β7 integrins and their ligands in lymphocyte migration to the gut

Chemical Immunology

Volumn 71, Issue , 1998, Pages 64-76

  Viney, Joanne L ^a   Fong, Sherman ^b  

^a Immunex ^*  (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; LYMPHOCYTE RECEPTOR; MONOCLONAL ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

B LYMPHOCYTE; ENDOTHELIUM CELL; ENTERITIS; EOSINOPHIL; HUMAN; INTESTINE CELL; INTESTINE LYMPHATIC TISSUE; INTESTINE MUCOSA; LIGAND BINDING; LYMPHOCYTE MIGRATION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; REVIEW; T LYMPHOCYTE;

ANIMALS; CELL COMPARTMENTATION; CHEMOTAXIS, LEUKOCYTE; HUMANS; IMMUNOGLOBULINS; INTEGRIN BETA CHAINS; INTEGRINS; INTESTINAL MUCOSA; LIGANDS; LYMPHOCYTES; MUCOPROTEINS;

EID: 0031755443     PISSN: 10150145     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. Phillips-Quagliata JM, Lamm ME: Migration of lymphocytes in the mucosal immune system; in Husband AJ (ed): Migration and Homing of Lymphoid Cells. Boca Raton, CRC Press, 1988, vol 2, pp 53-75.
2. Lamm ME: Cellular aspects of immunoglobulin A. Adv Immunol 1976;22:223-290.
3. Hamann A, Andrew DP, Jablonski Westrich D, Holzmann B, Butcher EC: Role of α4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol 1994;152:3282-3293.
4. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 1994;76:301-314.
5. Butcher EC, Picker LJ: Lymphocyte homing. Science 1996;272:60-66.
6. Girard J-P, Springer TA: High endothelial venules (HEVs): Specialized endothelium for lymphocyte migration. Immunology Today 1995;16:449-457.
7. Streeter PR, Berg EL, Rouse BN, Bargatze RF, Butcher EC: A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature 1988;331:41-46.
8. Nakache M, Berg EL, Streeter PR, Butcher EC: The mucosal vascular addressin is a tissue-specific endothelial cell adhesion molecule for circulating lymphocytes. Nature 1989;337:179-181.
9. Holzmann B, Weissman IL: Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. EMBO J 1989;8:1735-1741.
10. Holzmann B, McIntyre BW, Weissman IL: Identification of a murine Peyer's patch-specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4. Cell 1989;56:37-46.
11. Neuhaus H, Hu MC-T, Hemler ME, Takada Y, Holzmann B, Weissman IL: Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule. J Cell Biol 1991;115:1149-1158.
12. Hu MC-T, Crowe DT, Weissman IL, Holzmann B: Cloning and expression of mouse integrin βp (β7): A functional role in Peyer's patch specific lymphocyte homing. Proc Natl Acad Sci USA 1992; 89:8254-8258.
13. Yuan Q, Jiang W-M, Leung E, Hollander D, Watson JD, Krissansen GW: Molecular cloning of the mouse integrin β7 subunit. J Biol Chem 1992;267:7352-7358.
14. Parker CM, Cepek KL, Russell GJ, Shaw SK, Posnett DN, Schwarting R, Brenner MB: A family of β7 integrins on human mucosal lymphocytes. Proc Natl Acad Sei USA 1992;89:1924-1928.
15. Briskin MJ, McEvoy LM, Butcher EC: MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. Nature 1993;363:481-464.
16. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamman A, Butcher EC: α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993;74:185-195.
17. Andrew DP, Berlin C, Honda S, Yoshino T, Hamann A, Holzman B, Kilshaw PJ, Butcher EC: Distinct but overlapping epitopes are involved in α4β7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J Immunol 1994;153:3847-3861.
18. Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M: Expression and function of the MAdCAM-1 receptor, integrin α4β7, on human leukocytes. J Immunol 1994;153:517-528.
