouse liver
    • [46] Beaumier, P.L. and Hwang, K.J. (1983) Effects of liposome size on the degradation of bovine brain sphingomyelin/cholesterol liposomes in the mouse liver. Biochim. Biophys. Acta 731, 23-30.
    • (1983) Biochim. Biophys. Acta , vol.731 , pp. 23-30
    • Beaumier, P.L.1    Hwang, K.J.2
  • 47
    • 0024603656 scopus 로고
    • Targeting small unilamellar liposomes to hepatic parenchymal cells by dose effect
    • [47] Chow, D.D., Essien, H.E., Padki, M.M. and Hwang, K.J. (1989) Targeting small unilamellar liposomes to hepatic parenchymal cells by dose effect. J. Pharm. Exp. Ther. 248, 506-513.
    • (1989) J. Pharm. Exp. Ther. , vol.248 , pp. 506-513
    • Chow, D.D.1    Essien, H.E.2    Padki, M.M.3    Hwang, K.J.4
  • 48
    • 0018387296 scopus 로고
    • Activation of human complement by liposomes: A model for membrane activation of the alternative pathway
    • [48] Cunningham, C.M., Kingzette, M., Richards, R.L., Alving, C.R., Lint, T.F. and Gewurz, H. (1979) Activation of human complement by liposomes: A model for membrane activation of the alternative pathway. J. Immunol. 122, 1237-1242.
    • (1979) J. Immunol. , vol.122 , pp. 1237-1242
    • Cunningham, C.M.1    Kingzette, M.2    Richards, R.L.3    Alving, C.R.4    Lint, T.F.5    Gewurz, H.6
  • 49
    • 0020077916 scopus 로고
    • Activation of the alternative complement pathway of guinea-pig by liposomes incorporated with trinitrophenylated phosphatidylethanolamine
    • [49] Okada, N., Yasuda, T., Tsumita, T. and Okada, H. (1982) Activation of the alternative complement pathway of guinea-pig by liposomes incorporated with trinitrophenylated phosphatidylethanolamine. Immunology 45, 115-124.
    • (1982) Immunology , vol.45 , pp. 115-124
    • Okada, N.1    Yasuda, T.2    Tsumita, T.3    Okada, H.4
  • 50
    • 0026067843 scopus 로고
    • Role of complements C3 and C5 in the phagocytosis of liposomes by human neutrophils
    • [50] Scieszka, J.F., Maggiora, L.L., Wright, S.D. and Cho, M.J. (1991) Role of complements C3 and C5 in the phagocytosis of liposomes by human neutrophils. Pharm. Res. 8, 65-69.
    • (1991) Pharm. Res. , vol.8 , pp. 65-69
    • Scieszka, J.F.1    Maggiora, L.L.2    Wright, S.D.3    Cho, M.J.4
  • 51
    • 0023701134 scopus 로고
    • Fluorescence analysis of size distribution and mode of dye release from carboxyfluorescein-loaded vesicles: Application to the study of complement-membrane interactions
    • [51] Liu, Z. and Hu, V.W. (1988) Fluorescence analysis of size distribution and mode of dye release from carboxyfluorescein-loaded vesicles: application to the study of complement-membrane interactions. Biochim. Biophys. Acta 945, 253-262.
    • (1988) Biochim. Biophys. Acta , vol.945 , pp. 253-262
    • Liu, Z.1    Hu, V.W.2
  • 52
    • 0021858187 scopus 로고
    • The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse
    • [52] Wisse, E., De Zanger, R.B., Charels, K., Van Der Smisse, P. and McCuskey, R.S. (1985) The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 5, 683-692.
    • (1985) Hepatology , vol.5 , pp. 683-692
    • Wisse, E.1    De Zanger, R.B.2    Charels, K.3    Van Der Smisse, P.4    McCuskey, R.S.5
  • 53
    • 0025267123 scopus 로고
    • Fine structure and function of Kupffer cells
    • [53] McCuskey, R.S. and McCuskey, P.A. (1990) Fine structure and function of Kupffer cells. J. Elec. Microsc. Techn. 14, 237-246.
    • (1990) J. Elec. Microsc. Techn. , vol.14 , pp. 237-246
    • McCuskey, R.S.1    McCuskey, P.A.2
  • 54
    • 0019832509 scopus 로고
    • Liposome disposition in vivo III. Dose and vesicle-size effects
    • [54] Abra, R.M. and Hunt, C.A. (1981) Liposome disposition in vivo III. Dose and vesicle-size effects. Biochim. Biophys. Acta 666, 493-503.
    • (1981) Biochim. Biophys. Acta , vol.666 , pp. 493-503
    • Abra, R.M.1    Hunt, C.A.2
  • 55
    • 0020682334 scopus 로고
    • Effect of liposome dose on the elimination of small unilamellar sphingomyelin/cholesterol vesicles from circulation
    • [55] Beaumier, P.L., Hwang, K.J. and Slattery, J.T. (1983) Effect of liposome dose on the elimination of small unilamellar sphingomyelin/cholesterol vesicles from circulation. Res. Commun. Chem. Pathol. Pharmacol. 39, 277-289.
    • (1983) Res. Commun. Chem. Pathol. Pharmacol. , vol.39 , pp. 277-289
    • Beaumier, P.L.1    Hwang, K.J.2    Slattery, J.T.3
  • 56
    • 0022995648 scopus 로고
    • Effects of dose and vesicle size on the pharmacokinetics of liposomes
    • [56] Sato, Y., Kiwada, H. and Kato, Y. (1986) Effects of dose and vesicle size on the pharmacokinetics of liposomes. Chem. Pharm. Bull. 34, 4244-4252.
