Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs

British Journal of Pharmacology

Volumn 117, Issue 8, 1996, Pages 1744-1748

  Mammoto, Tadanori ^a   Kamibayashi, Takahiko ^a   Hayashi, Yukio ^b   Yamatodani, Atsushi ^c   Takada, Koji ^a   Yoshiya, Ikuto ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Arrhythmias; Autonomic nervous system; Halothane anaesthesia; Imidazoline receptor; Rilmenidine; Sympathetic neural activity; Vagus nerve

Indexed keywords

ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIARRHYTHMIC AGENT; HALOTHANE; IDAZOXAN; IMIDAZOLINE RECEPTOR; RAUWOLSCINE; RECEPTOR BLOCKING AGENT; RILMENIDINE;

ANIMAL EXPERIMENT; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; HEART ARRHYTHMIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; VAGOTOMY; VAGUS TONE;

EID: 0029881209     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15348.x     Document Type: Article

References (37)

1. ATLEE, J.L. & BOSNJAK, Z.J. (1990). Mechanisms for cardiac dysrhythmias during anesthesia. Anesthesiology, 72, 347-374.
2. BOUCHER, M., DUBAR, M., CHASSAING, C., VIVET, P. & DUCHÊNE-MARULLAZ, P. (1994). Cardiac clectrophysiological effects of rilmenidine, a novel antihypertensive agent, in the conscious dog: comparison with clonidine. Life Sci. 54, 381-387.
3. 3H] idazoxan in rat brain. J. Pharmacol. Exp. Ther., 241, 1079-1091.
4. BRICCA, G., DONTENWILL, M., MOLINES, A., FELDMAN, J., TIBIRICA, E., BELCOURT, A. & BOUSQUET, P. (1989). Rilmenidine selectivity for imidazoline receptors in human brain. Eur. J. Pharmacol., 163, 373-377.
5. 3H] clonidine. Eur. J. Pharmacol., 266, 25-33.
6. 3H]-clonidine to identify imidazoline receptors in the rabbit brainstem. Br. J. Pharmacol., 110, 1537-1543.
7. 2-Adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br. J. Pharmacol. 99, 803-809.
8. 2-adrenoceptors in cats. Br. J. Pharmacol., 103, 1114-1118.
9. EGER, E.I., SMITH, N.T., STOELTING, R.K., CULLEN, D.J., KADIS, L.B. & WHITCHER, C.E. (1970). Cardiovascular effects of halothane in man. Anesthesiology, 32, 396-409.
10. ERNSBERGER, P., DAMON, T.H., GRAFF, L.M., SCHÄFER, S.G. & CHRISTEN, M.O. (1993). Moxonidine, a centrally acting anti-hypertensive agent, is a selective ligand for 11-imidazoline sites. J. Pharmacol. Exp. Ther., 264, 172-182.
11. ERNSBERGER, P., GIULIANO, R., WILLETTE, R.N. & REIS, D.J. (1990). Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther., 253, 408-418.
12. FELDMAN, J., TIBIRICA, E., BRICCA, G., DONTENWILL, M., BELCOURT, A. & BOUSQUET, P. (1990). Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit. Br. J. Pharmacol., 100, 600-604.
13. GOMEZ, R.E., ERNSBERGER, P., FEINLAND, G & REIS, D.J. (1991). Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area. Eur. J. Pharmacol., 195, 181-191.
14. HAYASHI, Y., KAMIBAYAHSI, T., MAZE, M., YAMATODANI, A., SUMIKAWA, K., KURO, M. & YOSHIYA, I. (1993a). Role of imidazoline-preferring receptors in the genesis of epinephrine-induced arrhythmias in halothane-anesthetized dogs. Anesthesiology, 78, 524-530.
15. HAYASHI, Y., KAMIBAYASHI, T., SUMIKAWA, K., YAMATODANI, A., KURO, M. & YOSHIYA, I. (1993b). Adrenoceptor mechanism involved in thiopental-epinephrine-induced arrhythmias in dogs. Am. J. Physiol., 265, H1380-H1385.
16. HAYASHI, Y., KAMIBAYASHI, T., SUMIKAWA, K., YAMATODANI, A., KURO, M. & YOSHIYA, I. (1991a). Phenytoin prevents epinephrine-induced arrhythmias through central nervous system in halothane-anesthetized dogs. Res. Commun. Chem. Pathol. Pharmacol., 74, 59-70.
17. HAYASHI, Y., SUMIKAWA, K., MAZE, M., YAMATODANI, A., KAMIBAYAHSI, T., KURO, M. & YOSHIYA, I. (1991b). Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central α2 adrenoceptors in halothane-anesthetized dogs. Anesthesiology, 75, 113-117.
