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Volumn 45, Issue 5, 1998, Pages 510-532

Maintenance chemotherapy of acute lymphoblastic leukemia in children. Clinical and pharmacological aspects of the monitoring and adjustment of oral methotrexate and 6-mercaptopurine dosage

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; MERCAPTOPURINE; METHOTREXATE;

EID: 0031762961     PISSN: 09078916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (291)
  • 1
    • 0015237616 scopus 로고
    • Treatment of acute lymphoblastic leukaemia. Comparison of immunotherapy (B.C.G.), intermittent methotrexate, and no therapy after a five-month intensive cytotoxic regimen (Concord trial). Preliminary report to the Medical Research Council by the Leukaemia Committee and the Working Party on Leukaemia in Childhood
    • Anonymous (1971). Treatment of acute lymphoblastic leukaemia. Comparison of immunotherapy (B.C.G.), intermittent methotrexate, and no therapy after a five-month intensive cytotoxic regimen ((Concord trial). Preliminary report to the Medical Research Council by the Leukaemia Committee and the Working Party on Leukaemia in Childhood. Br Med J 4: 189-194.
    • (1971) Br Med J , vol.4 , pp. 189-194
  • 2
    • 84920204460 scopus 로고
    • Treatment of childhood acute lymphoblastic leukemia
    • Anonymous (1988), Treatment of childhood acute lymphoblastic leukemia. Lancet ii: 683-685.
    • (1988) Lancet , vol.2 , pp. 683-685
  • 3
    • 0029119276 scopus 로고
    • Biology and pharmacology of thiopurines
    • Aarbakke J (1995). Biology and pharmacology of thiopurines. Pediatr Hematol Oncol 12: 511-519.
    • (1995) Pediatr Hematol Oncol , vol.12 , pp. 511-519
    • Aarbakke, J.1
  • 4
    • 0015083328 scopus 로고
    • Identification and isolation on a large scale of guanylate kinase from human erythrocytes. Effects of monophosphate nucleotides of purine analogs
    • Agarwal RP, Scholar EM, Agarwal KC, Parks RE (1971). Identification and isolation on a large scale of guanylate kinase from human erythrocytes. Effects of monophosphate nucleotides of purine analogs. Biochem Pharmacol 20: 1341-1354.
    • (1971) Biochem Pharmacol , vol.20 , pp. 1341-1354
    • Agarwal, R.P.1    Scholar, E.M.2    Agarwal, K.C.3    Parks, R.E.4
  • 5
    • 0019834136 scopus 로고
    • Techniques for the measurement of methotrexate in biological samples
    • Aherne GW, Quinton M (1981). Techniques for the measurement of methotrexate in biological samples. Cancer Treat Rep 65 Suppl 1: 55-60.
    • (1981) Cancer Treat Rep , vol.65 , Issue.1 SUPPL. , pp. 55-60
    • Aherne, G.W.1    Quinton, M.2
  • 6
    • 0028007058 scopus 로고
    • Hepatitis C virus infection in children treated for acute lymphoblastic leukemia
    • Arico M, Maggiore G, Silini E, Bono F, Vigano F, Cerino A, Mondelli MU (1994). Hepatitis C virus infection in children treated for acute lymphoblastic leukemia. Blood 84: 2919-2922.
    • (1994) Blood , vol.84 , pp. 2919-2922
    • Arico, M.1    Maggiore, G.2    Silini, E.3    Bono, F.4    Vigano, F.5    Cerino, A.6    Mondelli, M.U.7
  • 7
    • 0018222963 scopus 로고
    • Childhood acute lymphocytic leukemia Study VIII
    • Aur RJA, Simone JV, Verzosa MS, et al. (1978). Childhood acute lymphocytic leukemia Study VIII. Cancer 42: 2123-2134.
    • (1978) Cancer , vol.42 , pp. 2123-2134
    • Aur, R.J.A.1    Simone, J.V.2    Verzosa, M.S.3
  • 8
    • 0020611303 scopus 로고
    • Pharmacokinetics of oral methotrexate in children
    • Balis FM, Savitch JL, Bleyer WA (1983). Pharmacokinetics of oral methotrexate in children. Cancer Res 43: 2342-2345.
    • (1983) Cancer Res , vol.43 , pp. 2342-2345
    • Balis, F.M.1    Savitch, J.L.2    Bleyer, W.A.3
  • 9
    • 0023148505 scopus 로고
    • The effect of methotrexate on the bioavilability of oral 6-mercaptopurine
    • Balis FM, Holcenberg JS, Zimm S, et al. (1987). The effect of methotrexate on the bioavilability of oral 6-mercaptopurine. Clin Pharmacol Ther 41: 384-387.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 384-387
    • Balis, F.M.1    Holcenberg, J.S.2    Zimm, S.3
  • 10
    • 0024329911 scopus 로고
    • Chronopharmacokinetics of oral methotrexate and 6-mercaptopurine: Is there diurnal variation in the disposition of antileukemic therapy?
    • Balis FM, Jeffries SL, Lange B, et al. (1989). Chronopharmacokinetics of oral methotrexate and 6-mercaptopurine: is there diurnal variation in the disposition of antileukemic therapy?. Am J Pediatr Hematol Oncol 11: 324-326.
    • (1989) Am J Pediatr Hematol Oncol , vol.11 , pp. 324-326
    • Balis, F.M.1    Jeffries, S.L.2    Lange, B.3
  • 11
    • 0028291535 scopus 로고
    • Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia
    • Barredo JC, Synold TW, Laver J, Relling MV, Pui CH, Priest DG, Evans WE (1994). Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia. Blood 84: 564-569.
    • (1994) Blood , vol.84 , pp. 564-569
    • Barredo, J.C.1    Synold, T.W.2    Laver, J.3    Relling, M.V.4    Pui, C.H.5    Priest, D.G.6    Evans, W.E.7
  • 13
    • 0018142351 scopus 로고
    • Sex and prognosis in childhood acute lymphoblastic leukemia
    • Baumer JH, Mott MG (1978). Sex and prognosis in childhood acute lymphoblastic leukemia. Lancet ii: 128-129.
    • (1978) Lancet , vol.2 , pp. 128-129
    • Baumer, J.H.1    Mott, M.G.2
  • 14
    • 0015009229 scopus 로고
    • Formation and significance of 6-methylthiopurine ribonucleotide as a metabolite of 6-mercaptopurine
    • Bennett LL, Jr., Allan PW (1971). Formation and significance of 6-methylthiopurine ribonucleotide as a metabolite of 6-mercaptopurine. Cancer Res 31: 152-158.
    • (1971) Cancer Res , vol.31 , pp. 152-158
    • Bennett Jr., L.L.1    Allan, P.W.2
  • 15
    • 0030050184 scopus 로고    scopus 로고
    • Hepatotoxicity of 6-mercaptopurine in childhood acute lymphoblastic leukemia: Pharmacokinetic characteristics
    • Berkovitch M, Matsui D, Zipursky A, et al. (1996). Hepatotoxicity of 6-mercaptopurine in childhood acute lymphoblastic leukemia: pharmacokinetic characteristics. Med Ped Oncol 26: 85-89.
    • (1996) Med Ped Oncol , vol.26 , pp. 85-89
    • Berkovitch, M.1    Matsui, D.2    Zipursky, A.3
  • 16
    • 0028814790 scopus 로고
    • Studying survivors of childhood cancer for late effects of therapy
    • Blatt J (1995). Studying survivors of childhood cancer for late effects of therapy. Int J Ped Hematol Oncol 2: 325-336.
    • (1995) Int J Ped Hematol Oncol , vol.2 , pp. 325-336
    • Blatt, J.1
  • 17
    • 0017750034 scopus 로고
    • Clinical pharmacology of intrathecal methotrexate. II. An improved dosage regimen derived from age-related pharmacokinetics
    • Bleyer WA (1977). Clinical pharmacology of intrathecal methotrexate. II. An improved dosage regimen derived from age-related pharmacokinetics. Cancer Treat Rep 61: 1419-1425.
    • (1977) Cancer Treat Rep , vol.61 , pp. 1419-1425
    • Bleyer, W.A.1
  • 18
    • 0017873070 scopus 로고
    • The clinical pharmacology of methotrexate
    • Bleyer WA (1978). The clinical pharmacology of methotrexate. Cancer 41: 36-51.
    • (1978) Cancer , vol.41 , pp. 36-51
    • Bleyer, W.A.1
  • 20
    • 0023508521 scopus 로고
    • Systemic clearance of methotrexate in the prognosis of acute lymphoblastic leukemia in children
    • Borsi JD, Moe PJ (1987). Systemic clearance of methotrexate in the prognosis of acute lymphoblastic leukemia in children, Cancer 60: 3020-3024.
    • (1987) Cancer , vol.60 , pp. 3020-3024
    • Borsi, J.D.1    Moe, P.J.2
  • 21
    • 0027405396 scopus 로고
    • Cellular pharmacology of 6-mercaptopurine in acute lymphoblastic leukemia
    • Bostrom B, Erdmann G (1993). Cellular pharmacology of 6-mercaptopurine in acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol 15: 80-86.
    • (1993) Am J Pediatr Hematol Oncol , vol.15 , pp. 80-86
    • Bostrom, B.1    Erdmann, G.2
  • 22
    • 0342673075 scopus 로고
    • Association of relapse with mercaptopurine (6MP) cellular pharmacokinetics (CPK) in children with acute lymphoblastic leukemia (ALL)
    • Abstract
    • Bostrom B, Erdmann G (1992). Association of relapse with mercaptopurine (6MP) cellular pharmacokinetics (CPK) in children with acute lymphoblastic leukemia (ALL). Proc Am Soc Clin Oncol 11: 278 (Abstract).
    • (1992) Proc Am Soc Clin Oncol , vol.11 , pp. 278
    • Bostrom, B.1    Erdmann, G.2
  • 23
    • 0023886769 scopus 로고
    • Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages
    • Bökkerink JPM, Bakker MAH, Hulscher TW, DeAbreu RA, Schretlen EDAM (1988). Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages. Biochem Pharmacol 37: 2321-2327.
    • (1988) Biochem Pharmacol , vol.37 , pp. 2321-2327
    • Bökkerink, J.P.M.1    Bakker, M.A.H.2    Hulscher, T.W.3    DeAbreu, R.A.4    Schretlen, E.D.A.M.5
  • 24
    • 0024989232 scopus 로고
    • Biochemical evidence for synergistic combination treatment with methotrexate and 6-mercaptopurine in acute lymphoblastic leukemia
    • Bökkerink JPM, Damen FJ, Hulscher MW, Bakker MA, De Abreu RA (1990). Biochemical evidence for synergistic combination treatment with methotrexate and 6-mercaptopurine in acute lymphoblastic leukemia. Hamatol Bluttransfus 33: 110-117.
    • (1990) Hamatol Bluttransfus , vol.33 , pp. 110-117
    • Bökkerink, J.P.M.1    Damen, F.J.2    Hulscher, M.W.3    Bakker, M.A.4    De Abreu, R.A.5
  • 25
    • 0027976273 scopus 로고
    • Outcome prediction in childhood acute lymphoblastic leukaemia by molecular quantification of residual disease at the end of induction
    • Brisco MJ, Condon J, Hughes E, et al. (1994). Outcome prediction in childhood acute lymphoblastic leukaemia by molecular quantification of residual disease at the end of induction. Lancet 343: 196-200.
    • (1994) Lancet , vol.343 , pp. 196-200
    • Brisco, M.J.1    Condon, J.2    Hughes, E.3
  • 26
    • 0015606968 scopus 로고
    • Studies on the xanthine oxidase activity in mammalian cells
    • Brunschede H, Krooth RS (1973). Studies on the xanthine oxidase activity in mammalian cells. Biochem Genet 8: 341-350.
    • (1973) Biochem Genet , vol.8 , pp. 341-350
    • Brunschede, H.1    Krooth, R.S.2
  • 27
    • 0024822385 scopus 로고
    • Analysis of 6-mercaptopurine, 6-thioguanine nucleotides, and 6-thiouric acid in biological fluids by high-performance liquid chromatography
    • Bruunshuus I, Schmiegelow K (1989). Analysis of 6-mercaptopurine, 6-thioguanine nucleotides, and 6-thiouric acid in biological fluids by high-performance liquid chromatography. Scand J Clin Lab Invest 49: 779-784.
    • (1989) Scand J Clin Lab Invest , vol.49 , pp. 779-784
    • Bruunshuus, I.1    Schmiegelow, K.2
  • 28
    • 0000284526 scopus 로고
    • Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases
    • Burchenal JH, Murphy ML, Ellison RR, et al. (1953). Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases. Blood 8: 965-987.
    • (1953) Blood , vol.8 , pp. 965-987
    • Burchenal, J.H.1    Murphy, M.L.2    Ellison, R.R.3
  • 30
    • 0024343162 scopus 로고
    • Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: A Pediatric Oncology Group study
    • Camitta BM, Leventhal B, Lauer S, et al. (1989). Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: a Pediatric Oncology Group study. J Clin Oncol 7: 1539-1544.
    • (1989) J Clin Oncol , vol.7 , pp. 1539-1544
    • Camitta, B.M.1    Leventhal, B.2    Lauer, S.3
  • 31
    • 4243850218 scopus 로고
    • Hyperploid acute lymphoblastic leukemia (ALL): A distinct biologic entity with marked propensity to programmed cell death
    • Abstract
    • Campana D, Kumagai M, Manabe A, et al. (1993). Hyperploid acute lymphoblastic leukemia (ALL): a distinct biologic entity with marked propensity to programmed cell death. Blood 82 (suppl. 1): 49a (Abstract).
    • (1993) Blood , vol.82 , Issue.1 SUPPL.
    • Campana, D.1    Kumagai, M.2    Manabe, A.3
  • 32
    • 0024041237 scopus 로고
    • Regulation of the production and function og granulocytes and monocytes
    • Cannistra SA, Griffin JD (1988). Regulation of the production and function og granulocytes and monocytes. Semin Hematol 25: 173-188.
    • (1988) Semin Hematol , vol.25 , pp. 173-188
    • Cannistra, S.A.1    Griffin, J.D.2
  • 33
    • 0021075273 scopus 로고
    • A dose and time response analysis in the treatment of Hodgkin's disease with MOPP chemotherapy
    • Carde P, MacKintosh FR, Rosenberg SA (1983). A dose and time response analysis in the treatment of Hodgkin's disease with MOPP chemotherapy. J Clin Oncol 1: 146-153.
    • (1983) J Clin Oncol , vol.1 , pp. 146-153
    • Carde, P.1    MacKintosh, F.R.2    Rosenberg, S.A.3
  • 35
    • 0024281043 scopus 로고
    • In celebration of a Nobel Prize
    • Chabner BA (1988). In celebration of a Nobel Prize (editorial). J Natl Cancer Inst 80: 1512-1513.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 1512-1513
    • Chabner, B.A.1
  • 37
    • 0017585128 scopus 로고
    • Acute lymphoblastic leukaemia in children: Classification and prognosis
    • Chessells JM, Hardisty RM, Rapson NT (1977). Acute lymphoblastic leukaemia in children: Classification and prognosis. Lancet ii: 1307-1309.