    • (1986) Chem. Pharm. Bull. , vol.34 , pp. 4244-4252
    • Sato, Y.1    Kiwada, H.2    Kato, Y.3
  • 57
    • 0027489170 scopus 로고
    • Kinetic analysis of AUC-dependent saturable clearance of liposomes: Mathematical description of AUC dependency
    • [57] Harashima, H., Yamane, C., Kume, Y. and Kiwada, H. (1993) Kinetic analysis of AUC-dependent saturable clearance of liposomes: Mathematical description of AUC dependency. J. Pharmacokin. Biopharm. 21, 299-308.
    • (1993) J. Pharmacokin. Biopharm. , vol.21 , pp. 299-308
    • Harashima, H.1    Yamane, C.2    Kume, Y.3    Kiwada, H.4
  • 58
    • 0026082939 scopus 로고
    • Saturable, non-Michaelis-Menten uptake of liposomes by the reticuloendothelial system
    • [58] Kume, Y., Maeda, F., Harashima, H. and Kiwada, H. (1991) Saturable, non-Michaelis-Menten uptake of liposomes by the reticuloendothelial system. J. Pharm. Pharmacol. 43, 162-166.
    • (1991) J. Pharm. Pharmacol. , vol.43 , pp. 162-166
    • Kume, Y.1    Maeda, F.2    Harashima, H.3    Kiwada, H.4
  • 59
    • 0026767902 scopus 로고
    • Non-Michaelis-Menten type hepatic uptake of liposomes in the rat
    • [59] Harashima, H., Kume, Y., Yamane, C. and Kiwada, H. (1992) Non-Michaelis-Menten type hepatic uptake of liposomes in the rat. J. Pharm. Pharmacol. 44, 707-712.
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 707-712
    • Harashima, H.1    Kume, Y.2    Yamane, C.3    Kiwada, H.4
  • 60
    • 0014896886 scopus 로고
    • Physiology and physiopathology of the reticuloendothelial system
    • [60] Saba, T.M. (1970) Physiology and physiopathology of the reticuloendothelial system. Arch. Intern. Med. 126, 1031-1052.
    • (1970) Arch. Intern. Med. , vol.126 , pp. 1031-1052
    • Saba, T.M.1
  • 61
    • 0027467823 scopus 로고
    • Distinction between the depletion of opsonins and the saturation of uptake in the dose-dependent hepatic uptake clearance of liposomes
    • [61] Harashima, H., Sakata, K. and Kiwada, H. (1993) Distinction between the depletion of opsonins and the saturation of uptake in the dose-dependent hepatic uptake clearance of liposomes. Pharm. Res. 10, 606-610.
    • (1993) Pharm. Res. , vol.10 , pp. 606-610
    • Harashima, H.1    Sakata, K.2    Kiwada, H.3
  • 62
    • 0019974098 scopus 로고
    • Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics
    • [62] Boxenbaum, H. (1982) Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics. J. Pharmacokin. Biopharm. 10, 201-227.
    • (1982) J. Pharmacokin. Biopharm. , vol.10 , pp. 201-227
    • Boxenbaum, H.1
  • 63
    • 0021746592 scopus 로고
    • Prediction of the volume of distribution of basic drugs in humans based on data from animals
    • [63] Sawada, Y., Hanano, M., Sugiyama, Y., Harashima, H. and Iga, T. (1984) Prediction of the volume of distribution of basic drugs in humans based on data from animals. J. Pharmacokin. Biopharm. 12, 587-596.
    • (1984) J. Pharmacokin. Biopharm. , vol.12 , pp. 587-596
    • Sawada, Y.1    Hanano, M.2    Sugiyama, Y.3    Harashima, H.4    Iga, T.5
  • 64
    • 0026063359 scopus 로고
    • Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins
    • [64] Mordenti, J., Chen, S.A., Moore, J.A., Ferraiolo, B.L. and Green, J.D. (1991) Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins. Pharm. Res. 8, 1351-1359.
    • (1991) Pharm. Res. , vol.8 , pp. 1351-1359
    • Mordenti, J.1    Chen, S.A.2    Moore, J.A.3    Ferraiolo, B.L.4    Green, J.D.5
  • 65
    • 0029739890 scopus 로고    scopus 로고
    • Species difference in the disposition of liposomes among mice, rats and rabbits: Allometric relationship and species dependent: Hepatic uptake mechanism
    • in press
    • [65] Harashima, H., Komatsu, S., Kojima, S., Yanagi, C., Morioka, Y., Naito, M. and Kiwada, H. (1996) Species difference in the disposition of liposomes among mice, rats and rabbits: Allometric relationship and species dependent: hepatic uptake mechanism. Pharm. Res., in press.
    • (1996) Pharm. Res.
    • Harashima, H.1    Komatsu, S.2    Kojima, S.3    Yanagi, C.4    Morioka, Y.5    Naito, M.6    Kiwada, H.7
  • 66
    • 0021066575 scopus 로고
    • Targeting of lactosylceramide-containing liposomes to hepatocytes in vivo
    • [66] Spanjer, H.H. and Scherphof, G.L. (1983) Targeting of lactosylceramide-containing liposomes to hepatocytes in vivo. Biochim. Biophys. Acta 734, 40-47.
