Potent CD14-mediated signalling of human leukocytes by Escherichia coli can be mediated by interaction of whole bacteria and host cells without extensive prior release of endotoxin

Infection and Immunity

Volumn 64, Issue 9, 1996, Pages 3592-3600

  Katz, Seth S ^a   Chen, Kun ^a   Chen, Shu ^a   Doerfler, Martin E ^a   Elsbach, Peter ^a   Weiss, Jerrold ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CD14 ANTIGEN; ESCHERICHIA COLI ENDOTOXIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN DETECTION; ARTICLE; ENTEROBACTER INFECTION; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RESPIRATORY BURST;

EID: 0029781288     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.9.3592-3600.1996     Document Type: Article

References (63)

1. Dedrick, R. L., and P. J. Conlon. 1995. Prolonged expression of lipopolysaccharide (LPS)-induced inflammatory genes in whole Mood requires continual exposure to LPS. Infect. Immun. 63:1362-1368.
2. Doerfler, M. E., J. Weiss, J. D. Clark, and P. Elsbach. 1994. Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2. J. Clin. Invest. 93:1583-1591.
3. Elbein, A. D., and E. C. Heath. 1965. The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. I. The biochemical properties of a uridine diphosphate galactose 4-epimeraseless mutant. J. Biol. Chem. 240:1919-1925.
4. Elsbach, P. 1990. Antibiotics from within: antibacterials from human and animal sources. Trends Biotechnol. 8:26-30.
5. Elsbach, P., and J. Weiss. 1992. Oxygen-independent antimicrobial systems of phagocytes, p. 603-636. In J 1. Gallin, I. M. Goldstein, and R. Snyderman (ed.), Inflammation: basic principles and clinical correlates, 2nd ed. Raven Press, Now York.
6. Elsbach, P., and J. Weiss. 1993. The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide. Immunobiology 187:417-429.
7. Elsbach, P., and J. Weiss. 1995. Prospects for the use of recombinant BPI in the treatment of Gram-negative bacterial infections. Infect. Agents Dis. 4:102-109.
8. Elsbach, P., J. Weiss, and O. Levy. 1994. Integration of antimicrobial host defenses: role of the bacterieidal/permeability-increasing protein. Trends Microbiol. Sci. 2:324-328.
9. Galanos, C., V. Lehmann, O. Lüderitz, E. T. Rietschel, O. Westphal, H. Brade, L. Brade, M. A. Freudenberg, T. Hansen-Hagge, T. Lüderitz, G. McKenzie, U. Schade, W. Strittmatter, K. Tanamoto, U. Zähringer, M. Imoto, H. Yoshimura, M. Yamamoto, T. Shimamoto, S. Kusumoto, and T. Shiba. 1984. Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A. Eur. J. Biochem. 140:221-227.
10. Gallay, P., S. Carrel, M. P. Glauser, C. Barras, R. J. Ulevitch, P. S. Tobias, J. D. Baumgartner, and D. Heumann. 1993. Purification and characterization of murine lipopolysaccharide-binding protein. Infect. Immun. 61:378-383.
11. Galloway, S. M., and C. R. Raetz. 1990. A mutant of Escherichia coli defective in the first step of endotoxin biosynthesis. J. Biol. Chem. 265:6394-6402.
12. Gazzano-Santoro, H., J. B. Parent, L. Grinna, A. Horwitz, T. Parsons, G. Theofan, P. Elsbach, J. Weiss, and P. J. Conlon. 1992. High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide. Infect. Immun. 60:4754-4761.
13. Golenbock, D. T., R. Y. Hampton, C. R. Raetz, and S. D. Wright. 1990. Human phagocytes have multiple lipid A-binding sites. Infect. Immun. 58: 4069-4075.
14. Grunwald, U., G. Oeser, H. D. Schröder, D. Ritscher, and C. Schütt. 1992. Binding of LPS to CD14. Immun. Infekt. 20:86-87.
15. Haziot, A., S. Chen, E. Ferrero, M. G. Low, R. Silber, and S. M. Goyert. 1988. The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J. Immunol. 141:547-552.
16. Haziot, A., B. Z. Tsuberi, and S. M. Goyert. 1993. Neutrophil CD14: biochemical properties and role in the secretion of tumor necrosis factor-alpha in response to lipopolysaccharide. J. Immunol. 150:5556-5565.
17. Howard, C. J., and A. A. Glynn. 1971. The virulence for mice of strains of Escherichia coli related to the effects of K antigens on their resistance to phagocytosis and killing by complement. Immunology 20:767-777.
18. Ingalls, R. R., and D. T. Golenbock. 1995. CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide. J. Exp. Med. 181:1473-1479.
19. Jack, R. S., U. Grunwald, F. Stelter, G. Workalemahu, and C. Schütt. 1995. Both membrane-bound and soluble forms of CD14 bind to gram-negative bacteria. Eur. J. Immunol. 25:1436-1441.