    • (1977) Lancet , vol.2 , pp. 1307-1309
    • Chessells, J.M.1    Hardisty, R.M.2    Rapson, N.T.3
  • 38
    • 0023103086 scopus 로고
    • Long survival in childhood lymphoblastic leukaemia
    • Chessells JM, Hardisty RM, Richards S (1987a). Long survival in childhood lymphoblastic leukaemia. Br J Cancer 55: 315-319.
    • (1987) Br J Cancer , vol.55 , pp. 315-319
    • Chessells, J.M.1    Hardisty, R.M.2    Richards, S.3
  • 39
    • 0023102448 scopus 로고
    • Oral methotrexate is as effective as intramuscular in maintenance therapy of acute lymphoblastic leukaemia
    • Chessells JM, Leiper AD, Tiedemann K, Hardisty RM, Richards S (1987b). Oral methotrexate is as effective as intramuscular in maintenance therapy of acute lymphoblastic leukaemia. Arch Dis Child 62: 172-176.
    • (1987) Arch Dis Child , vol.62 , pp. 172-176
    • Chessells, J.M.1    Leiper, A.D.2    Tiedemann, K.3    Hardisty, R.M.4    Richards, S.5
  • 40
    • 0025255362 scopus 로고
    • Neurotoxicity in lymphoblastic leukaemia: Comparison of oral and intramuscular methotrexate and two doses of radiation
    • Chessells JM, Cox TC, Kendall B, Cavanagh NP, Jannoun L, Richards S (1990). Neurotoxicity in lymphoblastic leukaemia: comparison of oral and intramuscular methotrexate and two doses of radiation. Arch Dis Child 65: 416-422.
    • (1990) Arch Dis Child , vol.65 , pp. 416-422
    • Chessells, J.M.1    Cox, T.C.2    Kendall, B.3    Cavanagh, N.P.4    Jannoun, L.5    Richards, S.6
  • 41
    • 0027103631 scopus 로고
    • Treatment of childhood acute lymphoblastic leukaemia: Present issues and future prospects
    • Chessells JM (1992). Treatment of childhood acute lymphoblastic leukaemia: present issues and future prospects. Blood Rev 6: 193-203.
    • (1992) Blood Rev , vol.6 , pp. 193-203
    • Chessells, J.M.1
  • 42
    • 0025758201 scopus 로고
    • Chemotherapy dose intensity correlates strongly with response, median survival, and median, progression-free survival in metastatic neuroblastoma
    • Cheung NK, Heller G (1991). Chemotherapy dose intensity correlates strongly with response, median survival, and median, progression-free survival in metastatic neuroblastoma. J Clin Oncol 9: 1050-1058.
    • (1991) J Clin Oncol , vol.9 , pp. 1050-1058
    • Cheung, N.K.1    Heller, G.2
  • 43
    • 10144246581 scopus 로고    scopus 로고
    • Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukemia: Overview of 42 trials involving 12000 randomised children
    • Childhood ALL Collaborative Group (1996). Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukemia: overview of 42 trials involving 12000 randomised children. Lancet 347: 1783-1788.
    • (1996) Lancet , vol.347 , pp. 1783-1788
  • 44
    • 0021148310 scopus 로고
    • 6-Thioguanine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells
    • Christie NT, Drake S, Meyn RE, Nelson JA (1984). 6-Thioguanine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells. Cancer Res 44: 3665-3671.
    • (1984) Cancer Res , vol.44 , pp. 3665-3671
    • Christie, N.T.1    Drake, S.2    Meyn, R.E.3    Nelson, J.A.4
  • 45
    • 0021134619 scopus 로고
    • Prognostic factors for relapsefree survival in childhood acute lymphoblastic leukemia
    • Clausen N, Scheibel E, Nyboe J (1984). Prognostic factors for relapsefree survival in childhood acute lymphoblastic leukemia. Scand J Haematol 33: 295-300.
    • (1984) Scand J Haematol , vol.33 , pp. 295-300
    • Clausen, N.1    Scheibel, E.2    Nyboe, J.3
  • 46
    • 7844227512 scopus 로고
    • Reference values for hematological investigations
    • Conn J, Jordal R (1982). Reference values for hematological investigations. Scand J Soc Med Suppl.30: 11-17.
    • (1982) Scand J Soc Med Suppl. , vol.30 , pp. 11-17
    • Conn, J.1    Jordal, R.2
  • 47
    • 0018765431 scopus 로고
    • Adjuvant treatment of primary osteosarcoma: Cancer and Leukemia Group B experience
    • Cortes EP, Holland JF, Glidewell O (1979). Adjuvant treatment of primary osteosarcoma: Cancer and Leukemia Group B experience. Recent Results Cancer Res 68: 16-24.
    • (1979) Recent Results Cancer Res , vol.68 , pp. 16-24
    • Cortes, E.P.1    Holland, J.F.2    Glidewell, O.3
  • 48
    • 0023761801 scopus 로고
    • Cognitive effects of cranial irradiation in leukaemia: A survey and meta-analysis
    • Cousens P, Waters B, Said J, Stevens M (1988). Cognitive effects of cranial irradiation in leukaemia: a survey and meta-analysis. J Child Psychol Psychiatry 29: 839-852.
    • (1988) J Child Psychol Psychiatry , vol.29 , pp. 839-852
    • Cousens, P.1    Waters, B.2    Said, J.3    Stevens, M.4
  • 49
    • 0000336139 scopus 로고
    • Regression models and life-tables (with discussion)
    • Cox DR (1972). Regression models and life-tables (with discussion). J R Stat Soc (B) 34: 187-220.
    • (1972) J r Stat Soc (B) , vol.34 , pp. 187-220
    • Cox, D.R.1
  • 50
    • 0017666482 scopus 로고
    • Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia
    • Craft AW, Kay H, Lawson DN, McElwain TJ (1977). Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia. Br Med J 2: 1511-1512.
    • (1977) Br Med J , vol.2 , pp. 1511-1512
    • Craft, A.W.1    Kay, H.2    Lawson, D.N.3    McElwain, T.J.4
  • 51
    • 0019799409 scopus 로고
    • Methotrexate absorption in children with acute lymphocytic leukemia
    • Craft AW, Rankin A, Aherne W (1981). Methotrexate absorption in children with acute lymphocytic leukemia. Cancer Treat Rep 65 (suppl 1): 77-81.
    • (1981) Cancer Treat Rep , vol.65 , Issue.1 SUPPL. , pp. 77-81
    • Craft, A.W.1    Rankin, A.2    Aherne, W.3
  • 52
    • 0019773777 scopus 로고
    • The transport and accumulation of methotrexate in human erythrocytes
    • da Costa M, Iqbal MP (1981). The transport and accumulation of methotrexate in human erythrocytes. Cancer 48: 2427-2432.
    • (1981) Cancer , vol.48 , pp. 2427-2432
    • Da Costa, M.1    Iqbal, M.P.2
  • 53
    • 0017325603 scopus 로고
    • Structural and functional abnormalities of the small intestine due to nutritional folic acid deficiency in infancy
    • Davidson GP, Townley RRW (1977). Structural and functional abnormalities of the small intestine due to nutritional folic acid deficiency in infancy. J Pediatr 90: 590.
    • (1977) J Pediatr , vol.90 , pp. 590
    • Davidson, G.P.1    Townley, R.R.W.2
  • 54
    • 0027298618 scopus 로고
    • Variable mercaptopurine metabolism in children with leukaemia: A problem of non-compliance?
    • Davies HA, Lennard L, Lilleyman JS (1993). Variable mercaptopurine metabolism in children with leukaemia: a problem of non-compliance? BMJ 306: 1239-1240.
    • (1993) BMJ , vol.306 , pp. 1239-1240
    • Davies, H.A.1    Lennard, L.2    Lilleyman, J.S.3
  • 56
    • 0024436346 scopus 로고
    • Prognostic importance of myelosuppression during maintenance treatment of lymphoblastic leukaemia. Leukaemia in Childhood Working Party of the Medical Research Council
    • Dolan G, Lilleyman JS, Richards SM (1989). Prognostic importance of myelosuppression during maintenance treatment of lymphoblastic leukaemia. Leukaemia in Childhood Working Party of the Medical Research Council. Arch Dis Child 64: 1231-1234.
    • (1989) Arch Dis Child , vol.64 , pp. 1231-1234
    • Dolan, G.1    Lilleyman, J.S.2    Richards, S.M.3
  • 57
    • 0023080978 scopus 로고
    • Medical Research Council Childhood Leukaemia Trial VIII compared with trials II-VII: Lessons for future management
    • Eden OB, Lilleyman J, Shaw MP, Richards S, Peto J (1987). Medical Research Council Childhood Leukaemia Trial VIII compared with trials II-VII: lessons for future management. Hamatol Bluttransfus 30: 448-455.
    • (1987) Hamatol Bluttransfus , vol.30 , pp. 448-455
    • Eden, O.B.1    Lilleyman, J.2    Shaw, M.P.3    Richards, S.4    Peto, J.5
  • 58
    • 0000378195 scopus 로고
    • Hepatotoxicity of mercaptopurine
    • Einhorn M, Davidson I (1964). Hepatotoxicity of mercaptopurine. JAMA 188: 802-806.
    • (1964) JAMA , vol.188 , pp. 802-806
    • Einhorn, M.1    Davidson, I.2
  • 59
    • 0014087635 scopus 로고
    • Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues
    • Elion GB (1967). Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues. Fed Proc 26: 898-904.
    • (1967) Fed Proc , vol.26 , pp. 898-904
    • Elion, G.B.1
  • 60
    • 0023184783 scopus 로고
    • Pharmacologically guided dose escalation in phase I trial. Commentary and proposed guidelines
    • EORTC Pharmacokinetic and Metabolism Group (1987). Pharmacologically guided dose escalation in phase I trial. Commentary and proposed guidelines. Eur J Cancer Clin Oncol 23: 1083-1087.
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 1083-1087
  • 61
    • 0015167496 scopus 로고
    • Pertuberation of generation cycle of human leukemic myeloblasts in vivo by methotrexate
    • Ernst P, Killman S (1971). Pertuberation of generation cycle of human leukemic myeloblasts in vivo by methotrexate. Blood 38: 689-705.
    • (1971) Blood , vol.38 , pp. 689-705
    • Ernst, P.1    Killman, S.2
  • 62
    • 0021044399 scopus 로고
    • Pharmacokinetics of anticancer drugs in children
    • Evans WE, Crom WR, Sinkule JA, et al. (1983). Pharmacokinetics of anticancer drugs in children. Drug Metab Rev 14: 847-886.
    • (1983) Drug Metab Rev , vol.14 , pp. 847-886
    • Evans, W.E.1    Crom, W.R.2    Sinkule, J.A.3
  • 63
    • 0021337107 scopus 로고
    • Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukemia
    • Evans WE, Crom WR, Stewart CF, et al. (1984). Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukemia. Lancet 1: 359-362.
    • (1984) Lancet , vol.1 , pp. 359-362
    • Evans, W.E.1    Crom, W.R.2    Stewart, C.F.3
  • 64
    • 0022591568 scopus 로고
    • Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia - Identification of a relation between concentration and effect
    • Evans WE, Crom WR, Abromowitch M, et al. (1986). Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia - identification of a relation between concentration and effect. N Eng J Med 314: 471-477.
    • (1986) N Eng J Med , vol.314 , pp. 471-477
    • Evans, W.E.1    Crom, W.R.2    Abromowitch, M.3
  • 65
    • 0025837127 scopus 로고
    • Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
    • Evans WE, Horner M, Chu YQ, Kalwinsky D, Roberts WM (1991a). Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia. J Pediatr 119: 985-989.
    • (1991) J Pediatr , vol.119 , pp. 985-989
    • Evans, W.E.1    Horner, M.2    Chu, Y.Q.3    Kalwinsky, D.4    Roberts, W.M.5
  • 66
    • 0025856668 scopus 로고
    • Individualized dosages of chemotherapy as a strategy to improve response for acute lymphocytic leukemia
    • Evans WE, Rodman J, Relling MV, Crom WR, Rivera GK, Crist WM, Pui CM (1991b). Individualized dosages of chemotherapy as a strategy to improve response for acute lymphocytic leukemia. Semin Hematol 28: 15-21.
    • (1991) Semin Hematol , vol.28 , pp. 15-21
    • Evans, W.E.1    Rodman, J.2    Relling, M.V.3    Crom, W.R.4    Rivera, G.K.5    Crist, W.M.6    Pui, C.M.7
  • 68
    • 0021167732 scopus 로고
    • Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro
    • Fabre I, Fabre G, Goldman ID (1984). Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro. Cancer Res 44: 3190-3195.
    • (1984) Cancer Res , vol.44 , pp. 3190-3195
    • Fabre, I.1    Fabre, G.2    Goldman, I.D.3
  • 69
    • 0023002521 scopus 로고
    • Concurrent unilateral chromatid damage and DNA strand breakage in response to 6-thioguanine treatment
    • Fairchild CR, Maybaum J, Kennedy KA (1986). Concurrent unilateral chromatid damage and DNA strand breakage in response to 6-thioguanine treatment. Biochem Pharmacol 35: 3533-3541.
    • (1986) Biochem Pharmacol , vol.35 , pp. 3533-3541
    • Fairchild, C.R.1    Maybaum, J.2    Kennedy, K.A.3
  • 70
    • 78651010566 scopus 로고
    • Temporary remissions in acute leukemia in children produced by folic acid antagonist 4-aminopteroylglutamic acid
    • Farber S, Diamond LK, Mercer RD, Sylvester RF, Wolff JA (1948). Temporary remissions in acute leukemia in children produced by folic acid antagonist 4-aminopteroylglutamic acid (aminopterin). N Engl J Med 238: 787-793.
    • (1948) N Engl J Med , vol.238 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2    Mercer, R.D.3    Sylvester, R.F.4    Wolff, J.A.5
  • 71
    • 0016212839 scopus 로고
    • Purine and pyrimidine pool sizes and purine utilization in human lymphocytes and cultured lymphoblasts
    • Fields T, Brox L (1974). Purine and pyrimidine pool sizes and purine utilization in human lymphocytes and cultured lymphoblasts. Can J Biochem 52: 441-446.
    • (1974) Can J Biochem , vol.52 , pp. 441-446
    • Fields, T.1    Brox, L.2
  • 72
    • 0000705586 scopus 로고
    • Studies of sequential and combination antimetabolite therapy in acute leukemia: 6-mercaptopurine and methotrexate
    • Frei E 3rd., Freireich EJ, Gehan E, et al. (1961). Studies of sequential and combination antimetabolite therapy in acute leukemia: 6-mercaptopurine and methotrexate. Blood 18: 431-454.
    • (1961) Blood , vol.18 , pp. 431-454
    • Frei III, E.1    Freireich, E.J.2    Gehan, E.3
  • 73
    • 0013811894 scopus 로고
    • The effectiveness of combinations of antileukemia agents in inducing and maintaining remission in children with acute leukemia
    • Frei E 3rd., Caron M, Levin RH, et al. (1965). The effectiveness of combinations of antileukemia agents in inducing and maintaining remission in children with acute leukemia. Blood 26: 642-656.
    • (1965) Blood , vol.26 , pp. 642-656
    • Frei III, E.1    Caron, M.2    Levin, R.H.3
  • 74
    • 0018931869 scopus 로고
    • Dose: A critical factor in cancer chemotherapy
    • Frei E 3rd., Canellos G (1980). Dose: A critical factor in cancer chemotherapy. Am J Med 69: 585-594.