19. Strauch UG, Lifka A, Gosslar U, Kilshaw PJ, Clements J, Holzmann B: Distinct binding specificities of integrins α4β7 (LPAM-1), α4β1 (VLA-4), and αIELβ7. Int Immunol 1994;6:263-275.
20. Viney JL, Jones S, Chiu HH, Lagrimas B, Renz ME, Presta LG, Jackson D, Hillan KJ, Lew S, Fong S: Mucosal Addressin Cell Adhesion Molecule-1: A structural and functional analysis demarcates the integrin binding motif. J Immunol 1996;157:2488-2497.
21. Kraal G, Schornagel K, Streeter PR, Holzmann B, Butcher EC: Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. Am J Pathol 1995;147:763-771.
22. Gurish MF, Bell AF, Smith TJ, Ducharme LA, Wang R-K, Weis JH: Expression of murine β7, α4, and β1 integrin genes by rodent mast cells. J Immunol 1992;149:1964-1972.
23. Palecenda A, Briskin MJ, Issekutz TB: Rat mast cell lines bind to the vascular cell adhesion molecule-1 (VCAM-1) and the mucosal cell adhesion molecule-1 (MAdCAM-1). J Immunol 1997; 158:2904-2910.
24. Lazarovits AI, Moscicki RA, Kurnick JT, Camerini D, Bhan AK, Baird LG, Erikson M, Colvin RB: Lymphocyte activation antigens. I. A monoclonal antibody Act-1, defines a new late lymphocyte activation antigen. J Immunol 1984;133:1857-1862.
25. Farstad I, Halstensen TS, Lazarovits AI, Norstein J, Fausa O, Brandtzaeg P: Human intestinal B-cell blasts and plasma cells express the mucosal homing receptor integrin α4β7. Scand J Immunol 1995;42:662-672.
26. Farstad IN, Halstensen TS, Kvale D, Fausa O, Brandtzaeg P: Topographic distribution of homing receptors on B and T cells in human gut-associated lymphoid tissue: Relation of L-selectin and integrin α4β7 to naive and memory phenotypes. Am J Pathol 1997;150:187-199.
27. Farstad IN, Halstensen TS, Lien B, Kilshaw PJ, Lazarovits AI, Brandtzaeg P: Distribution of β7 integrins in human intestinal mucosa and organized gut-associated lymphoid tissue. Immunology 1996;89:227-237.
28. Walsh GM, Symon FA, Lazarovits AI, Wardlaw AJ: Integrin α4β7 mediates human eosinophil interaction with MAdCAM-1, VCAM-1 and fibronectin. Immunology 1996;89:112-119.
29. Schweighoffer T, Tanaka Y, Tidswell M, Erle DJ, Morgan KJ, Luce GEG, Lazarovits AI, Buck D, Shaw S: Selective expression of integrin α4β7 on a subset of human CD4+ memory T cells with hallmarks of gut tropism. J Immunol 1993;151:717-729.
30. Mackay CR, Andrew DP, Briskin M, Ringler DJ, Butcher EC: Phenotype, and migration properties of three major subsets of tissue homing T cells in sheep. Eur J Immunol 1996;26:2433-2439.
31. Abitorabi MA, Mackay CR, Jerome EH, Osorio O, Butcher EC, Erle DJ: Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral and lung lymph. J Immunol 1996;156:3111-3117.
32. Crowe DT, Chiu H, Fong S, Weissman IL: Regulation of the avidity of integrin α4β7 by the β7 cytoplasmic domain. J Biol Chem 1994;269:14411-14418.
33. Chiu HH, Crowe DT, Renz ME, Presta LG, Jones S, Weissman IL, Fong S: Similar but non-identical amino acid residues on vascular cell adhesion molecule-1 are involved in the interaction with α4β1 and α4β7 under different activity states. J lmmunol 1995;155:5257-5267.
34. Rott LS, Briskin MJ, Andrew DP, Berg EL, Butcher EC: A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell adhesion molecule-1: Comparison with vascular cell adhesion molecule-1 and correlation with β7 integrins and memory differentiation. J Immunol 1996;156:3727-3736.
35. Bargatze R, Jutila MA, Butcher EC: Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined. Immunity 1995;3:99-108.
