A recombinant vaccinia virus encoding inducible nitric oxide synthase is attenuated in vivo

Journal of Virology

Volumn 70, Issue 11, 1996, Pages 7678-7685

  Rolph, Michael S ^a   Cowden, William B ^a   Medveczky, C Jill ^a   Ramshaw, Ian A ^a  

^a Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR;

ANTIMICROBIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; MORTALITY; PRIORITY JOURNAL; VACCINIA VIRUS; VIROGENESIS;

EID: 0029819871     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.11.7678-7685.1996     Document Type: Article

References (59)

1. Adams, L. B., S. C. Franzblau, Z. Vavrin, J. B. Hibbs, Jr., and J. L. Krahenbuhl. 1991. L-Arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae. J. Immunol. 147:1642-1646.
2. Akarid, K., M. Sinet, B. Desforges, and M. A. Gougerot-Pocidalo. 1995. Inhibitory effect of nitric oxide on the replication of a murine retrovirus in vitro and in vivo. J. Virol. 69:7001-7005.
3. Albina, J. E., J. A. Abate, and W. L. J. Henry. 1991. Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogenstimulated T cell proliferation. Role of IFN-γ in the induction of the nitric oxide-synthesizing pathway. J. Immunol. 147:144-148.
4. Amber, I. J., J. B. Hibbs, Jr., R. R. Taintor, and Z. Vavrin. 1988. Cytokines induce an L-arginine-dependent effector system in nonmacrophage cells. J. Leukocyte Biol. 44:58-65.
5. Beckman, J. S., T. W. Beckman, J. Chen, P. A. Marshall, and B. A. Freeman. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87:1620-1624.
6. Bi, Z., and C. S. Reiss. 1995. Inhibition of vesicular stomatitis virus infection by nitric oxide. J. Virol. 69:2208-2213.
7. Bosse, D. C., W. G. J. Campbell, and W. A. Cassel. 1982. Light and electron microscopic studies of the pathogenesis of vaccinia virus infection in mouse brain. Proc. Soc. Exp. Biol. Med. 171:72-78.
8. Boyle, D. B., and B. E. Coupar. 1986. Identification and cloning of the fowlpox virus thymidine kinase gene using vaccinia virus. J. Gen. Virol. 67:1591-1600.
9. Boyle, D. B., and B. E. H. Coupar. 1988. A dominant selectable marker for the construction of recombinant poxviruses. Gene 65:123-128.
10. Campbell, I. L., A. Samimi, and C. S. Chiang. 1994. Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis. J. Immunol. 153:3622-3629.
11. Chan, J., Y. Xing, R. S. Magliozzo, and B. R. Bloom. 1992. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. Exp. Med. 175:1111-1122.
12. Cifone, M. G., C. Festuccia, L. Cironi, G. Cavallo, M. A. Chessa, V. Pensa, E. Tubaro, and A. Santoni. 1994. Induction of the nitric oxide-synthesizing pathway in fresh and interleukin 2-cultured rat natural killer cells. Cell. Immunol. 157:181-194.
13. Coupar, B. E. H., M. E. Andrew, G. W. Both, and D. B. Boyle. 1986. Temporal regulation of influenza hemagglutinin expression in vaccinia virus recombinants and effects on the immune response. Eur. J. Immunol. 16: 1479-1487.
14. Coupar, B. E. H., M. E. Andrew, and D. B. Boyle. 1988. A general method for the construction of recombinant vaccinia viruses expressing multiple foreign genes. Gene 68:1-10.
15. Croen, K. D. 1993. Evidence for an antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication. J. Clin. Invest. 91:2446-2452.
16. Dawson, V. L., T. M. Dawson, E. D. London, D. S. Bredt, and S. H. Snyder. 1991. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88:6368-6371.
17. Deguchi, M., K. Inaba, and S. Muramatsu. 1995. Counteracting effect (if interferon-alpha and -beta on interferon-gamma-induced production of nitric oxide which is suppressive for antibody response. Immunol. Lett. 45: 157-162.
18. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407-2412.
19. Garside, P., A. K. Hutton, A Severn, F. Y. Liew, and A. M. Mowat. 1992. Nitric oxide mediates intestinal pathology in graft-vs.-host disease. Eur. J. Immunol. 22:2141-2145.
20. Harris, N., R. M. L. Buller, and G. Karupiah. 1995. Gamma interferoninduced, nitric oxide-mediated inhibition of vaccinia virus replication. J. Virol. 69:910-915.
21. Hoffman, R. A., J. M. Langrehr, T. R. Billiar, R. D. Curran, and R. L. Simmons. 1990. Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine. J. Immunol. 145:2220-2226.
22. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamjo, J. Vilcek, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-γ receptor. Science 259:1742-1745.
23. James, S. L., and J. Glaven. 1989, Macrophage cytotoxicity against schistosomula of Schislosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J. Immunol. 143:4208-4212.
24. Jensen, F. C., A. J. Girardi, R. V. Gilden, and H. Koprowski. 1964. Infection of human and simian tissue cultures with Rous sarcoma virus. Proc. Natl. Acad. Sci. USA 52:53-59.
25. Karupiah, G., B. E. H. Coupar, M. E. Andrew, D. B. Boyle, S. M. Phillips, A. Müllbacher, R. V. Blanden, and I. A. Ramshaw. 1990. Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2. J. Immunol. 144:290-298.
26. Karupiah, G., T. N. Fredrickson, K. L. Holmes, L. H. Khairallah, and R. M. L. Buller. 1993. Importance of interferons in recovery from mousepox. J. Virol. 67:4214-4226.
27. Karupiah, G., and N. Harris. 1995. Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites. J. Exp. Med. 181:2171-2179.
28. Karupiah, G., C. Nathan, J. Mudgett, and J. MacMicking. Personal communication.
29. Karupiah, G., Q. W. Xie, R. M. L. Buller, C. Nathan, C. Duarte, and J. D. MacMicking. 1993. Inhibition of viral replication by interferon-gamma induced nitric oxide synthase. Science 261:1445-1448.
30. Kiessling, R., E. Klein, H. Pross, and H. Wigzell. 1975. "Natural" killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukaemia cells. Characteristics of the killer cell. Eur. J. Immunol. 5:117-121.
31. Knowles, R. G., and S. Moncada. 1994. Nitric oxide synthases in mammals. Biochem. J. 298:249-258.
32. Koprowski, H., Y. M. Zheng, E. Heber-Katz, N. Fraser, L. Rorke, Z. F. Fu, C. Hanlon, and B. Dietzschold. 1993. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proc. Natl. Acad. Sci. USA 90:3024-3027.
33. Lander, H. M., P. Sehajpal, D. M. Levine, and A. Novgrodsky. 1993. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds. J. Immunol. 150:1509-1516.
34. Langrehr, J. M., R. A. Hoffman, T. R. Billiar, K. K. W. Lee, W. H. Schraut, and R. L. Simmons. 1991. Nitric oxide synthesis in the in vivo allograft response - a possible regulatory mechanism. Surgery 110:335-342.
35. Lei, S. Z., Z. H. Pan, S. K. Aggarwal, H. S. V. Chen, J. Hartman, N. J. Sucher, and S. A. Lipton. 1992. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron 8:1087-1099.
36. Liew, F. Y., S. Millott, C. Parkinson, R. M. J. Palmer, and S. Moncada. 1990. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-atginine. J. Immunol. 144:4794-4797.
37. Lipton, S. A., Y. B. Choi, Z. H. Pan, S. Z. Z. Lei, H. S. V. Chen, N. J. Sucher, J. Loscalzo, D. J. Singel, and J. S. Stamler. 1993. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature (London) 364:626-632.
38. Lipton, S. A., D. J. Singel, and J. S. Stamler. 1994. Nitric oxide in the central nervous system. Prog. Brain Res. 103:359-364.
39. Lowenstein, C. J., C. S. Glatt, D. S. Bredt, and S. H. Snyder. 1992. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc. Natl. Acad. Sci. USA 89:6711-6715.