    • (1980) Am J Med , vol.69 , pp. 585-594
    • Frei III, E.1    Canellos, G.2
  • 75
    • 0000946552 scopus 로고
    • The effect of 6-mercaptopurine on the duration of steroid-induced remission in acute leukemia: A model for evaluation of other potentially useful therapy
    • Freireich EJ, Gehan E, Frei E 3rd., et al. (1963). The effect of 6-mercaptopurine on the duration of steroid-induced remission in acute leukemia: a model for evaluation of other potentially useful therapy. Blood 21: 699-716.
    • (1963) Blood , vol.21 , pp. 699-716
    • Freireich, E.J.1    Gehan, E.2    Frei III, E.3
  • 76
    • 0027429687 scopus 로고
    • Therapeutic drug monitoring in cancer management
    • Galpin AJ, Evans WE (1993). Therapeutic drug monitoring in cancer management. Clin Chem 39: 2419-2430.
    • (1993) Clin Chem , vol.39 , pp. 2419-2430
    • Galpin, A.J.1    Evans, W.E.2
  • 77
    • 7844239950 scopus 로고
    • Impact of treatment dose and delay on the disease free survival (DFS) of children with acute lymphoblastic leukemia (ALL) and unfavourable prognostic features
    • Gaynon P, Bleyer WA, Steinherz P, et al. (1987). Impact of treatment dose and delay on the disease free survival (DFS) of children with acute lymphoblastic leukemia (ALL) and unfavourable prognostic features. Proc Am Soc Clin Oncol 6: 156.
    • (1987) Proc Am Soc Clin Oncol , vol.6 , pp. 156
    • Gaynon, P.1    Bleyer, W.A.2    Steinherz, P.3
  • 78
    • 0025365178 scopus 로고
    • Day 7 marrow response and outcome for children with acute lymphoblastic leukemia and unfavourable presenting features
    • Gaynon P, Bleyer WA, Steinherz PG, et al. (1990). Day 7 marrow response and outcome for children with acute lymphoblastic leukemia and unfavourable presenting features. Med Ped Oncol 18: 273-279.
    • (1990) Med Ped Oncol , vol.18 , pp. 273-279
    • Gaynon, P.1    Bleyer, W.A.2    Steinherz, P.G.3
  • 79
    • 0025915547 scopus 로고
    • Association of delivered drug dosage and outcome for children with acute lymphoblastic leukemia and unfavorable presenting features
    • Gaynon P, Steinherz P, Bleyer WA, et al. (1991). Association of delivered drug dosage and outcome for children with acute lymphoblastic leukemia and unfavorable presenting features. Med Pediatr Oncol 19: 221-227.
    • (1991) Med Pediatr Oncol , vol.19 , pp. 221-227
    • Gaynon, P.1    Steinherz, P.2    Bleyer, W.A.3
  • 80
    • 0026884999 scopus 로고
    • Effect of dose intensity and therapy-induced leukocytopenia in intensive therapy on the prognosis of acute lymphatic leukemia in childhood. Results in 213 patients of the COALL-85 study
    • Gobrecht O, Gobel U, Graubner U, Gutjahr P, Schock V, Spaar HJ, Janka Schaub GE (1992). Effect of dose intensity and therapy-induced leukocytopenia in intensive therapy on the prognosis of acute lymphatic leukemia in childhood. Results in 213 patients of the COALL-85 study. Klin Padiatr 204: 230-235.
    • (1992) Klin Padiatr , vol.204 , pp. 230-235
    • Gobrecht, O.1    Gobel, U.2    Graubner, U.3    Gutjahr, P.4    Schock, V.5    Spaar, H.J.6    Janka Schaub, G.E.7
  • 81
    • 0026443245 scopus 로고
    • Red blood cell methotrexate and folate levels in children with acute lymphoblastic leukemia undergoing therapy: A Pediatric Oncology Group pilot study
    • Graham ML, Shuster JJ, Kamen BA, et al. (1992). Red blood cell methotrexate and folate levels in children with acute lymphoblastic leukemia undergoing therapy: a Pediatric Oncology Group pilot study. Cancer Chemother Pharmacol 31: 217-222.
    • (1992) Cancer Chemother Pharmacol , vol.31 , pp. 217-222
    • Graham, M.L.1    Shuster, J.J.2    Kamen, B.A.3
  • 82
    • 0019402366 scopus 로고
    • Immunologically defined subclasses of acute lymphoblastic leukemia in children: Their relationship to presentation features and prognosis
    • Greaves M, Janossy G, Peto J, et al. (1981). Immunologically defined subclasses of acute lymphoblastic leukemia in children: their relationship to presentation features and prognosis. Br J Haematol 48: 179-197.
    • (1981) Br J Haematol , vol.48 , pp. 179-197
    • Greaves, M.1    Janossy, G.2    Peto, J.3
  • 83
    • 0026346078 scopus 로고
    • Human liver xanthine oxidase: Nature and extent of individual variation
    • Guerciolini R, Szumlanski C, Weinshilboum RM (1991). Human liver xanthine oxidase: nature and extent of individual variation. Clin Pharmacol Ther 50: 663-672.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 663-672
    • Guerciolini, R.1    Szumlanski, C.2    Weinshilboum, R.M.3
  • 84
    • 0024494213 scopus 로고
    • A population-based study of children with standard risk acute lymphoblastic leukemia in the five Nordic countries
    • Gustafsson G, Berglund G, Garwicz S, et al. (1989). A population-based study of children with standard risk acute lymphoblastic leukemia in the five Nordic countries. Acta Paediatr Scand 78: 104-109.
    • (1989) Acta Paediatr Scand , vol.78 , pp. 104-109
    • Gustafsson, G.1    Berglund, G.2    Garwicz, S.3
  • 85
    • 0025910714 scopus 로고
    • Importance of 6-mercaptopurine dose in lymphoblastic leukemia
    • Hale JP, Lilleyman JS (1991). Importance of 6-mercaptopurine dose in lymphoblastic leukemia. Arch Dis Child 66: 462-466.
    • (1991) Arch Dis Child , vol.66 , pp. 462-466
    • Hale, J.P.1    Lilleyman, J.S.2
  • 86
    • 0344099828 scopus 로고
    • The fate of 6-mercaptopurine in man
    • Hamilton L, Elion GB (1954). The fate of 6-mercaptopurine in man. Ann N Y Acad Sci 60: 304-314.
    • (1954) Ann N Y Acad Sci , vol.60 , pp. 304-314
    • Hamilton, L.1    Elion, G.B.2
  • 87
    • 0022915421 scopus 로고
    • Analysis of prognostic factors in acute lymphoblastic leukemia
    • Hammond D, Sather H, Nesbit M, et al. (1986). Analysis of prognostic factors in acute lymphoblastic leukemia. Med Ped Oncol 14: 124-134.
    • (1986) Med Ped Oncol , vol.14 , pp. 124-134
    • Hammond, D.1    Sather, H.2    Nesbit, M.3
  • 88
    • 0025940510 scopus 로고
    • Drug monitoring in cancer therapy
    • Hande KR (1991). Drug monitoring in cancer therapy. J Natl Cancer Inst 83: 1523-1524.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 1523-1524
    • Hande, K.R.1
  • 90
    • 0025735163 scopus 로고
    • Chronobiology. Suggestions for integrating it into drug development
    • Harter JG, Peck CC (1991). Chronobiology. Suggestions for integrating it into drug development. Ann N Y Acad Sci 618: 563-571.
    • (1991) Ann N Y Acad Sci , vol.618 , pp. 563-571
    • Harter, J.G.1    Peck, C.C.2
  • 91
    • 0021280624 scopus 로고
    • The bioavailability of oral intermediate-dose methotrexate. Effect of dose subdivision, formulation, and timing in the chemotherapy cycle
    • Harvey VJ, Slevin ML, Woollard RC, Johnston A, Barnett MJ, Wrigley PF, Turner P (1984). The bioavailability of oral intermediate-dose methotrexate. Effect of dose subdivision, formulation, and timing in the chemotherapy cycle. Cancer Chemother Pharmacol 13: 91-94.
    • (1984) Cancer Chemother Pharmacol , vol.13 , pp. 91-94
    • Harvey, V.J.1    Slevin, M.L.2    Woollard, R.C.3    Johnston, A.4    Barnett, M.J.5    Wrigley, P.F.6    Turner, P.7
  • 92
    • 0024428165 scopus 로고
    • 6-mercaptopurine plasma levels in children with acute lymphoblastic leukemia: Relation to relapse risk and myelotoxicity
    • Hayder S, Lafolie P, Björk O, Peterson C (1989). 6-mercaptopurine plasma levels in children with acute lymphoblastic leukemia: relation to relapse risk and myelotoxicity. Ther Drug Monit 11: 617-622.
    • (1989) Ther Drug Monit , vol.11 , pp. 617-622
    • Hayder, S.1    Lafolie, P.2    Björk, O.3    Peterson, C.4
  • 93
    • 0025145056 scopus 로고
    • The course of biological parameters and 6-mercaptopurine pharmacokinetics during maintenance treatment of children with acute lymphoblastic leukaemia
    • Hayder S, Björk O, Lafolie P (1990). The course of biological parameters and 6-mercaptopurine pharmacokinetics during maintenance treatment of children with acute lymphoblastic leukaemia. Acta Paediatr Scand 79: 832-837.
    • (1990) Acta Paediatr Scand , vol.79 , pp. 832-837
    • Hayder, S.1    Björk, O.2    Lafolie, P.3
  • 94
    • 0026549023 scopus 로고
    • Relapse factors during maintenance therapy of acute lymphoblastic leukemia in children
    • Hayder S, Björk O, Nilsson B (1992). Relapse factors during maintenance therapy of acute lymphoblastic leukemia in children. Pediatr Hematol Oncol 9: 21-27.
    • (1992) Pediatr Hematol Oncol , vol.9 , pp. 21-27
    • Hayder, S.1    Björk, O.2    Nilsson, B.3
  • 95
    • 0022400479 scopus 로고
    • Clinical pharmacokinetics of methotrexate in psoriasis therapy
    • Hendel J (1985). Clinical pharmacokinetics of methotrexate in psoriasis therapy. Dan Med Bull 32: 329-337.
    • (1985) Dan Med Bull , vol.32 , pp. 329-337
    • Hendel, J.1
  • 96
    • 0021861419 scopus 로고
    • Changes in liver histology during methotrexate therapy of psoriasis correlated to the concentration of methotrexate and folate in erythrocytes
    • Hendel J, Poulsen H, Nyfors B, Nyfors A (1985). Changes in liver histology during methotrexate therapy of psoriasis correlated to the concentration of methotrexate and folate in erythrocytes. Acta Pharmacol Toxicol Copenh 56: 321-326.
    • (1985) Acta Pharmacol Toxicol Copenh , vol.56 , pp. 321-326
    • Hendel, J.1    Poulsen, H.2    Nyfors, B.3    Nyfors, A.4
  • 97
    • 0021690820 scopus 로고
    • Pharmacokinetics of methotrexate in erythrocytes in psoriasis
    • Hendel J, Nyfors A (1984a). Pharmacokinetics of methotrexate in erythrocytes in psoriasis. Eur J Clin Pharmacol 27: 607-610.
    • (1984) Eur J Clin Pharmacol , vol.27 , pp. 607-610
    • Hendel, J.1    Nyfors, A.2
  • 98
    • 0021359905 scopus 로고
    • Nonlinear renal elimination kinetics of methotrexate due to saturation of renal tubular reabsorption
    • Hendel J, Nyfors A (1984b). Nonlinear renal elimination kinetics of methotrexate due to saturation of renal tubular reabsorption. Eur J Clin Pharmacol 26: 121-124.
    • (1984) Eur J Clin Pharmacol , vol.26 , pp. 121-124
    • Hendel, J.1    Nyfors, A.2
  • 99
    • 0023779590 scopus 로고
    • Single-point MTX erythrocyte levels in relation to progressive liver fibrosis
    • Hendel J, Nyfors A (1988). Single-point MTX erythrocyte levels in relation to progressive liver fibrosis. Acta Derm Venereol Stockh 68: 91.
    • (1988) Acta Derm Venereol Stockh , vol.68 , pp. 91
    • Hendel, J.1    Nyfors, A.2
  • 100
    • 0019981311 scopus 로고
    • 6-mercaptopurine: Apparent lack of relation between prescribed dose and biological effect in children with leukaemia
    • Herber S, Lennard L, Lilleyman JS, Maddocks JL (1982). 6-mercaptopurine: Apparent lack of relation between prescribed dose and biological effect in children with leukaemia. Br J Cancer 46: 138-141.
    • (1982) Br J Cancer , vol.46 , pp. 138-141
    • Herber, S.1    Lennard, L.2    Lilleyman, J.S.3    Maddocks, J.L.4
  • 101
    • 0017131460 scopus 로고
    • Metabolism of 6-mercaptopurine in human leukemic cells
    • Higuchi T, Nakamura T, Wakisaka G (1976). Metabolism of 6-mercaptopurine in human leukemic cells. Cancer Res 36: 3779-3783.
    • (1976) Cancer Res , vol.36 , pp. 3779-3783
    • Higuchi, T.1    Nakamura, T.2    Wakisaka, G.3
  • 102
    • 0017689430 scopus 로고
    • Comparative study of 6-mercaptopurine metabolism in human leukemic leukocytes and L1210 cells
    • Higuchi T, Nakamura T, Uchino H, Wasikaka G (1977). Comparative study of 6-mercaptopurine metabolism in human leukemic leukocytes and L1210 cells. Antimicr Agents Chemother 12: 518-522.
    • (1977) Antimicr Agents Chemother , vol.12 , pp. 518-522
    • Higuchi, T.1    Nakamura, T.2    Uchino, H.3    Wasikaka, G.4
  • 103
    • 0014448404 scopus 로고
    • Purification and properties of 5-phosphoribosyl pyrophosphate amidotransferase from adenocarcinoma 755 cells
    • Hill DL, Bennett LL (1980). Purification and properties of 5-phosphoribosyl pyrophosphate amidotransferase from adenocarcinoma 755 cells. Biochemistry 8: 122-130.
    • (1980) Biochemistry , vol.8 , pp. 122-130
    • Hill, D.L.1    Bennett, L.L.2
  • 104
    • 0015918864 scopus 로고
    • Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties
    • Holmes EW, McDonald JA, McCord JM, Wyngaarden JB, Kelley WN (1973). Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties. J Biol Chem 248: 144-150.
    • (1973) J Biol Chem , vol.248 , pp. 144-150
    • Holmes, E.W.1    McDonald, J.A.2    McCord, J.M.3    Wyngaarden, J.B.4    Kelley, W.N.5
  • 106
    • 0021744793 scopus 로고
    • The importance of dose intensity in chemotherapy of metastatic breast cancer
    • Hryniuk W, Bush H (1984). The importance of dose intensity in chemotherapy of metastatic breast cancer. J Clin Oncol 2: 1281-1288.
    • (1984) J Clin Oncol , vol.2 , pp. 1281-1288
    • Hryniuk, W.1    Bush, H.2
  • 107
    • 0023747871 scopus 로고
    • The importance of dose intensity in the outcome of chemotherapy
    • DeVita VT, Hellman S, Rosenberg SA (eds) J.B.Lippincott, Philadelphia
    • Hryniuk WM (1988). The importance of dose intensity in the outcome of chemotherapy. In: DeVita VT, Hellman S, Rosenberg SA (eds) Important advances in oncology. J.B.Lippincott, Philadelphia: 121-141.
