Regulation of hepatic glutamine metabolism during exercise in the dog

American Journal of Physiology - Endocrinology and Metabolism

Volumn 275, Issue 4 38-4, 1998, Pages

  Halseth, Amy E ^a   Rhéaume, Nathalie ^a   Messina, Allison B ^a   Reed, Erica K ^a   Krishna, Mahesh G ^a   Flakoll, Paul J ^a   Lacy, D Brooks ^a   Wasserman, David H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amino acids; Gastrointestinal tract; Liver; Nitrogen; Stable isotope

Indexed keywords

GLUTAMINE;

ADAPTATION; ANIMAL EXPERIMENT; ARTICLE; DIET RESTRICTION; DOG; EXERCISE; LIVER METABOLISM; NITROGEN METABOLISM; NONHUMAN; PRIORITY JOURNAL; UREA CYCLE;

EID: 0031773492     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.275.4.e655     Document Type: Article

References (56)

1. Abumrad, N. N., E. L. Morse, H. Lochs, P. E. Williams, and S. A. Adibi. Possible sources of glutamine for parenteral nutrition: impact on glutamine metabolism. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E228-E234, 1989.
2. Brautsch-Marrain, P. R., W. K. Waldhausl, S. Gasic, A. Korn, and P. Nowotny. Oral glucose tolerance test: effect of different glucose loads on splanchnic carbohydrate and substrate metabolism in healthy man. Metabolism 29: 289-295, 1980.
3. Brosnan, J. T., H. S. Ewart, and S. A. Squires. Hormonal control of hepatic glutaminase. Adv. Enzyme Regul. 35: 131-146, 1995.
4. Buttrose, M., D. McKellar, and T. C. Welbourne. Gut-liver interaction in glutamine homeostasis: portal ammonia role in uptake and metabolism. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E746-E750, 1987.
5. Cahill, G. F. Starvation in man. N. Engl. J. Med. 282: 668-675, 1970.
6. Carraro, F., T. D. Kimbrough, and R. R. Wolfe. Urea kinetics in humans at two levels of exercise intensity. J. Appl. Physiol. 75: 1180-1185, 1993.
7. Cersosimo, E., R. L. Judd, and J. M. Miles. Insulin regulation of renal glucose metabolism in conscious dogs. J. Clin. Invest. 93: 2584-2589, 1994.
8. Cersosimo, E., P. Williams, R. J. Geer, T. Lairmore, F. Ghishan, and N. N. Abumrad. Importance of ammonium ions in regulating hepatic glutamine synthesis during fasting. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E514-E519, 1989.
9. Cersosimo, E., P. Williams, B. Hoxworth, W. Lacy, and N. Abumrad. Glutamine blocks lipolysis and ketogenesis of fasting. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E248-E252, 1986.
10. Cersosimo, E., P. E. Williams, D. O'Donovan, D. B. Lacy, and N. N. Abumrad. Role of acidosis in regulating hepatic nitrogen metabolism during fasting in conscious dog. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E313-E319, 1987.
11. Cherrington, A. D. Gluconeogenesis: its regulation by glucagon and insulin. In: Diabetes Mellitus, edited by M. Brownlee. New York: Garland, 1981, p. 49-113.
12. Darmaun, D., and P. Dechelotte. Role of leucine as a precursor of glutamine α-amino nitrogen in vivo in humans. Am. J. Physiol. 260 (Endocrinol. Metab. 23): E326-E329, 1991.
13. Davis, M. A., P. E. Williams, and A. D. Cherrington. Effect of a mixed meal on hepatic lactate and gluconeogenic precursor metabolism in dogs. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E362-E369, 1984.
14. De Bruijne, J. J., and P. DeKoster. Glycogenolysis in the fasting dog. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 75: 553-555, 1983.
15. Eriksson, L. S., S. Broberg, O. Bjorkman, and J. Wahren. Ammonia metabolism during exercise in man. Clin. Physiol. 5: 325-336, 1985.
16. Felig, P., and J. Wahren. Amino acid metabolism in exercising man. J. Clin. Invest. 50: 2703-2711, 1971.
17. Felig, P., J. Wahren, and R. Hendler. Influence of oral glucose ingestion on splanchnic glucose and gluconeogenic substrate metabolism. Diabetes 24: 468-475, 1975.