    • (1983) Biochim. Biophys. Acta , vol.734 , pp. 40-47
    • Spanjer, H.H.1    Scherphof, G.L.2
  • 67
    • 0023217578 scopus 로고
    • Specific incorporation of asialofetuinlabeled liposomes into hepatocytes through the action of galactose-binding protein
    • [67] Hara, T., Aramaki, Y., Tsuchiya, S., Hosoi, K. and Okada, A. (1987) Specific incorporation of asialofetuinlabeled liposomes into hepatocytes through the action of galactose-binding protein. Biopharm. Drug Dispos. 8, 327-339.
    • (1987) Biopharm. Drug Dispos. , vol.8 , pp. 327-339
    • Hara, T.1    Aramaki, Y.2    Tsuchiya, S.3    Hosoi, K.4    Okada, A.5
  • 68
    • 0025930905 scopus 로고
    • A membrane-bound form of the acute phase protein C-reactive protein is the galactose-specific particle receptor on rat liver macrophages
    • [68] Kolb-Bachofen, V. (1991) A membrane-bound form of the acute phase protein C-reactive protein is the galactose-specific particle receptor on rat liver macrophages. Pathobiology 59, 272-275.
    • (1991) Pathobiology , vol.59 , pp. 272-275
    • Kolb-Bachofen, V.1
  • 69
    • 0020162411 scopus 로고
    • Electron microscopic evidence for an asialoglycoprotein receptor on Kupffer cells: Localization of lectin-mediated endocytosis
    • [69] Kolb-Bachofen, V., Schlepper-Schaefer, J., Vogell, W. and Kolb, H. (1982) Electron microscopic evidence for an asialoglycoprotein receptor on Kupffer cells: Localization of lectin-mediated endocytosis. Cell 29, 859-866.
    • (1982) Cell , vol.29 , pp. 859-866
    • Kolb-Bachofen, V.1    Schlepper-Schaefer, J.2    Vogell, W.3    Kolb, H.4
  • 70
    • 0019359354 scopus 로고
    • Hapatic receptor for asialoglycoproteins: Ultrastructural demonstration of ligand-induced microaggregation of receptors
    • [70] Kolb-Bachofen, V. (1981) Hapatic receptor for asialoglycoproteins: Ultrastructural demonstration of ligand-induced microaggregation of receptors. Biochim. Biophys. Acta 645, 293-299.
    • (1981) Biochim. Biophys. Acta , vol.645 , pp. 293-299
    • Kolb-Bachofen, V.1
  • 72
    • 0025778627 scopus 로고
    • Targeting of liposomes surface-modified with glycyrrhizin to the liver. I. Preparation and biological disposition
    • [72] Tsuji, H., Osaka, S. and Kiwada, H. (1991) Targeting of liposomes surface-modified with glycyrrhizin to the liver. I. Preparation and biological disposition. Chem. Pharm. Bull. 39, 1004-1008.
    • (1991) Chem. Pharm. Bull. , vol.39 , pp. 1004-1008
    • Tsuji, H.1    Osaka, S.2    Kiwada, H.3
  • 73
    • 0028000384 scopus 로고
    • Uptake of liposomes surface-modified with glycyrrhizin by primary cultured rat hepatocytes
    • [73] Osaka, S., Tsuji, H. and Kiwada, H. (1994) Uptake of liposomes surface-modified with glycyrrhizin by primary cultured rat hepatocytes. Biol. Pharm. Bull. 17, 940-943.
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 940-943
    • Osaka, S.1    Tsuji, H.2    Kiwada, H.3
  • 74
    • 0019308886 scopus 로고
    • Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines
    • [74] Fidler, I.J. (1980) Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines. Science 208, 1469-1471.
    • (1980) Science , vol.208 , pp. 1469-1471
    • Fidler, I.J.1
  • 75
    • 0020061756 scopus 로고
    • Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide
    • [75] Schroit, A.J. and Fidler, I.J. (1982) Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide. Cancer Res. 42, 161-167.
    • (1982) Cancer Res. , vol.42 , pp. 161-167
    • Schroit, A.J.1    Fidler, I.J.2
  • 76
    • 0022226321 scopus 로고
    • Abrogation of species specificity for activation of tumoricidal properties in macrophages by recombinant mouse or human interferon-γ encapsulated in liposomes
    • [76] Fidler, I.J., Fogler, W.E., Kleinerman, E.S. and Saiki, I. (1985) Abrogation of species specificity for activation of tumoricidal properties in macrophages by recombinant mouse or human interferon-γ encapsulated in liposomes. J. Immunol. 135, 4289-4296.
    • (1985) J. Immunol. , vol.135 , pp. 4289-4296
    • Fidler, I.J.1    Fogler, W.E.2    Kleinerman, E.S.3    Saiki, I.4
  • 77
    • 0023037506 scopus 로고
    • Preparation and characterisation of liposomes containing mannosylated phospholipids capable of targeting drugs to macrophages
    • [77] Barratt, G., Tenu, J.P., Yapo, A. and Peti, J.F. (1986) Preparation and characterisation of liposomes containing mannosylated phospholipids capable of targeting drugs to macrophages. Biochim. Biophys. Acta 862, 153-164.
    • (1986) Biochim. Biophys. Acta , vol.862 , pp. 153-164
    • Barratt, G.1    Tenu, J.P.2    Yapo, A.3    Peti, J.F.4
  • 78
    • 0024432192 scopus 로고
    • Neo-mannosylated liposomes: Synthesis and interaction with mouse Kupffer cells and resident peritoneal macrophages
    • [78] Muller, C.D. and Schuber, F. (1989) Neo-mannosylated liposomes: synthesis and interaction with mouse Kupffer cells and resident peritoneal macrophages. Biochim. Biophys. Acta 986, 97-105.
