Deregulation of BCL6 in non-Hodgkin lymphoma by insertion of IGH sequences in complex translocations involving band 3q27

Genes Chromosomes and Cancer

Volumn 23, Issue 4, 1998, Pages 328-336

  Chaganti, Seeta R ^a   Rao, Pulivarthi H ^a   Chen, Weiyi ^a   Dyomin, Vadim ^a   Jhanwar, Suresh C ^a   Parsa, Nasser Z ^b   Dalla Favera, Riccardo ^c   Chaganti, R S K ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 1Q; CHROMOSOME 3Q; CHROMOSOME 6P; CHROMOSOME TRANSLOCATION 3; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE INSERTION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 14; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOGLOBULINS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LYMPHOMA, MIXED-CELL, DIFFUSE; LYMPHOMA, NON-HODGKIN; MALE; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0031767914     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199812)23:4<328::AID-GCC8>3.0.CO;2-M     Document Type: Article

References (33)

1. Akasaka T, Miura I, Takahashi N, Akasaka H, Yonetani N, Ohno H, Fukuhara S, Okuma M (1997) A recurring translocation, t(3;6)(q27; p21), in non-Hodgkin's lymphoma results in replacement of the 5′ regulatory region of BCL6 with a novel H4 histone gene. Cancer Res 57:7-12.
2. Baron BW, Nucifora G, McCabe N, Espinosa R III, Le Beau MM, McKeithan TW (1993) Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q24;q32) and t(3;22)(q27;q11) in B-cell lymphomas. Proc Natl Acad Sci USA 90:5262-5266.
3. Bastard C, Deweindt C, Kerckaert JP, Lenormand B, Rossi A, Pezzella F, Fruchart C, Duval C, Monconduit M, Tilly H (1994) LAZ3 rearrangements in non-Hodgkin's lymphoma: Correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 83:2423-2427.
4. Cattoretti G, Chang C-C, Cechova K, Zhang J, Ye BH, Falini B, Louie DC, Offit K, Chaganti RSK, Dalla-Favera R (1995) BCL-6 protein is expressed in germinal center B-cells. Blood 86:45-53.
5. Chaganti SR, Chen W, Parsa N, Offit K, Louie DC, Dalla-Favera R, Chaganti RSK (1998) Involvement of BCL6 in chromosomal aberrations affecting band 3q27 in B-cell non-Hodgkin's lymphoma. Genes Chromosomes Cancer 23:323-327.
6. Chang C-C, Ye BH, Chaganti RSK, Dalla-Favera R (1996) Bcl-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc Natl Acad Sci USA 93:6947-6952.
7. Chen W, Ida S, Louie DC, Dalla-Favera R, Chaganti RSK (1998a) Heterologous promoters fused to BCL6 by chromosomal translocations affecting band 3q27 cause its deregulated expression during B-cell differentiation. Blood 91:603-608
8. Chen W, Rao PH, Chaganti SR, Louie DC, Butler M, Dalla-Favera R, Chaganti RSK (1998b) The t(2;3)(q21;q27) translocation in non-Hodgkin's lymphoma displays BCL6 mutations in the 5′ regulatory region and chromosomal breakpoints distant from the gene. Oncogene (in press).
9. Dallery E, Galiègue-Zouitina S, Collyn-d'Hooghe M, Quief S, Denis C, Hilderbrand M-P, Lantoine D, Deweindt C, Tilly H, Bastard C, Kerckaert J-P (1995) TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. Oncogene 10:2171-2178.
10. Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276:589-592.
11. Deweindt C, Kerckaert J-P, Tilly H, Quief S, Nguyen VC, Bastard C (1993) Cloning of a breakpoint cluster region at band 3q27 involved in human non-Hodgkin's lymphoma. Genes Chromosomes Cancer 8:149-154.
12. Dyer MJS, Lillington DM, Bastard C, Tilly H, Lens D, Howard JM, Stranks G, Morilla R, Monard S, Gugliemli P, Kluin-Nelemans JC, Hagemeijer A, Young BD, Catovsky D (1996) Concurrent activation of MYC and BCL2 in B cell non-Hodgkin lymphoma cell lines by translocation of both oncogenes to the same immunoglobulin heavy chain locus. Leukemia 10:1198-1208.
