Does a second generation of centrally acting antihypertensive drugs really exist?

Journal of the Autonomic Nervous System

Volumn 72, Issue 2-3, 1998, Pages 94-97

  Feldman, Josiane ^a   Greney, Hugues ^a   Monassier, Laurent ^a   Vonthron, Catherine ^a   Bruban, Véronique ^a   Dontenwill, Monique ^a   Bousquet, Pascal ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Blood pressure; Brainstem; Clonidine; Imidazoline receptors; Rilmenidine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ANTIHYPERTENSIVE AGENT; BRAIN RECEPTOR; CATECHOLAMINE DERIVATIVE; CLONIDINE; DRUG RECEPTOR; HYPERTENSIVE AGENT; IDAZOXAN; IMIDAZOLINE; IMIDAZOLINE RECEPTOR; MOXONIDINE; RILMENIDINE; TRITIUM;

ADVERSE DRUG REACTION; ANTIHYPERTENSIVE ACTIVITY; BINDING COMPETITION; BLOOD PRESSURE; BRAIN; BRAIN STEM; CONFERENCE PAPER; CONGESTIVE HEART FAILURE; DRUG BINDING SITE; HEART ARRHYTHMIA; HUMAN; HYPERTENSION; HYPOTENSION; HYPOTHALAMUS; KIDNEY; LATERAL RETICULAR NUCLEUS; NONHUMAN; PRIORITY JOURNAL; SEDATION; TISSUE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BRAIN; HUMANS; IMIDAZOLES; RECEPTORS, DRUG;

EID: 0031753166     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(98)00093-9     Document Type: Conference Paper

References (42)