    • (1988) Important Advances in Oncology , pp. 121-141
    • Hryniuk, W.M.1
  • 108
    • 0024995273 scopus 로고
    • Integrating the concept of dose intensity into a strategy for systemic therapy of malignant disease
    • Hryniuk WM (1990). Integrating the concept of dose intensity into a strategy for systemic therapy of malignant disease. Prog Clin Biol Res 354B: 93-101.
    • (1990) Prog Clin Biol Res , vol.354 B , pp. 93-101
    • Hryniuk, W.M.1
  • 109
    • 0016634038 scopus 로고
    • Stoichiometric inhibition of mammalian dihydrofolate reductase by the gamma-glutamyl metabolite of methotrexate 4-amino-4-deoxy-N10-methylpteroylglutamyl-gamma-glutamate
    • Jacobs SA, Adamson RH, Chabner BA, Derr CJ, Johns DG (1975). Stoichiometric inhibition of mammalian dihydrofolate reductase by the gamma-glutamyl metabolite of methotrexate 4-amino-4-deoxy-N10-methylpteroylglutamyl-gamma-glutamate. Biochem Biophys Res Commun 63: 9692-698.
    • (1975) Biochem Biophys Res Commun , vol.63 , pp. 9692-9698
    • Jacobs, S.A.1    Adamson, R.H.2    Chabner, B.A.3    Derr, C.J.4    Johns, D.G.5
  • 110
    • 0025812976 scopus 로고
    • Initial response to therapy as an important prognostic factor in acute lymphoblastic leukemia in childhood. COALL study group
    • Janka Schaub GE, Stuhrk H, Kortum B, et al. (1991). Initial response to therapy as an important prognostic factor in acute lymphoblastic leukemia in childhood. COALL study group, Klin Padiatr 203: 231-235.
    • (1991) Klin Padiatr , vol.203 , pp. 231-235
    • Janka Schaub, G.E.1    Stuhrk, H.2    Kortum, B.3
  • 111
    • 0021846386 scopus 로고
    • The effects of 6-mercaptopurine nucleotide derivatives on the growth and survival of 6-mercaplopurine-sensitive and -resistant cell culture lines
    • Johnston HP, Hawley P, White SE, Gibson I, Tidd DM (1985). The effects of 6-mercaptopurine nucleotide derivatives on the growth and survival of 6-mercaplopurine-sensitive and -resistant cell culture lines. Br J Cancer 51: 505-514.
    • (1985) Br J Cancer , vol.51 , pp. 505-514
    • Johnston, H.P.1    Hawley, P.2    White, S.E.3    Gibson, I.4    Tidd, D.M.5
  • 112
    • 0020554087 scopus 로고
    • The pharmacology and clinical use of methotrexate
    • Jolivet J, Cowan KH, Curt GA, et al. (1983). The pharmacology and clinical use of methotrexate. N Eng J Med 309: 1094-1104.
    • (1983) N Eng J Med , vol.309 , pp. 1094-1104
    • Jolivet, J.1    Cowan, K.H.2    Curt, G.A.3
  • 113
    • 0017261233 scopus 로고
    • A rapid, radiochemical-ligand binding assay for methotrexate
    • Kamen BA, Takach PL, Vatev R, Caston JD (1976). A rapid, radiochemical-ligand binding assay for methotrexate. Anal Biochem 70: 54-63.
    • (1976) Anal Biochem , vol.70 , pp. 54-63
    • Kamen, B.A.1    Takach, P.L.2    Vatev, R.3    Caston, J.D.4
  • 114
    • 0019486066 scopus 로고
    • Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug
    • Kamen BA, Nylen PA, Camitta BM, Bertino JR (1981). Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug. Br J Haematol 49: 355-360.
    • (1981) Br J Haematol , vol.49 , pp. 355-360
    • Kamen, B.A.1    Nylen, P.A.2    Camitta, B.M.3    Bertino, J.R.4
  • 115
    • 0021341695 scopus 로고
    • Methotrexate and folate content of erythrocytes in patients receiving oral vs intramuscular therapy with methotrexate
    • Kamen BA, Holcenberg JS, Turo K, Whitehead VM (1984). Methotrexate and folate content of erythrocytes in patients receiving oral vs intramuscular therapy with methotrexate. J Pediatr 104: 131-133.
    • (1984) J Pediatr , vol.104 , pp. 131-133
    • Kamen, B.A.1    Holcenberg, J.S.2    Turo, K.3    Whitehead, V.M.4
  • 116
    • 0022621387 scopus 로고
    • The influence of extracellular folate concentration on the methotrexate uptake by human KB cells
    • Kane MA, Portillo RM, Elwood PC, Antony AC, Kolhouse JF (1961). The influence of extracellular folate concentration on the methotrexate uptake by human KB cells. J Biol Chem 261: 44-49.
    • (1961) J Biol Chem , vol.261 , pp. 44-49
    • Kane, M.A.1    Portillo, R.M.2    Elwood, P.C.3    Antony, A.C.4    Kolhouse, J.F.5
  • 117
    • 33845382806 scopus 로고
    • Non-parametric estimation from incomplete observations
    • Kaplan EL, Meier P (1958). Non-parametric estimation from incomplete observations. J Am Stat Assoc 53: 457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 118
    • 0025767862 scopus 로고
    • Dose-dependent kinetics of orally administered 6-mercaptopurine in children with leukemia
    • Kato Y, Matsushita T, Chiba K, Hijiya N, Yokoyama T, Ishizaki T (1991). Dose-dependent kinetics of orally administered 6-mercaptopurine in children with leukemia. J Pediatr 119: 311-316.
    • (1991) J Pediatr , vol.119 , pp. 311-316
    • Kato, Y.1    Matsushita, T.2    Chiba, K.3    Hijiya, N.4    Yokoyama, T.5    Ishizaki, T.6
  • 119
    • 0018729607 scopus 로고
    • Unpredictable serum levels after oral methotrexate in children with acute lymphoblastic leukemia
    • Kearney PJ, Light PA, Preece A, Mort MG (1979). Unpredictable serum levels after oral methotrexate in children with acute lymphoblastic leukemia. Cancer Chemother Pharmacol 3: 117-120.
    • (1979) Cancer Chemother Pharmacol , vol.3 , pp. 117-120
    • Kearney, P.J.1    Light, P.A.2    Preece, A.3    Mort, M.G.4
  • 120
    • 0001014921 scopus 로고
    • Effects of azathioprine on purine synthesis in clinical disorders of purine metabolism
    • Kelley WN, Rosenbloom FM, Seegmiller JE (1967). Effects of azathioprine on purine synthesis in clinical disorders of purine metabolism. J Clin Invest 46: 1518-1529.
    • (1967) J Clin Invest , vol.46 , pp. 1518-1529
    • Kelley, W.N.1    Rosenbloom, F.M.2    Seegmiller, J.E.3
  • 121
    • 0002906872 scopus 로고
    • Inhibition of thymidylate synthetase by poly-gamma-glutamyl derivates of folate and methotrexate
    • Kisliuk RL, Brown (eds) Elsevier North Holland, Amsterdam
    • Kisliuk RL, Gaumont Y, Baugh CM, Galivan JH, Maley GF, Maley F (1979). Inhibition of thymidylate synthetase by poly-gamma-glutamyl derivates of folate and methotrexate. In: Kisliuk RL, Brown (eds) Chemistry and biology of pteridines. Elsevier North Holland, Amsterdam: 431-435.
    • (1979) Chemistry and Biology of Pteridines , pp. 431-435
    • Kisliuk, R.L.1    Gaumont, Y.2    Baugh, C.M.3    Galivan, J.H.4    Maley, G.F.5    Maley, F.6
  • 122
    • 0027773021 scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of anticancer agents in pediatric patients
    • Knoester PD, Underberg WJ, Beijnen JH (1993). Clinical pharmacokinetics and pharmacodynamics of anticancer agents in pediatric patients (review). Anticancer Res 13: 1795-1808.
    • (1993) Anticancer Res , vol.13 , pp. 1795-1808
    • Knoester, P.D.1    Underberg, W.J.2    Beijnen, J.H.3
  • 123
    • 0027787737 scopus 로고
    • Pharmacodynamic-pharmacokinetic relationships and therapeutic drug monitoring
    • Kobayashi K, Jodrell DI, Ratain MJ (1993). Pharmacodynamic-pharmacokinetic relationships and therapeutic drug monitoring. Cancer Surv 17: 51-78.
    • (1993) Cancer Surv , vol.17 , pp. 51-78
    • Kobayashi, K.1    Jodrell, D.I.2    Ratain, M.J.3
  • 124
    • 0016606260 scopus 로고
    • Incorporation of the purine moieties of guanosine and inosine analogs into nucleotide pools of erythrocytes
    • Kong CM, Parks RE (1975). Incorporation of the purine moieties of guanosine and inosine analogs into nucleotide pools of erythrocytes. Biochem Pharmacol 24: 807-813.
    • (1975) Biochem Pharmacol , vol.24 , pp. 807-813
    • Kong, C.M.1    Parks, R.E.2
  • 125
    • 0018344243 scopus 로고
    • Transfer of purines from liver to erythrocytes. in vivo and in vitro studies
    • Konishi Y, Ichihara A (1979). Transfer of purines from liver to erythrocytes. In vivo and in vitro studies. J Biochem Tokyo 85: 295-301.
    • (1979) J Biochem Tokyo , vol.85 , pp. 295-301
    • Konishi, Y.1    Ichihara, A.2
  • 126
    • 0024820035 scopus 로고
    • Disposition of oral methotrexate in children with acute lymphoblastic leukemia and its relation to 6-mercaptopurine pharmacokinetics
    • Koren G, Solh H, Klein J, Soldin SJ, Greenberg M (1989). Disposition of oral methotrexate in children with acute lymphoblastic leukemia and its relation to 6-mercaptopurine pharmacokinetics. Med Pediatr Oncol 17: 450-454.
    • (1989) Med Pediatr Oncol , vol.17 , pp. 450-454
    • Koren, G.1    Solh, H.2    Klein, J.3    Soldin, S.J.4    Greenberg, M.5
  • 127
    • 0025351578 scopus 로고
    • Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children
    • Koren G, Ferrazini G, Sulh H, et al. (1990a). Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children. N Engl J Med 323: 17-21.
    • (1990) N Engl J Med , vol.323 , pp. 17-21
    • Koren, G.1    Ferrazini, G.2    Sulh, H.3
  • 128
    • 0025195805 scopus 로고
    • Diurnal variation in the pharmacokinetics and myelotoxicity of mercaptopurine in children with acute lymphocytic leukemia
    • Koren G, Langevin AM, Olivieri N, Giesbrecht E, Zipursky A, Greenberg M (1990b). Diurnal variation in the pharmacokinetics and myelotoxicity of mercaptopurine in children with acute lymphocytic leukemia. Am J Dis Child 144: 1135-1137.
    • (1990) Am J Dis Child , vol.144 , pp. 1135-1137
    • Koren, G.1    Langevin, A.M.2    Olivieri, N.3    Giesbrecht, E.4    Zipursky, A.5    Greenberg, M.6
  • 131
    • 0021160366 scopus 로고
    • The reticulocytic rat: A model for analysis of methotrexate polyglutamate dynamics in situ
    • Krakower GR, Kamen BA (1984). The reticulocytic rat: a model for analysis of methotrexate polyglutamate dynamics in situ. J Pharmacol Exp Ther 231: 43-47.
    • (1984) J Pharmacol Exp Ther , vol.231 , pp. 43-47
    • Krakower, G.R.1    Kamen, B.A.2
  • 132
    • 0022538388 scopus 로고
    • Large interindividual variations in the pharmacokinetics of oral 6-mercaptopurine in maintenance therapy of children with acute leukaemia and non-Hodgkin lymphoma
    • Lafolie P, Hayder S, Björk O, Åhström L, Liliemark J, Peterson C (1986). Large interindividual variations in the pharmacokinetics of oral 6-mercaptopurine in maintenance therapy of children with acute leukaemia and non-Hodgkin lymphoma. Acta Paediatr Scand 75: 797-803.
    • (1986) Acta Paediatr Scand , vol.75 , pp. 797-803
    • Lafolie, P.1    Hayder, S.2    Björk, O.3    Åhström, L.4    Liliemark, J.5    Peterson, C.6
  • 133
    • 0024815605 scopus 로고
    • Variability of 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute leukemia
    • Lafolie P, Björk O, Hayder S, Ahstrom L, Peterson C (1989). Variability of 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute leukemia. Med Oncol Tumor Pharmacother 6: 259-265.
    • (1989) Med Oncol Tumor Pharmacother , vol.6 , pp. 259-265
    • Lafolie, P.1    Björk, O.2    Hayder, S.3    Ahstrom, L.4    Peterson, C.5
  • 134
    • 0025851655 scopus 로고
    • Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia
    • Lafolie P, Hayder S, Björk O, Peterson C (1991). Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia. Eur J Clin Pharmacol 40: 599-601.
    • (1991) Eur J Clin Pharmacol , vol.40 , pp. 599-601
    • Lafolie, P.1    Hayder, S.2    Björk, O.3    Peterson, C.4
  • 135
    • 0023251335 scopus 로고
    • Pharmacokinetic case for giving 6-mercaptopurine maintenance doses at night
    • Langevin A, Koren G, Soldin SJ, Greenberg M (1987). Pharmacokinetic case for giving 6-mercaptopurine maintenance doses at night. Lancet 2: 505-506.
    • (1987) Lancet , vol.2 , pp. 505-506
    • Langevin, A.1    Koren, G.2    Soldin, S.J.3    Greenberg, M.4
  • 136
    • 0021984080 scopus 로고
    • A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells
    • Lavi LE, Holcenberg JS (1985). A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells. Anal Biochem 144: 514-521.
    • (1985) Anal Biochem , vol.144 , pp. 514-521
    • Lavi, L.E.1    Holcenberg, J.S.2
  • 137
    • 0019829529 scopus 로고
    • The effects of inhibitors of DNA biosynthesis on the cytotoxicity of 6-thioguanine
    • Lee SH, Sartorelli AC (1981). The effects of inhibitors of DNA biosynthesis on the cytotoxicity of 6-thioguanine. Cancer Biochem Biophys 5: 189-194.
    • (1981) Cancer Biochem Biophys , vol.5 , pp. 189-194
    • Lee, S.H.1    Sartorelli, A.C.2
  • 138
    • 0028305699 scopus 로고
    • Chronopharmacokinetics. Are they clinically relevant?
    • Lemmer B, Bruguerolle B (1994). Chronopharmacokinetics. Are they clinically relevant? Clin Pharmacokinet 26: 419-427.
    • (1994) Clin Pharmacokinet , vol.26 , pp. 419-427
    • Lemmer, B.1    Bruguerolle, B.2
  • 139
    • 0020512528 scopus 로고
    • Childhood leukemia: A relationship between intracellular 6-mercaptopurine metabolism and neutropenia
    • Lennard L, Rees CA, Lilleyman JS, et al. (1983). Childhood leukemia: A relationship between intracellular 6-mercaptopurine metabolism and neutropenia. Br J Clin Pharmacol 16: 359-363.
