Effect of granulocyte colony-stimulating factor (G-CSF) in human immunodeficiency virus-infected patients: Increase in numbers of naive CD4 cells and CD34 cells makes G-CSF a candidate for use in gene therapy or to support antiretroviral therapy

Journal of Infectious Diseases

Volumn 177, Issue 6, 1998, Pages 1733-1736

  Nielsen, Susanne D ^b   Afzelius, Pia ^b   Dam Larsen, Sanne ^b   Nielsen, Claus ^b   Nielsen, Jens O ^b   Mathiesen, Lars ^b   Hansen, John Erik S ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG DESIGN; DRUG EFFECT; GENE THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOTHERAPY; LYMPHOCYTE COUNT; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031750252     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/517434     Document Type: Article

References (15)

1. Miles SA, Mitsuyasu RT, Moreno J, et al. Combined therapy with recombinant granulocyte colony-stimulatmg factor and erythropoietin decreases hematologic toxicity from zidovudine. Blood 1991;77:2109-17.
2. + progenitor cells by granulocyte colony-stimulating factor in human immunodeficiency virus type 1-infected adults. Blood 1996;88:3329-35.
3. Stricker RB, Goldberg B. Increase in lymphocyte subsets following treatment of HIV-associated neutropenia with granulocyte colony-stimulating factor. Clin Immunol Immunopathol 1996;79:194-6.
4. Nielsen SD, Dam-Larsen S, Nielsen C, Wantzin P, Mathiesen L, Hansen JES. Recombinant human granulocyte colony-stimulating factor increases circulating CD34 positive cells in patients with AIDS. Ann Hematol 1997;74:215-20.
5. Afzelius P, Nielsen SD, Hofmann B, Nielsen JO. The serotonin analogue Buspirone increases the function of PBMC from HIV-infected individuals in vitro. Scand J Infect Dis 1997;29:117-20.
6. Mackall CL, Granger L, Sheard MA, Cepeda R, Gress RE. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny. Blood 1993;82:2585-94.
7. Bell EB, Sparshott SM. Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 1990;348:163-6.
8. Mackall CL, Bare CV, Granger LA, Sharrow SO, Titus JA, Gress RE. Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J Immunol 1996;156: 4609-16.
9. + T cells. Immunology 1990;69:460-7.
10. Mardiney M, Brown MR, Fleisher TA. Measurement of T-cell CD69 expression: a rapid and efficient means to assess mitogen- or antigeninduced proliferative capacity in normals. Cytometry 1996;26:305-10.
11. Hartung T, Docke WD, Gantner F, et al. Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood 1995;85:2482-9.
12. + T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nature Med 1997;3:533-40.
13. Jacobson MA, Zegans M, Pavan PR, et al. Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy. Lancet 1997;349:1443-5.
14. Walker RE, Blaese RM, Davey RT, Falloon J, Mullen C, Polis MA. A phase I/II pilot study of the safety of the adoptive transfer of syngeneic gene-modified cytotoxic T lymphocytes in HIV-infected identical twins. Hum Gene Ther 1996;7:367-400.
15. Woffendin C, Ranga U, Yang ZY, Xu L, Nable GJ. Expression of a protective gene prolongs survival of T cells in human immunodeficiency virus-infected patients. Proc Natl Acad Sci USA 1996;93: 2889-94.