40. MacMicking, J. D., C. Nathan, G. Horn, N. Chartrain, D. S. Fletcher, M. Trumbauer, K. Stevens, Q. Xie, K. Sokol, N. Hutchinson, H. Chen, and J. S. Mudgett. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650.
41. Magrinat, G., S. N. Mason, P. J. Shami, and J. B. Weinberg. 1992. Nitric oxide modulation of human leukaemia cell differentiation and gene expression. Blood 80:1880-1884.
42. Melkova, Z., and M. Esteban. 1995. Inhibition of vaccinia virus DNA replication by inducible expression of nitric oxide synthase. J. Immunol. 155: 5711-5718.
43. Merrill, J. E., L. J. Ignarro, M. P. Sherman, J. Melinek, and T. E. Lane. 1993. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151:2132-2141.
44. Muñoz-Fernández, M. A., M. A. Fernández, and M. Fresno. 1992. Synergism between tumor necrosis factor-α and Interferon-γ on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxidedependent mechanism. Eur. J. Immunol. 22:301-307.
45. Nussler, A. K., and T. R. Billiar. 1993. Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leukocyte Biol. 54:171-178.
46. Panicali, D., and E. Paoletti. 1982. Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus. Proc. Nail. Acad. Sci. USA 79: 4927-4931.
47. G-mono-, di-, and trimethylated arginines. Acta Biochim. Biophys. Acad. Sci. Hung. 12:191-195.
48. Ramshaw, I., J. Ruby, A. Ramsay, G. Ada, and G. Karupiah. 1992. Expression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo. Immunol. Rev. 127:157-182.
49. Rhim, J. S., H. Y. Cho, and R. J. Heubner. 1975. Non-producer human cells induced by murine sarcoma virus. Int. J. Cancer 15:23-29.
50. Ralph, M. S. Unpublished observations.
51. Rolph, M. S., I. A. Ramshaw, K. A. Rockett, J. Ruby, and W. B. Cowden. 1996. Nitric oxide production is increased during murine vaccinia virus infection, but may not be essential for virus clearance. Virology 217:470-477.
52. Sanford, K. K., W. R. Earle, and G. D. Likely. 1948. The growth in vitro of single isolated tissue cells. J. Natl. Cancer Inst. 9:229-234.
53. Smith, G. L., and B. Moss. 1983. Infectious poxvirus vectors have capacity for at least 25,000 hase pairs of foreign DNA. Gene 25:21-28.
54. Stamler, J. S. 1994. Redox signalling: nitrosylation and related target interactions of nitric oxide. Cell 78:931-936.
55. Summersgill, J. T., L. A. Powell, B. L. Buster, R. D. Miller, and J. A. Ramirez. 1992. Killing of Legionella pneumophila by nitric oxide in γ-interferon-activated macrophages. J. Leukocyte Biol. 52:625-629.
56. Takagi, K., I. Nukaya, K. Yasukawa, and Y. Suketa. 1994. Inhibitory mechanisms of antibody production by nitrogen oxides released from activated macrophages during the immune response: relationship to energy consumption. Immunol. Cell. Biol. 72:241-248.
57. Van Dam, A.-M., J. Bauer, W. K. H. Man-A-Hing, C. Marquette, F. J. H. Tilders, and F. Berkenbosch. 1995. Appearance of inducible nitric oxide synthase in the rat central nervous system after rabies virus infection and during experimental allergic encephalomyelitis but not after peripheral administration of endotoxin. J. Neurosci. Res. 40:251-260.
58. Wink, D. A., K. S. Kasprzak, C. M. Maragos, R. K. Elespuru, M. Misra, T. M. Dunams, T. A. Cebula, W. H. Koch, A. W. Andrews, J. S. Allen, and L. K. Keefer. 1991. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science 254:1001-1003.
59. Xiao, L., P. H. E. Eneroth, and G. A. Qureshi. 1995. Nitric oxide synthase pathway may mediate human natural killer cell cytotoxicity. Scand. J. Immunol. 42:505-511.