A defect in renal calcium conservation may contribute to the pathogenesis of postmenopausal osteoporosis

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 6, 1998, Pages 1916-1920

  Heshmati, Hassan M ^a   Khosla, Sundeep ^a   Burritt, Mary F ^a   O'fallon, W Michael ^a   Riggs, B Lawrence ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34];

AGED; ARTICLE; BONE ATROPHY; CALCIUM ABSORPTION; CALCIUM BALANCE; CALCIUM BLOOD LEVEL; CALCIUM TRANSPORT; CALCIUM URINE LEVEL; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; ESTROGEN DEFICIENCY; FEMALE; HUMAN; KIDNEY TUBULE ABSORPTION; OSTEOLYSIS; PATHOGENESIS; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL;

ABSORPTION; AGED; BIOLOGICAL TRANSPORT; BONE RESORPTION; CALCIUM; FEMALE; HUMANS; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TUBULES; OSTEOPOROSIS, POSTMENOPAUSAL; POSTMENOPAUSE; TERIPARATIDE;

EID: 0031733219     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.6.1916     Document Type: Article

References (24)

1. Eriksen EF, Hodgson SF, Eastell R, O'Fallon WF, Riggs BL. 1988 Trabecular bone formation and resorption rates in type I (postmenopausal) osteoporosis. J Bone Miner Res. 3:S203.
2. Nordin BEC. 1962 Calcium balance and calcium requirement in spinal osteoporosis. Am J Clin Nutr. 10:384-310.
3. Aloia JF, Vaswani A, Yeh JK, Ellis K, Yasumura S, Cohn SH. 1988 Calcitriol in the treatment of postmenopausal osteoporosis. Am J Med. 84:401-408.
4. Riggs BL, Melton III LJ. 1983 Evidence for two distinct syndromes of involutional osteoporosis. Am J Med. 75:899-901.
5. Marshall DH, Crilly RG, Nordin BEC. 1977 Plasma androstenedione and oestrone levels in normal and osteoporotic postmenopausal women. Br Med J. 2:1177-1179.
6. Heaney RP. 1965 A unified concept of osteoporosis. Am J Med. 39:877-880.
7. Francis RM, Peacock M, Taylor GA, Storer JH, Nordin BEC. 1984 Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites on the bowel. Clin Sci. 66:103-107.
8. Manolagas SC, Jilka RL. 1995 Bone marrow, cytokines, and bone remodeling: emerging insights into the pathophysiology of osteoporosis. N Engl J Med. 332:305-311.
9. Pacifici R, Rifas L, Teitelbaum S, et al. 1987 Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis. Proc Natl Acad Sci USA. 84:4616-4620.
10. Davidson BJ, Riggs BL, Wahner HW, Judd HL. 1983 Endogenous cortisol and sex steroids in patients with osteoporotic spinal fractures. Obstet Gynecol. 61:275-278.
11. Tsai KS, Ebeling PR, Riggs BL. 1989 Bone responsiveness to parathyroid hormone in normal and osteoporotic postmenopausal women. J Clin Endocrinol Metab. 69:1024-1027.
12. Eastell R, Yergey AL, Vieira NE, Cedel SL, Kumar R, Riggs BL. 1991 Interrelationship among vitamin D metabolism, true calcium absorption, parathyroid function, and age in women: evidence of an age-related intestinal resistance to 1,25-dihydroxyvitamin D action. J Bone Miner Res. 6:125-132.
13. Kassem M, Khosla S, Spelsberg TC, Riggs BL. 1996 Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women. J Clin Endocrinol Metab. 81:513-518.
14. McKane WR, Khosla S, Burritt MF, et al. 1995 Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause - a clinical research center study. J Clin Endocrinol Metab. 80:3458-3464.
15. Schreiner GE. 1949 Determination of inulin by means of resorcinol. Proc Soc Exp Biol Med. 62:117-120.
16. Eastell R, Calvo MS, Burritt MF, Offord KP, Russell RGG, Riggs BL. 1992 Abnormalities in circadian patterns of bone resorption and renal calcium conservation in type I osteoporosis. J Clin Endocrinol Metab. 74:487-494.
17. Nordin BEC, Horowitz M, Need A, Morris HA. 1994 Renal leak of calcium in post-menopausal osteoporosis. Clin Endocrinol (Oxf). 41:41-15.
18. Law Jr WM, Heath III H. 1983 Rapid development of renal resistance to low doses of synthetic bovine parathyroid hormone fragment 1-34. Dissociation of urinary cyclic adenosine monophosphate, phosphaturic, and calciuric responses. J Clin Invest. 72:1106-1113.
19. Hagenfeldt Y, Eriksson HA. 1988 The estrogen receptor in the rat kidney. Ontogeny, properties and effects of gonadectomy on its concentration. J Steroid Biochem. 31:49-56.
20. Nordin BEC, Need AG, Morris HA, Horowitz M, Robertson WG. 1991 Evidence for a renal calcium leak in postmenopausal women. J Clin Endocrinol Metab. 72:401-407.
21. Horowitz MC. 1993 Cytokines and estrogen in bone: anti-osteoporotic effects. Science. 260:626-627.
22. Ammann P, Rizzoli R, Bonjour JP, et al. 1997 Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. J Clin Invest. 99:1699-1703.
23. McLean FC, Urist MR. 1961 Radiation, isotopes and bone. In: McLean FC, Urist MR, eds. Bone: an introduction to the physiology of skeletal tissue. 2nd ed. Chicago, IL: University of Chicago Press; 108-120.
24. Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF. 1979 Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest. 64:729-736.