p15s (15-kD antimicrobial proteins) are stored in the secondary granules of rabbit granulocytes: Implications for antibacterial synergy with the bactericidal/permeability-increasing protein in inflammatory fluids

Blood

Volumn 89, Issue 2, 1997, Pages 672-679

  Zarember, Kol ^a   Elsbach, Peter ^a   Shin Kim, Kwang ^a   Weiss, Jerrold ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERICIDAL PERMEABILITY INCREASING PROTEIN; MESSENGER RNA; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL GRANULE; ELECTRON MICROSCOPY; EXOCYTOSIS; GRANULOCYTE; IMMUNOFLUORESCENCE; NEUTROPHIL; NONHUMAN; NORTHERN BLOTTING; PERITONEUM EXUDATE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA PURIFICATION;

EID: 0031033223     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.2.672     Document Type: Article

References (48)

1. Levy O: Antibiotic proteins of polymorphonuclear leukocytes. Eur J Haematol 56:263, 1996
2. Borregaard N, Lollike K, Kjeldsen L, Sengelov H, Bastholm L, Nielsen MH, Bainton DF: Human neutrophil granules and secretory vesicles. Eur J Haematol 51:187, 1993
3. Wright DG, Bralove DA, Gallin JI: The differential mobilization of human neutrophil granules. Am J Pathol 87:273, 1977
4. Zinsser H: On bactericidal substances extracted from normal leucocytes. J Med Res 22:397, 1910
5. Weiss J, Kao L, Victor M, Eisbach P: Oxygen-independent intracellular and oxygen-dependent extracellular killing of Escherichia coli S15 by human polymorphonuclear leukocytes. J Clin Invest 76:206, 1985
6. Weinrauch Y, Elsbach P, Madsen LM, Foreman A, Weiss J: The potent anti-Staphylococcus aureus activity of a sterile rabbit inflammatory fluid is due to a 14 kDa phospholipase A2. J Clin Invest 97:250, 1996
7. Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T: Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J Lab Clin Med 122:202, 1993
8. McClelland DB, Van Furth R: Antimicrobial factors in the exudates of skin windows in human subjects. Clin Exp Immunol 25:442, 1976
9. Hohn DC, Granelli SG, Burton RW, Hunt TK: Antimicrobial systems of the surgical wound. II. Detection of antimicrobial protein in cell-free wound fluid. Am J Surg 133:601, 1977
10. Calvano SE, Thompson WA, Marra MN, Coyle SM, Riesthal HF, Trousdale RK, Barie PS, Scott RW, Moldawer LL, Lowery SF: Changes in polymorphonuclear leukocyte surface and plasma bactericidal/permeability-increasing protein and plasma lipopolysaccharide binding protein during endotoxemia or sepsis. Arch Surg 129:220, 1994
11. Weinrauch Y, Foreman A, Shu C, Zarember K, Levy O, Elsbach P, Weiss J: Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein and p15s in an evolving sterile rabbit peritoneal exudate. J Clin Invest 95:1916, 1995
12. Levy O, Ooi CE, Weiss J, Lehrer R, Elsbach P: Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli. J Clin Invest 94:672, 1994
13. Cohn ZA, Hirsch JG: The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonculear leukocytes. J Exp Med 112:983, 1960
14. Brown T: Northern hybridization of RNA fractionated by agarose-formaldehyde gel electrophoresis, in Ausubel FM, Brent R, Kingston RE. Moore DD, Seidman JG, Smith JA, Struhl K (eds): Current Protocols in Molecular Biology. New York, NY, Wiley, 1995, p 4.9.1
15. Sengelov H, Kjeldsen L, Borregaard N: Control of exocytosis in early neutrophil activation. J Immunol 150:1535, 1993
16. 12 binding capacity. Blood 15:875, 1965
17. Bainton DF: Sequential degranulation of the two types of polymorphonuclear leukocyte granules during phagocytosis of microorganisms. J Cell Biol 58:249, 1973
18. Leffell MS, Spitznagel JK: Intracellular and extracellular degranulation of human polymorphonuclear azurophil and specific granules induced by immune complexes. Infect Immunol 10:1241, 1974
19. Palma C, Cassone A, Serbousek D, Pearson CA, Djeu JY: Lactoferrin release and interleukin-1, interleukin-6, and tumor necrosis factor production by human polymorphonuclear cells stimulated by various lipopolysaccharides: Relationship to growth inhibition of Candida albicans. Infect Immunol 60:4604, 1992
20. Lew PD, Monod A, Waldvogel FA, Dewald B, Baggiolini M, Pozzan T: Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils. J Cell Biol 102:2197, 1986
21. Egesten A, Breton-Gorius J, Guichard J, Urbab G, Olsson I: The heterogeneity of azurophil granules in neutrophil promyelocytes: Immunogold localization of myeloperoxidase, cathepsin G, elastase, proteinase 3, and bactericidal/permeability-increasing protein. Blood 83:2985, 1994