    • (1989) Biochim. Biophys. Acta , vol.986 , pp. 97-105
    • Muller, C.D.1    Schuber, F.2
  • 79
    • 0025904202 scopus 로고
    • Enhancing effect of cetylmannoside on targeting of liposomes to Kupffer cells in rats
    • [79] Yamashita, C., Matsuo, H., Akiyama, K. and Kiwada, H. (1991) Enhancing effect of cetylmannoside on targeting of liposomes to Kupffer cells in rats. Int. J. Pharm. 70, 225-233.
    • (1991) Int. J. Pharm. , vol.70 , pp. 225-233
    • Yamashita, C.1    Matsuo, H.2    Akiyama, K.3    Kiwada, H.4
  • 80
    • 0025844925 scopus 로고
    • Potential value of cetylmannoside-modified liposomes as carriers of macrophage activators to human blood monocytes
    • [80] Yamashita, C., Sone, S., Ogura, T. and Kiwada, H. (1991) Potential value of cetylmannoside-modified liposomes as carriers of macrophage activators to human blood monocytes. Jpn. J. Cancer Res. 82, 569-576.
    • (1991) Jpn. J. Cancer Res. , vol.82 , pp. 569-576
    • Yamashita, C.1    Sone, S.2    Ogura, T.3    Kiwada, H.4
  • 81
    • 0028357719 scopus 로고
    • The complement-but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ
    • [81] Matsuo, H., Funato, K., Harashima,. H. and Kiwada, H. (1994) The complement-but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ. J. Drug Targ. 2, 141-146.
    • (1994) J. Drug Targ. , vol.2 , pp. 141-146
    • Matsuo, H.1    Funato, K.2    Harashima, H.3    Kiwada, H.4
  • 82
    • 0029882165 scopus 로고    scopus 로고
    • Size-dependent release of carboxy-fluorescein from cetylmannoside-modified liposomes in human plasma
    • [82] Ferdous, A.J., Ishida, T., Shinohara, M., Harashima, H. and Kiwada, H. (1996) Size-dependent release of carboxy-fluorescein from cetylmannoside-modified liposomes in human plasma. Biopharm. Drug Disposit. 17, 145-154.
    • (1996) Biopharm. Drug Disposit. , vol.17 , pp. 145-154
    • Ferdous, A.J.1    Ishida, T.2    Shinohara, M.3    Harashima, H.4    Kiwada, H.5
  • 83
    • 0028198199 scopus 로고
    • Plasma factor triggering alternative complement pathway activation by liposomes
    • [83] Funato, K., Yamashita, C., Kamada, J., Tominaga, S. and Kiwada, H. (1994) Plasma factor triggering alternative complement pathway activation by liposomes. Pharm. Res. 11, 372-376.
    • (1994) Pharm. Res. , vol.11 , pp. 372-376
    • Funato, K.1    Yamashita, C.2    Kamada, J.3    Tominaga, S.4    Kiwada, H.5
  • 84
    • 0023659741 scopus 로고
    • Large unilamellar liposomes with low uptake into the reticuloendothelial system
    • [84] Allen, T.M. and Chonn, A. (1987) Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett. 223, 42-46.
    • (1987) FEBS Lett. , vol.223 , pp. 42-46
    • Allen, T.M.1    Chonn, A.2
  • 85
    • 0842279809 scopus 로고
    • Liposome formulation with prolonged circulation time in blood and enhanced uptake by tumors
    • [85] Gabizon, A. and Papahadjopoulos, U. (1988) Liposome formulation with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. USA 85, 6949-6953.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6949-6953
    • Gabizon, A.1    Papahadjopoulos, U.2
  • 86
    • 0002474701 scopus 로고
    • Efficient evaluation of long-circulating or "stealth" liposomes by studied of in vivo blood circulation: Kinetics and final organ distribution
    • [86] Woodle, M.C., Newman, M., Collins, L., Redemann, C. and Martin, F.J. (1990) Efficient evaluation of long-circulating or "stealth" liposomes by studied of in vivo blood circulation: kinetics and final organ distribution. Proc. Int. Symp. Control. Rel. Bioact. Mater. 17, 77-78.
    • (1990) Proc. Int. Symp. Control. Rel. Bioact. Mater. , vol.17 , pp. 77-78
    • Woodle, M.C.1    Newman, M.2    Collins, L.3    Redemann, C.4    Martin, F.J.5
  • 87
    • 0025341615 scopus 로고
    • Amphipatic polyethyleneglycols effectively prolong the circulation time of liposomes
    • [87] Klibanov, A.L., Maruyama, K., Torchilin, V.P. and Huang, L. (1990) Amphipatic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 268, 235-237.
    • (1990) FEBS Lett. , vol.268 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 88
    • 0025053067 scopus 로고
    • Liposomes for the sustained drug release in vivo
    • [88] Blume, G. and Cevc, C. (1990) Liposomes for the sustained drug release in vivo. Biochim. Biophys. Acta 1029, 91-97.
    • (1990) Biochim. Biophys. Acta , vol.1029 , pp. 91-97
    • Blume, G.1    Cevc, C.2
  • 89
    • 0025071084 scopus 로고
    • Glucuronate-modified liposomes with prolonged circulation time
    • [89] Namba, Y., Sakakibara, T., Masada, M., Ito, F. and Oku, N. (1990) Glucuronate-modified liposomes with prolonged circulation time. Chem. Pharm. Bull. 38, 1663-1666.
