Defective antigen-presenting cell function in patients with systemic lupus erythematosus: Role of the B7-1 (CD80) costimulatory molecule

Arthritis and Rheumatism

Volumn 39, Issue 4, 1996, Pages 600-609

  Tsokos, George C ^a,d   Kovacs, Birgit ^a   Sfikakis, Peter P ^a,c   Theocharis, Stamatis ^a,c   Vogelgesang, Scott ^a   Via, Charles S ^b  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^d WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; B7 ANTIGEN; FC RECEPTOR; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 2; MONOCLONAL ANTIBODY CD3; OKT 3; TETANUS TOXOID;

ADOLESCENT; ADULT; ANTIGEN DETECTION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; IMMUNOSTIMULATION; MALE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; ADULT; ANTIBODY FORMATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD3; ANTIGENS, CD80; FEMALE; HUMANS; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MALE; RECEPTORS, IGG; TETANUS TOXOID;

EID: 0029929607     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390409     Document Type: Article

References (30)

1. Cohen PL: T- and B-cell abnormalities in systemic lupus. J Invest Dermatol 100:69S-72S, 1993
2. Tsokos GC: Overview of cellular immune function in systemic lupus erythematosus. In, Systemic Lupus Erythematosus. Edited by RG Lahita. New York, Churchill Livingstone, 1992
3. Tsokos GC: Lymphokines, cytokines, inflammation and immune trafficking. Curr Opin Rheumatol 6:461-467, 1994
4. Via CS, Handwerger BS: B-cell and T-cell function in systemic lupus erythematosus. Curr Opin Rheumatol 5:570-574, 1993
5. Via CS, Tsokos GC, Bermas B, Clerici M, Shearer GM: T cell-antigen-presenting cell interactions in human systemic lupus erythematosus: evidence for heterogeneous expression of multiple defects. J Immunol 151:3914-3922, 1993
6. June CH, Bluestone JA, Nadler LM, Thompson CB: The B7 and CD28 receptor families. Immunol Today 15:321-331, 1994
7. June CH, Ledbetter JA, Linsley PS, Thompson CB: Role of the CD28 receptor in T-cell activation. Immunol Today 11:211-216, 1990
8. Guinan EC, Gribben JG, Boussiotis VA, Freeman GJ, Nadler LM: Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood 84:3261-3282, 1994
9. Zhou T, Weaver C, Linsley PS, Mountz JD: T cells of staphylococcal enterotoxin B-tolerized autoimmune MRL-lpr/lpr mice require co-stimulation through the B7-CD28/CTL-4 pathway for activation and can be reenergized in vivo by stimulation of the T cell receptor in the absence of this costimulatory signal. Eur J Immunol 24:1019-1025, 1994
10. Linker-Israeli M, Bakke AC, Kitridou RC, Gendler S, Gillis S, Horwitz DA: Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE). J Immunol 130:2651-2655, 1983
11. Nagai H, Sztein MB, Steeg PS, Hooks JJ, Oppenheim JJ, Steinberg AD: Diminished peripheral blood monocyte DR antigen expression in systemic lupus erythematosus. Clin Exp Rheumatol 2:131-137, 1984
12. Shirakawa F, Vamashito V, Susuki H: Decrease to HLA-DR-positive monocyte in patients with SLE. J Immunol 134:3560-3562, 1985
13. Frank MM, Hamburger MI, Lawley TJ, et al: Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med 300:518-523, 1979
14. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277, 1982
15. Urowitz MB, Gladman DD, Tozman EC, Goldsmith CH: The lupus activity criteria count (LACC). J Rheumatol 11:783-787, 1984
16. Shivakumar S, Tsokos GC, Datta SK: T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J Immunol 143: 103-112, 1989
17. Freedman AS, Freeman G, Ryhnhart K, Nadler LM: Selective induction of B7/BB1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol 137:429-437, 1991
18. Azuma M, Cayabyab M, Buck D, Phillips JH, Lanier LL: CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J Exp Med 175:353-360, 1992
19. Yokochi TR, Holly D, Clark EA: B lymphoblast antigen (BB1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines and Burkitt's lymphomas. J Immunol 128:823-827, 1982
20. Bermas BL, Petri M, Goldman D, Mittleman B, Miller MW, Stocks NI, Via CS, Shearer GM: T helper cell dysfunction in systemic lupus erythematosus (SLE): relation to disease activity. J Clin Immunol 14:169-177, 1994
21. Sfikakis PP, Oglesby R, Sfikakis P, Tsokos GC: B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 96:8-14, 1994
22. Crow MK, DelGiudice-Asch G, Zehetbauer JB, Lawson JL, Brot N, Weissbach H, Elkon KB: Autoantigen-specific T cell proliferation induced by the ribosomal P2 protein in patients with systemic lupus erythematosus. J Clin Invest 94:345-352, 1994
23. Crow MK: Enhancement of the impaired autologous mixed leukocyte reaction in patients with systemic lupus erythematosus. J Clin Invest 76:807-815, 1985
24. Plana M, Font J, Vinas O, Martorell J, Ingelmo M, Vives J: Responsiveness of T lymphocytes from systemic lupus erythematosus to signals provided through CD26 antigen. Clin Immunol Immunopathol 72:227-232, 1994
25. Finck BK, Linsley PS, Wofsy D: Treatment of murine lupus with CTLA4Ig. Science 265:1225-1227, 1994
26. Via C, Rus V, Linsley P, Cause W: CTL4 Ig prevents acute and chronic murine graft-versus-host disease in the parent-into-F1 model. FASEB J 9:499, 1995
27. Nickoloff BJ, Mitra RS, Lee K, Turka LA, Green J, Thompson C, Shimizu Y: Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo. Am J Pathol 142:1029-1040, 1993
28. Harlan DM, Hengartner H, Huang ML, Kang YH, Abe R, Moreadith RW, Pircher H, Gray GS, Ohashi PS, Freeman GJ: Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc Natl Acad Sci U S A 91:3137-3141, 1994
29. Lanier LL, O'Fallon S, Somoza C, Phillips JH, Linsley PS, Okumura K, Ito D, Azuma M: CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol 154: 97-105, 1995
30. Rajagopalan S, Zordan T, Tsokos GC, Datta SK: Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: isolation of CD4-8- T helper cell lines that express the gamma delta T-cell antigen receptor. Proc Natl Acad Sci U S A 87:7020-7024, 1990