p53 protein accumulation is a specific marker of malignant potential in Barrett's metaplasia

Digestive Diseases and Sciences

Volumn 42, Issue 4, 1997, Pages 697-701

  Younes, Mamoun ^a   Ertan, Atilla ^b   Lechago, Lia V ^b   Somoano, Jacqueline R ^b   Lechago, Juan ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

adenocarcinoma; Barrett's esophagus; dysplasia; immunohistochemistry; p53

Indexed keywords

PROTEIN P53; TUMOR MARKER;

ARTICLE; BARRETT ESOPHAGUS; BIOPSY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS;

EID: 0031003486     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018828207371     Document Type: Article

References (30)

1. Phillips RW, Wong RKH: Barrett's esophagus. Natural history, incidence, etiology, and complications. Gastroenterol Clin North Am 20:791-816, 1991
2. Haggitt RC, Tryzelaar J, Ellis H, Colcher H: Adenocarcinoma complicating columnar epithelium-lined (Barrett's) esophagus. Am J Clin Pathol 70:1-5, 1978
3. Skinner DB, Walther BC, Riddell RH, Schmidt H, Iascone C, DeMeester TR: Barrett's esophagus. Comparison of benign and malignant cases. Ann Surg 198:554-566, 1983
4. Naef AP, Savary M, Ozzello L, Pearson FG: Columnar-lined lower esophagus. An acquired lesion with malignant predisposition. Report on 140 cases of Barrett's esophagus with 12 adenocarcinomas. Ann Thorac Surg 13:543-551, 1972
5. Young JR Jr, Percy CL, Asire AJ: Surveillance, epidemiology, and end results: Incidence and mortality data 1973-1977. Monogr Natl Cancer Inst 57:140-141, 1981
6. Bolt WJ, Devesa SS, Kneller RW, Fraumeni JF Jr: Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 265:1287-1289, 1991
7. Bolt WJ, Devesa SS, Fraumeni JF Jr: Continuing climb in rates of esophageal adenocarcinoma: An update. JAMA 270:1320, 1993
8. Steritz JM, Ellis FH, Gibb SP, Balogh K, Watkins E: Adenocarcinoma in Barrett's esophagus. A clinicopathologic study of 65 cases. Ann Surg 213:122-125, 1991
9. Paraf F, Flejou J-F, Pignon J-P, Fekete F, Potet F: Surgical pathology of adenocarcinoma arising in Barrett's esophagus. Am J Surg Pathol 19:183-191, 1995
10. Miros M, Kerlin P, Walker N: Only patients with dysplasia progress to adenocarcinoma in Barrett's oesophagus. Gut 32:1441-1446, 1991
11. Reid BJ, Weinstein WM, Lewin KJ, Haggitt RC, VanDeventer G, DenBesten L, Rubin CE: Endoscopic biopsy can detect high-grade dysplasia or early adenocarcinoma in Barrett's esophagus without grossly recognizable neoplastic lesions. Gastroenterology 94:81-90, 1988
12. Tytgat GNJ, Hameeteman W: The neoplastic potential of columnar-lined (Barrett's) esophagus. World J Surg 16:308-312, 1992
13. Reid BJ, Haggitt RC, Rubin CE, Roth G, Surawicz CM, Van Belle G, Lewin K, Weinstein WM, Antonioli DA, Goldman H, MacDonald W, Owen D: Observer variation in the diagnosis of dysplasia in Barrett's esophagus. Hum Pathol 19:166-178, 1988
14. Achkar E, Carey WC: The cost of surveillance for adenocarcinoma complicating Barrett's esophagus. Am J Gastroenterol 83:291-294, 1988
15. Isobe M, Emanuel BS, Givol D, Oren M, Croce CM: Localization of gene for human p53 tumor antigen to band 17p13. Nature 320:84-85, 1986
16. Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, VanTuinen P, Ledbetter DH, Barker DF, Nakamura Y, White R, Vogelstein B: Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244:217-221, 1989
17. Porter PL, Gown AM, Kramp SG, Coltrera MD: Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacran-fixed, embedded tissue. Am J Pathol 140:145-153, 1992
18. Hinds PW, Finlay CA, Quartin RS, Baker SJ, Fearon ER, Vogelstein B, Levine AJ: Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes. Cell Growth Differ 1:571-580, 1990
19. Hamelin R, Flejou J-F, Muzeau F, Potet F, Laurent-Puig P, Fekete F, Thomas G: TP53 gene mutations and p53 protein immunoreactivity in malignant and premalignant Barrett's esophagus. Gastroenterology 107:1012-1018, 1994
20. Blount PL, Ramel S, Raskind WH, Haggitt RC, Sanchez CA, Dean PJ, Rabinovitch PS, Reid BJ: 17p allelic deletions and p53 protein overexpression in Barrett's adenocarcinoma. Cancer Res 51:5482-5486, 1991
21. Ramel S, Reid BJ, Sanchez CA, Blount PL, Levine DS, Neshat K, Haggitt RC, Dean PJ, Thor K, Rabinovitch P: Evaluation of p53 protein expression in Barrett's esophagus by two-parameter flow cytometry. Gastroenterology 102:1220-1228, 1992
22. Symmans PJ, Linehan JM, Brito MJ, Filipe ME: p53 expression in Barrett's esophagus, dysplasia, and adenocarcinoma using antibody DO-7. J Pathol 173:221-226, 1994
23. Hardwick RH, Shephard NA, Moorghen M, Newcomb PV, Alderson D: Adenocarcinoma arising in Barrett's oesophagus: Evidence for the participation of p53 dysfunction in the dysplasia/carcinoma sequence. Gut 35:764-768, 1994
24. Younes M, Lebovitz R, Lechago LV, Lechago J: p53 protein accumulation in Barrett's metaplasia, dysplasia, and carcinoma: A follow-up study. Gastroenterology 105:1637-1642. 1993
25. Haggitt RC: Barrett's esophagus, dysplasia, and adenocarcinoma. Hum Pathol 25:982-993, 1994
26. Dawson-Saunders B, Trapp RG: Evaluating diagnostic procedures. In Basic and Clinical Biostatistics. B Dawson-Saunders, RG Trapp (eds). Norwalk, Appelton and Lange, 1990, pp 229-244
27. Younes M, Riley S, Genta R, Mosharaf M, Mody D: p53 protein accumulation in tumors of the ampulla of Vater. Cancer 76:1150-1154, 1995
28. Shiao YH, Rugge M, Correa P, Lehmann HP, Scheer WD: p53 alteration in gastric precancerous lesions. Am J Pathol 144:511-517, 1994
29. Rodriguez NA, Rowan A, Smith MEF, Kerr IB, Bodmer WF, Gannon JV, Lane DP: p53 mutations in colorectal cancer. Proc Natl Acad Sci USA 87:7555-7559, 1990
30. Bartek J, Iggo R, Gannon J, Lane DP: Genetic and immunohistochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene 5:893-899, 1990