1. Atlas, D., Burstein, Y., 1984a. Isolation of an endogenous clonidine-displacing substance from rat brain. FEBS Lett. 170, 387-390.
2. Atlas, D., Burstein, Y., 1984b. Isolation and partial purification of a clonidine displacing endogenous brain substance. Eur. J. Biochem. 144, 287-293.
3. Bennai, F., Greney, H., Stutzmann, J., Bousquet, P., Dontenwill, M., 1995. Development of anti-idiotypic antibodies specific for the human cerebral imidazoline receptor. N.Y. Acad. Sci. 763, 140-148.
4. Bousquet, P., 1995. Recent advances in imidazoline receptor research. Exp. Opin. Invest. Drugs 4, 431-442.
5. Bousquet, P., 1997. Imidazoline receptors - Commentary. Neruochem. Int. 30, 3-7.
6. Bousquet, P., Feldman, J., Bloch, R., Schwartz, J., 1981. The nucleus reticularis lateralis: a region highly sensitive to clonidine. Eur. J. Pharmacol. 69, 389-392.
7. Bousquet, P., Feldman, J., Schwartz, J., 1984. Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 230, 232-236.
8. Bousquet, P., Greney, H., Bennai, F., Feldman, J., Stutzmann, J., Belcourt, A., Dontenwill, M., 1995. Imidazoline receptors and cardiovascular regulations. A statement. Ann. N.Y. Acad. Sci. 763, 526-530.
9. Brasili, L., Pigini, M., Bousquet, P., Carrotti, A., Dontenwill, M., Giannella, M., Moriconi, R., Piergentili, A., Quaglia, W., Tayebati, S.K., 1996. Discovery of highly selective imidazoline receptor ligands. Perspective in Receptor Research 24, 361-376.
10. Bricca, G., Dontenwill, M., Molines, A., Feldman, J., Belcourt, A., Bousquet, P., 1988. Evidence for the existence of a homogeneous population of imidazoline receptors in the human brainstem. Eur. J. Pharmacol. 150, 401-402.
11. Bricca, G., Dontenwill, M., Molines, A., Feldman, J., Tibirica, E., Belcourt, A., Bousquet, P., 1989. Rilmenidine selectivity for imidazoline receptors in human brain. Eur. J. Pharmacol. 163, 373-377.
12. 3H]idazoxan in the human cerebral cortex. Neurochem. Int. 22, 153-163.
13. 3H]clonidine. Eur. J. Pharmacol. Mol. Pharm. 266, 25-33.
14. Coupry, I., Podevin, R.A., Dausse, J.P., Parini, A., 1987. Evidence for imidazoline binding sites in basolateral membranes from rabbit kidney. Biochem. Biophys. Res. Commun. 147, 1055-1060.
15. Ernsberger, P., Meeley, M.P., Mann, J.J., Reis, D.J., 1987. Clonidine binds to imidazole binding sites as well as α 2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134, 1-13.
16. Ernsberger, P., Meeley, M.P., Reis, D.J., 1988. An endogenous substance with clonidine-like properties: selective binding to imidazole sites in the ventrolateral medulla. Brain Res. 441, 309-318.
17. Ernsberger, P., Guiliano, R., Willette, R.N., Reis, D.J., 1990. Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther. 253, 408-418.
18. Ernsberger, P., Friedman, J.E., Koletsky, R.J., 1997. The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease. J. Hypertens. 15, S9-S23, Suppl.
19. Escriba, P.V., Sastre, M., Wang, H., Regunathan, S., Reis, D.J., Garcia-sevilla, J.A., 1994. Immunodetection of putative imidazoline receptor proteins in the human and rat brain and other tissues. Neurosci. Lett. 178, 81-84.
20. Feldman, J., Tibirica, E., Bricca, G., Dontenwill, M., Belcourt, A., Bousquet, P., 1990. Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit. Br. J. Pharmacol. 100, 600-604.
21. Greney, H., Bennai, F., Molines, A., Belcourt, A., Dontenwill, M., Bousquet, P., 1994. Isolation of a human cerebral imidazoline-specific binding protein. Eur. J. Pharmacol. 265, R1-R2.
22. Head, G.A., 1995. Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents, in: D.J. Reis, P. Bousquet, A. Parini (Eds.), The Imidazoline Receptor, Pharmacology, Functions, Ligands, and Relevance to Biology and Medicine, Vol. 763, The New York Academy of Sciences, New York, pp. 531-540.
23. Head, G.A., Godwin, S.J., Sannajust, F., 1993. Differential receptors involved in the cardiovascular effects of clonidine and rilmenidine in conscious rabbits. J. Hypertens. 11 (suppl. 5), S322-S323.
24. Heemskerk, F.M.I., Dontenwill, M., Greney, H., Vonthron, C., Bousquet, P., 1998. Evidence for the existence of imidazoline specific binding sites in synaptosomal plasma membranes of the bovine brainstem, J. Neurochem., in press.
25. 3H]idazoxan binding at non-alpha 2-adrenoceptors in rabbit adipocyte membranes. Eur. J. Pharmacol. 159, 199-203.
26. Lepran, I., Papp, J.G., 1994. Effect of moxonidine on arrhythmias induced by coronary artery occlusion and reperfusion. J. Cardiovasc. Pharmacol. 24, S9-15.
27. Li, G., Regunathan, S., Barrow, C.J., Eshraghi, J., Cooper, R., Reis, D.J., 1994. Agmatine - an endogenous clonidine-displacing substance in the brain. Science 263, 966-969.
28. Limon, I., Coupry, I., Lanier, S.M., Parini, A., 1992. Purification and characterization of mitochondrial imidazoline-guanidinium receptive site from rabbit kidney. J. Biol. Chem. 267, 21645-21649.
29. MacMillan, L.B., Hein, L., Smith, M.S., Piascik, M.T., Limbird, L.E., 1996. Central hypotensive effects of the a2a-adrenergic receptor subtype. Science 273, 801-803.
30. Mammoto, T., Kamibayashi, T., Hayashi, Y., Yamatodani, A., Takada, K., Yoshiya, I., 1996. Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br. J. Pharmacol. 117, 1744-1748.
31. Meeley, M.P., Ernsberger, P.R., Granata, A.R., Reis, D.J., 1986. An endogenous clonidine-displacing substance from bovine brain: receptor binding and hypotensive actions in the ventrolateral medulla. Life Sci. 38, 1119-1126.
32. Mest, H.J., Thomsen, P., Raap, A., 1995. Antiarrhythmic effect of the selective I1-imidazoline receptor modulator moxonidine on ouabain-induced cardiac arrhythmia in guinea pigs. Ann. N.Y. Acad. Sci. 763, 620-633.
33. Molderings, G.J., 1997. Imidazoline receptors: basic knowledge, recent advances and future prospects for therapy and diagnosis. Drugs of the Future 22, 757-772.
34. Molderings, G.J., Hentrich, F., Gothert, M., 1991. Pharmacological characterisation of the imidazoline receptor which mediates inhibition of noradrenaline release in the rabbit pulmonary artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 344, 630-638.
35. Parini, A., Coupry, I., Graham, R.M., Uzielli, I., Atlas, D., Lanier, S.M., 1989. Characterization of an imidazoline/guanidinium receptive site distinct from the α2-adrenergic receptor. J. Biol. Chem. 264, 11874-11878.
36. Piletz, J.E., Sletten, K., 1993. Nonadrenergic imidazoline binding sites on human platelets. J. Pharmacol. Exp. Ther. 267, 1493-1502.
37. Regunathan, S., Reis, D.J., 1996. Imidazoline receptors and their endogenous ligands. Annu. Rev. Pharmacol. Toxicol. 36, 511-544.
38. Roegel, J.C., Yannoulis, N., De Jong, W., Monassier, L., Feldman, J., Bousquet, P., 1996. Inhibition of centrally induced ventricular arrhythmias by rilmenidine and idazoxan in rabbits. Naunyn-Schmiedeberg's Arch. Pharmacol. 354, 598-605.
39. Separovic, D., Kestr, M., Ernsberger, P., 1996. Coupling of I1-Imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells. Mol. Pharmacol. 49, 668-675.
40. Verbeuren, T.J., Dinh Xuan, A.T., Koenig-Berard, E., Vitou, P., 1990. Rilmenidine. Cardiovasc. Drug Rev. 8, 56-70.
41. Wang, H., Regunathan, S., Meeley, M.P., Reis, D.J., 1992. Isolation and characterization of imidazoline receptor protein from bovine adrenal chromaffin cells. Mol. Pharmacol. 42, 792-801.
42. Wikberg, J.E.S., 1989. High affinity binding of idazoxan to a non-catecholaminergic binding site in the central nervous system: description of putative idazoxan-receptor. Pharmacol. Toxicol. 64, 152-155.