Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level

Archives of Biochemistry and Biophysics

Volumn 337, Issue 2, 1997, Pages 251-260

  Peffley, Dennis M ^a   Gayen, Apurba K ^a,b  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

4,4,10 trimethyl trans decal 3 ol; cholesterol biosynthesis; lovastatin; protein degradation; translational control; zaragozic acid

Indexed keywords

25 HYDROXYCHOLESTEROL; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; MEVALONIC ACID; MEVINOLIN; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR; ZARAGOZIC ACID A;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LABELING; CELL LINE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOPRECIPITATION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0031568243     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1996.9796     Document Type: Article

References (50)

1. 1. Brown, M. S., and Goldstein, J. L. (1980) J. Lipid. Res. 21, 505-517.
2. 2. Goldstein, J. L., and Brown, M. S. (1990) Nature 343, 425-430.
3. 3. Clarke, C. F., Edward, P. A., Lau, S. F., Tanaka, R. D., Tanaka, A. M., and Fogelmen, A. M. (1983) Proc. Natl. Acad. Sci. USA 80, 3305-3308.
4. 4. Nakanishi, M., Goldstein, J. L., and Brown, M. S. (1988) J. Biol. Chem. 264, 8929-8937.
5. 5. Peffley, D. M. (1992) Somat. Cell. Mol. Genet. 18, 19-32.
6. 6. Osborne, T. F., Gil, G., Goldstein, J. L., and Brown, M. S. (1988) J. Biol. Chem. 263, 3380-3387.
7. 7. Choi, J. W., Lundquist, E. N., and Peffley, D. M. (1993) Biochem. J. 296, 859-866.
8. 8. Kumagai, H., Chun, K. T., and Simoni, R. D. (1995) J. Biol. Chem. 270, 19107-19113.
9. 9. Correll, C. C., and Edward, P. A. (1994) J. Biol. Chem. 269, 633-638.
10. 10. Peffley, D., and Sinensky, M. (1985) J. Biol. Chem. 260, 9949-9952.
11. 11. Panini, S. R., Delate, T. A., and Sinensky, M. (1992) J. Biol. Chem. 267, 12647-12654.
12. 12. Trzaskos, J. M., Magolda, R. L., Favata, M. G., Fischer, R. T., Johnson, P. R., Chen, H. W., Ko, S. S., Leonard, D. A., and Gaylor, J. L. (1993) J. Biol. Chem. 268, 22591-22599.
13. 13. Tam, S.-P., Brissette, L., Ramharack, R., and Deeley, R. T. (1991) J. Biol. Chem. 266, 1674-1677.
14. 14. Ness, G. C., Eales, S., Lopez, D., and Zhihong, Z. (1994) Arch. Biochem. Biophys. 308, 420-425.
15. 15. Simonet, W. S., and Ness, G. C. (1989) J. Biol. Chem. 264, 569-573.
16. 16. Osborne, T. F. (1991) J. Biol. Chem. 266, 13947-13951.
17. 17. Osborne, T. F., Bennett, M., and Rhee, K. (1992) J. Biol. Chem. 267, 18973-18982.
18. 18. Vallet, S. M., Sanchez, H. B., Rosenfeld, J. M., and Osborne, T. F. (1996) J. Biol. Chem. 271, 12247-12253.
19. 19. Sanchez, H. B., Yieh, L., and Osborne, T. F. (1995) J. Biol. Chem. 270, 1161-1169.
20. 20. Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., and Brown, M. S. (1993) Cell 75, 187-197.
21. 21. Roitelman, J., and Simoni, R. D. (1992) J. Biol. Chem. 267, 25264-25273.
22. 22. Bradfute, D. L., and Simoni, R. D. (1994) J. Biol. Chem. 269, 6645-6650.
23. 23. Roitelman, J., Oleander, E. H., Bar-Nun, S., Dunn, W. A., and Simoni, R. D. (1992) J. Cell. Biol. 117, 959-973.
