A spectroscopic and molecular dynamics study of native and of a mutant of Xenopus laevis Cu,Zn superoxide dismutase: Mechanistic consequences of replacing four charged amino acids on the 'electrostatic' loop

Biophysical Chemistry

Volumn 75, Issue 3, 1998, Pages 235-248

  Falconi, M ^a   Venerini, F ^a   Desideri, A ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Molecular dynamics simulation; Site directed mutagenesis; Structure function relationship; Xenopus laevis Cu,Zn superoxide dismutase

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE;

ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME STRUCTURE, FUNCTION AND VARIABILITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SURFACE PROPERTY;

AMINO ACID SEQUENCE; ANIMALS; CHEMISTRY, PHYSICAL; ELECTROSTATICS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SUPEROXIDE DISMUTASE; THERMODYNAMICS; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 0031740189     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-4622(98)00209-9     Document Type: Article

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