    • (1983) Br J Clin Pharmacol , vol.16 , pp. 359-363
    • Lennard, L.1    Rees, C.A.2    Lilleyman, J.S.3
  • 140
    • 0022551875 scopus 로고
    • Oral 6-mercaptopurine in childhood leukemia: Parent drug pharmacokinetics and active metabolite concentrations
    • Lennard L, Keen D, Lilleyman JS (1986). Oral 6-mercaptopurine in childhood leukemia: Parent drug pharmacokinetics and active metabolite concentrations. Clin Pharmacol Ther 40: 287-292.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 287-292
    • Lennard, L.1    Keen, D.2    Lilleyman, J.S.3
  • 141
    • 0023119219 scopus 로고
    • Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
    • Lennard L, Van Loon JA, Lilleyman JS, Weinshilboum RM (1987). Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin Pharmacol Ther 41: 18-25.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 18-25
    • Lennard, L.1    Van Loon, J.A.2    Lilleyman, J.S.3    Weinshilboum, R.M.4
  • 142
    • 0024451147 scopus 로고
    • Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
    • Lennard L, Van Loon JA, Weinshilboum RM (1989). Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther 46: 149-154.
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 149-154
    • Lennard, L.1    Van Loon, J.A.2    Weinshilboum, R.M.3
  • 143
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
    • Lennard L, Lilleyman JS, Van Loon J, Weinshilboum RM (1990). Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 336: 225-229.
    • (1990) Lancet , vol.336 , pp. 225-229
    • Lennard, L.1    Lilleyman, J.S.2    Van Loon, J.3    Weinshilboum, R.M.4
  • 144
    • 0026758498 scopus 로고
    • The clinical pharmacology of 6-mercaptopurine
    • Lennard L (1992). The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol 43: 329-339.
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 329-339
    • Lennard, L.1
  • 145
    • 0027524983 scopus 로고
    • Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia
    • Lennard L, Gibson BE, Nicole T, Lilleyman JS (1993a). Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. Arch Dis Child 69: 577-579.
    • (1993) Arch Dis Child , vol.69 , pp. 577-579
    • Lennard, L.1    Gibson, B.E.2    Nicole, T.3    Lilleyman, J.S.4
  • 146
    • 0027361660 scopus 로고
    • Red blood cell hypoxanthine phosphoribosyltransferase activity measured using 6-mercaptopurine as a substrate: A population study in children with acute lymphoblastic leukemia
    • Lennard L, Hale JP, Lilleyman JS (1993b). Red blood cell hypoxanthine phosphoribosyltransferase activity measured using 6-mercaptopurine as a substrate: a population study in children with acute lymphoblastic leukemia. Br J Clin Pharmacol 36: 277-284.
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 277-284
    • Lennard, L.1    Hale, J.P.2    Lilleyman, J.S.3
  • 147
    • 0028832238 scopus 로고
    • Intracellular metabolites of mercaptopurine in children with lymphoblastic leukaemia: A possible indicator of non-compliance?
    • Lennard L, Welch J, Lilleyman JS (1995). Intracellular metabolites of mercaptopurine in children with lymphoblastic leukaemia: a possible indicator of non-compliance? Br J Cancer 72: 1004-1006.
    • (1995) Br J Cancer , vol.72 , pp. 1004-1006
    • Lennard, L.1    Welch, J.2    Lilleyman, J.S.3
  • 148
    • 0023202469 scopus 로고
    • Are children with lymphoblastic leukemia given enough 6-mercaptopurine?
    • Lennard L, Lilleyman JS (1987). Are children with lymphoblastic leukemia given enough 6-mercaptopurine? Lancet 2: 785-787.
    • (1987) Lancet , vol.2 , pp. 785-787
    • Lennard, L.1    Lilleyman, J.S.2
  • 149
    • 0024818659 scopus 로고
    • Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia
    • [published erratum appears in J Clin Oncol 1990 Mar; 8(3): 567]
    • Lennard L, Lilleyman JS (1989). Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia [published erratum appears in J Clin Oncol 1990 Mar; 8(3): 567]. J Clin Oncol 7: 1816-1823.
    • (1989) J Clin Oncol , vol.7 , pp. 1816-1823
    • Lennard, L.1    Lilleyman, J.S.2
  • 150
    • 0020677815 scopus 로고
    • Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine, and 6-thioguanine, in human red blood cells
    • Lennard L, Maddocks JL (1983). Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine, and 6-thioguanine, in human red blood cells. J Pharm Pharmacol 35: 15-18.
    • (1983) J Pharm Pharmacol , vol.35 , pp. 15-18
    • Lennard, L.1    Maddocks, J.L.2
  • 151
    • 0027520058 scopus 로고
    • Importance of multiagent chemotherapy regimens in ovarian carcinoma: Dose intensity analysis
    • Levin L, Simon R, Hryniuk W (1993). Importance of multiagent chemotherapy regimens in ovarian carcinoma: dose intensity analysis. J Natl Cancer Inst 85: 1732-1742.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1732-1742
    • Levin, L.1    Simon, R.2    Hryniuk, W.3
  • 152
    • 0021348004 scopus 로고
    • Inhibition of mammalian xanthine oxidase by folate compounds and amethopterin
    • Lewis AS, Murphy L, McCalla C, Fleary M, Purcell S (1984). Inhibition of mammalian xanthine oxidase by folate compounds and amethopterin. J Biol Chem 259: 12-15.
    • (1984) J Biol Chem , vol.259 , pp. 12-15
    • Lewis, A.S.1    Murphy, L.2    McCalla, C.3    Fleary, M.4    Purcell, S.5
  • 153
    • 0025873389 scopus 로고
    • Pharmacokinetic optimisation of anticancer therapy
    • Liliemark J, Peterson C (1991). Pharmacokinetic optimisation of anticancer therapy. Clin Pharmacokinet 21: 213-231.
    • (1991) Clin Pharmacokinet , vol.21 , pp. 213-231
    • Liliemark, J.1    Peterson, C.2
  • 154
    • 0028269944 scopus 로고
    • Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukemia
    • Lilleyman JS, Lennard L (1994). Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukemia. Lancet 343: 1188-1190.
    • (1994) Lancet , vol.343 , pp. 1188-1190
    • Lilleyman, J.S.1    Lennard, L.2
  • 155
    • 0027074626 scopus 로고
    • Consequences of 6-thioguanine incorporation into DNA on polymerase, ligase, and endonuclease reactions
    • Ling YH, Chan JY, Beattie KL, Nelson JA (1992a). Consequences of 6-thioguanine incorporation into DNA on polymerase, ligase, and endonuclease reactions. Mol Pharmacol 42: 802-807.
    • (1992) Mol Pharmacol , vol.42 , pp. 802-807
    • Ling, Y.H.1    Chan, J.Y.2    Beattie, K.L.3    Nelson, J.A.4
  • 156
    • 0026571129 scopus 로고
    • Utilization of 2′-deoxy-6-thioguanosine 5′-triphosphate in DNA synthesis catalysed by DNA polymerase I Klenow fragment of Escherichia coli
    • Ling YH, Nelson JA, Farquhar D, Beattie KL (1992b). Utilization of 2′-deoxy-6-thioguanosine 5′-triphosphate in DNA synthesis catalysed by DNA polymerase I Klenow fragment of Escherichia coli. Nucleosides Nucleotides 11: 23-35.
    • (1992) Nucleosides Nucleotides , vol.11 , pp. 23-35
    • Ling, Y.H.1    Nelson, J.A.2    Farquhar, D.3    Beattie, K.L.4
  • 159
    • 0023475347 scopus 로고
    • Prognostic value of cellular DNA content in acute lymphoblastic leukemia of childhood
    • Look AT, Roberson PK, Murphy SB (1987). Prognostic value of cellular DNA content in acute lymphoblastic leukemia of childhood. N Eng J Med 315: 1666.
    • (1987) N Eng J Med , vol.315 , pp. 1666
    • Look, A.T.1    Roberson, P.K.2    Murphy, S.B.3
  • 161
    • 0024407072 scopus 로고
    • Oral mercaptopurine in childhood leukemia: Influence of food intake on bioavailability
    • Lönnerholm G, Kreuger A, Lindstrom B, Myrdal U (1989). Oral mercaptopurine in childhood leukemia: influence of food intake on bioavailability. Pediatr Hematol Oncol 6: 105-112.
    • (1989) Pediatr Hematol Oncol , vol.6 , pp. 105-112
    • Lönnerholm, G.1    Kreuger, A.2    Lindstrom, B.3    Myrdal, U.4
  • 162
    • 0026716028 scopus 로고
    • Relapse in acute lymphoblastic leukemia as a function of white blood cell and absolute neutrophil counts during maintenance chemotherapy
    • Lucas K, Gula MJ, Blatt J (1992). Relapse in acute lymphoblastic leukemia as a function of white blood cell and absolute neutrophil counts during maintenance chemotherapy. Pediatr Hematol Oncol 9: 91-97.
    • (1992) Pediatr Hematol Oncol , vol.9 , pp. 91-97
    • Lucas, K.1    Gula, M.J.2    Blatt, J.3
  • 163
    • 0026782292 scopus 로고
    • Pattern of 6-mercaptopurine urinary excretion in children with acute lymphoblastic leukemia: Urinary assays as a measure of drug compliance
    • Macdougall LG, McElligott SE, Ross E, Greeff MC, Poole JE (1992). Pattern of 6-mercaptopurine urinary excretion in children with acute lymphoblastic leukemia: urinary assays as a measure of drug compliance. Ther Drug Monit 14: 371-375.
    • (1992) Ther Drug Monit , vol.14 , pp. 371-375
    • Macdougall, L.G.1    McElligott, S.E.2    Ross, E.3    Greeff, M.C.4    Poole, J.E.5
  • 164
    • 4243920868 scopus 로고
    • Dose rate: An important prognostic determination in non-Hodgkin's lymphoma in young patients
    • Magrath IT, Steinberg SM, Adde MA, et al. (1989), Dose rate: An important prognostic determination in non-Hodgkin's lymphoma in young patients. Blood 74(suppl): 25a.
    • (1989) Blood , vol.74 , Issue.SUPPL.
    • Magrath, I.T.1    Steinberg, S.M.2    Adde, M.A.3
  • 166
    • 0030034467 scopus 로고    scopus 로고
    • Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate
    • Masson E, Relling MV, Synold TW, et al. (1996). Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate. J Clin Invest 97: 73-80.
    • (1996) J Clin Invest , vol.97 , pp. 73-80
    • Masson, E.1    Relling, M.V.2    Synold, T.W.3
  • 167
    • 0003055882 scopus 로고
    • Diurnal variation of proliferative activity in the human bone marrow
    • Mauer AM (1965), Diurnal variation of proliferative activity in the human bone marrow. Blood 26: 1-7.
    • (1965) Blood , vol.26 , pp. 1-7
    • Mauer, A.M.1
  • 169
    • 0028044714 scopus 로고
    • Thiopurine methyltransferase activity in American white subjects and black subjects
    • McLeod HL, Lin JS, Scott EP, Pui CH, Evans WE (1994). Thiopurine methyltransferase activity in American white subjects and black subjects. Clin Pharmacol Ther 55: 15-20.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 15-20
    • McLeod, H.L.1    Lin, J.S.2    Scott, E.P.3    Pui, C.H.4    Evans, W.E.5
  • 171
    • 0026087583 scopus 로고
    • The role of dose intensity in determining outcome in intermediate-grade non-Hodgkin's lymphoma
    • Meyer RM, Hryniuk WM, Goodyear MD (1991). The role of dose intensity in determining outcome in intermediate-grade non-Hodgkin's lymphoma. J Clin Oncol 9: 339-347.
    • (1991) J Clin Oncol , vol.9 , pp. 339-347
    • Meyer, R.M.1    Hryniuk, W.M.2    Goodyear, M.D.3
  • 172
    • 0024818410 scopus 로고
    • Early response to induction therapy as a predictor of disease-free survival and late recurrence of childhood acute lymphoblastic leukemia: A report from the Childrens Cancer Study Group
    • Miller DR, Coccia PF, Bleyer WA, et al. (1989). Early response to induction therapy as a predictor of disease-free survival and late recurrence of childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group. J Clin Oncol 7: 1807-1815.
    • (1989) J Clin Oncol , vol.7 , pp. 1807-1815
    • Miller, D.R.1    Coccia, P.F.2    Bleyer, W.A.3
  • 174
    • 0023933661 scopus 로고
    • Impaired methotrexate polyglutamation in a human leukemia cell line resistant to short-term, high-dose methotrexate
    • Mini E, Pizzorno G, Coronnello M, McGuire JJ, Mazzei T, Periti P, Bertino JR (1988). Impaired methotrexate polyglutamation in a human leukemia cell line resistant to short-term, high-dose methotrexate. Pharmacol Res Comm 20: 445-446.
    • (1988) Pharmacol Res Comm , vol.20 , pp. 445-446
    • Mini, E.1    Pizzorno, G.2    Coronnello, M.3    McGuire, J.J.4    Mazzei, T.5    Periti, P.6    Bertino, J.R.7
  • 176
    • 0016702193 scopus 로고
    • Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine
    • Nelson JA, Carpenter JW, Rose LM, Adamson DJ (1975). Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine. Cancer Res 35: 2872-2878.
    • (1975) Cancer Res , vol.35 , pp. 2872-2878
    • Nelson, J.A.1    Carpenter, J.W.2    Rose, L.M.3    Adamson, D.J.4
  • 177
    • 0017255763 scopus 로고
    • Acute and chronic effects of methotrexate on hepatic, pulmonary, and skeletal systems
    • Nesbit M, Krivit W, Heyn R, Sharp H (1976). Acute and chronic effects of methotrexate on hepatic, pulmonary, and skeletal systems. Cancer 37: 1048-1057.
    • (1976) Cancer , vol.37 , pp. 1048-1057
    • Nesbit, M.1    Krivit, W.2    Heyn, R.3    Sharp, H.4
  • 178
    • 0027488001 scopus 로고
    • Carboplatin pharmacokinetics in children: The development of a pediatric dosing formula
    • Newell DR, Pearseon ADJ, Balmanno K, et al. (1993). Carboplatin pharmacokinetics in children: The development of a pediatric dosing formula. J Clin Oncol 11: 2314-2323.
    • (1993) J Clin Oncol , vol.11 , pp. 2314-2323
    • Newell, D.R.1    Pearseon, A.D.J.2    Balmanno, K.3
  • 179
    • 0344331236 scopus 로고
    • Laboratory medicine and reference tables
    • Behrman RE, Kliegman RM, Nelson WE, Vaughan III VC (eds) W.B.Saunders Company, Philadelphia
    • Nicholson JF, Pesce MA (1992). Laboratory medicine and reference tables. In: Behrman RE, Kliegman RM, Nelson WE, Vaughan III VC (eds) Nelson - Textbook of Pediatrics. 14th edn. W.B.Saunders Company, Philadelphia: 1797-1849.
    • (1992) Nelson - Textbook of Pediatrics. 14th Edn. , pp. 1797-1849
    • Nicholson, J.F.1    Pesce, M.A.2
  • 180
    • 0025838821 scopus 로고
    • Comparative results of two intensive treatment programs for childhood acute lymphoblastic leukemia: The Berlin-Frankfurt-Munster and Dana-Farber Cancer Institute protocols
    • Niemeyer CM, Reiter A, Riehm H, Donnelly M, Gelber RD, Sallan SE (1991). Comparative results of two intensive treatment programs for childhood acute lymphoblastic leukemia: The Berlin-Frankfurt-Munster and Dana-Farber Cancer Institute protocols. Ann Oncol 2: 745-749.
