Nitric oxide: A protective or pathogenic molecule?

Reviews and Research in Medical Microbiology

Volumn 9, Issue 4, 1998, Pages 179-189

  Piedrafita, D ^a   Liew, F Y ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Inducible NOS; Infection; Microbial infection; Nitric oxide; Nitric oxide synthase (NOS)

Indexed keywords

ARGININE; CITRULLINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ARTICLE; BACTERIUM; CHRONIC DISEASE; DEAMINATION; ENZYME INDUCTION; HOST PARASITE INTERACTION; HOST RESISTANCE; HUMAN; IMMUNE SYSTEM; INFECTION; INFLAMMATORY CELL; NONHUMAN; PARASITE; PATHOGENICITY; PRIORITY JOURNAL; PROTOZOON; VIRUS; YEAST;

EID: 0031756435     PISSN: 0954139X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00013542-199810000-00001     Document Type: Article

References (64)

1. Moncada S, Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med 1993, 329:2002-2012.
2. Marietta MA: Nitric oxide synthase: aspects concerning structure and catalysis. Cell 1994, 78:927-930.
3. Nathan C: Nitric oxide as a secretory product of mammalian cells. FASEB J 1992, 6:3051-3064.
4. Bredt DS, Snyder SHA: Nitric oxide: a physiological messenger molecule. Annu Rev Biochem 1994, 63:175-195
5. MacMicking J, Xie Q, Nathan C: Nitric oxide and macrophage function. Annu Rev Immunol 1997, 15:323-350.
6. Hibbs Jr JB, Tainter RR, Vavrin Z, et al: In Nitric Oxide from L-arginine: a Bioregulatory System. Edited by Moncada S, Higgs JB. Amsterdam: Excepta Medica; 1990:189-223.
7. Hibbs Jr JB, Tainter RR, Vavrin Z, Rachlin EM: Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 1988, 157:87-94.
8. James SL, Glaven JA: Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J Immunol 1989, 143:4208-4212.
9. Mauel J, Ransijn A, Buchmuller-Rouiller Y: Killing of Leishmania parasites in activated murine macrophages is based on an L-arginine-dependent process that produces nitrogen derivatives. J Leukocyte Biol 1991, 49:73-82.
10. Henry Y, Lepoivre M, Drapier J, Ducrocq C, Boucher J, Guissani A: EPR characterization of molecular targets for NO in mammalian cells and organelles. FASEB J 1993, 7:1124-1134.
11. Hausladen A, Privalle CT, Keng T, DeAngelo J, Stamler JS: Nitrosative stress: activation of the transcription factor OxyR. Cell 1996 86:719-729.
12. Kroncke K, Fehsel K, Kolb-Bachofen V: Nitric oxide: cytotoxicity versus cytoprotection - how, why, when, and where. Nitric Oxide 1997, 1:107-120.
13. Albina JE, Martin BA, Henry WL, Louis CA, Reichner JS: B cell lymphoma-2 transfected P815 cells resist reactive nitrogen intermediate-mediated macrophage-dependent cytotoxicity J Immunol 1996, 157:279-283.
14. Green SJ, Nacy CA: Antimicrobial and immunopathologic effects of cytokine-induced nitric oxide synthesis. Curr Opin Infect Dis 1993, 6:384-396.
15. Liew FY: The role of nitric oxide in parasitic diseases. Ann Trop Med Parasitol 1993, 87:637-642.
16. Sternberg JS, McGuigan F: Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection. Eur J Immunol 1992, 22:2741-2744.
17. Schleifer KW, Mansfield JM: Suppressor macrophages in African trapanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. J Immunol 1993, 151:5492-5503.
18. Lyons CR: The role of nitric oxide in inflammation. Adv Immunol 1995, 60:323-360.
19. Rolph MS, Cowden WB, Medvecsky CJ, Ramshaw IA: A recombinant vaccina virus encoding inducible nitric oxide synthase is attenuated in vivo. J Virol 1996, 70:7678-7685.
20. Koprowski H, Zheng YM, Heber-Katz E, et al: In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proc Natl Acad Sci USA 1993, 90:3024-3027.
