Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in Syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl)-methanone (Ro 48-8071): Comparison to simvastatin

Biochemical Pharmacology

Volumn 56, Issue 4, 1998, Pages 439-449

  Peffley, Dennis M ^a   Gayen, Apurba K ^a   Morand, Olivier H ^b  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

2,3 oxidosqualene:lanosterol cyclase; 3 hydroxy 3 methylglutaryl CoA reductase; Cholesterol; Post transcriptional; Ro 48 8071; Transcriptional

Indexed keywords

[4 (6 ALLYLETHYLAMINOHEXYLOXY) 2' FLUOROPHENYL](4 BROMOPHENYL)METHANONE; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LANOSTEROL SYNTHASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; RO 48 8071; SIMVASTATIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; FEEDBACK SYSTEM; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; SYRIAN HAMSTER;

ANIMALS; BENZOPHENONES; CELLS, CULTURED; CRICETINAE; DOWN-REGULATION; ENZYME INHIBITORS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTRAMOLECULAR TRANSFERASES; LIPOPROTEINS, LDL; MESOCRICETUS; RNA, MESSENGER; SIMVASTATIN;

EID: 0031750617     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00083-5     Document Type: Article

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