    • (1990) Chem. Pharm. Bull. , vol.38 , pp. 1663-1666
    • Namba, Y.1    Sakakibara, T.2    Masada, M.3    Ito, F.4    Oku, N.5
  • 90
    • 0025731906 scopus 로고
    • Liposomes containing synthetic lipid derivatives of poly(ethyleneglycol) show prolonged circulation half-lives in vivo
    • [90] Allen, T.M., Hansen, C., Martin, F., Redemann, C. and Yau-Young, A. (1991) Liposomes containing synthetic lipid derivatives of poly(ethyleneglycol) show prolonged circulation half-lives in vivo. Biochim. Biophys. Acta 1066, 29-36.
    • (1991) Biochim. Biophys. Acta , vol.1066 , pp. 29-36
    • Allen, T.M.1    Hansen, C.2    Martin, F.3    Redemann, C.4    Yau-Young, A.5
  • 92
    • 0025789143 scopus 로고
    • Pharmacokinetics of stealth versus conventional liposomes: Effect of dose
    • [92] Allen, T.M. and Hansen, C. (1991) Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim. Biophys. Acta 1068, 133-141.
    • (1991) Biochim. Biophys. Acta , vol.1068 , pp. 133-141
    • Allen, T.M.1    Hansen, C.2
  • 93
    • 0025934604 scopus 로고
    • Sterically stabilized liposomes: A hypothesis on the molecular origin of the extended circulation times
    • [93] Lasic, D.D., Martin, F.J., Gabizon, A., Huang, S.K. and Papapadjopoulos, D. (1991) Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times. Biochim. Biophys. Acta 1070, 187-192.
    • (1991) Biochim. Biophys. Acta , vol.1070 , pp. 187-192
    • Lasic, D.D.1    Martin, F.J.2    Gabizon, A.3    Huang, S.K.4    Papapadjopoulos, D.5
  • 95
    • 0027533843 scopus 로고
    • M1 on liposome circulation time: Evidence supporting the dysopsonin hypothesis
    • M1 on liposome circulation time: evidence supporting the dysopsonin hypothesis. Biochim. Biophys. Acta 1166, 105-114.
    • (1993) Biochim. Biophys. Acta , vol.1166 , pp. 105-114
    • Park, Y.S.1    Huang, L.2
  • 97
    • 0028986113 scopus 로고
    • 1 shortens the blood circulation time of liposomes in rats
    • 1 shortens the blood circulation time of liposomes in rats. Pharm. Res. 12, 508-512.
    • (1995) Pharm. Res. , vol.12 , pp. 508-512
    • Liu, D.1    Liu, F.2    Song, Y.K.3
  • 99
    • 0027399121 scopus 로고
    • Molecular mechanism of the lipid vesicle longevity in vivo
    • [99] Blume, G. and Cevc, G. (1993) Molecular mechanism of the lipid vesicle longevity in vivo. Biochim. Biophys. Acta 1146, 157-168.
    • (1993) Biochim. Biophys. Acta , vol.1146 , pp. 157-168
    • Blume, G.1    Cevc, G.2
  • 100
    • 0026774346 scopus 로고
    • Sterically stabilized liposomes
    • [100] Woodle, M.C. and Lasic, D.D. (1992) Sterically stabilized liposomes. Biochim. Biophys. Acta 1113, 171-199.
    • (1992) Biochim. Biophys. Acta , vol.1113 , pp. 171-199
    • Woodle, M.C.1    Lasic, D.D.2
  • 101
    • 0015898287 scopus 로고
    • Experimental studies on the uptake and retention of labelled proteins in a rat tumor
    • [101] Peterson, H.M. and Applelgren, K.L. (1973) Experimental studies on the uptake and retention of labelled proteins in a rat tumor. Eur. J. Cancer 9, 543-547.
    • (1973) Eur. J. Cancer , vol.9 , pp. 543-547
    • Peterson, H.M.1    Applelgren, K.L.2
  • 103
    • 0026733476 scopus 로고
    • Microscopic localization of Sterically stabilized liposomes in colon carcinoma-bearing mice
    • [103] Huang, S.K., Lee, K-D., Hong, K., Friend, S.S. and Papahadjopoulos, D. (1992) Microscopic localization of Sterically stabilized liposomes in colon carcinoma-bearing mice. Cancer Res. 52, 5135-5143.
    • (1992) Cancer Res. , vol.52 , pp. 5135-5143
    • Huang, S.K.1    Lee, K.-D.2    Hong, K.3    Friend, S.S.4    Papahadjopoulos, D.5
  • 104
    • 0028304405 scopus 로고
    • Microvascular permeability and interstitial penetration of sterically stabilized (Stealth) liposomes in a human tumor xenograft
    • [104] Yuan, F., Leunig, M., Huang, S.K., Berk, D.A., Papahadjopoulos, D. and Jain, R.K. (1994) Microvascular permeability and interstitial penetration of sterically stabilized (Stealth) liposomes in a human tumor xenograft. Cancer Res. 54, 3352-3356.
    • (1994) Cancer Res. , vol.54 , pp. 3352-3356
    • Yuan, F.1    Leunig, M.2    Huang, S.K.3    Berk, D.A.4    Papahadjopoulos, D.5    Jain, R.K.6
  • 105
    • 0027242138 scopus 로고
    • Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumor tissue
    • [105] Wu, N.Z., Da, D., Rudoll, T.L., Needham, D., Whorton, A.R. and Dewhirst, M.W. (1993) Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumor tissue. Cancer Res. 53, 3765-3770.