22. Weiss J, Olsson I: Cellular and subcellular localization of the bactericidal/permeability-increasing protein. Blood 69:652, 1987
23. Pereira HA, Spitznagel JK, Winton EF, Shafer WM, Martin LE, Guzman GS, Pohl J, Scott RW, Marra MN, Kinkade JM Jr: The ontogeny of a 57-Kd cationic antimicrobial protein of human polymorphonuclear leukocytes to a novel granule population. Blood 76:825, 1990
24. Bainton DF, Farquhar MG: Origin of granules in polymorphonuclear leukocytes. J Cell Biol 28:277, 1966
25. Fouret P, DuBois RM, Bernaudin J-F, Takahashi H, Ferrans VJ, Crystal RG: Expression of the neutrophil elastase gene during human bone marrow cell differentiation. J Exp Med 169:833, 1989
26. Beaulieu AD, Lang F, Belles-Isles M, Poubelle P: Protein biosynthetic activity of polymorphonuclear leukocytes in inflammatory arthropathies. Increased synthesis and release of fibronectin. J Rheumatol 14:656, 1987
27. Humphreys JM, Hughes V, Edwards SW: Stimulation of protein synthesis in human neutrophils by gamma-interferon. Biochem Pharmacol 38:1241, 1989
28. Eid NS, Kravath RE, Lanks KW: Heat-shock protein synthesis by human polymorphonuclear cells. J Exp Med 165:1448, 1987
29. Mori S, Goto K, Goto F, Murakami K, Ohkawara S, Yoshinaga M: Dynamic changes in mRNA expression of neutrophils during the course of acute inflammation in rabbits. Int Immunol 6:149, 1994
30. Silber R, Unger KW, Ellman L: RNA metabolism in normal and leukaemic leucocytes: Further studies on RNA synthesis. Br J Haematol 14:261, 1968
31. Waksman Y, Golde DW, Savion N, Fabian I: Granulocyte-macrophage colony stimulating factor enhances cationic antimicrobial protein synthesis by human neutrophils. J Immunol 144:3437, 1990
32. Winkler K: Protein synthesis in human leucocytes. III: Kinetics of the flow of amino acids from the extracellular space and the intracellular pools resulting in protein synthesis. Hoppe Seyler Z Physiol Chem 353:782, 1972
33. Rotrosen D: The respiratory burst oxidase, in Gallin JI, Goldstein IM, Snyderman R (eds): Inflammation: Basic Principles and Clinical Correlates (ed 2). New York, NY, Raven, 1992, p 589
34. Scocchi M, Skerlavaj B, Romeo D, Gennaro R: Proteolytic cleavage by neutrophil elastase converts inactive storage proforms to antibacterial bactenecins. Eur J Biochem 209:589, 1992
35. Ooi CE, Weiss J, Levy O, Elsbach P: Isolation of two isoforms of a novel 15-kDa protein from rabbit polymorphonuclear leukocytes that modulate the antibacterial actions of other leukocyte proteins. J Biol Chem 265:15956, 1990
36. Weersink AJL, Kessel KPMv, Toi MEvd, Strijp JAGv, Torensma R, Verhoef J, Elsbach P, Weiss J: Human granulocytes express a 55-kDa lipopolysaccharide-binding protein on the cell surface that is identical to the bactericidal/permeability-increasing protein. J Immunol 150:251, 1993
37. Bainton DF, Ullyot JL, Farquhar MG: The development of neutrophilic polymorphonuclear leukocytes in human bone marrow. J Exp Med 134:907, 1971
38. Ganz T, Rayner JR, Valore EV, Tumolo A, Talmadge K, Fuller F: The structure of the rabbit macrophage defensin genes and their organ-specific expression. J Immunol 143:1358, 1989
39. Zanetti M, Sal GD, Storici P, Schneider C, Romeo D: The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrohil antibiotics. J Biol Chem 268:522, 1993
40. Cassatella MA, Bazzoni F, Ceska M, Ferro I, Baggiolini M, Berton G: IL-8 production by human polymorphonuclear leukocytes. J Immunol 148:3216, 1992
41. Zanetti M, Gennaro R, Romeo D: Cathelicidins: A novel protein family with a common proregion and a variable C-terminal domain. FEBS Lett 374:1, 1995
42. Mahoney MM, Lee AY, Brezinski-Caliguri DJ, Huttner KM: Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide. FEBS Lett 377:519, 1995
43. Levy O, Weiss J, Zarember K, Ooi CE, Elsbach P: Antibacterial 15-kDa protein isoforms (p15s) are members of a novel family of leukocyte proteins. J Biol Chem 268:6058, 1993
44. Cowland JB, Johnsen AH, Borregaard N: hCAP-18, a cathelin/pro-bactenecin-like proteins of human neutrophil specific granules. FEBS Lett 368:173, 1995
45. Agerberth B, Gunne H, Odeberg J, Kogner P, Boman HG: FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proc Natl Acad Sci USA 92:195, 1995
46. Bagella L, Scocchi M, Zanetti M: cDNA sequences of three sheep myeloid cathelicidins. FEBS Lett 376:225, 1995
47. Gallo RL, Ono M, Povsic T, Page C, Eriksson E, Klagsbrun M, Bernfield M: Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 91:11035, 1994
48. Verbanac D, Zanetti M, Romeo D: Chemotactic and protease-inhibiting activities of antibiotic peptide precursors. FEBS Lett 317:255, 1993