DNA breaks detected by in situ end-labelling in dorsal root ganglia of patients with AIDS

Neuropathology and Applied Neurobiology

Volumn 24, Issue 5, 1998, Pages 373-380

  Adle Biassette, H ^a   Bellt, J E ^b   Creange, A ^c   Sazdovitcht, V ^d   Authier, F J ^a   Gray, F ^a   Hauwt, J J ^b   Gherardi, R ^c  

^a HENRI MONDOR HOSPITAL   (France)

^b Groupe d'Etude et de Recherche Sur le Muscle et le Nerfs   (France)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

AIDS; Apoptosis; Distal sensory axonal polyneuropathy; Dorsal root ganglia; HIV; Neuropathology

Indexed keywords

CD4 ANTIGEN; DNA FRAGMENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; FEMALE; HUMAN; HUMAN TISSUE; LYMPHOCYTE COUNT; MALE; PATHOGENESIS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; SENSORY NERVE CELL; SPINAL GANGLION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AGED; APOPTOSIS; DNA FRAGMENTATION; FEMALE; GANGLIA, SPINAL; HUMANS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; NEURONS, AFFERENT; POLYNEUROPATHIES;

EID: 0031785637     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.1998.00135.x     Document Type: Article

References (34)

1. Adle-Biassette H, Levy Y, Colombel M et al. Neuronal apoptosis in HIV infection in adults. Neuropathol Appl Neiirobid 1995; 21: 218-27
2. Ahlgren S, Li GL, OIsson Y. Accumulation of beta-amyloid precursor protein and ubiquitin in axons after spinal cord trauma in humans: immunohistochemical observations on autopsy material. Acta Neuropathol (Berl) 1996; 92: 49-55
3. Ameisen JC. Programmed cell death (apoptosis) and AIDS pathogenesis. Aids Res Human Retroviruses 1994; 10 (Suppl. l):S3-5
4. An SF, Giometto B, Groves M et al. Axonal damage revealed by accumulation of beta-AI'P in HIV-positive individuals without AIDS. J Neuropathol Exp Neurol 1997; 56: 1262-8
5. An SF, Giometto B, Scaravilli T, Tavolato B, Gray F, Scaravilli F. Programmed cell death in brains of HIV1-positive AIDS and pre-AIDS patients. Acta Neuropathologica 1996; 91: 169-73
6. Barohn RJ, Gronseth GS, LeForce BR et al. Peripheral nervous system involvement in a large cohort of human immunodeficiency virus-infected individuals [published erratum appears in Arch Neurol 1993, 50, 388]. Arch Neurol 1993: 50: 167-71
7. Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. JNeuroscience 1994; 14:4368-74
8. Cohen J. Apoptosis. Iininwwl Today 1993; 14: 126-30
9. Cornblath DR, McArthur JC. Predominantly sensory neuropathy in patients with AIDS and AIDS-related complex. Neurology 1988: 38: 794-6
10. Cottrez F, Manca F, Dalgleish AG, Arenzana-Seisdedos F, Capron A, Groux II. Priming of human CD4-f antigenspecific T cells to undergo apoptosis by HIV-infected monocytes. A two-step mechanism involving the gp120 molecule. J Clin Invest 1997; 99: 257-66
11. de la Monte SM, Gabuzda DH, Ho DD et al. Peripheral neuropathy in the acquired immunodeficiency syndrome. Aim Neurol 1988; 23: 485-92
12. Esiri MM, Morris CS, Millard PR. Sensory and sympathetic ganglia in HIV-1 infection. Immunocytochemical demonstration of HIV-1 viral antigens, increased MHC class II antigen expression and mild reactive inflammation. J Neurol Sci 1993; 114: 178-87
13. Everall IP, Glass JD, McArthur J, Spargo E, Lantos P. Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia. Acta Neuropathol (Ecrl) 1994; 88: 538-44
14. Everall IP, Luthert PJ, Lantos PL. Neuronal loss in the frontal cortex in HIV infection [see comments]. Lancet 1991; 337: 1119-21