    • (1991) Ann Oncol , vol.2 , pp. 745-749
    • Niemeyer, C.M.1    Reiter, A.2    Riehm, H.3    Donnelly, M.4    Gelber, R.D.5    Sallan, S.E.6
  • 181
    • 0027500844 scopus 로고
    • Second malignant neoplasms after cancer in childhood or adolescence. Nordic Society of Paediatric Haematology and Oncology and Association of the Nordic Cancer Registries
    • Olsen JH, Garwicz S, Hertz H, et al. (1993). Second malignant neoplasms after cancer in childhood or adolescence. Nordic Society of Paediatric Haematology and Oncology and Association of the Nordic Cancer Registries. BMJ 307: 1030-1036.
    • (1993) BMJ , vol.307 , pp. 1030-1036
    • Olsen, J.H.1    Garwicz, S.2    Hertz, H.3
  • 182
    • 7844233860 scopus 로고
    • Total, differential and absolute leukocyte counts and sedimentation rates for healthy children
    • Osgood EE, Baker RL, Brownlee IE, Osgood MW, Ellis DM, Cohen W (1939). Total, differential and absolute leukocyte counts and sedimentation rates for healthy children. Am J Dis Child 58: 282-294.
    • (1939) Am J Dis Child , vol.58 , pp. 282-294
    • Osgood, E.E.1    Baker, R.L.2    Brownlee, I.E.3    Osgood, M.W.4    Ellis, D.M.5    Cohen, W.6
  • 186
    • 0025741478 scopus 로고
    • The influence of serum methotrexate concentrations and drug dosage on outcome in childhood acute lymphoblastic leukaemia
    • Pearson AD, Amineddine HA, Yule M, Mills S, Long DR, Craft AW, Chessells JM (1991). The influence of serum methotrexate concentrations and drug dosage on outcome in childhood acute lymphoblastic leukaemia. Br J Cancer 64: 169-173.
    • (1991) Br J Cancer , vol.64 , pp. 169-173
    • Pearson, A.D.1    Amineddine, H.A.2    Yule, M.3    Mills, S.4    Long, D.R.5    Craft, A.W.6    Chessells, J.M.7
  • 187
    • 0023902239 scopus 로고
    • Physician compliance and relapse rates of acute lymphoblastic leukemia in children
    • Peelers M, Koren G, Jakubovicz D, Zipursky-A (1988). Physician compliance and relapse rates of acute lymphoblastic leukemia in children. Clin Pharmacol Ther 43: 228-232.
    • (1988) Clin Pharmacol Ther , vol.43 , pp. 228-232
    • Peelers, M.1    Koren, G.2    Jakubovicz, D.3    Zipursky-A4
  • 188
  • 189
    • 0017365573 scopus 로고
    • Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples
    • Peto R, Pike MC, Armitage P, et al. (1977). Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer 35: 1-39.
    • (1977) Br J Cancer , vol.35 , pp. 1-39
    • Peto, R.1    Pike, M.C.2    Armitage, P.3
  • 190
    • 0026029704 scopus 로고
    • Pharmacokinetics of continuous-infusion amsacrine and teniposide for the treatment of relapsed childhood acute nonlymphocytic leukemia
    • Petros WP, Rodman JH, Mirro JJ, Evans WE (1991). Pharmacokinetics of continuous-infusion amsacrine and teniposide for the treatment of relapsed childhood acute nonlymphocytic leukemia. Cancer Chemother Pharmacol 27: 397-400.
    • (1991) Cancer Chemother Pharmacol , vol.27 , pp. 397-400
    • Petros, W.P.1    Rodman, J.H.2    Mirro, J.J.3    Evans, W.E.4
  • 193
    • 0019161556 scopus 로고
    • Can food influence the absorption of methotrexate in children with acute lymphoblastic leukemia
    • Pinkerton CR, Welshman SG, Glasgow JF, Bridges JM (1980). Can food influence the absorption of methotrexate in children with acute lymphoblastic leukemia. Lancet 2: 944-946.
    • (1980) Lancet , vol.2 , pp. 944-946
    • Pinkerton, C.R.1    Welshman, S.G.2    Glasgow, J.F.3    Bridges, J.M.4
  • 194
    • 0019799195 scopus 로고
    • Enterotoxic effect of methotrexate: Does it influence the drug's absorption in children with acute lymphoblastic leukaemia?
    • Pinkerton CR, Glasgow JF, Bridges JM, Welshman SG (1981). Enterotoxic effect of methotrexate: does it influence the drug's absorption in children with acute lymphoblastic leukaemia? Br Med J Clin Res Ed 282: 1276-1277.
    • (1981) Br Med J Clin Res Ed , vol.282 , pp. 1276-1277
    • Pinkerton, C.R.1    Glasgow, J.F.2    Bridges, J.M.3    Welshman, S.G.4
  • 195
    • 0020358328 scopus 로고
    • Pharmacokinetics of low-dose methotrexate in children receiving maintenance therapy for acute lymphoblastic leukaemia
    • Pinkerton CR, Welshman SG, Kelly JG, Shanks RG, Bridges JM (1982). Pharmacokinetics of low-dose methotrexate in children receiving maintenance therapy for acute lymphoblastic leukaemia. Cancer Chemother Pharmacol 10: 36-39.
    • (1982) Cancer Chemother Pharmacol , vol.10 , pp. 36-39
    • Pinkerton, C.R.1    Welshman, S.G.2    Kelly, J.G.3    Shanks, R.G.4    Bridges, J.M.5
  • 196
    • 0022486648 scopus 로고
    • The pharmacology of orally administered chemotherapy. A reappraisal
    • Poplack DG, Balis FM, Zimm S (1986). The pharmacology of orally administered chemotherapy. A reappraisal. Cancer 58 (suppl): 473-480.
    • (1986) Cancer , vol.58 , Issue.SUPPL. , pp. 473-480
    • Poplack, D.G.1    Balis, F.M.2    Zimm, S.3
  • 197
    • 0023795391 scopus 로고
    • Acute lymphoblastic leukemia in childhood
    • Poplack D (ed) WB Saunders, Philadelphia
    • Poplack DG (1988). Acute lymphoblastic leukemia in childhood. In: Poplack D (ed) The Leukemias. WB Saunders, Philadelphia: 903-932.
    • (1988) The Leukemias , pp. 903-932
    • Poplack, D.G.1
  • 198
    • 7844226808 scopus 로고
    • Does drug dose intensity of chemotherapy determine the prognosis of primary high-grade osteosarcoma?
    • Abstract
    • Prasad R, Bacci G, Campanacci M, et al. (1990). Does drug dose intensity of chemotherapy determine the prognosis of primary high-grade osteosarcoma? Proc Am Soc Clin Oncol 9:311 (Abstract).
    • (1990) Proc Am Soc Clin Oncol , vol.9 , pp. 311
    • Prasad, R.1    Bacci, G.2    Campanacci, M.3
  • 199
    • 0026079804 scopus 로고
    • Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia
    • Pui CH, Ribeiro RC, Hancock ML, et al. (1991). Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N Engl J Med 325: 1682-1687.
    • (1991) N Engl J Med , vol.325 , pp. 1682-1687
    • Pui, C.H.1    Ribeiro, R.C.2    Hancock, M.L.3
  • 200
    • 0029140694 scopus 로고
    • Childhood leukemias
    • Pui CH (1995). Childhood leukemias. N Eng J Med 332: 1618-1630.
    • (1995) N Eng J Med , vol.332 , pp. 1618-1630
    • Pui, C.H.1
  • 201
    • 0017198029 scopus 로고
    • Blood leucocyte enzymes. III. Diurnal rhythm of activity in isolated lymphocytes of normal subjects and chronic lymphatic leukaemia patients
    • Ramot B, Brok Simoni F, Chweidan E, Ashkenazi YE (1976). Blood leucocyte enzymes. III. Diurnal rhythm of activity in isolated lymphocytes of normal subjects and chronic lymphatic leukaemia patients. Br J Haematol 34: 79-85.
    • (1976) Br J Haematol , vol.34 , pp. 79-85
    • Ramot, B.1    Brok Simoni, F.2    Chweidan, E.3    Ashkenazi, Y.E.4
  • 202
    • 0026783081 scopus 로고
    • Therapeutic relevance of pharmacokinetics and pharmacodynamics
    • Ratain MJ (1992). Therapeutic relevance of pharmacokinetics and pharmacodynamics. Semin Oncol 4 (Suppl 11): S8-13.
    • (1992) Semin Oncol , vol.4 , Issue.11 SUPPL.
    • Ratain, M.J.1
  • 203
    • 0028152851 scopus 로고
    • Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86
    • Reiter A, Schrappe M, Ludwig WD, et al. (1994). Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood 84: 3122-3133.
    • (1994) Blood , vol.84 , pp. 3122-3133
    • Reiter, A.1    Schrappe, M.2    Ludwig, W.D.3
  • 204
    • 0026621673 scopus 로고
    • Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities
    • Relling MV, Lin JS, Ayers GD, Evans WE (1992). Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities. Clin Pharmacol Ther 52: 643-658.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 643-658
    • Relling, M.V.1    Lin, J.S.2    Ayers, G.D.3    Evans, W.E.4
  • 205
    • 0022871348 scopus 로고
    • Influence of food intake on bioavailability of oral 6-mercaptopurine i children with acute lymphoblastic leukemia
    • Riccardi R, Balis FM, Ferrasa P, Poplack DG, Mastrangelo R (1986). Influence of food intake on bioavailability of oral 6-mercaptopurine i children with acute lymphoblastic leukemia. Pediatr Hematol Oncol 3: 319-324.
    • (1986) Pediatr Hematol Oncol , vol.3 , pp. 319-324
    • Riccardi, R.1    Balis, F.M.2    Ferrasa, P.3    Poplack, D.G.4    Mastrangelo, R.5
  • 206
    • 0025071916 scopus 로고
    • Results and significance of six randomized trials in four consecutive ALL-BFM studies
    • Riehm H, Gadner H, Henze G, et al. (1990). Results and significance of six randomized trials in four consecutive ALL-BFM studies. Hamatol Bluttransfus 33: 439-450.
    • (1990) Hamatol Bluttransfus , vol.33 , pp. 439-450
    • Riehm, H.1    Gadner, H.2    Henze, G.3
  • 207
    • 0022350968 scopus 로고
    • Maintenance chemotherapy for childhood acute lymphoblastic leukemia: Better in the evening
    • Rivard GE, Infante-Rivard C, Hoyoux C (1985). Maintenance chemotherapy for childhood acute lymphoblastic leukemia: better in the evening. Lancet 2: 1264-1266.
    • (1985) Lancet , vol.2 , pp. 1264-1266
    • Rivard, G.E.1    Infante-Rivard, C.2    Hoyoux, C.3
  • 208
    • 0027322297 scopus 로고
    • Circadian time-dependent response of childhood lymphoblastic leukemia to chemotherapy: A long-term follow-up study of survival
    • Rivard GE, Infante Rivard C, Dresse MF, Leclerc JM, Champagne J (1993). Circadian time-dependent response of childhood lymphoblastic leukemia to chemotherapy: a long-term follow-up study of survival. Chronobiol Int 10: 201-204.
    • (1993) Chronobiol Int , vol.10 , pp. 201-204
    • Rivard, G.E.1    Infante Rivard, C.2    Dresse, M.F.3    Leclerc, J.M.4    Champagne, J.5
  • 209
    • 0027497166 scopus 로고
    • Treatment of acute lymphoblastic leukemia. 30 years' experience at St. Jude Children's Research Hospital
    • Rivera GK, Pinkel D, Simone JV, Hancock ML, Crist WM (1993). Treatment of acute lymphoblastic leukemia. 30 years' experience at St. Jude Children's Research Hospital. N Engl J Med 329: 1289-1295.
    • (1993) N Engl J Med , vol.329 , pp. 1289-1295
    • Rivera, G.K.1    Pinkel, D.2    Simone, J.V.3    Hancock, M.L.4    Crist, W.M.5
  • 211
    • 0027480869 scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of anticancer drugs in children
    • Rodman JH, Relling MV, Stewart CF, et al. (1993). Clinical pharmacokinetics and pharmacodynamics of anticancer drugs in children. Semin Oncol 20: 18-29.
    • (1993) Semin Oncol , vol.20 , pp. 18-29
    • Rodman, J.H.1    Relling, M.V.2    Stewart, C.F.3
  • 212
    • 0017008791 scopus 로고
    • Absorption and malabsorption of folates
    • Rosenberg IH (1976). Absorption and malabsorption of folates. Clin Haematol 5: 589-618.
    • (1976) Clin Haematol , vol.5 , pp. 589-618
    • Rosenberg, I.H.1
  • 213
    • 0016196030 scopus 로고
    • Mechanisms of resistance to 6-thiopurines in human leukemia
    • Rosman M, Lee MH, Creasey WA, Sartorelli AC (1974). Mechanisms of resistance to 6-thiopurines in human leukemia. Cancer Res 34: 1952-1956.
    • (1974) Cancer Res , vol.34 , pp. 1952-1956
    • Rosman, M.1    Lee, M.H.2    Creasey, W.A.3    Sartorelli, A.C.4
  • 214
    • 0015828761 scopus 로고
    • Leukocyte purine phosphoribosyl-transferases in human leukemias sensitive and resistant to 6-thiopurines
    • Rosman M, Williams HE (1973). Leukocyte purine phosphoribosyl-transferases in human leukemias sensitive and resistant to 6-thiopurines. Cancer Res 33: 1202-1209.
    • (1973) Cancer Res , vol.33 , pp. 1202-1209
    • Rosman, M.1    Williams, H.E.2
  • 215
    • 7844252085 scopus 로고
    • 6-methylmercaptopurine: Identifica tion as metabolite of 6-mercaptopurine in vivo and in vitro
    • Sarcione EJ, Stutzman L (1959). 6-methylmercaptopurine: identifica tion as metabolite of 6-mercaptopurine in vivo and in vitro. Proc Soc Exp Biol Med 101: 766-769.
    • (1959) Proc Soc Exp Biol Med , vol.101 , pp. 766-769
    • Sarcione, E.J.1    Stutzman, L.2
  • 216
    • 0019494990 scopus 로고
    • Disappearance of the predictive value of prognostic variables in childhood acute lymphoblastic leukemia; a report from Childrens Cancer Study Group
    • Sather H, Coccia P, Nesbit M, Level C, Hammond D (1981). Disappearance of the predictive value of prognostic variables in childhood acute lymphoblastic leukemia; a report from Childrens Cancer Study Group. Cancer 48: 370-376.
    • (1981) Cancer , vol.48 , pp. 370-376
    • Sather, H.1    Coccia, P.2    Nesbit, M.3    Level, C.4    Hammond, D.5
  • 217
    • 0020504881 scopus 로고
    • Increasing the therapeutic response rates to anticancer drugs by applying the basic principles of pharmacology
    • Schabel FM, Jr., Griswold DP, Jr., Corbett TH, Laster WR, Jr. (1983). Increasing the therapeutic response rates to anticancer drugs by applying the basic principles of pharmacology. Pharmacol Ther 20: 283-305.