    • (1993) Cancer Res. , vol.53 , pp. 3765-3770
    • Wu, N.Z.1    Da, D.2    Rudoll, T.L.3    Needham, D.4    Whorton, A.R.5    Dewhirst, M.W.6
  • 106
    • 0029057852 scopus 로고
    • Prediction of the maximal tolerated dose (MTD) and therapeutic effect of anticancer drugs in human: Integration of pharmacokinetics with pharmacodynamics and toxicodynamics
    • [106] Fuse, E., Kobayashi, T., Inaba, M. and Sugiyama, Y. (1995) Prediction of the maximal tolerated dose (MTD) and therapeutic effect of anticancer drugs in human: integration of pharmacokinetics with pharmacodynamics and toxicodynamics. Cancer Treat. Rev. 21, 133-157.
    • (1995) Cancer Treat. Rev. , vol.21 , pp. 133-157
    • Fuse, E.1    Kobayashi, T.2    Inaba, M.3    Sugiyama, Y.4
  • 107
    • 0023268886 scopus 로고
    • Influence of lipid composition on the antitumor activity exerted by doxorubicin-containing liposomes in a rat solid tumor model
    • [107] Storm, G., Roerdink, F.H., Steerenberg, P.A., de Jong, W.H. and Crommelin, D.J.A. (1987) Influence of lipid composition on the antitumor activity exerted by doxorubicin-containing liposomes in a rat solid tumor model. Cancer Res. 47, 3366-3372.
    • (1987) Cancer Res. , vol.47 , pp. 3366-3372
    • Storm, G.1    Roerdink, F.H.2    Steerenberg, P.A.3    De Jong, W.H.4    Crommelin, D.J.A.5
  • 108
    • 0028101079 scopus 로고
    • Effects of fluidity and vesicle size on antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin
    • [108] Nagayasu, A., Shimooka, T., Kinouchi, Y., Uchiyama, K., Takeichi, Y. and Kiwada, H. (1994) Effects of fluidity and vesicle size on antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin. Biol. Pharm. Bull. 17, 935-939.
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 935-939
    • Nagayasu, A.1    Shimooka, T.2    Kinouchi, Y.3    Uchiyama, K.4    Takeichi, Y.5    Kiwada, H.6
  • 109
    • 0027050420 scopus 로고
    • Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma
    • [109] Huang, S.K., Mayhew, E., Gilani, S., Lasic, D.D., Marin, F.J. and Papahadjopoulos, D. (1992) Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma. Cancer Res. 52, 6774-6781.
    • (1992) Cancer Res. , vol.52 , pp. 6774-6781
    • Huang, S.K.1    Mayhew, E.2    Gilani, S.3    Lasic, D.D.4    Marin, F.J.5    Papahadjopoulos, D.6
  • 110
    • 0028587933 scopus 로고
    • Endocytosis does not necessarily augment the cytotoxicity of adriamycin encapsulated in immunoliposomes
    • [110] Suzuki, S., Watanabe, S., Uno, S., Tanaka, M., Masuko, T. and Hashimoto, Y. (1994) Endocytosis does not necessarily augment the cytotoxicity of adriamycin encapsulated in immunoliposomes. Biochim. Biophys. Acta 1224, 445-453.
    • (1994) Biochim. Biophys. Acta , vol.1224 , pp. 445-453
    • Suzuki, S.1    Watanabe, S.2    Uno, S.3    Tanaka, M.4    Masuko, T.5    Hashimoto, Y.6
  • 111
    • 0027359026 scopus 로고
    • Identification of vesicle properties that enhance the antitumor activity of liposomal vincristine against murine L1210 leukemia
    • [111] Mayer, L.D., Nayar, R., Thies, R.L., Boman, N.L., Cullis, P.R. and Bally, M.B. (1993) Identification of vesicle properties that enhance the antitumor activity of liposomal vincristine against murine L1210 leukemia. Cancer Chemother. Pharmacol. 33, 17-24.
    • (1993) Cancer Chemother. Pharmacol. , vol.33 , pp. 17-24
    • Mayer, L.D.1    Nayar, R.2    Thies, R.L.3    Boman, N.L.4    Cullis, P.R.5    Bally, M.B.6
  • 112
    • 0025103345 scopus 로고
    • Liposomal vincristine preparations which exhibit decreased drug toxicity and increased activity against murine L1210 and P388 tumors
    • [112] Mayer, L.D., Bally, M.B., Loughrey, H., Masin, D. and Cullis, P.R. (1990) Liposomal vincristine preparations which exhibit decreased drug toxicity and increased activity against murine L1210 and P388 tumors. Cancer Res. 50, 575-579.
    • (1990) Cancer Res. , vol.50 , pp. 575-579
    • Mayer, L.D.1    Bally, M.B.2    Loughrey, H.3    Masin, D.4    Cullis, P.R.5
  • 113
    • 0017623677 scopus 로고
    • Liposome-cell interaction: Transfer and intracellular release of trapped fluorescent marker
    • [113] Weinstein, J.N., Yoshikami, S., Henkart, P., Bumenthal, R. and Hagins, W.A. (1977) Liposome-cell interaction: transfer and intracellular release of trapped fluorescent marker. Science, 195, 489-492.