20. Kelly, N. M., L. Young, and A. S. Cross. 1991. Differential induction of tumor necrosis factor by bacteria expressing rough and smooth lipopolysaccharide phenotypes. Infect. Immun. 25:293-298.
21. Landmann, R., F. Scherer, R. Schumann, S. Link, S. Sansano, and W. Zimmerli. 1995. LPS directly induces oxygen radical production in human monocytes via LPS binding protein and CD14. J. Leukocyte Biol. 57:440-449.
22. Levy, O., C. E. Ooi, P. Elsbach, M. E. Doerfler, R. I. Lehrer, and J. Weiss. 1995. Antibacterial proteins of granulocytes differ in interaction with endotoxin. Comparison of bactericidal/permeability-increasing protein, p15s, and defensins. J. Immunol. 154:5403-5410.
23. Mannion, B. A., E. S. Kalatzis, J. Weiss, and P. Elsbach. 1989. Preferential binding of the neutrophil cytoplasmic granule-derived bactericidal/permeability increasing protein to target bacteria. Implications and use as a means of purification. J. Immunol. 142:2807-2812.
24. Marra, M. N., M. B. Thornton, J. L. Snable, C. G. Wilde, and R. W. Scott. 1994. Endotoxin-binding and -neutralizing properties of recombinant bactericidal/permeability-increasing protein and monoclonal antibodies HA-1A and E5. Crit. Care Med. 22:559-565.
25. Marra, M. N., C. G. Wilde, M. S. Collins, J. L. Snable, M. B. Thornton, and R. W. Scott. 1992. The role of bactericidal/permeability-increasing protein as a natural inhibitor of bacterial endotoxin. J. Immunol. 148:532-537.
26. Marra, M. N., C. G. Wilde, J. E. Griffith, J. L. Snable, and R. W. Scott. 1990. Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity. J. Immunol. 144:662-666.
27. Mattsby-Baltzer, I., K. Lindgren, B. Lindholm, and L. Edebo. 1991. Endotoxin shedding by enterobacteria: free and cell-bound endotoxin differ in Limulus activity. Infect. Immun. 59:689-695.
28. Mészáros, K., J. B. Parent, S. H. Gazzano, R. Little, A. Horwitz, T. Parsons, G. Theofan, L. Grinna, J. Weickmann, and P. Elsbach. 1993. A recombinant amino terminal fragment of bactericidal/permeability-increasing protein inhibits the induction of leukocyte responses by LPS. J. Leukocyte Biol. 54: 558-563.
29. Neidhardt, F. C. 1987. Chemical composition of Escherichia coli, p. 3-6. In F. C. Neidhardt, J. L. Ingraham, K. B. Low, B. Magasanik, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: cellular and molecular biology, vol. 1. American Society for Microbiology, Washington, D.C.
30. Ooi, C. E., J. Weiss, M. E. Doerfler, and P. Elsbach. 1991. Endotoxin-neutralizing properties of the 25 kD N-terminal fragment and a newly isolated 30 kD C-terminal fragment of the 55-60 kD bactericidal/permeability-increasing protein of human neutrophils. J. Exp. Med. 174:649-655.
31. Ooi, C. E., J. Weiss, P. Elsbach, B. Frangione, and B. Mannion. 1987. A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein. J. Biol. Chem. 262:14891-14894.
32. Peterson, P. K., G. Gekker, S. Hu, W. S. Sheng, W. R. Anderson, R. J. Ulevitch, P. S. Tobias, K. V. Gustafson, T. W. Molitor, and C. C. Chao. 1995 CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Infect. Immun. 63:1598-1602.
33. Raetz, C. R. 1990. Biochemistry of endotoxins. Annu. Rev. Biochem. 59:129-170.
34. Rietschel, E. T., and H. Brade. 1992. Bacterial endotoxins. Sci. Am. 267:54-61.
35. Rietschel, E. T., Y. B. Kim, D. W. Watson, C. Galanos. O. Lüderitz, and O. Westphal. 1973. Pyrogenicity and immunogenicity of lipid A complexed with bovine serum albumin or human serum albumin. Infect. Immun. 8:173-177.
36. Rietschel, E. T., T. Kirikae, F. U. Schade, U. Mamat, G. Schmidt, H. Loppnow, A. J. Ulmer, U. Zähringer, U. Seydel, F. Di Padova, M. Schreier, and H. Brade. 1994. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 8:217-225.
37. Rietschel, E. T., T. Kirikae, F. U. Schade, A. J. Ulmer, O. Holst, H. Brade, G. Schmidt, U. Mamat, H. D. Grimmecke, S. Kusumoto, and U. Zäbringer. 1993. The chemical structure of bacterial endotoxin in relation to bioactivity. Immunobiology 187:169-190.
38. Rietschel, E. T., U. Schade, M. Jensen, H. W. Wollenweber, O. Lüderitz, and S. G. Greisman. 1982. Bacterial endotoxins: chemical structure, biological activity and role in septicaemia. Scand. J. Infect. Dis. Suppl. 31:8-21.
39. Schumann, R. R., S. R. Leong, G. W. Flaggs, P. W. Gray, S. D. Wright, J. C. Mathison, P. S. Tobias, and R. J. Ulevitch. 1990. Structure and function of lipopolysaccharide binding protein. Science 249:1429-1431.