36. Berlin C, Bargatze RF, Campbell JJ, von Andrian UH, Szabo MC, Hasslen SR, Nelson RD, Berg EL, Erlansen SL, Butcher EC: α4 integrins mediate lymphocyte attachment and rolling under physiological flow. Cell 1995;80:413-422.
37. Berg EL, McEvoy LM, Berlin C, Bargatze RF, Butcher EC: L-selectin mediated lymphocyte rolling on MAdCAM-1. Nature 1993;366:695-698.
38. Mebius RE, Streeter PR, Michie S, Butcher EC, Weissman IL: A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3-cells to colonize lymph nodes. Proc Natl Acad Sci USA 1996;93:11019-11024.
39. Chan BMC, Elices M, Murphy E, Hemler ME: Adhesion to vascular cell adhesion molecule 1 and fibronectin: Comparison of α4β1 (VLA-4) and α4β7 on human B cell line JY. J Biol Chem 1992; 267:8366-8370.
40. Ruegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle D: Role of integrin α4β7/α4βp in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J Cell Biol 1992;117:179-189.
41. Sampaio SO, Li X, Takeuchi M, Mei C, Francke U, Butcher EC, Briskin MJ: Organization, regulatory sequences, and alternatively spliced transcripts of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) gene. J Immunol 1995;155:2477-2486.
42. Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ: Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the α4β7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences. J Immunol 1996;156:2851-2857.
43. Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, Ni J, Carter KC, Spurr N, Choo KHA, Krissansen GW: Genomic organization, chromosomal mapping, and analysis of the 5′ promoter region of the human MAdCAM-1 gene. Immunogenetics 1997;46:111-119.
44. Briskin M, Winsor-Hines D, Shyjan A, Cochran N, Bloom S, Wilson J, McEvoy LM, Butcher EC, Kassam N, Mackay CR, Newman W, Ringler DJ: Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol 1997; 151:97-110.
45. Briskin MJ, Rott L, Butcher EC: Structural requirements for mucosal vascular addressin binding to its lymphocyte receptor α4β7. J Immunol 1996;156:719-726.
46. Newham P, Craig SE, Seddon GN, Schofield NR, Rees A, Edwards RM, Jones EY, Humphries MJ: Alpha4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity. J Biol Chem 1997;272: 19429-19440.
47. Osborn L, Vassallo C, Griffiths B, Browning R, Tizard R, Haskard D, Benjamin CD, Douglas I, Kirchhausen T: Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter receptor VLA-4 (α4β1). J Cell Biol 1994;124:601-608.
48. Renz ME, Chiu HH, Jones S, Fox J, Presta LG, Fong S: Structural requirements for adhesion of soluble recombinant murine vascular cell adhesion molecule-1 to α4β1. J Cell Biol 1994;125: 1395-1405.
49. Vonderheide RH, Tedder TF, Springer TA, Staunton DE: Residues within a conserved amino acid motif of domain 1 and 4 of VCAM are required for binding. J Cell Biol 1994;125:215-222.
50. Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ: Structure-function analysis of the integrin β7 subunit: Identification of domains involved in adhesion to MAdCAM-1. J Immunol 1997;159:1497-1505.
51. McDonald SA, Palmen MJ, Van-Rees EP, MacDonald TT: Characterization of the mucosal cell-mediated immune response in IL2 knockout mice before and after the onset of colitis. Immunology 1997;91:73-80.
52. Picarella D, Hurlbut P, Rottman J, Shi X, Butcher EC, Ringler DJ: Monoclonal antibodies specific for β7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of SCID mice reconstituted with CD45RBhigh CD4+ T cells. J Immunol 1997;158: 2099-2106.