24. 24. Correll, C. C., Ng, L., and Edward, P. A. (1994) J. Biol. Chem. 269, 17390-17393.
25. 25. Meigs, T. E., Roseman, D. S., and Simoni, R. D. (1996) J. Biol. Chem. 271, 7916-7922.
26. 26. Choi, J. W., and Peffley, D. M. (1995) Biochem. J. 307, 233-238.
27. 27. Straka, M. S., and Panini, S. R. (1995) Arch. Biochem. Biophys. 317, 235-243.
28. 28. Peffley, D. M., and Gayen, A. K. (1995) Somat. Cell. Mol. Genet. 21, 189-204.
29. 29. Bergstrom, J. D., Kurtz, M. M., Rew, D. J., Amend, A. M., Karkas, J. D., Bostedor, R. G., Bansal, V. S., Dufresne, C., VanMiddlesworth, F. L., Hensens, O. D., Liesch, J. M., Zink, D. L., Wilson, K. E., Onishi, J., Milligan, J. A., Bills, G., Kaplan, L., Nallin Omstead, M., Jenkins, R. G., Huang, L., Meinz, M. S., Quinn, L., Burg, R. W., Kong, Y. L., Mochales, S., Mojena, M., Martin, I., Pelaez, F., Diez, M. T., and Alberts, A. W. (1993) Proc. Natl. Acad. Sci. USA 90, 80-84.
30. 30. Bergstrom, J. D., Dufresne, C., Bills, G. F., Nallin-Omstead, M., and Byrne, K. (1995) Annu. Rev. Microbiol. 49, 607-639.
31. 31. Panini, S. R., Schnitzer-Polokoff, R. S., Spencer, T. A., and Sinensky, M. (1989) J. Biol. Chem. 264, 11044-11052.
32. 32. Chang, T. Y., Schiavoni, E. S., McCrae, K. R., Nelson, J. A., and Spencer, T. A. (1979) J. Biol. Chem. 254, 11258-11263.
33. 33. Burki, E., Logel, J., and Sinensky, M. (1987) J. Lipids Res. 28, 1199-1205.
34. 34. Chomczynski, P. I., and Sacchi, N. (1987) Anal. Biochem. 162, 156-159.
35. 35. Peffley, D., Miyake, J., Leonard, S., vonGunten, C., and Sinensky, M. (1988) Somat. Cell. Mol. Genet. 14, 527-539.
36. 36. Hardeman, E. C., Jenke, H-S., and Simoni, R. D. (1984) Proc. Natl. Acad. Sci. USA 80, 1516-1520.
37. 37. Peffley, D. M., and Sinensky, M. (1985) J. Biol. Chem. 260, 9949-9952.
38. 38. Saucier S. E., Kandutsch, A. A., Phirwa, S., and Spencer, T. A. (1987) J. Biol. Chem. 262, 14056-14062.
39. 39. Leonard, D. A., Kotarski, M. A., Tessiatore, J. E., Favata, M. F., and Trzaskos, J. M. (1994) Arch. Biochem. Biophys. 310, 152-157.
40. 40. Taylor, F. R., Kandutsch, A. A., Anzalone, L., Phirwa, S., and Spencer, T. A. (1988) J. Biol. Chem. 263, 2264-2269.
41. 41. Giron, M. D., Havel, C. M., and Watson, J. A. (1994) Proc. Natl. Acad. Sci. USA 91, 6398-6340.
42. 42. Biardi, L., and Krisans, S. K. (1996) J. Biol. Chem. 271, 1784-1788.
43. 43. Stamellos, K. D., Shackelford, J. E., Schechter, I., Jiang, G., Conrad, D., Keller, G. A., and Krisans, S. K. (1992) J. Biol. Chem. 268, 12825-12836.
44. 44. Keller, R. K., Zhao, Z., Chambers, C., and Ness, G. C. (1996) Arch. Biochem. Biophys. 328, 324-330.
45. 45. Trzaskos, J. M., Ko, S. S., Magolda, R. L., Favata, M. F., Fischer, R. T., Stam, S. H., Johnson, P. R., and Gaylor, J. L. (1995) Biochemistry 34, 9670-9676.
46. 46. Dolis, D., and Schuber, F. (1994) Biochem. Pharmacol. 48, 49-57.
47. 47. Ross, J. (1995) Microbiol. Rev. 59, 423-450.
48. 48. Gayen, A. K., and Peffley, D. M. (1995) Arch. Biochem. Biophys. 322, 475-485.
49. 49. Axelson, M., and Larsson, O. (1995) J. Biol. Chem. 270, 15102-15110.
50. 50. Axelson, M., Larsson, O., Zhang, J., Shoda, J., and Sjovall, J. (1995) J. Lipid Res. 36, 290-298.