40. Somerville, J., Jr., L. Cassiano, B. Bainbridge, M. D. Cunningham, and R. P. Darveau. 1996. A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J. Clin. Invest. 97:359-365.
41. Tesh, V. L., R. Duncan, Jr., and D. C. Morrison. 1986. The interaction of Escherichia coli with normal human serum: the kinetics of serum-mediated lipopolysaccharide release and its dissociation from bacterial killing. J. Immunol. 137:1329-1335.
42. Tesh, V. L., and D. C. Morrison. 1988. The interaction of Escherichia coli with normal human serum: factors affecting the capacity of serum to mediate lipopolysaccharide release. Microb. Pathog. 4:175-187.
43. Tesh, V. L., and D. C. Morrison. 1988. The physical-chemical characterization and biologic activity of serum released lipopolysaccharides. J. Immunol. 141:3523-3531.
44. Tobias, P. S., J. C. Mathison, J. D. Lee, V. Kravchenko, D. Mintz, J. Pugin, J. Han, J. Gegner, and R. J. Ulevitch. 1993. LPS binding protein, LPS, and CD14-mediated activation of myeloid cells, p. 135-137. In J. Levin, C. R. Alving, R. S. Munford, and P. L. Stutz (ed.), Bacterial endotoxin: recognition and effector mechanisms. Excerpta Medica, New York.
45. Tobias, P. S., K. Soldau, J. A. Gegner, D. Mintz, and R. J. Ulevitch. 1995. Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J. Biol. Chem. 270:10482-10488.
46. Tobias, P. S., K. Soldau, L. Kline, J. D. Lee, K. Kato, T. P. Martin, and R. J. Ulevitch. 1993. Cross-linking of lipopolysaccharide (LPS) to CD14 on THP-1 cells mediated by LPS-binding protein. J. Immunol. 150:3011-3021.
47. Tobias, P. S., K. Soldau, and R. J. Ulevitch. 1986. Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J. Exp. Med. 164: 777-793.
48. Tobias, P. S., K. Soldau, and R. J. Ulevitch. 1989. Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein. J. Biol. Chem. 264:10867-10871.
49. Ulevitch, R. J., and P. S. Tobias. 1995. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13:437-457.
50. Van Dijk, W. C., H. A. Verbrugh, M. E. van der Tol, R. Peters, and J. Verhoef. 1979. Role of Escherichia coli K capsular antigens during complement activation, C3 fixation, and opsonization. Infect. Immun. 25:603-609.
51. Vosbeck, K., P. Tobias, H. Mueller, R. A. Allen, K. E. Arfors, R. J. Ulevitch, and L. A. Sklar. 1990. Priming of polymorphonuclear granulocytes by lipopolysaccharides and its complexes with lipopolysaccharide binding protein and high density lipoprotein. J. Leukocyte Biol. 47:97-104.
52. Weiss, J., P. Elsbach, C. Shu, J. Castillo, L. Grinna, A. Horwitz, and G. Theofan. 1992. Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gramnegative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria. J. Clin. Invest. 90:1122-1130.
53. Weiss, J., M. Inada, P. Elsbach, and R. M. Crowl. 1994. Structural determinants of the action against Escherichia coli of a human inflammatory fluid phospholipase A2 in concert with polymorphonuclear leukocytes. J. Biol. Chem. 269:26331-26337.
54. Williams, P., P. A. Lambert, M. R. Brown, and R. J. Jones. 1983. The role of the O and K antigens in determining the resistance of Klebsiella aerogenes to serum killing and phagocytosis. J. Gen. Microbiol. 129:2181-2191.
55. Wright, S. D. 1991. Multiple receptors for endotoxin. Curr. Opin. Immunol. 3:83-90.
56. Wright, S. D., P. A. Detmers, Y. Aida, R. Adamowski, D. C. Anderson, Z. Chad, L. G. Kabbash, and M. J. Pabst. 1990. CD18-deficient cells respond to lipopolysaccharide in vitro. J. Immunol. 144:2566-2571.
57. Wright, S. D., and M. T. Jong. 1986. Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide. J. Exp. Med. 164:1876-1888.
58. Wright, S. D., S. M. Levin, M. T. Jong, Z. Chad, and L. G. Kabbash. 1989. CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide. J. Exp. Med. 169:175-183.
59. Wright, S. D., R. A. Ramos, V. A. Hermanowski, P. Rockwell, and P. A. Detmers. 1991. Activation of the adhesive capacity of CR3 on neutrophils by endotoxin: dependence on lipopolysaccharide binding protein and CD14. J. Exp. Med. 173:1281-1286.
60. Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433.
61. Wurfel, M. M., E. Hailman, and S. D. Wright. 1995. Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein. J. Exp. Med. 181:1743-1754.
62. Wurfel, M. M., S. T. Kunitake, H. Lichenstein, J. P. Kane, and S. D. Wright. 1994. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J. Exp. Med. 180:1025-1035.
63. Yu, B., and S. D. Wright. 1996. Catalytic properties of lipopolysaccharide (LPS) binding protein. J. Biol. Immunol. 271:4100-4105.