18. HAYASHI, Y., SUMIKAWA, K., YAMATODANI, A., KAMIBAYASHI, T., KURO, M. & YOSHIYA, I. (1991c). Myocardial epinephrine sensitization with subanesthetic concentrations of halothane in dogs. Anesthesiology, 74, 134-137.
19. ILLEUS, P. & NÖRENBERG, W. (1990). Blockade of α2-adrenoceptors increases opioid μ-receptor-mediated inhibition of the firing rate of rat locus coeruleus neurones. Naunyn-Schmied. Arch Pharmacol., 342, 490-496.
20. KAMIBAYASHI, T., HAYASHI, Y., MAMMOTO, T., YAMATODANI, A., TAENAKA, N. & YOSHIYA, I. (1995). Thoracic epidural anesthesia attenuates halothane-induced myocardial sensitization to dysrhythmogenic effect of epinephrine in dogs. Anesthesiology, 82, 129-134.
21. KAMIBAYAHSI, T., HAYASHI, Y., SUMIKAWA, K., YAMATODANI, A. & YOSHIYA, I. (1992). A role of vagus nerve in antiarrhythmic effects of doxazosin and dexmedetomidine on halothane-epinephrine arrhythmias. Anesthesiology, 77, A642.
22. LEHMANN, J., KOENIG-BÉRARD, E. & VITOU, P. (1989). The imidazoline-preferring receptor. Life Sci., 45, 1609-1615.
23. MAYOROV, D., CHERNOBELSKI, M. & MEDVEDEV, O. (1993). Sympathoinhibitory action of rilmenidine in conscious sinoaortically denervated rats. J. Cardiovasc. Pharmacol., 22, 314-320.
24. MICHEL, M.C. & ERNSBERGER, P. (1992) Keeping an eye on the I site: imidazoline-preferring receptors. Trends Pharmacol. Sci., 13, 369-370.
25. 3H] rauwolscine α-yohimbine): a specific antagonist radioligand for brain α2-adrenergic receptors. Eur. J. Pharmacol., 76, 461-464.
26. PODRID, P.J., FUCHS, T. & CANDINAS, R. (1990). Role of the sympathetic nervous system in the genesis of ventricular arrhythmia. Circulation, 82, 1103-1113.
27. REYNOLDS, A.K. (1984). On the mechanism of myocardial sensitization to catecholamines by hydrocarbon anesthetics. Can. J. Physiol. Pharmacol., 62, 183-198.
28. ROSS, C.A., RUGGIERO, D.A. & REIS, D.J. (1985). Projections from the nucleus tractus solitarii to the rostral ventrolateral medulla. J. Comp. Neurol., 242, 511-534.
29. RUGGIERO, D.A., CRAVO, S.L., ARANGO, V. & REIS, D.J. (1989). Central control of the circulation by the rostral ventrolateral reticular nucleus: anatomical substrates. Prog. Brain Res., 81, 49-79.
30. SPIERS, J.P., HARRON, D.W.G. & WILSON, R. (1990). Acute and chronic effects of rilmenidine on baroreflex function in conscious dogs. Eur. J. Pharmacol., 181, 235-240.
31. TIBIRICA, E., FELDMAN, J., MERMET, C., GONON, F. & BOUSQUET, P. (1991). An imidazoline-specific mechanism for the hypotensive effect of clonidine: a study with yohimbine and idazoxan. J. Pharmacol. Exp. Ther., 256, 606-613.
32. URBAN, R., SZABO, B. & STARKE, K. (1994). Is the Sympathoinhibitory effect of rilmenidine mediated by alpha-2 adrenoceptors or imidazoline receptors. J. Pharmacol. Exp. Ther., 270, 572-578.
33. 2 adrenoceptors in the human central nervous system. Neuroscience, 59, 589-598.
34. WAXMAN, M.B., SHARMA, A.D., ASTA, J., CAMERON, D.A. & WALD, R.W. (1989). The protective effect of vagus nerve stimulation on catecholamine-halothane-induced ventricular fibrillation in dogs. Can. J. Physiol. Pharmacol., 67, 801-809.
35. WIKBERG, J.E. & UHLÉN, S. (1990). Further characterization of the guinea pig cerebral cortex idazoxan receptor: solubilization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor-selective drug. J. Neurochem., 55, 192-203.
36. WIKBERG, J.E., UHLÉN, S. & CHHAJLANI, V. (1991). Medetomidine stereoisomers delineate two closely related subtypes of idazoxan (imidazoline) I-receptors in the guinea pig. Eur. J. Pharmacol., 193, 335-340.
37. ZINK, J., SC, B., SASYNIUK, B.I. & DRESEL, P.E. (1975). Halothane-epinephrine-induced cardiac arrhythmias and the role of heart rate. Anesthesiology, 43, 548-555.