21. Campbell IL, Samimi A, Chiang CS: Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis. J Immunol 1994, 153:3622-3629.
22. Akaike T, Noguchi Y, Ijiri S, et al.: Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc Natl Acad Sci USA 1996, 93:2448-2453.
23. Kreil TR, Eibl MM: Nitric oxide viral infection: no antiviral activity against a flavivirus in vitro, and evidence for contribution to pathogenesis in experimental infection in vivo. Virology 1996, 219:304-306.
24. Chan J, Xing Y, Magliozzo RS, Bloom BR: Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med 1992, 175:1111-1122.
25. Cooper AM, Dalton DK, Stewart TK, Griffin JP, Russell DG, Orme IM: Disseminated tuberculosis in IFN-gamma gene-disrupted mice. J Exp Med 1993, 178:2243-2248.
26. O'Brien L, Carmichael J, Lowrie DB, Andrew PW: Strains of Mycobacterium tuberculosis differ in susceptibility to reactive nitrogen intermediates in vitro. Infect Immun 1994, 62:5187-5190.
27. Chan J, Tanaka K, Carrol D, Flynn J, Bloom BR: Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect Immun 1995, 63:736-740.
28. Doi T, Ando M, Akaike T, Suga M, Sato K, Maeda H: Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis. Infect Immun 1993, 61:1980-1989.
29. Turco J, Winkler HH: Role of the nitric oxide synthase pathway in inhibition of growth of interferon-sensitive and interferon-resistant Rickettsia prowazekii strains. Infect Immun 1993, 61:4317-4325.
30. Seiler KP, Vavrin Z, Eichwald E, Hibbs Jr JB, Weis JJ: Nitric oxide production during murine lyme disease: lack of involvement in host resistance or pathology. Infect Immun 1995, 63:3886-3895.
31. Gross SS, Kilbourn RG, Griffith OW: NO in septic shock: good, bad or ugly? Learning from iNOS knockouts. Trends Microbiol 1996, 4:47-49.
32. Nussler A, Drapier JC, Renia L, et al.: L-Arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation. Eur J Immunol 1991, 21:227-230.
33. Mellouk S, Hoffman SL, Liu ZZ, de la Vega P, Billiar TR, Nussler AK: Nitric oxide-mediated anti-plasmodial activity in human and murine hepatocytes induced by gamma interferon and the parasite itself: enhancement by exogenous tetrahydrobiopterin. Infect Immun 1994, 62:4043-4046.
34. Taylor-Robinson AW, Phillips RS, Severn A, Moncada S, Liew FY: The role of Th1 and Th2 cells in a rodent malaria infection. Science 1993, 260:1931-1934.
35. Taylor-Robinson AW, Severn A, Phillips RS: Kinetics of nitric oxide production during infection and reinfection of mice with Plasmodium chabaudi. Parasite Immunol 1996, 18:425-430.
36. Eling WMC, Sauerwein RW: Severe and cerebral malaria: common or distinct pathophysiology? Rev Med Microbiol 1995, 6:17-25.
37. Nussler AK, Eling W, Kremsner P: Patients with Plasmodium falciparum malaria and Plasmodium vivax malaria show increased nitrite and nitrate plasma levels. J Infect Dis 1994, 169:1418-1419.
38. Cot S, Ringwald P, Mulder B, et al.: Nitric oxide in cerebral malaria. J Infect Dis 1994, 169:1417-1418.
39. Anstey NM, Weinberg JB, Hassanali MY, et al: Nitric oxide in Tanzanian children with malaria: Inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med 1996, 184:557-567.
40. Mauel J: Intracellular survival of protozoan parasites with special reference to Leishmania spp., Toxoplasma gondii and Trypanosoma cruzi. Adv Parasitol 1996, 38:1-39.
41. Vespa GNR, Cunha FQ, Silva JS: Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro. Infect Immun 1994, 62:5177-5182.
42. Sternberg J, Mabbott N, Sutherland I, Liew FY: Inhibition of nitric oxide synthesis leads to reduced parasitemia in murine Trypanosoma brucei infection. Infect Immun 1994, 62:2135-2137.