18. Felig, P., J. Wahren, I. Karl, E. Cerasi, R. Luft, and D. M. Kipnis. Glutamine and glutamate metabolism in normal and diabetic subjects. Diabetes 22: 573-576, 1973.
19. Geer, R. J., P. E. Williams, T. Lairmore, and N. N. Abumrad. Glucagon: an important stimulator of gut and heptic glutamine metabolism. Surg. Forum 38: 27-29, 1987.
20. Halseth, A. E., P. J. Flakoll, E. K. Reed, A. B. Messina, M. G. Krishna, D. B. Lacy, P. E. Williams, and D. H. Wasserman. Effect of physical activity and fasting on gut and liver proteolysis in the dog. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E1073-E1082, 1997.
21. Hamadeh, M., and L. J. Hoffer. Tracer methods underestimate short-term variations in urea production in humans. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E547-E553, 1998.
22. Hamilton, K. S., F. K. Gibbons, D. P. Bracy, D. B. Lacy, A. D. Cherrington, and D. H. Wasserman. Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle. J. Clin. Invest. 98: 125-135, 1996.
23. Hankard, R. G., D. Darmaun, B. K. Sager, D. D'Amore, W. R. Parsons, and M. W. Raymond. Response of glutamine metabolism to exogenous glutamine in humans. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E663-E670, 1995.
24. Hankard, R. G., M. W. Raymond, and D. Darmaun. Role of glutamine as a glucose precursor in fasting humans. Diabetes 46: 1535-1541, 1997.
25. Haralambie, G., and L. Senser. Metabolic changes in man during long-distance swimming. Eur. J. Appl. Physiol. 43: 115-125, 1980.
26. Hartley, C. J., H. G. Hanley, R. M. Lewis, and J. S. Cole. Synchronized pulsed doppler blood flow and ultrasonic dimension measurement in conscious dogs. Ultrasound Med. Biol. 4: 99-110, 1978.
27. Haussinger, D., W. Gerok, and H. Sies. Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver. Biochim. Biophys. Acta 755: 272-278, 1983.
28. Haussinger, D., and H. Sies. Hepatic glutamine metabolism under the influence of the portal ammonia concentration in the perfused rat liver. Eur. J. Biochem. 101: 179-184, 1979.
29. Hoxworth, B., B. Miller, P. Radosevich, R. Buckspan, W. Lacy, and N. N. Abumrad. Insulin's effect on leucine turnover changes during early fasting in the conscious dog. Diabetes 34: 295-299, 1985.
30. Ishida, T., R. M. Lewis, C. J. Hartley, M. L. Entman, and J. B. Field. Comparison of hepatic extraction of insulin and glucagon in conscious and anesthetized dog. Endocrinology 112: 1098-1109, 1983.
31. Jungermann, K., and N. Katz. Functional specialization of different hepatocyte populations. Physiol. Rev. 69: 708-764, 1989.
32. Kreider, M. E., M. Stumvoll, C. Meyer, D. Overkamp, S. Welle, and J. Gerich. Steady-state and non-steady-state measurements of plasma glutamine turnover in humans. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E621-E627, 1997.
33. Lloyd, B., J. Burrin, P. Smythe, and K. G. M. M. Alberti. Enzymatic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin. Chem. 24: 1724-1729, 1978.
34. Lund, P. L-Glutamine determination with glutaminase and glutamate dehydrogenase. In: Methods in Enzymatic Analysis, edited by H. U. Bergmeyer. New York: Academic, 1974, p. 1719-1722.
35. 13C nuclear magnetic resonance study. J. Clin. Invest. 90: 1323-1327, 1992.
36. Marliss, E. B., T. T. Aoki, T. Pozefsky, A. S. Most, and G. F. Cahill. Muscle and splanchnic glutamine and glutamate metabolism in postabsorptive and starved man. J. Clin. Invest. 50: 814-817, 1971.
37. Matthews, D. E., and R. S. Downey. Measurement of urea kinetics in humans: a validation of stable isotope tracer methods. Am. J. Physiol. 246 (Endocrinol. Metab. 9): E519-E527, 1984.