15. Gelbard HA, James HJ, Sharer LR et al. Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol Appl Neurobiol 1995:21:208-17
16. Gougeon ML, Laurent ÇA, Hovanessian AG, Montagnier L. Direct and indirect mechanisms mediating apoptosis during HIV infection. Contribution to vivo CD4 T cell depletion. Semin Immimol 1993; 5: 187-94
17. Gray F, Adle-Biassette H, Wingertsmann L, Héry C. Tardieu M, Scaravilli F. Axonal damage in AIDS brains, its relationship to neuronal apoptosis and to blood brain barrier alteration. Brain Pathol 1997; 7: 1258-60
18. Gray F, Haug H, Chimelli L et al. Prominent cortical atrophy with neuronal loss as correlate of human immunodeficiency virus encephalopathy. Ada Neuropathol (Berl) 1991; 82: 229-33
19. Groves MJ, Christopherson T, Giometto B, Scaravilli F. Axotomy-induced apoptosis in adult rat primary sensory neurons. J Neurocytol 1997; 26: 615-24
20. Hall CD, Snyder CR, Messenheimer JA et al Peripheral neuropathy in a cohort of human immunodeficiency virusinfected patients. Incidence relationship to other nervous system dysfunction. Arch Neurol 1991; 48: 1273-4
21. Harouse JM, Kunsch C, Hartle HT et al. CD4-indepcndent infection of human neural cells by human immunodeficiency virus type 1. J Virol 1989; 63: 2527-33
22. Ketzler S, Weis S, Haug H, Budka H. Loss of neurons in the frontal cortex in AIDS brains. Ada Neuropathol (Berl) 1990; 80: 92-4
23. Kozlowski MR, Sandier P, Lin PF, Watson A. Brain-derived cells contain a specific binding site for Gpl20 which is not the CD4 antigen. Brain Res 1991; 553: 300-4
24. Lefaucheur JP, Authier FJ, Verroust J, Gherardi RK. Zidovudine and human immunodeficiency virus-associated peripheral neuropathies. Low intake patients with mononeuropathy multiplex no evidence for neurotoxicity. Muscle Nen'c 1997; 20: 106-9
25. Li XL, Moudgil T, Vinters HV, Ho DD. CD4-independent. productive infection of a neuronal cell line by human immunodeficiency virus type 1. J Virol 1990; 64: 1383-7
26. Masson C. Ratinahirana H, Henin D et al. Morphometric stydy of the superficial peroneal nerve and L5 posterior root ganglion in 26 cases of AIDS. Neurology 1990; 40 (Suppl. 1): 428: 1132P (Abstract)
27. Oster S, Christoffersen P, Gundersen HJ, Nielsen JO, Pedersen C, Pakkenberg B. Six billion neurons lost in AIDS. A stereological study of the neocortex. APMIS 1995; 103: 525-9
28. Petito CK, Roberts B. Evidence of apoptotic cell death in HIV encephalitis [see comments]. Am ] Pathol 1995; 146: 1121-30
29. Scaravilli F. Sinclair E. Arango JC, Manji H, Lucas S, Harrison MJ. The pathology of the posterior root ganglia in AIDS and its relationship to the pallor of the gracile tract. Ada Neuropathol (Berl) 1992; 84: 163-70
30. Seilhean D, Duyckaerts C, Vazeux R et al. HIV-1-associated cognitive/motor complex. Absence neuronal loss cerebral neocortex [see comments]. Neurology 1993; 43: 1492-9
31. Shapshak P, Sun NC, Resnick L et ni. HIV-1 propagates in human neuroblastoma cells. J Acquir Immune Deßc Syndr 1991:4:228-37
32. Shi B, De Guiolami U, He J et al. Apoptosis induced by HIV-1 infection of the central nervous system. J Clin Invest 1996; 98: 1979-90
33. Suzuki H. Oyamagi K, Takahashi H, Kono M, Yokoyama M, Ikuta F. A quantitative pathological investigation of the cervical cord, roots and ganglia after long-term amputation of the unilateral upper arm. Acta Neuropathol 1993; 85: 666-73
34. Wyllie A, Duvall E. Cell injury and death. In Oxford Textbook of Pathology. Eds J O'D McGee. PG Isaacson, NA \Vright. Oxford: Oxford University Press. 1992 171