53. Fong S, Jones S, Renz ME, Chiu HH, Ryan AM, Presta LG, Jackson D: Mucosal addressin cell adhesion molecule-1 (MAdCAM-1): Its binding motif for α4β7 and role in experimental colitis. Immunol Res 1997;16:299-311.
54. Podolsky DK, Lobb R, King N, Benjamin CD, Pepinsky B, Sehgal P, deBeaumont M: Attenuation of colitis in the cotton-top tamarin by anti-α4 integrin monoclonal antibody. J Clin Invest 1993;92:372-380.
55. Bell RG, Issekutz T: Expression of a protective intestinal immune response can be inhibited at three distinct sites by treatment with anti-α4 integrin. J Immunol 1993;151:4790-4802.
56. Hesterberg P, Winsor-Hines D, Briskin MJ, Soler-Ferran D, Merrill C, Mackay CR, Newman W, Ringler DJ: Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7. Gastroenterology 1996;111:1373-1380.
57. Koizumi M, King N, Lobb R, Benjamin C, Podolsky DK: Expression of adhesion molecules in inflammatory bowel disease. Gastroenterology 1992;103:840-847.
58. Teague TK, Lazarovits AI, McIntyre BW: Integrin α4β7 costimulation of human peripheral blood T cell proliferation. Cell Adhes Commun 1994;2:539-547.
59. Kilshaw PJ, Baker KC: A unique surface antigen on intraepithelial lymphocytes in the mouse. Immunol Lett 1988;18:149-154.
60. Kilshaw PJ, Murant SJ: Expression and regulation of β7 (βp) integrins on mouse lymphocytes: Relevance to the mucosal immune system. Eur J Immunol 1991;21:2591-2597.
61. Kilshaw PJ, Murant SJ: A new surface antigen on intraepithelial lymphocytes in intestine. Eur J Immunol 1990;20:2201-2207.
62. Cerf-Bensussan N, Jarry A, Brousse N, Lisowska-Grospierre B, Guy-Grand D, Griscelli C: A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes. Eur J Immunol 1987;17:1279-1285.
63. Cerf-Bensussan N, Begue B, Gagnon J, Meo T: The human intraepithelial lymphocyte marker HML-1 is an integrin consisting of a β7 subunit associated with a distinctive α chain. Eur J Immunol 1992;22:273-277.
64. Austrup F, Rebstock S, Kilshaw PJ, Hamann A: Transforming growth factor-β1-induced expression of the mucosa related integrin αE on lymphocytes is not associated with mucosa-specific homing. Eur J Immunol 1995;25:1487-1491.
65. Roberts K, Kilshaw PJ: The mucosal T cell integrin αM290 β7 recognizes a ligand on mucosal epithelial cell lines. Eur J Immunol 1993;23:1630-1635.
66. Cepek KL, Parker CM, Madara J L, Brenner MB: Integrin αEβ7 mediates adhesion of T lymphocytes to epithelial cells. J Immunol 1993;150:3459-3470.
67. Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, Brenner MB: Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin. Nature 1994;372:190-193.
68. Karecla P, Bowden SJ, Green SJ, Kilshaw PJ: Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin αM290β7 (αEβ7). Eur J Immunol 1995;25:852-856.
69. Karecla PI, Green SJ, Bowden SJ, Coadwell J, Kilshaw PJ: Identification of a binding site for integrin αEβ7 in the N-terminal domain of E-cadherin. J Biol Chem 1996;271:30909-30915.
70. Sarnacki S, Begue B, Buc H, Le Deist F, Cerf-Bensussan N: Enhancement of CD3-induced activation of human intestinal intraepithelial lymphocytes by stimulation of the β7-containing integrin defined by HML-1 antibody. Eur J Immunol 1992;22:2887-2892.
71. Wagner N, Lohler J, Kunkel EJ, Ley K, Leung E, Krissansen G, Rajewsky K, Muller W: Critical role for β7 integrins in formation of the gut-associated lymphoid tissue. Nature 1996;382:366-370.
72. Arroyo AG, Yang JT, Rayburn H, Hynes RO: Differential requirements for α4 integrins during fetal and adult hematopoiesis. Cell 1996;85:997-1008.