13. Galiegue-Zouitina S, Quief S, Hilderband M-P, Denis C, Lecocq G, Collyn-d'Hooghe M, Bastard C, Yuille M, Dyer MJS, Kerckaert J-P (1995) Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3;11)(q27;q23) chromosomal translocation. CR Acad Sci Paris, Life Sci 318:1125-1131.
14. Gu Y, Cimino G, Adler H, Nakamura T, Prasad R, Canaani O, Moir DT, Jones C, Nowell PC, Croce CM, Canaani E (1992) The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase. Proc Natl Acad Sci USA 89:10464-10468.
15. Haluska FG, Tsujimoto Y, Croce CM (1987) Mechanisms of chromosome translocation in B- and T-cell neoplasia. Trends Genet 3:11-15.
16. Kirsch IR (1997) Molecular genetics of lymphomagenesis: An overview. In Magrath IT (ed): The Non-Hodgkin's Lymphomas, 2nd Ed. London: Arnold, pp 253-275.
17. Lieber MR (1993) The role of site-directed recombinases in physiologic and pathologic chromosomal rearrangements. In Kirsch IR (cd): The Causes and Consequences of Chromosomal Aberrations. Boca Raton, FL: CRC Press, pp 239-275.
18. Lo Coco F, Ye BH, Lista F, Corradiani P, Offit K, Knowels DM, Chaganti RSK, Dalla-Favera R (1994) Rearrangement of the BCL6 gene in diffuse large-cell non-Hodgkin's lymphoma. Blood 83:1753-1759.
19. Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R (1995) Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci USA 92:12520-12524.
20. Miki T, Kawamata N, Hirosawa S, Aoki N (1994) Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes Kruppel-like zinc finger protein. Blood 83:26-32.
21. Nishida K, Taniura A, Nakazawa N, Ueda Y, Abe T, Matsuda F, Kashima K, Taniwaki M (1997) The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization. Blood 90:526-534.
22. Offit K, Jhanwar S, Ebrahim SAD, Filippa D, Clarkson BD, Chaganti RSK (1989) t(3;22)(q27;q11): A novel translocation associated with diffuse non-Hodgkin's lymphoma. Blood 74:1876-1879.
23. Offit K, Wong G, Filippa DA, Tao Y, Chaganti RSK (1991) Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: Clinical correlations. Blood 77:1508-1515.
24. Offit K, Lo Coco F, Louie DC, Parsa NZ, Leung D, Portlock C, Ye BH, Lista F, Filippa DA, Rosenbaum A, Ladanyi M, Jhanwar S, Dalla-Favera R, Chaganti RSK (1994) Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. New Engl J Med 331:74-80.
25. Onizuka T, Moriyama M, Yamochi T, Kuroda T, Kazama A, Kanazawa N, Sato K, Kato T, Ota H, Mori S (1995) BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counter-parts. Blood 86:28-37.
26. Rao PH, Murty VVVS, Gaidano G, Huptschein RS, Dalla-Favera R, Chaganti RSK (1993) Sub-regional localization of 20 single copy loci to chromosome 6 by fluorescence in situ hybridization. Genomics 16:426-430.
27. H segment rearrangements in lymphoid cells. Nature 312:418-432.
28. Schröck E, du Manoir S, Veldman T, Schoell B, Wienberg L, Ferguson-Smith MA, Ning Y, Ledbetter DH, Bar-Am I, Soenksen D, Garini Y, Ried T (1996) Multicolor spectral karyotyping of human chromosomes. Science 273:494-497.
29. Tweeddale ME, Lim B, Jamal N, Robinson J, Zalcberg J, Lockwood G, Minden M, Messner HA (1987) The presence of clonogenic cells in high-grade malignant lymphoma: A prognostic factor. Blood 69:1307-1314.
30. Ye BH, Rao PH, Chaganti RSK, Dalla-Favera R (1993a) Cloning of bcl-6, the locus involved in chromosomal translocations affecting 3q27 in B-cell lymphmoma. Cancer Res 53:2732-2735.
31. Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R (1993b) Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large cell lymphomas. Science 262:747-750.
32. Ye BH, Chaganti S, Chang C-C, Niu H, Corradini P, Chaganti RSK, Dalla-Favera R (1995) Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J 14:6209-6217.
33. Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RSK, Rothman P, Stall A, Pandolfi P-P, Dalla-Favera R (1997) The BCL-6 proto-oncogene controls germinal-center formation and Th2-type inflammation. Nat Genet 16:161-170.