Clinical studies on the use of lamotrigine in bipolar disorder

Neuropsychobiology

Volumn 38, Issue 3, 1998, Pages 185-191

  Calabrese, Joseph R ^a,b   Rapport, Daniel J ^a   Shelton, Melvin D ^a   Kimmel, Susan E ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Mood Disorders Program   (United States)

Author keywords

Antiepileptic; Bipolar disorder; Depression; Lamotrigine; Manic depression; Mood stabilizers

Indexed keywords

AMFEBUTAMONE; ANTIDEPRESSANT AGENT; CARBAMAZEPINE; DESIPRAMINE; FLUOXETINE; FOLIC ACID; IMIPRAMINE; LAMOTRIGINE; LITHIUM; LIVER ENZYME; MOCLOBEMIDE; PYRIMETHAMINE; SODIUM CHANNEL; TRANYLCYPROMINE;

CLINICAL TRIAL; CONFERENCE PAPER; DEPRESSION; DRUG MECHANISM; HEADACHE; HUMAN; HYPOMANIA; INSOMNIA; MANIA; MANIC DEPRESSIVE PSYCHOSIS; META ANALYSIS; MOOD; NAUSEA; NONHUMAN; PRIORITY JOURNAL; RASH; SEIZURE; SOMNOLENCE; TREMOR; VERTIGO;

ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; ANTIMANIC AGENTS; BIPOLAR DISORDER; CLINICAL TRIALS; HUMANS; TRIAZINES;

EID: 0031754858     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000026535     Document Type: Conference Paper

References (46)

