Novobiocin inhibits both UDP-glucuronosyltransferase and cytochrome P450-mediated enzyme activities in pig liver microsomes

Veterinary Research Communications

Volumn 22, Issue 6, 1998, Pages 405-414

  Villar, D ^a   Furusawa, N ^b   Monshouwer, M ^c   Van Miert, A S J P A M ^c  

^a SCOTTISH CROP RESEARCH INSTITUTE   (United Kingdom)

^b Osaka Prefecture University   (Japan)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Cytochrome P450; Drug interactions; Novobiocin; Pig; UDP glucuronosyltransferase

Indexed keywords

1 NAPHTHOL; ANTIBIOTIC AGENT; CYTOCHROME P450; ERYTHROMYCIN; GLUCURONOSYLTRANSFERASE; NOVOBIOCIN; PARACETAMOL; TESTOSTERONE;

ANIMAL TISSUE; ARTICLE; DEMETHYLATION; DRUG EFFECT; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER MICROSOME; MALE; NONHUMAN; SWINE;

ACETAMINOPHEN; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; ERYTHROMYCIN; GLUCURONOSYLTRANSFERASE; MALE; MICROSOMES, LIVER; NAPHTHOLS; NOVOBIOCIN; SWINE; TESTOSTERONE;

ANIMALIA; SUS SCROFA;

EID: 0031789619     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006101530107     Document Type: Article

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