Analysis of apoptosis in solid tumors by laser-scanning cytometry

Modern Pathology

Volumn 11, Issue 11, 1998, Pages 1052-1058

  Gorczyca, Wojciech ^a   Bedner, Elzbieta ^a   Burfeind, Patricia ^a   Darzynkiewicz, Zbigniew ^a   Melamed, M R ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Apoptosis; Cancer; Cytometry

Indexed keywords

DNA;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SELECTION; CHILD; CONTROLLED STUDY; DNA STRAND BREAKAGE; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; MALE; PLOIDY; PRIORITY JOURNAL; SOLID TUMOR;

ADULT; AGED; APOPTOSIS; BRAIN NEOPLASMS; BREAST NEOPLASMS; CHILD, PRESCHOOL; COLONIC NEOPLASMS; DNA; DNA FRAGMENTATION; FEMALE; FLOW CYTOMETRY; GENITAL NEOPLASMS, FEMALE; HL-60 CELLS; HUMANS; IN SITU NICK-END LABELING; KIDNEY NEOPLASMS; LASERS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASMS; OVARIAN NEOPLASMS;

EID: 0031758161     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Arends MJ, Morris RG, Wyllie AH, Apoptosis. The role of endonuclease. Am J Pathol 1990;136:593-608.
2. Wyllie AH. Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Metastasis Rev 1992;11:95-103.
3. Vaux DL. Toward the understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad Sci U S A 1993;90:786-9.
4. Bowen ID, Bowen SM, Jones AH. Mitosis and apoptosis: matters of life and death. London: Chapman and Hall; 1998. p. 17-27, 134-56.
5. Fisher DE. Apoptosis in cancer therapy: crossing the threshold. Cell 1994;78:539-542.
6. Arends MJ, Wyllie AH. Apoptosis: mechanisms and role in pathology. Int Rev Exp Pathol 1991;32:223-54.
7. Majno G, Joris I. Apoptosis, oncosis, and necrosis: an overview of cell death. Am J Pathol 1995;146:3-16.
8. Gorczyca W, Melamed MR, Darzynkiewicz Z. Analysis of apoptosis by flow cytometry. In: Jaroszeski MJ, Heller R, editors. Methods in molecular biology. Flow cytometry protocols. Vol. 91. Totowa, NJ: Humana Press; 1998. p. 217-38.
9. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T, Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 1997; 27:1-20.
10. Dive C, Gregory CD, Phipps DJ, Evans DI, Milner AE, Wyllie AH. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim Biophys Acta 1992;1133:275-85.
11. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P, et al. Features of apoptotic cells measured by flow cytometry. Cytometry 1992;13:795-808.
12. Elstein KH, Zucker RM. Comparison of cellular and nuclear flow cytometric techniques for discriminating apoptotic subpopulations. Exp Cell Res 1994;211:322-31.
13. Gorczyca W, Bruno S, Darzynkiewicz RJ, Gong J, Darzynkiewicz Z. DNA strand breaks occurring during apoptosis: their early in situ detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int J Oncol 1992;1:639-48.
14. Gorczyca W, Gong J, Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 1993;52:1945-51.
15. Gorczyca W, Darzynkiewicz Z, Melamed MR. Laser scanning cytometry in pathology of solid tumors. Acta Cytol 1997;41: 98-108.
16. Gorczyca W, Bigman K, Mittelman A, Ahmed T, Gong J, Melamed MR, et al. Induction of DNA strand breaks associated with apoptosis during treatment of leukemia. Leukemia 1993;7:659-70.
17. Gorczyca W, Tuziak T, Kram A, Melamed MR, Darzynkiewicz Z. Detection of apoptosis-associated DNA strand breaks in fine-needle aspiration biopsies by in situ end labeling of fragmented DNA. Cytometry 1994;15:169-75.
18. Kamentsky LA, Kamentsky LD. Microscope-based multiparameter laser scanning cytometry yielding data comparable to flow cytometry. Cytometry 1991;12:381-7.
19. Kamentsky LA, Burger DE, Gershman RJ, Kamentsky LD, Luther E. Slide-based laser scanning cytometry. Acta Cytol 1997;41:123-43.
20. Samoszuk MK, Sallash G, Chen K, Carlton E, Odlaker T. Association between flow cytometric S-phase fraction and apoptotic rate in breast cancer. Cytometry 1996;26:281-5.
21. Steck K, McDonnel T, Sneige N, El-Naggar A. Flow cytometric analysis of apoptosis and bcl-2 in primary breast carcinomas: clinical and biological implications. Cytometry 1996; 24:116-22.
22. Gorczyca W, Sarode V, Juan G, Melamed MR, Darzynkiewicz Z. Laser scanning cytometric analysis of cyclin B1 in primary human malignancies. Mod Pathol 1997;10:457-62.