1. Physicians Desk Reference: Prescribing Information for Lamictal. Montvale, Medical Economics Data Production Co., 1997.
2. Calabrese JR, Bowden CL, Woyshville MJ: Lithium and anticonvulsants in bipolar disorder; in Bloom FE, Kupfer DJ (eds): Psychopharmacology: The Fourth Generation of Progress. New York. Raven Press, 1994, pp 1099 1111.
3. Keller MB, Lavori PW, Coryell W, Andreasen NC, Endicott J, Clayton PJ, Klerman GL, Hirschfeld RMA: Differential outcome of pure manic, mixed/cycling, and pure depressive episodes in patients with bipolar illness. JAMA 1986;255:3138 3142.
4. Fieve R, Platman S, Plutchik R: The use of lithium in affective disorders. I. Acute endogenous depression. Am J Psychiatry 1968;125: 487-491.
5. Goodwin FK, Murphy DL: Lithium carbonate treatment in depression and mania: A longitudinal double blind study. Arch Gen Psychiatry 1969;21:486-496.
6. Greenspan K, Schildkraut JJ, Gordon EK, Baer L, Arnonoff MS, Durell J: Catecholamine metabolism in affective disorders. III. MHPG and other catecholamine metabolites in patients treated with lithium carbonate. J Psychiatry Res 1970;7:171-183.
7. Stokes PE, Stoll PM, Shamoian CA, Patton MJ: Efficacy of lithium as acute treatment of manic depressive illness. Lancet 1971;i:1319-1325.
8. Goodwin FK, Murphy DL, Dunner DL, Bunney WE: Lithium response in unipolar versus bipolar depression. Am J Psychiatry 1972;129: 44-47.
9. Noyes R, Dempsey GM, Blum A, Cavanaugh GL: Lithium treatment of depression. Comprehensive Psychiatry 1974;15:187 193.
10. Baron M, Gershon ES, Rudy V, Jonas WZ, Buchsbaum M: Lithium carbonate response in depression. Arch Gen Psychiatry 1975;32:1107 1111.
11. Mendels J: Lithium in the treatment of depression. Am J Psychiatry 1976;133:373 378.
12. Donnelly EF, Goodwin FK, Waldan IN, Murphy DL: Prediction of antidepressant responses to lithium. Am J Psychiatry 1978;135: 552 556.
13. Bauer MS, Calabrese JC, Dunner DL, Post R, Whybrow PC, Gyulai L, Tay LK, Younkin S, Bynum D, Lavori P, Price A: Multi-Site Data Reanalysis: Validity of rapid cycling as a course modifier for bipolar disorder in DSM-IV. Am J Psychiatry 1996;151:506-515.
14. Kessel A, Holt NF: A controlled study of a tetracyclic antidepressant maprotiline (Ludiomil). Med J Austr 1975;1:773-776.
15. Watanabe S, Ishino J, Otsuki S: Double blind comparison of lithium and imipramine in treatment of depression. Arch Gen Psychiatry 1975; 32:659 668.
16. Cohn JB, Collins G, Ashbrook E. Wernicke F: A comparison of fluoxetine, imipramine, and placebo in patients with bipolar depressive disorder. International Clin Psychopharmacol 1989;4:313 322.
17. Baumhackl U, Biziere K, Fischbach R, Geretsegger C, Hebenstreit G. Radmayr E, Stabl M: Efficacy and tolerability of moclobemide compared with imipramine in depressive disorder (DSM-III): An Austrian double-blind, multicentre study. Br J Psychiatry 1989;155:78-83.
18. Himmelhoch JM, Thase ME, Mallinger AG, Houck P: Tranylcypromine versus imipramine in anergic bipolar depression. Am J Psychiatry 1991;148:910-916.
19. Sachs GS, Lafer B, Stoll AL, Banor M, Thibault AB, Tohen M, Rosenbaum JF: A double blind trial of bupropion versus desipramine for bipolar depression. J Clin Psychiatry 1994;55:391 393.
20. Silverstone T and the Moclobemide Depression Research Group: Moclobemide vs imipramine in bipolar depression. Ann Meet ECNP. Vienna, Austria, 1997.
21. Post RM, Uhde TW, Ballenger JC, Squillace KM: Antidepressant effects of carbamazepine. Am J Psychiatry 1986;143:29-34.
22. Schachter SC, Leppik E, Matsuo F, Messenheimer JA, Faught E, Moore EL, Risner ME: Lamotrigine: A six-month, placebo-controlled, safety and tolerance study. 1995;8:201-209.
23. Weisler R, Risner M, Houser T: Use of lamotrigine in the treatment of bipolar disorder. Ann Meet Am Psychiatr Assoc, Philadelphia, May 21 26, 1994.
24. Calabrese JR, Fatemi SH, Woyshville MJ: Anti-depressant effects of lamotrigine in bipolar rapid cycling. Am J Psychiatry 1996;153:1236.
25. Calabrese JR, Bowden CL, McElroy SL, Cookson J, Andersen J, Rhodes L, Keck PE, Bolden-Watson C, Zhou J, Ascher J: Lamotrigine in treatment refractory bipolar disorder. Ann Meet Am Psychiatr Assoc. New York, May 4 9, 1996.
26. Walden J, Hesslinger B, van Calker D, Berger M: Addition of lamotrigine to valproate may enhance efficacy in the treatment of bipolar affective disorder. Pharmacopsychiatry 1996;29: 193-195.
27. Berlant JL: Attention deficit hyperactivity disorder and bipolar disorder as predictors of clinical response to lamotrigine. Ann Meet Int Conf Bipolar Disorder, June, 1997
28. Berlant JL: Case report of synergistic response of rapid cycling bipolar disorder to lamotrigine, risperidone, and verapamil. Ann Meet Int Conf Bipolar Disorder, June, 1997.
29. Hoopes S, Snow M: Clinical effectiveness of lamotrigine in affective disorders. Ann Meet Int Conf Bipolar Disorder, June, 1997.
30. Fatemi S, Rapport D, Calabrese J, Thuras P: Lamotrigine in rapid cycling bipolar disorder. J Clin Psychiatry 1997;58:522-527.
31. Ferner IN, Potkins D, Eccleston D: Lamotrigine treatment in rapid cycling bipolar disorder: Clinical and biological correlates. Ann Meet Int Conf Bipolar Disorder, June, 1997.
32. Fogelson DL, Sternbach H: Lamotrigine treatment of refractory bipolar disorder. J Clin Psychiatry 1997;58:271-273.
33. Kusumakar V, Yatham LN: Lamotrigine treatment of rapid cycling bipolar disorder. Am J Psychiatry 1997;154:1171-1172.
34. Kusumakar V, Yatham LN: Lamotrigine in treatment refractory bipolar depression. Psychiatry Res, in press.
35. Mandoki M: Lamotrigine/valproate in treatment-resistant bipolar disorder in children and adolescents. Ann Meet Soc Biol Psychiatry, San Diego, May, 1997.
36. Mauri MC, Laini V, Somaschini E, Ami A, Giannelli A, Sostero M: Lamotrigine: An alternative drug in the prophylaxis of bipolar disorder. Eur Neuropsychopharmacol 1997:6: S161.
37. Sporn J, Sachs GS: The anticonvulsant lamotrigine in treatment-resistant manic depressive illness. J Clin Psychopharmacol 1997;17:185-189.
38. Leach MJ, Marden CM, Miller AA: Pharmacological studies on lamotrigine: A novel potential antiepileptic drug. II. Neurocheimcal studies on the mechanism of action. Epilepsia 1986;27: 490-497.
39. Messenheimer JA: Lamotrigine. Epilepsia. 1995;36(suppl 2):S87 S94.
40. Xie X: Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na + channels and with native Na + channels in rat hippocampal neurones. Arch Eur J Physiol 1995;430:437-446.
41. Gilman JT: Lamotrigine: An antiepileptic agent for the treatment of partial seizures. Ann Pharmacother 1995;29:144-151.
42. Post RM: Transduction of psychosocial stress into the neurobiology of recurrent affective disorders. Am J Psychiatry 1992;149:999-1010.
43. Yuen AWC, Land G, Weatherly BC, Peck AW: Sodium valproate acutely inhibits lamotrigine metabolism. BrJ Clin Pharmacol 1992;33:511 513.
44. Anderson GD, Wau MK, Gidal BE, Harris SJ, Levy RH, Lai AA, Wolf KB, Wargan WA, Dren AT: Bidirectional interaction of valproate and lamotrigine in healthy subjects. Clin Pharmacol Ther 1996;60:145-156.
45. Holdrich T, Whiteman P, Orme M, Back D, Ward S: Effect of lamotrigine on pharmacology of the combined oral contraceptive pill. Epilcpsia 1992:32(suppl 1):96.
46. Messenheimer JA, Keaney PA, Rudd GD, Risner ME: Adjunetive Lamictal treatment is associated with stable body weight in patients with epilepsy. Epilepsia 1996;37:164.