Steady-state and non-steady-state measurements of plasma glutamine turnover in humans

American Journal of Physiology - Endocrinology and Metabolism

Volumn 272, Issue 4 35-4, 1997, Pages

  Kreider, M E ^a   Stumvoll, M ^b   Meyer, C ^a   Overkamp, D ^b   Welle, S ^a   Gerich, J ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

pool fraction; volume of distribution

Indexed keywords

GLUTAMINE;

ADULT; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ARTICLE; EXTRACELLULAR FLUID; FEMALE; GLUCOSE INFUSION; HUMAN; HUMAN EXPERIMENT; INSULIN INFUSION; INTESTINE ABSORPTION; MALE; NITROGEN BALANCE; NORMAL HUMAN; PRIORITY JOURNAL; STEADY STATE; TISSUE DISTRIBUTION; TRANSAMINATION;

EID: 0030896318     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.272.4.e621     Document Type: Article

References (31)

1. Bergstrom, J., P. Furst, L. O. Norel, and E. Vinnars. Intracellular free amino acid concentration in human muscle tissue. J. Appl. Physiol. 36: 693-697, 1974.
2. Brooks, D., M. Black, T. Arcangeli, T. Aoki, and D. Wilmore. The heated dorsal hand vein: an alternative arterial sampling site. J. Parenter. Enteral Nutr. 13: 102-105, 1989.
3. Cobelli, C., A. Mari, and E. Ferrannini. Non-steady state error analysis of Steele's model and developments for glucose kinetics. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E679-E689, 1987.
4. Darmaun, D., and P. Déchelotte. Role of Ieucine as a precursor of glutamine α-amino nitrogen in vivo in humans. Am. J. Physiol. 260 (Endocrinol. Metab. 23): E326-E329, 1991.
5. Darmaun, D., B. Just, B. Messing, M. Rongier, F. Thuillier, J. Koziet, and E. Grasset. Glutamine metabolism in healthy adult men: response to enteral and intravenous feeding. Am. J. Clin. Nutr. 59: 1395-1402, 1994.
6. Darmaun, D., D. E. Matthews, and D. M. Bier. Glutamine and glutamate kinetics in humans. Am. J. Physiol. 251 (Endocrinol. Metab. 14): E117-E126, 1986.
7. Darmaun, D., D. E. Matthews, and D. M. Bier. Physiological hypcrcortisolemia increases proteolysis, glutamine, and alanine production. Am. J. Physiol. 255 (Endocrinol. Metab. 18): E366-E373, 1988.
8. 14C glucose. Recent Prog. Horm. Res. 19: 445-448, 1963.
9. Finegood, D., R. Bergman, and M. Vranic. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabelled and labeled exogenous glucose infusates. Diabetes 36: 914-924, 1987.
10. Fisher, S., Z. Shi, L. Lickley, S. Efendic, M. Vranic, and A. Giacca. A moderate decline in specific activity does not lead to an underestimation of hepatic glucose production during a glucose clamp. Metabolism 45: 587-593, 1996.
11. Hankard, R. G., D. Darmon, B. K. Sager, D. D'Amore, W. R. Parsons, and M. Raymond. Response of glutamine metabolism to exogenous glutamine in humans. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E663-E670, 1995.
12. Haussinger, D. Nitrogen metabolism in liver: structural and functional organization and physiological relevance. Biochem. J. 267: 281-290, 1990.
13. Hother-Nielsen, O., J. Henriksen, J. Holst, and H. Beck-Nielson. Effects of insulin on glucose turnover rates in vivo: isotope dilution versus constant specific activity technique. Metabolism 45: 82-91, 1996.
14. 14C-glucose in the dog. Can. J. Physiol. Pharmacol. 52: 215-224, 1974.
15. 14C]glutamine specific activity in plasma. J. Liq. Chromatogr. 17: 1337-1348, 1994.
16. Matthews, D., and G. Campbell. The effect of dietary protein intake on glutamine and glutamate nitrogen metabolism in humans. Am. J. Clin. Nutr. 55: 963-970, 1992.
17. Matthews, D. E., M. A. Marano, and R. G. Campbell. Splanchnic bed utilization of glutamine and glutamic acid in humans. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E848-E854, 1993.
18. Matthews, D. E., G. Pesola, and R. G. Campbell. Effect of epinephrine on amino acid and energy metabolism in humans. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E948-E956, 1990.
19. Matthews, D., R. Yang, D. Bier, and V. Young. What is whole-body metabolism when studied with labeled alanine tracers? In: Substrate and Energy Metabolism, edited by J. Garrow, D. Halliday, and J. Libbey. London: Wiley, 1985, p. 187-194.
20. Nurjhan, N., A. Bucci, G. Perriello, M. Stumvoll, G. Dailey, D. Bier, I. Toft, T. Jenssen, and J. Gerich. Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J. Clin. Invest. 95: 272-277, 1995.
21. Perriello, G., R. Jorde, N. Nurjhan, M. Stumvoll, G. Dailey, T. Jenssen, D. M. Bier, and J. E. Gerich. Estimation of the glucose-alanine-lactate-glutamine cycles in postabsorptive man: role of the skeletal muscle. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E443-E450, 1995.
22. Radziuk, J., K. H. Norwich, and M. Vranic. Experimental validation of measurements of glucose turnover in nonsteady state. Am. J. Physiol. 234 (Endocrinol. Metab. Gastrointest. Physiol. 3): E84-E93, 1978.
23. Rhoades, R., and G. Tanner. Regulation of fluid and electrolyte balance. In: Medical Physiology, edited by R. Rhoades and G. Tanner. Boston, MA: Little, Brown, 1995, p. 446-463.
24. Smith, R., and K. Panico. Automated analyses of o-phthalaldehyde derivatives of amino acids in physiological fluids by reverse phase high-performance liquid chromatography. J. Liq. Chromatogr. 8: 1783-1795, 1985.
25. Strowig, S., and P. Raskin. Insulin treatment and patient management. In: Diabetes Mellitus: Theory and Practice, edited by H. Rifkin and D. Porte. New York: Elsevier, 1990, p. 514-524.
26. Stumvoll, M., G. Perriello, N. Nurjhan, A. Bucci, S. Welle, G. Dailey, D. M. Bier, T. G. Jenssen, and J. E. Gerich. Glutamine and alanine metabolism in NIDDM. Diabetes 45: 863-868, 1996.
27. Watford, M., E. Erbelding, and E. Smith. Glutamine metabolism in rat intestine: response to lactation. Biochem. Soc. Trans. 14: 1058-1059, 1986.
28. 15N glutamine enrichment with tertiary butyldimethylsilyl derivatives. Biol. Mass Spectrom. 23: 682-688, 1994.
29. Wolfe, R. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York: Wiley-Liss, 1992.
30. World Health Organization Expert Committee. Second Report on Diabetes Mellitus. Geneva: World Health Org., 1980, p. 641-646. (Tech. Rep. Ser.)
31. Yang, R. D., D. E. Matthews, D. M. Bier, C. Lo, and V. R. Young. Alanine kinetics in humans: influence of different isotopic tracers. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E634-E638, 1984.