Mice lacking the type I interleukin-1 receptor do not lose bone mass after ovariectomy

Endocrinology

Volumn 139, Issue 6, 1998, Pages 3022-3025

  Lorenzo, Joseph A ^a   Naprta, Anica ^b   Rao, Yue ^b   Alander, Cynthia ^b   Glaccum, Moira ^c   Widmer, Michael ^c   Gronowicz, Gloria ^b   Kalinowski, Judith ^a   Pilbeam, Carol C ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; INTERLEUKIN 1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE TURNOVER; CONTROLLED STUDY; FEMALE; HORMONAL REGULATION; HUMERUS; MOUSE; NONHUMAN; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRABECULAR BONE;

EID: 0031786374     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.6.6128     Document Type: Article

References (20)

1. Horowitz, M.C. 1993. Cytokines and estrogen in bone: Anti-osteoporotic effects. Science 260:626-627.
2. Riggs, B.L. and L.J. Melton, III. 1992. Drug Therapy: The prevention and treatment of osteoporosis. N Engl J Med 327:620-627.
3. Manolagas, S.C. and R.L. Jilka. 1995. Mechanisms of disease: Bone marrow, cytokines, and bone remodeling-Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332:305-311.
4. Pacifici, R. 1996. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res 11:1043-1051.
5. Dinarello, C.A. 1991. Interleukin-1 and interleukin-1 antagonism. Blood 77:1627-1652.
6. Colotta, F., S.K. Dower, J.E. Sims, and A. Mantovani. 1994. The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1. [Review]. Immunol Today 15:562-566.
7. Sims, J.E., M.A. Gayle, J.L. Slack, M.R. Alderson, T.A. Bird, J.G. Giri, F. Colotta, F. Re, A. Mantovani, and K. Shanebeck. 1993. Interleukin 1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci U.S.A. 90:6155-6159.
8. Colotta, F., F. Re, M. Muzio, R. Bertini, N. Polentarutti, M. Sironi, J.G. Giri, S.K. Dower, J.E. Sims, and A. Mantovani. 1993. Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4. Science 261:472-475.
9. Vargas, S.J., A. Naprta, M. Glaccum, S.K. Lee, J. Kalinowski, and J.A. Lorenzo. 1996. Interleukin-6 expression and histomorphometry of bones from mice deficient in receptors for interleukin-1 or tumor necrosis factor. J Bone Miner Res 11:1736-1744.
10. Glaccum, M.B., K.L. Stocking, K. Clarrier, J.L. Smith, C.R. Willis, C. Maliszewski, D. J. Livingston, J.J. Peschon, and P.J. Morrissey. 1997. Phenotypic and functional characterization of mice that lack the type 1 receptor for IL-1. J Immunol 159:3364-3371.
11. Bancroft, J.D. 1990. Enzymatic Histochemistry. p. 379-399. In: J.D. Bancroft and A. Stevens. (ed.), The Theory and Practice of Histologic Techniques. Churchill Livingstone, London, U.K.
12. Luna, L.G. 1968. Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology, p. 32-46. McGraw-Hill, New York, NY, U.S.A.
13. Zeller, R. 1989. Fixation, embedding and sectioning of tissues, embryos, and single cells, p. 14.1.1-14.1.8. F.M. Ausubel, R. Brent, R.E. Kingston, D.D. More, J.G. Seidmen, J.A. Smith, and K. Struhl. (ed.), Current Protocols in Molecular Biology. John Wiley and Sons, New York, NY, U.S.A.
14. Parfitt, A. M., Drezner, M. K., Glorieux, F., Kanis, J. A., Malluche, H. H., Meunier, P. J., Ott, S. M., and Recker, R. R. 1987 Bone histomorphometry: Standardization of nomenclature, symbols and units. J Bone Min Res 2:595-610.
15. Ammann, P., R. Rizzoli, J.P. Bonjour, S. Bourrin, J.M. Meyer, P. Vassalli, and I. Garcia. 1997. Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. J Clin Invest 99:1699-1703.
16. Kawaguchi, H., C.C. Pilbeam, S.J. Vargas, E.E. Morse, J.A. Lorenzo, and L.G. Raisz. 1995. Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae. J Clin Invest 96:539-548.
17. Miyaura, C., K. Kusano, T. Masuzawa, O. Chaki, Y. Onoe, M. Aoyagi, T. Sasaki, T. Tamura, Y. Koishihara, Y. Ohsugi, and T. Suda. 1995. Endogenous bone-resorbing factors in estrogen deficiency: Cooperative effects of IL-1 and IL-6. J Bone Min Res 10:1365-1373.
18. Pilbeam, C., Y. Rao, C. Alander, O. Voznesensky, Y. Okada, J.E. Sims, L. Raisz, and J. Lorenzo. 1997. Downregulation of mRNA expression for the "decoy" interleukin-1 receptor 2 by ovariectomy in mice. J Bone Min Res 12 Supp. 1:S433 (Abstract)
19. Sunyer, T., J. Lewis, and P. Osdoby. 1997. Estrogen decreases the steady state levels of the IL-1 signaling receptor (Type I) while increasing those of the IL-1 decoy receptor (Type II) mRNAs in human osteoclast-like cells. J Bone Min Res 12 Supp. 1:S135 (Abstract)
20. Re, F., M. Sironi, M. Muzio, C. Matteucci, M. Introna, S. Orlando, G. Penton-Rol, S.K. Dower, J.E. Sims, F. Colotta, and A. Mantovani. 1996. Inhibition of interleukin-1 responsiveness by type II receptor gene transfer: A surface "receptor" with anti-interleukin-1 function. J Exp Med 183:1841-1850.