38. Matthews, D. E., M. A. Marano, and R. G. Campbell. Splanchnic bed utilization of glutamine and glutamic acid in humans. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E848-E854, 1993.
39. Meijer, A. J. Channeling of ammonia from glutamine to carbamoyl-phosphate synthetase in liver mitochondria. FEBS Lett. 191: 249-251, 1985.
40. Moore, M. C., P. J. Flakoll, P. S. Hsieh, M. Pagliassotti, D. W. Neal, M. T. Monohan, C. Venable, and A. D. Cherrington. Hepatic glucose disposition during concomitant portal glucose and amino acid infusions in the dog. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E893-E902, 1998.
41. Musch, T. I., D. B. Friedman, K. H. Pitetti, G. C. Haidet, J. Stray-Gundersen, J. H. Mitchell, and G. A. Ordway. Regional distribution of blood flow of dogs during graded dynamic exercise. J. Appl. Physiol. 63: 2269-2276, 1987.
42. Newsholme, E. A., P. Newsholme, R. Curi, B. Crabtree, and M. Ardawi. Glutamine metabolism in different tissues. Its physiological and pathological importance. In: Perspectives in Clinical Nutrition, edited by J. M. Kinney and P. R. Borum. Baltimore, MD: Urban & Schwarzenberg, 1989, p. 71-98.
43. Nurjhan, N., A. Bucci, G. Perriello, M. Stumvoll, G. Dailey, D. M. Bier, L. Toft, T. G. Jenssen, and J. E. Gerich. Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J. Clin. Invest. 95: 272-277, 1995.
44. Refsum, H. E., R. Gjessing, and S. B. Stromme. Changes in plasma amino acid distribution and urine amino acid excretion during prolonged heavy exercise. Scand. J. Clin. Lab. Invest. 39: 407-413, 1979.
45. Rennie, M. J. Influence of exercise on protein and amino acid metabolism. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 3, p. 995-1035.
46. Tamarappoo, B. K, N. Nam, M. S. Kilberg, and T. C. Welbourne. Glucocorticoid regulation of splanchnic glutamine, alanine, glutamate, ammonia, and glutathione fluxes. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E526-E533, 1993.
47. Tessari, P., S. L. Nissen, J. Miles, and M. W. Haymond. Inverse relationship of leucine flux and oxidation to free fatty acid availability in vivo. J. Clin. Invest. 77: 575-581, 1986.
48. Wasserman, D. H., R. J. Geer, D. E. Rice, D. Bracy, P. J. Flakoll, L. L. Brown, J. O. Hill, and N. N. Abumrad. Interaction of exercise and insulin action in man. Am. J. Physiol. 260 (Endocrinol. Metab. 23): E37-E45, 1991.
49. Wasserman, D. H., R. J. Geer, P. E. Williams, D. B. Lacy, and N. N. Abumrad. Interaction of gut and liver in nitrogen metabolism during exercise. Metabolism 40: 307-314, 1991.
50. Wasserman, D. H., D. B. Lacy, D. Bracy, and P. E. Williams. Metabolic regulation in peripheral tissues and transition to increased gluconeogenic mode during prolonged exercise. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E345-E354, 1992.
51. Wasserman, K., A. L. VanKessel, and G. G. Burton. Interaction of physiological mechanisms during exercise. J. Appl. Physiol. 22: 71-85, 1967.
52. Welbourne, T. C., and S. Joshi. Interorgan glutamine metabolims during acidosis. J. Parenter. Enteral Nutr. 14: 77S-85S, 1990.
53. Welbourne, T. C., and V. Phromphetcharat. Renal glutamine metabolism and hydrogen ion homeostasis. In: Glutamine Metabolism in Mammalian Tissues, edited by D. Haussinger and H. Sies. Berlin: Springer-Verlag, 1984, p. 161-177.
54. Williams, B. D. Protein, Amino Acid, and Carbohydrate Metabolism at Rest and During Exercise: Stable Isotope Tracer Applications (PhD thesis). Galveston: The Univ. of Texas Medical Branch, 1995.
55. Williams, B. D., R. R. Wolfe, D. P. Bracy, and D. H. Wasserman. Gut contributes essential amino acids during exercise. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E85-E90, 1996.
56. 2 and exercise on carbohydrate metabolism in the dog. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E409-E417, 1995.