    • (1983) Pharmacol Ther , vol.20 , pp. 283-305
    • Schabel Jr., F.M.1    Griswold Jr., D.P.2    Corbett, T.H.3    Laster Jr., W.R.4
  • 220
    • 0023768405 scopus 로고
    • White-cell count during maintenance chemotherapy for standard-risk childhood acute lymphoblastic leukemia: Relation to relapse rate
    • Schmiegelow K, Pulczynska MK, Seip M (1988). White-cell count during maintenance chemotherapy for standard-risk childhood acute lymphoblastic leukemia: relation to relapse rate. J Pediatr Hematol Oncol 5: 259-267.
    • (1988) J Pediatr Hematol Oncol , vol.5 , pp. 259-267
    • Schmiegelow, K.1    Pulczynska, M.K.2    Seip, M.3
  • 221
    • 0024377081 scopus 로고
    • Maintenance chemotherapy for childhood acute lymphoblastic leukemia: Relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes
    • Schmiegelow K, Schrøder H, Pulczynska MK, Hejl M (1989). Maintenance chemotherapy for childhood acute lymphoblastic leukemia: relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes. Cancer Chemother Pharmacol 25: 65-69.
    • (1989) Cancer Chemother Pharmacol , vol.25 , pp. 65-69
    • Schmiegelow, K.1    Schrøder, H.2    Pulczynska, M.K.3    Hejl, M.4
  • 222
    • 0025838273 scopus 로고
    • Prognostic significance of methotrexate and 6-mercaptopurine dosage during maintenance chemotherapy for childhood acute lymphoblastic leukemia
    • published erratum appears in Pediatr Hematol Oncol 1992 Apr-Jun;9(2): following 198.
    • Schmiegelow K (1991). Prognostic significance of methotrexate and 6-mercaptopurine dosage during maintenance chemotherapy for childhood acute lymphoblastic leukemia [published erratum appears in Pediatr Hematol Oncol 1992 Apr-Jun;9(2): following 198]. Pediatr Hematol Oncol 8: 301-312.
    • (1991) Pediatr Hematol Oncol , vol.8 , pp. 301-312
    • Schmiegelow, K.1
  • 223
    • 0028342978 scopus 로고
    • Methotrexate and 6-mercaptopurine maintenance chemotherapy for childhood acute lymphoblastic leukemia: Dose adjustments by white cell counts or by pharmacokinetic parameters
    • Schmiegelow K, Schrøder H, Schmiegelow M (1994). Methotrexate and 6-mercaptopurine maintenance chemotherapy for childhood acute lymphoblastic leukemia: Dose adjustments by white cell counts or by pharmacokinetic parameters. Cancer Chemother Pharmacol 34: 209-215.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 209-215
    • Schmiegelow, K.1    Schrøder, H.2    Schmiegelow, M.3
  • 224
    • 0028860142 scopus 로고
    • Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology
    • Schmiegelow K, Schrøder H, Gustafsson G, Kristinsson J, Glomstein A, Salmi T, Wranne L (1995). Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology. J Clin Oncol 13: 345-351.
    • (1995) J Clin Oncol , vol.13 , pp. 345-351
    • Schmiegelow, K.1    Schrøder, H.2    Gustafsson, G.3    Kristinsson, J.4    Glomstein, A.5    Salmi, T.6    Wranne, L.7
  • 225
    • 0030968669 scopus 로고    scopus 로고
    • Impact of morning versus evening schedule for oral methotrexate and 6-mercaptopurine on relapse risk for children with acute lymphoblastic leukemia
    • Schmiegelow K, Glomstein A, Kristinsson J, Salmi T, Schrøder H, Björk O (1997). Impact of morning versus evening schedule for oral methotrexate and 6-mercaptopurine on relapse risk for children with acute lymphoblastic leukemia. J Ped Hematol Oncol 1997; 19: 102-109.
    • (1997) J Ped Hematol Oncol 1997 , vol.19 , pp. 102-109
    • Schmiegelow, K.1    Glomstein, A.2    Kristinsson, J.3    Salmi, T.4    Schrøder, H.5    Björk, O.6
  • 226
    • 0025195675 scopus 로고
    • 6-Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia
    • Schmiegelow K, Bruunshuus I (1990). 6-Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia. Cancer Chemother Pharmacol 26: 288-292.
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 288-292
    • Schmiegelow, K.1    Bruunshuus, I.2
  • 227
    • 0029815146 scopus 로고    scopus 로고
    • Myelo- and hepatotoxicity, pharmacokinetics, and relapse rate with methotrexate/6-mercaptopurine maintenance therapy of childhood acute lymphoblastic leukemia
    • Schmiegelow K, Ifversen M (1996). Myelo- and hepatotoxicity, pharmacokinetics, and relapse rate with methotrexate/6-mercaptopurine maintenance therapy of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 13: 433-441.
    • (1996) J Pediatr Hematol Oncol , vol.13 , pp. 433-441
    • Schmiegelow, K.1    Ifversen, M.2
  • 228
    • 0025318491 scopus 로고
    • Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia
    • Schmiegelow K, Pulczynska M (1990). Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia. Br J Cancer 61: 767-772.
    • (1990) Br J Cancer , vol.61 , pp. 767-772
    • Schmiegelow, K.1    Pulczynska, M.2
  • 229
    • 0025242868 scopus 로고
    • Maintenance chemotherapy for childhood acute lymphoblastic leukemia: Should dosage be guided by white blood cell counts?
    • Schmiegelow K, Pulczynska MK (1990a). Maintenance chemotherapy for childhood acute lymphoblastic leukemia: should dosage be guided by white blood cell counts? Am J Pediatr Hematol Oncol 12: 462-467.
    • (1990) Am J Pediatr Hematol Oncol , vol.12 , pp. 462-467
    • Schmiegelow, K.1    Pulczynska, M.K.2
  • 230
    • 0025217418 scopus 로고
    • White-cell counts in childhood acute lymphoblastic leukemia
    • Schmiegelow K, Pulczynska MK (1990b). White-cell counts in childhood acute lymphoblastic leukemia. Eur J Haematol 44: 72-74.
    • (1990) Eur J Haematol , vol.44 , pp. 72-74
    • Schmiegelow, K.1    Pulczynska, M.K.2
  • 231
    • 0015540570 scopus 로고
    • Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemic cells
    • Scholar EM, Calabresi P (1973). Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemic cells. Cancer Res 33: 94-103.
    • (1973) Cancer Res , vol.33 , pp. 94-103
    • Scholar, E.M.1    Calabresi, P.2
  • 232
    • 0022870449 scopus 로고
    • Methotrexate pharmacokinetics in age-fractionated erythrocytes
    • Schnøder H (1986). Methotrexate pharmacokinetics in age-fractionated erythrocytes. Cancer Chemother Pharmacol 18: 203-207.
    • (1986) Cancer Chemother Pharmacol , vol.18 , pp. 203-207
    • Schnøder, H.1
  • 233
    • 0022644286 scopus 로고
    • Pharmacokinetics of erythrocyte methotrexate in children with acute lymphoblastic leukemia during maintenance treatment
    • Schrøder H, Clausen N, Østergaard E, Pressler T (1986a). Pharmacokinetics of erythrocyte methotrexate in children with acute lymphoblastic leukemia during maintenance treatment. Cancer Chemother Pharmacol 16: 190-193.
    • (1986) Cancer Chemother Pharmacol , vol.16 , pp. 190-193
    • Schrøder, H.1    Clausen, N.2    Østergaard, E.3    Pressler, T.4
  • 234
    • 0022885040 scopus 로고
    • Folic acid supplements in vitamin tablets: A determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia
    • Schrøder H, Clausen N, Østergard E, Pressler T (1986b). Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia, Pediatr Hematol Oncol 3: 241-247.
    • (1986) Pediatr Hematol Oncol , vol.3 , pp. 241-247
    • Schrøder, H.1    Clausen, N.2    Østergard, E.3    Pressler, T.4
  • 235
    • 0023875413 scopus 로고
    • In vivo decline of methotrexate and methotrexate poly glutamates in age-fractionated erythrocytes
    • Schrøder H, Fogh K, Herlin T (1988). In vivo decline of methotrexate and methotrexate poly glutamates in age-fractionated erythrocytes. Cancer Chemother Pharmacol 21: 150-155.
    • (1988) Cancer Chemother Pharmacol , vol.21 , pp. 150-155
    • Schrøder, H.1    Fogh, K.2    Herlin, T.3
  • 236
    • 0025348144 scopus 로고
    • In vivo methotrexate kinetics and metabolism in human hematopoietic cells. Clinical significance of methotrexate concentrations in erythrocytes
    • Schrøder H (1990). In vivo methotrexate kinetics and metabolism in human hematopoietic cells. Clinical significance of methotrexate concentrations in erythrocytes. Dan Med Bull 37: 22-40.
    • (1990) Dan Med Bull , vol.37 , pp. 22-40
    • Schrøder, H.1
  • 237
    • 0022509083 scopus 로고
    • Methotrexate in erythrocytes of patients with psoriasis
    • Schrøder H, Foged EK (1986). Methotrexate in erythrocytes of patients with psoriasis. Eur J Clin Pharmacol 30: 453-456.
    • (1986) Eur J Clin Pharmacol , vol.30 , pp. 453-456
    • Schrøder, H.1    Foged, E.K.2
  • 238
    • 0023852189 scopus 로고
    • Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia
    • Schrøder H, Fogh K (1988). Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia, Cancer Chemother Pharmacol 21: 145-149.
    • (1988) Cancer Chemother Pharmacol , vol.21 , pp. 145-149
    • Schrøder, H.1    Fogh, K.2
  • 239
    • 0014234283 scopus 로고
    • A cellulose mercurial: Preparation, properties and use in antibody formation
    • Shainoff JR (1968). A cellulose mercurial: preparation, properties and use in antibody formation. J Immunol 100: 187-193.
    • (1968) J Immunol , vol.100 , pp. 187-193
    • Shainoff, J.R.1
  • 240
    • 0015146137 scopus 로고
    • Genetic neutropenia in people of African origin
    • Sharper AG, Lewis P (1971). Genetic neutropenia in people of African origin. Lancet ii: 1021-1023.
    • (1971) Lancet , vol.2 , pp. 1021-1023
    • Sharper, A.G.1    Lewis, P.2
  • 243
    • 0022007270 scopus 로고
    • Methodological guidelines for reports on clinical trials
    • Simon R, Wittes RE (1985). Methodological guidelines for reports on clinical trials. Cancer Treat Rep 69: 1-3.
    • (1985) Cancer Treat Rep , vol.69 , pp. 1-3
    • Simon, R.1    Wittes, R.E.2
  • 244
    • 0018827986 scopus 로고
    • The treatment of acute lymphoblastic leukaemia
    • Simone JV (1980). The treatment of acute lymphoblastic leukaemia. Br J Haematol 45: 1-4.
    • (1980) Br J Haematol , vol.45 , pp. 1-4
    • Simone, J.V.1
  • 246
    • 0024995401 scopus 로고
    • Dose intensity versus total dose of chemotherapy: An experimental basis
    • DeVita VT, Hellman S, Rosenberg SA (eds) J.B.Lippincott, Philadelphia
    • Skipper HE (1990). Dose intensity versus total dose of chemotherapy: an experimental basis. In: DeVita VT, Hellman S, Rosenberg SA (eds) Important advances in oncology. J.B.Lippincott, Philadelphia: 43-64.
    • (1990) Important Advances in Oncology , pp. 43-64
    • Skipper, H.E.1
  • 247
    • 0026282931 scopus 로고
    • Cytometry and time-dependent variations in peripheral blood and bone marrow cells: A literature review and relevance to the chronotherapy of cancer
    • Sletvold O, Smaaland R, Laerum OD (1991). Cytometry and time-dependent variations in peripheral blood and bone marrow cells: a literature review and relevance to the chronotherapy of cancer. Chronobiol Int 8: 235-250.
    • (1991) Chronobiol Int , vol.8 , pp. 235-250
    • Sletvold, O.1    Smaaland, R.2    Laerum, O.D.3
  • 248
    • 0027185187 scopus 로고
    • DNA synthesis and ploidy in non-Hodgkin's lymphomas demonstrate intrapatient variation depending on circadian stage of cell sampling
    • Smaaland R, Lote K, Sothern RB, Laerum OD (1993). DNA synthesis and ploidy in non-Hodgkin's lymphomas demonstrate intrapatient variation depending on circadian stage of cell sampling. Cancer Res 53: 3129-3138.
    • (1993) Cancer Res , vol.53 , pp. 3129-3138
    • Smaaland, R.1    Lote, K.2    Sothern, R.B.3    Laerum, O.D.4
  • 249
    • 0025999634 scopus 로고
    • Influence of doxorubicin dose intensity on response and outcome for patients with osteogenic sarcoma and Ewing's sarcoma
    • Smith MA, Ungerleider RS, Horowitz M, E., Simon R (1991). Influence of doxorubicin dose intensity on response and outcome for patients with osteogenic sarcoma and Ewing's sarcoma. JNCI 83: 1460-1470.
    • (1991) JNCI , vol.83 , pp. 1460-1470
    • Smith, M.A.1    Ungerleider, R.S.2    Horowitz, M.E.3    Simon, R.4
  • 250
    • 0018402957 scopus 로고
    • A reliable method for evaluating drug compliance in children with cancer
    • Smith SD, Rosen D, Trueworthy RC, Lowman JT (1979). A reliable method for evaluating drug compliance in children with cancer. Cancer 43: 169-173.
    • (1979) Cancer , vol.43 , pp. 169-173
    • Smith, S.D.1    Rosen, D.2    Trueworthy, R.C.3    Lowman, J.T.4
  • 251
    • 0005832529 scopus 로고
    • Pediatric clinical pharmacology of 6-mercaptopurine: Lack of compliance as a factor in leukemia relapse
    • Abstract
    • Snodgrass W, Smith S, Trueworthy R, Vats T (1984). Pediatric clinical pharmacology of 6-mercaptopurine: Lack of compliance as a factor in leukemia relapse. Proc Am Soc Clin Oncol 3: 204 (Abstract).
    • (1984) Proc Am Soc Clin Oncol , vol.3 , pp. 204
    • Snodgrass, W.1    Smith, S.2    Trueworthy, R.3    Vats, T.4
  • 252
    • 0023026453 scopus 로고
    • Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in plasma and bone marrow of children receiving low-dose oral methotrexate
    • Sonneveld P, Schultz FW, Nooter K, Hahlen K (1986). Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in plasma and bone marrow of children receiving low-dose oral methotrexate. Cancer Chemother Pharmacol 18: 111-116.
    • (1986) Cancer Chemother Pharmacol , vol.18 , pp. 111-116
    • Sonneveld, P.1    Schultz, F.W.2    Nooter, K.3    Hahlen, K.4
  • 255
    • 0018637912 scopus 로고
    • Bioavailability of methotrexate: Implications for clinical use
    • Stuart JF, Calman KC, Watters J, et al. (1979). Bioavailability of methotrexate: implications for clinical use. Cancer Chemother Pharmacol 3: 239-241.
    • (1979) Cancer Chemother Pharmacol , vol.3 , pp. 239-241
    • Stuart, J.F.1    Calman, K.C.2    Watters, J.3
  • 256
    • 0023001398 scopus 로고
    • Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia
    • Sulh H, Koren G, Whalen C, et al. (1986). Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia. Clin Pharmacol Ther 40: 604-609.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 604-609
    • Sulh, H.1    Koren, G.2    Whalen, C.3
  • 257
    • 0030048791 scopus 로고    scopus 로고
    • Thiopurine methyltranferase pharmacogenetics: Human gene cloning and characterization of a common polymorphism
    • Szumlanski C, Otterness D, Her C, et al. (1996). Thiopurine methyltranferase pharmacogenetics: Human gene cloning and characterization of a common polymorphism. DNA Cell Biol 15: 17-30.
