Influence of stearylamine and dicetylphosphate on the physical properties of submicron O/W emulsions

Journal de Pharmacie de Belgique

Volumn 53, Issue 2, 1998, Pages 81-86

  Mbela, N ^a   Verschueren, E ^b   Ludwig, A ^b  

^a UNIVERSITY OF KINSHASA   (Congo)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Charge; Dicetylphosphate; Lecithins; Stability; Stearylamine; Submicron O W emulsions

Indexed keywords

DICETYL PHOSPHATE; MEDIUM CHAIN TRIACYLGLYCEROL; OCTADECYLAMINE; PHOSPHATIDYLCHOLINE; SORBITOL; SOYBEAN OIL; SUNFLOWER OIL;

ARTICLE; DRUG ANALYSIS; DRUG BIOAVAILABILITY; ELECTRICITY; EMULSION; LIPOPHILICITY; PARTICLE SIZE;

AMINES; EMULSIONS; EXCIPIENTS; PARTICLE SIZE; PHOSPHORIC ACID ESTERS;

EID: 0031807436     PISSN: 00472166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Harashima H. and Kiwada H. Liposomal targeting and drug delivery: kinetic consideration. Adv. Drug Delivery Rev., 19, 425-444 (1996).
2. Liu F. and Liu D. Long circulating emulsions (oil-in-water) as carriers for lipophilic drugs. Pharm. Res., 12, 1060-1064 (1995).
3. Elbaz E., Zeevi A., Klang S. and Benita S. Positively charged submicron emulsions - a new type of colloidal drug carrier. Int. J. Pharm., 96, R1-R6 (1993).
4. Li Y. and Mitra A.K. Effects of phospholipid chain length, concentration, charge, and vesicle size on pulmonary insulin absorption. Pharm. Res., 13, 76-79 (1996).
5. Klang S.H., Frucht-Pery J., Hoffman A. and Benita S. Physicochemical characterization and acute toxicity evaluation of a positively-charged submicron emulsion. J. Pharm. Pharmacol., 46, 986-993 (1994).
6. Klang S.H., Baszkin A. and Benita S. The stability of piroxicam incorporated in positively-charged submicron emulsion for ocular administration. Int. J. Pharm., 132, 33-44 (1996).
7. Mbela N. and Ludwig A. Physical properties and stability evaluation of submicron mefloquine emulsions. - S.T.P. Pharma Sci., 5, 225-231 (1995).
8. Mbela, N. and Verschueren, E. The influence of additives on physical properties of emulsions prepared using lecithins and non-ionic surfactants. J. Pharm. Belg., 52, 110 -116 (1997).
9. Crommelin D.J.A. Influence of lipid composition and ionic strength on the physical stability of liposomes.-J. Pharm. Sci., 73, 1559 -1563 (1984).
10. Korner D., Benita S., Albrecht G. and Baszkin A. - Surface properties of mixed phospholipid-stearylamine monolayers and their interaction with a non-ionic surfactant (poloxamer). - Colloids and Surfaces, 3, 101-109, 1994.