    • (1977) Science , vol.195 , pp. 489-492
    • Weinstein, J.N.1    Yoshikami, S.2    Henkart, P.3    Bumenthal, R.4    Hagins, W.A.5
  • 114
    • 0019364294 scopus 로고
    • Biochemical, morphological, an ultrastructural studies on the uptake of liposomes by murine macrophages
    • [114] Raz, A., Bucana, C., Fogler, W.E., Poste, G. and Fidler, I.J. (1981) Biochemical, morphological, an ultrastructural studies on the uptake of liposomes by murine macrophages. Cancer Res. 41, 487-494.
    • (1981) Cancer Res. , vol.41 , pp. 487-494
    • Raz, A.1    Bucana, C.2    Fogler, W.E.3    Poste, G.4    Fidler, I.J.5
  • 115
    • 0020742162 scopus 로고
    • Endocytosis of liposomes and intracellular fate of encapsulate molecules: Encounter with a low pH compartment after internalization in coated vesicles
    • [115] Straubinger, R.M., Hong, K., Friend, D.S. and Papahadjopoulos, D. (1983) Endocytosis of liposomes and intracellular fate of encapsulate molecules: Encounter with a low pH compartment after internalization in coated vesicles. Cell 32, 1069-1079.
    • (1983) Cell , vol.32 , pp. 1069-1079
    • Straubinger, R.M.1    Hong, K.2    Friend, D.S.3    Papahadjopoulos, D.4
  • 116
    • 0020036421 scopus 로고
    • Mannose specific endocytosis receptor of alveolar macrophages: Demonstration of two functionally distinct intracellular pools of receptor and their roles in receptor recycling
    • [116] Tietze, C., Schlesinger, P. and Stahl, P. (1982) Mannose specific endocytosis receptor of alveolar macrophages: Demonstration of two functionally distinct intracellular pools of receptor and their roles in receptor recycling. J. Cell Biol. 92, 417-424.
    • (1982) J. Cell Biol. , vol.92 , pp. 417-424
    • Tietze, C.1    Schlesinger, P.2    Stahl, P.3
  • 117
    • 0024996478 scopus 로고
    • Receptor-mediated disposition of polypeptides: Kinetic analysis of the transport of epidermal growth factor as a model peptide using in vitro isolated perfused organs and in vivo system
    • [117] Sugiyama, Y., Kim, D.C., Sato, H., Yanai, S., Satoh, H., Iga, T. and Hanano, M. (1990) Receptor-mediated disposition of polypeptides: Kinetic analysis of the transport of epidermal growth factor as a model peptide using in vitro isolated perfused organs and in vivo system. J. Control. Rel. 13, 157-174.
    • (1990) J. Control. Rel. , vol.13 , pp. 157-174
    • Sugiyama, Y.1    Kim, D.C.2    Sato, H.3    Yanai, S.4    Satoh, H.5    Iga, T.6    Hanano, M.7
  • 118
    • 0022395051 scopus 로고
    • Dual pathways for the intracellular processing of insulin: Relationship between retroendocytosis of intact hormone and the recycling of insulin receptors
    • [118] Marshall, S. (1985) Dual pathways for the intracellular processing of insulin: Relationship between retroendocytosis of intact hormone and the recycling of insulin receptors. J. Biol. Chem. 260, 13524-13531.
    • (1985) J. Biol. Chem. , vol.260 , pp. 13524-13531
    • Marshall, S.1
  • 119
    • 0025300324 scopus 로고
    • Endocytosis and intracellular fate of liposomes using pyranine as a probe
    • [119] Straubinger, R.M., Papahadjopoulos, D. and Hong, K. (1990) Endocytosis and intracellular fate of liposomes using pyranine as a probe. Biochemistry 29, 4929-4939.
    • (1990) Biochemistry , vol.29 , pp. 4929-4939
    • Straubinger, R.M.1    Papahadjopoulos, D.2    Hong, K.3
  • 120
    • 0025296897 scopus 로고
    • Endocytosis of liposomes by macrophages: Binding, acidification and leakage of liposomes monitored by a new fluorescence assay
    • [120] Daleke, D., Hong, K. and Papahadjopoulos, D. (1990) Endocytosis of liposomes by macrophages: binding, acidification and leakage of liposomes monitored by a new fluorescence assay. Biochim. Biophys. Acta 1024, 352-366.
    • (1990) Biochim. Biophys. Acta , vol.1024 , pp. 352-366
    • Daleke, D.1    Hong, K.2    Papahadjopoulos, D.3
  • 121
    • 0022555867 scopus 로고
    • Acidification of the endocytic and exocytic pathways
    • [121] Mellman, I., Fuchs, R. and Helenius, A. (1986) Acidification of the endocytic and exocytic pathways. Annu. Rev. Biochem. 55, 663-700.
    • (1986) Annu. Rev. Biochem. , vol.55 , pp. 663-700
    • Mellman, I.1    Fuchs, R.2    Helenius, A.3
  • 122
    • 0023589188 scopus 로고
    • Acidification of morphologically distinct endosomes in mutant and wild-type chinese hamster ovary cells
    • [122] Yamashiro, D.J. and Maxfield, F.R. (1987) Acidification of morphologically distinct endosomes in mutant and wild-type chinese hamster ovary cells. J. Cell Biol. 105, 2723-2733.