    • (1996) DNA Cell Biol , vol.15 , pp. 17-30
    • Szumlanski, C.1    Otterness, D.2    Her, C.3
  • 258
    • 0026907122 scopus 로고
    • Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozymes
    • Szumlanski CL, Honchel R, Scott MC, Weinshilboum RM (1992). Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenetics 2: 148-159.
    • (1992) Pharmacogenetics , vol.2 , pp. 148-159
    • Szumlanski, C.L.1    Honchel, R.2    Scott, M.C.3    Weinshilboum, R.M.4
  • 259
    • 0014501287 scopus 로고
    • Inhibition of phosphoribosyl pyrophosphate amidotransferase from Erlich ascites-tumor cells by thiopurine nucleotides
    • Tay BS, McLilley R, Murray AW, Atkinson MR (1969). Inhibition of phosphoribosyl pyrophosphate amidotransferase from Erlich ascites-tumor cells by thiopurine nucleotides. Biochem Pharmacol 18: 936-938.
    • (1969) Biochem Pharmacol , vol.18 , pp. 936-938
    • Tay, B.S.1    McLilley, R.2    Murray, A.W.3    Atkinson, M.R.4
  • 260
    • 0023195465 scopus 로고
    • Methotrexate bioavailability after oral and intramuscular administration in children
    • Teresi ME, Crom WR, Choi KE, Mirro J, Evans WE (1987). Methotrexate bioavailability after oral and intramuscular administration in children. J Pediatr 110: 788-792.
    • (1987) J Pediatr , vol.110 , pp. 788-792
    • Teresi, M.E.1    Crom, W.R.2    Choi, K.E.3    Mirro, J.4    Evans, W.E.5
  • 261
    • 0022350150 scopus 로고
    • Medical Research Council leukemia trial, UKALL VII
    • The Medical Research Council's Working Party on Leukemia in Childhood (1985). Medical Research Council leukemia trial, UKALL VII. Arch Dis Child 60: 1050-1054.
    • (1985) Arch Dis Child , vol.60 , pp. 1050-1054
  • 262
    • 0022625674 scopus 로고
    • Trial 1-8: Improvement in treatment for children with acute lymphoblastic leukemia
    • The Medical Research Council's Working Party on Leukemia in Childhood (1986). Trial 1-8: Improvement in treatment for children with acute lymphoblastic leukemia. Lancet i: 408-411.
    • (1986) Lancet , vol.1 , pp. 408-411
  • 263
    • 0016053656 scopus 로고
    • Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine
    • Tidd DM, Paterson AR (1974a). Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res 34: 733-737.
    • (1974) Cancer Res , vol.34 , pp. 733-737
    • Tidd, D.M.1    Paterson, A.R.2
  • 264
    • 0016053706 scopus 로고
    • A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine
    • Tidd DM, Paterson AR (1974b). A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res 34: 738-746.
    • (1974) Cancer Res , vol.34 , pp. 738-746
    • Tidd, D.M.1    Paterson, A.R.2
  • 266
    • 0019987157 scopus 로고
    • Thiopurine methyltransferase biochemical genetics: Human lymphocyte activity
    • Van Loon JA, Weinshilboum RM (1982). Thiopurine methyltransferase biochemical genetics: human lymphocyte activity. Biochem Genet 20: 637-658.
    • (1982) Biochem Genet , vol.20 , pp. 637-658
    • Van Loon, J.A.1    Weinshilboum, R.M.2
  • 267
    • 0023178112 scopus 로고
    • Human lymphocyte thiopurine methyltransferase pharmacogenetics: Effect of phenotype on 6-mercaptopurine-induced inhibition of mitogen stimulation
    • Van Loon JA, Weinshilboum RM (1987). Human lymphocyte thiopurine methyltransferase pharmacogenetics: effect of phenotype on 6-mercaptopurine-induced inhibition of mitogen stimulation. J Pharmacol Exp Ther 242: 21-26.
    • (1987) J Pharmacol Exp Ther , vol.242 , pp. 21-26
    • Van Loon, J.A.1    Weinshilboum, R.M.2
  • 268
    • 0022401174 scopus 로고
    • The pharmacology and metabolism of the thiopurine drugs 6-mercaptopurine and azathioprine
    • Van Scoik KG, Johnson CA, Porter WR (1985). The pharmacology and metabolism of the thiopurine drugs 6-mercaptopurine and azathioprine. Drug Metab Rev 16: 157-174.
    • (1985) Drug Metab Rev , vol.16 , pp. 157-174
    • Van Scoik, K.G.1    Johnson, C.A.2    Porter, W.R.3
  • 269
    • 0029960017 scopus 로고    scopus 로고
    • High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia: Results of protocol ALL VI. from the Dutch childhood leukemia study group
    • Veerman AJP, Hählen K, Kamps WA, et al. (1996). High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia: Results of protocol ALL VI. From the Dutch childhood leukemia study group. J Clin Oncol 14: 911-918.
    • (1996) J Clin Oncol , vol.14 , pp. 911-918
    • Veerman, A.J.P.1    Hählen, K.2    Kamps, W.A.3
  • 270
    • 0025909447 scopus 로고
    • The therapeutic index of cytotoxic chemotherapy depends upon circadian drug timing
    • Von Roemeling R (1991). The therapeutic index of cytotoxic chemotherapy depends upon circadian drug timing. Ann N Y Acad Sci 618: 292-311.
    • (1991) Ann N Y Acad Sci , vol.618 , pp. 292-311
    • Von Roemeling, R.1
  • 271
    • 0015642402 scopus 로고
    • Effect of methyl thioinosine on nucleotide concentrations in L5178Y cells
    • Warnick CT, Paterson ARP (1973). Effect of methyl thioinosine on nucleotide concentrations in L5178Y cells. Cancer Res 33: 1711-1715.
    • (1973) Cancer Res , vol.33 , pp. 1711-1715
    • Warnick, C.T.1    Paterson, A.R.P.2
  • 272
    • 0028963613 scopus 로고
    • Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurine-based maintenance therapy
    • Warren DJ, Andersen A, Slordal L (1995). Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurine-based maintenance therapy. Cancer Res 55: 1670-1674.
    • (1995) Cancer Res , vol.55 , pp. 1670-1674
    • Warren, D.J.1    Andersen, A.2    Slordal, L.3
  • 273
    • 0027432427 scopus 로고
    • A high-performance liquid Chromatographic method for the determination of 6-thioguanine residues in DNA using precolumn derivatization and fluorescence detection
    • Warren DJ, Slørdal L (1993). A high-performance liquid Chromatographic method for the determination of 6-thioguanine residues in DNA using precolumn derivatization and fluorescence detection. Anal Biochem 215: 278-283.
    • (1993) Anal Biochem , vol.215 , pp. 278-283
    • Warren, D.J.1    Slørdal, L.2
  • 274
    • 0017880983 scopus 로고
    • Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties
    • Weinshilboum RM, Raymond FH, Pazmino PA (1978). Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties. Clin Chim Acta 85: 823-833.
    • (1978) Clin Chim Acta , vol.85 , pp. 823-833
    • Weinshilboum, R.M.1    Raymond, F.H.2    Pazmino, P.A.3
  • 276
    • 0024289605 scopus 로고
    • Medical cost of curing childhood acute lymphoblastic leukemia
    • Wheeler K, Leiper AD, Jannoun L, Chessells JM (1988). Medical cost of curing childhood acute lymphoblastic leukemia. Br Med J 296: 162-166.
    • (1988) Br Med J , vol.296 , pp. 162-166
    • Wheeler, K.1    Leiper, A.D.2    Jannoun, L.3    Chessells, J.M.4
  • 277
    • 0017119286 scopus 로고
    • Mechanism of action of methotrexate. Free intracellular methotrexate required to suppress dihydrofolate reduction to tetrahydrofolate by Erlich ascites tumor cells in vitro
    • White JC, Goldman ID (1976). Mechanism of action of methotrexate. Free intracellular methotrexate required to suppress dihydrofolate reduction to tetrahydrofolate by Erlich ascites tumor cells in vitro. Mol Pharmacol 12: 711-719.
    • (1976) Mol Pharmacol , vol.12 , pp. 711-719
    • White, J.C.1    Goldman, I.D.2
  • 278
    • 0017344954 scopus 로고
    • Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells
    • Whitehead VM (1977). Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells. Cancer Res 37: 408-412.
    • (1977) Cancer Res , vol.37 , pp. 408-412
    • Whitehead, V.M.1
  • 279
    • 7844246989 scopus 로고
    • Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: A pilot prognostic factor analysis
    • Whitehead VM, Rosenblatt DS, Vuchich MJ, et al. (1990). Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: A pilot prognostic factor analysis. Blood 213: 1-6.
    • (1990) Blood , vol.213 , pp. 1-6
    • Whitehead, V.M.1    Rosenblatt, D.S.2    Vuchich, M.J.3
  • 280
    • 0023640869 scopus 로고
    • Methotrexate (MTX) concentration in tumors following low-dose MTX
    • Winick NJ, Kamen BA, Streckfuss A, et al. (1987). Methotrexate (MTX) concentration in tumors following low-dose MTX. Cancer Chemother Pharmacol 20: 78-80.
    • (1987) Cancer Chemother Pharmacol , vol.20 , pp. 78-80
    • Winick, N.J.1    Kamen, B.A.2    Streckfuss, A.3
  • 281
    • 0015918904 scopus 로고
    • Properties of 5-phosphoribosyl-1-pyrophosphate amidotransferase from human lymphoblasts
    • Wood AW, Seegmiller JE (1973). Properties of 5-phosphoribosyl-1-pyrophosphate amidotransferase from human lymphoblasts. J Biol Chem 248: 138-143.
    • (1973) J Biol Chem , vol.248 , pp. 138-143
    • Wood, A.W.1    Seegmiller, J.E.2
  • 282
    • 0019956940 scopus 로고
    • Pharmacogenetics of human thiopurine methyltransferase: Kidney-erythrocyte correlation and immunotitration studies
    • Woodson LC, Dunnette JH, Weinshilboum RM (1982). Pharmacogenetics of human thiopurine methyltransferase: kidney-erythrocyte correlation and immunotitration studies. J Pharmacol Exp Ther 222: 174-181.
    • (1982) J Pharmacol Exp Ther , vol.222 , pp. 174-181
    • Woodson, L.C.1    Dunnette, J.H.2    Weinshilboum, R.M.3
  • 283
    • 0021052544 scopus 로고
    • Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives
    • Woodson LC, Ames MM, Selassie CD, Mansch C, Weinshilboum RM (1983). Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives. Mol Pharmacol 24: 471-478.
    • (1983) Mol Pharmacol , vol.24 , pp. 471-478
    • Woodson, L.C.1    Ames, M.M.2    Selassie, C.D.3    Mansch, C.4    Weinshilboum, R.M.5
  • 284
    • 0027787738 scopus 로고
    • Pharmacokinetics and cancer: Successes, failures and future prospects
    • Workman P (1993). Pharmacokinetics and cancer: successes, failures and future prospects (editorial). Cancer Surv 17: 1-26.
    • (1993) Cancer Surv , vol.17 , pp. 1-26
    • Workman, P.1
  • 285
    • 0029240514 scopus 로고
    • Circadian rhythmometry of serum interleukin-2, interleukin-10, tumor necrosis factor-alfa, and granulocyte-macrophage colony-stimulating factor in men
    • Young MRI, Matthews JP, Kanabrocki EL, Sothern RB, Roitman-Johnson B, Scheving LE (1995). Circadian rhythmometry of serum interleukin-2, interleukin-10, tumor necrosis factor-alfa, and granulocyte-macrophage colony-stimulating factor in men. Chronobiol Int 1: 19-27.
    • (1995) Chronobiol Int , vol.1 , pp. 19-27
    • Young, M.R.I.1    Matthews, J.P.2    Kanabrocki, E.L.3    Sothern, R.B.4    Roitman-Johnson, B.5    Scheving, L.E.6
  • 287
    • 0023229263 scopus 로고
    • Methotrexate hepatotoxicity and concentrations of methotrexate and folate in erythrocytes-relation to liver fibrosis and cirrhosis
    • Zachariae H, Schrøder H, Foged E, Søgaard H (1987). Methotrexate hepatotoxicity and concentrations of methotrexate and folate in erythrocytes-relation to liver fibrosis and cirrhosis. Acta Derm Venereol Stockh 67: 336-340.
    • (1987) Acta Derm Venereol Stockh , vol.67 , pp. 336-340
    • Zachariae, H.1    Schrøder, H.2    Foged, E.3    Søgaard, H.4
  • 288
    • 0021028642 scopus 로고
    • Inhibition of first-pass metabolism in cancer chemotherapy: Interaction of 6-mercaptopurine and allopurinol
    • Zimm S, Collins JM, O'Neill D, Chabner BA, Poplack DG (1983a). Inhibition of first-pass metabolism in cancer chemotherapy: interaction of 6-mercaptopurine and allopurinol. Clin Pharmacol Ther 34: 810-817.
    • (1983) Clin Pharmacol Ther , vol.34 , pp. 810-817
    • Zimm, S.1    Collins, J.M.2    O'Neill, D.3    Chabner, B.A.4    Poplack, D.G.5
  • 289
    • 0020534019 scopus 로고
    • Variable bioavailability of oral mercaptopurine: Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?
    • Zimm S, Collins JM, Riccardi R, O'Neill D, Narang PK, Chabner BA, Poplack DG (1983b). Variable bioavailability of oral mercaptopurine: is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered? N Eng J Med 308: 1005-1009.
    • (1983) N Eng J Med , vol.308 , pp. 1005-1009
    • Zimm, S.1    Collins, J.M.2    Riccardi, R.3    O'Neill, D.4    Narang, P.K.5    Chabner, B.A.6    Poplack, D.G.7
  • 290
    • 0022550773 scopus 로고
    • Biochemical parameters of mercaptopurine activity in patients with acute lymphoblastic leukemia
    • Zimm S, Reaman G, Murphy RF, et al. (1986). Biochemical parameters of mercaptopurine activity in patients with acute lymphoblastic leukemia. Cancer Res 46: 1495-1498.
    • (1986) Cancer Res , vol.46 , pp. 1495-1498
    • Zimm, S.1    Reaman, G.2    Murphy, R.F.3
  • 291
    • 0015991085 scopus 로고
    • Identification of 6-methylmercaptopurine ribonucleoside 5′-diphosphate and 5′-triphosphate as metabolites of 6-mercaptopurine in man
    • Zimmerman TP, Chu LC, Bugge CJ, Nelson DJ, Lyon GM, Elion GB (1974). Identification of 6-methylmercaptopurine ribonucleoside 5′-diphosphate and 5′-triphosphate as metabolites of 6-mercaptopurine in man. Cancer Res 34: 221-224.
    • (1974) Cancer Res , vol.34 , pp. 221-224
    • Zimmerman, T.P.1    Chu, L.C.2    Bugge, C.J.3    Nelson, D.J.4    Lyon, G.M.5    Elion, G.B.6


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