43. Liew FY, Millott S, Parkinson C, Palmer RMJ, Moncada S: Macrophage killing of Leishmania parasites in vivo is mediated by nitric oxide from L-arginine. J Immunol 1990, 144:4794-4797.
44. Evans TG, Thai L, Granger DL, Hibbs Jr JB: Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis. J Immunol 1993, 151:907-915.
45. Stenger S, Donhauser N, Thuring H, Rollinghoff M, Bogdan C: Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase. J Exp Med 1996, 183:1501-1514.
46. Wei X, Charles IG, Smith A, et al.: Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 1995, 375:408-411.
47. -/-. mice. J Immunol 1996, 156:636-643.
48. Hayashi S, Chan C, Gazzinelli R, Roberge FG: Contribu-tion of nitric oxide to the host parasite equilibrium in toxoplasmosis. J Immunol 1996, 156:1476-1481.
49. Rajan T, Porte P, Yates J, Keefer L, Shutz L: Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi. Infect Immun 1996, 64:3351-3353.
50. Oswald I, James S: Nitrogen oxide in host defense against parasites. Methods: a Companion to Methods in Enzymology 1996, 10:8-14.
51. Coulson PS, Smythies LE, Betts C, et al: Nitric oxide produced in the lungs of mice immunized with the radiation-attenuated schistosome vaccine is not the major agent causing challenge parasite elimination. Immunology 1997 (in press).
52. Seguin MC, Klotz FW, Schneider I, et al: Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei Infected mosquitoes: involvement of interferon gamma and CD8+ T cells. J Exp Med 1994, 180:353-358.
53. Smith G: Virus proteins that bind cytokines, chemokines or interferons. Curr Opin Infect Dis 1996, 8:467-471.
54. Proudfoot L, Nikolaev AV, Feng GJ, et al.: Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proc Natl Acad Sci USA 1996, 93:10984-10989.
55. Green SJ, Scheller LF, Marletta MA, et al.: Nitric oxide: cytokine-regulation of nitric oxide in host resistance to intracellular pathogens. Immunol Lett 1994, 43:87-94.
56. Beckman JS, Beckmann TW, Chen J, Marshall PA, Freeman PA: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and Superoxide. Proc Natl Acad Sci USA 1990, 87:1620-1624.
57. Fridovich I: Superoxide radical and Superoxide dismutases. Annu Rev Biochem 1995, 64:97-112.
58. Li Y, Severan A, Roger MV, Palmer RMJ, Moncada S, Liew FY: Catalase inhibits nitric oxide synthesis and the killing of intracellular Leshmania major in murine macrophages. Eur J Immunol 1992, 22:441-446.
59. Kim Y, Hong S, Billiar T, Simmons R: Counterprotective effect of erythrocytes in experimental bacterial peritonitis is due to scavenging of nitric oxide and reactive oxygen intermediates. Infect Immun 1996, 64:3074-3080.
60. Liew FY, Li Y, Moss D, Parkinson C, Rogers MV, Moncada S: Resistance to Leishnania major infection correlates with the induction of nitric oxide synthase in murine macrophages. Eur J Immunol 1991, 21:3009-3014.
61. Stenger S, Thuring H, Rollinghoff M, Bogdan C: Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishinania major. J Exp Med 1994, 180:783-793.
62. Evans T, Reed S, Hibbs Jr J: Nitric oxide production in murine leishmaniasis: correlation of progressive infection with increasing systemic synthesis of nitric oxide. Am J Trop Med 1996, 54:486-489.
63. MacMicking JD, Nathan C, Hom G, et al: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995, 81:641-650.
64. Vouldoukis I, Riveros-Moreno V, Dugas B, et al.: The killing of Leishinania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilonRII/CD23 surface antigen. Proc Natl Acad Sci USA 1995, 92:7804-7808.