    • (1987) J. Cell Biol. , vol.105 , pp. 2723-2733
    • Yamashiro, D.J.1    Maxfield, F.R.2
  • 123
    • 0024517745 scopus 로고
    • Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro
    • [123] Gruenberg, J., Griffiths, G. and Howell, K.E. (1989) Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro. J. Cell Biol. 108, 1301-1316.
    • (1989) J. Cell Biol. , vol.108 , pp. 1301-1316
    • Gruenberg, J.1    Griffiths, G.2    Howell, K.E.3
  • 124
  • 125
    • 0028893192 scopus 로고
    • Kinetic analysis of endocytosis and intracellular fate of liposomes in single macrophages
    • [125] Yoshimura, T., Shono, M., Imai, K. and Hong, K. (1995) Kinetic analysis of endocytosis and intracellular fate of liposomes in single macrophages. J. Biochem. 117, 34-41.
    • (1995) J. Biochem. , vol.117 , pp. 34-41
    • Yoshimura, T.1    Shono, M.2    Imai, K.3    Hong, K.4
  • 126
    • 0023830811 scopus 로고
    • Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes
    • [126] Schmid, S.L., Fuchs, R.M., Male, P. and Mellman, I. (1988) Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes. Cell 52, 73-83.
    • (1988) Cell , vol.52 , pp. 73-83
    • Schmid, S.L.1    Fuchs, R.M.2    Male, P.3    Mellman, I.4
  • 127
    • 0023614572 scopus 로고
    • Processing of different liposome markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages
    • [127] Derksen, J.T.P., Morselt, H.W.M. and Scherphof, G.L. (1987) Processing of different liposome markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages. Biochim. Biophys. Acta 931, 33-40.
    • (1987) Biochim. Biophys. Acta , vol.931 , pp. 33-40
    • Derksen, J.T.P.1    Morselt, H.W.M.2    Scherphof, G.L.3
  • 128
    • 0028954992 scopus 로고
    • Kinetic modelling of liposome degradation in peritoneal macrophages
    • [128] Harashima, H., Hirai, N. and Kiwada, H. (1995) Kinetic modelling of liposome degradation in peritoneal macrophages. Biopharm. Drug Dispos. 16, 113-123.
    • (1995) Biopharm. Drug Dispos. , vol.16 , pp. 113-123
    • Harashima, H.1    Hirai, N.2    Kiwada, H.3
  • 129
    • 85009548619 scopus 로고    scopus 로고
    • The effect of liposomal dose on the intracellular fate of liposomes in rats in vivo
    • [129] Morioka, Y., Harashima, H., Yoshimura, K. and Kiwada, H. (1996) The effect of liposomal dose on the intracellular fate of liposomes in rats in vivo. Drug Deliv. Syst. 11, 27-35.
    • (1996) Drug Deliv. Syst. , vol.11 , pp. 27-35
    • Morioka, Y.1    Harashima, H.2    Yoshimura, K.3    Kiwada, H.4
  • 130
    • 0024516188 scopus 로고
    • Effect of cholesterol on the uptake and intracellular degradation of liposomes by liver and spleen; a combined biochemical and γ-ray perturbed angular correlation study
    • [130] Roerdink, F.H., Regts, J., Handel, T., Sullivan, S.M., Baldeschwieler, J.D. and Scherphof, G.L. (1989) Effect of cholesterol on the uptake and intracellular degradation of liposomes by liver and spleen; a combined biochemical and γ-ray perturbed angular correlation study. Biochim. Biophys. Acta 980, 234-240.
    • (1989) Biochim. Biophys. Acta , vol.980 , pp. 234-240
    • Roerdink, F.H.1    Regts, J.2    Handel, T.3    Sullivan, S.M.4    Baldeschwieler, J.D.5    Scherphof, G.L.6
  • 132
    • 0027640355 scopus 로고
    • Antigen processing and intracellular traffic of antigens and MHC molecules
    • [132] Harding, C.V. and Geuze, H.J. (1993) Antigen processing and intracellular traffic of antigens and MHC molecules. Curr. Opin. Cell Biol. 5, 596-605.
    • (1993) Curr. Opin. Cell Biol. , vol.5 , pp. 596-605
    • Harding, C.V.1    Geuze, H.J.2
  • 133
    • 0021962739 scopus 로고
    • Cytoplasmic delivery of a fluorescent dye by pH-sensitive immunoliposomes
    • [133] Connor, J. and Huang, L. (1985) Cytoplasmic delivery of a fluorescent dye by pH-sensitive immunoliposomes. J. Cell Biol. 101, 582-589.
    • (1985) J. Cell Biol. , vol.101 , pp. 582-589
    • Connor, J.1    Huang, L.2
  • 134
    • 0028346274 scopus 로고
    • Characterization and kinetics of MHC class I-restricted presentation of a soluble antigen delivered by liposomes
    • [134] Zhou, F., Watkins, S.C. and Huang, L. (1994) Characterization and kinetics of MHC class I-restricted presentation of a soluble antigen delivered by liposomes. Immunobiology 190, 35-52.
    • (1994) Immunobiology , vol.190 , pp. 35-52
    • Zhou, F.1    Watkins, S.C.2    Huang, L.3
  • 135
    • 0026057743 scopus 로고
    • Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells
    • [135] Harding, C.V., Collins, D.S., Slot. J.W., Geuze, H.J. and Unanue, E.R. (1991) Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells. Cell 64, 393-401.
    • (1991) Cell , vol.64 , pp. 393-401
    • Harding, C.V.1    Collins, D.S.2    Slot, J.W.3    Geuze, H.J.4    Unanue, E.R.5


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