Nephroprotection by long-term ACE inhibition with ramipril in spontaneously hypertensive stroke prone rats

Kidney International

Volumn 54, Issue 6, 1998, Pages 2037-2044

  Linz, Wolfgang ^a   Becker, Reinhard H A ^a   Schölkens, Bernward A ^a   Wiemer, Gabriele ^a   Keil, Manfred ^a   Langer, Karl Heinz ^a  

^a SANOFI   (France)

Author keywords

Angiotensin converting enzyme inhibition; Hypertension; Hypertrophy; Sclerosis; SHR SP

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PLACEBO; RAMIPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOSE RESPONSE; HISTOPATHOLOGY; KIDNEY DISEASE; LONG TERM CARE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STROKE;

EID: 0031725372     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00208.x     Document Type: Article

References (26)

1. LINZ W, JESSEN T, BECKER RHA, SCHÖLKENS BA, WIEMER G: Long-term angiotensin converting enzyme inhibition doubles lifespan of hypertensive rats. Circulation 96:3164-3172, 1997
2. NATIONAL HIGH BLOOD PRESSURE EDUCATION PROGRAM COORDINATING COMMITTEE: The sixth report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch Intern Med 157:2413-2446, 1997
3. THE GISEN GROUP: Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy - REIN Study. Lancet 349:1857-1863, 1997
4. FELD LG, CACHERO S, LIEW JBV, ZAMLAUSKI-TUCKER M, NOBLE B: Enalapril and renal injury in spontaneously hypertensive rats. Hypertension 16:544-554, 1990
5. LEE RMKW, DELANEY KH, LU M: Perindopril treatment prolonged the lifespan of spontaneously hypertensive rats. J Hypertens 13:471-476, 1995
6. KOMATSU K, FROHLICH ED, ONO H, ONO Y, NUMABE A, WILLIS GW: Glomerular dynamics and morphology of aged spontaneously hypertensive rats. Effects of ACE inhibition. Hypertension 25:207-213, 1995
7. BECKER RHA, BALDES L, FÜRST U, SCHULZE KJ: Sustained diurnal blood pressure reduction in SHR with ramipril assessed by telemetric monitoring. Clin Exp Hypertens 19:1233-1246, 1997
8. BECKER RHA, BALDES L, TREUDLER M, METZGER G, MAIER R: Long-term fall in blood pressure, plasma- and tissue converting enzyme inhibition. Two rat studies with ramipril. (abstract) Eur J Pharmacol 83:1309, 1990
9. SCHUNKERT H, TANG S-S, LITWIN SE, DIAMANT D, RIEGGER G, DZAU VJ, INGELFINGER JR: Regulation of intrarenal and circulating renin-angiotensin systems in severe heart failure in the rat. Cardiovasc Res 27:731-735, 1993
10. ZOJA C, DONADELLI R, CORNA D, TESTA D, FACCHINETTI D, MAFFI R, LUZZANA E, COLOSIO V, BERTANI T, REMUZZI G: The renoprotective properties of angiotensin-converting enzyme inhibitors in a chronic model of membranous nephropathy are solely due to the inhibition of angiotensin II: Evidence based on comparative studies with a receptor antagonist. Am J Kidney Dis 29:254-264, 1997
11. ROCHA R, CHANDER PN, KHANNA K, ZUCKERMAN A, STIER CT: Mineralcorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 31:451-458, 1998
12. NAITOH M, SUZUKI H, ARAKAWA K, MATSUMOTO A, ICHIHARA A, MATSUDA H, KUBOTA E, MURAKAMI M, NAKAMOTO H, SARUTA T: Role of kinin and renal ANG II blockade in acute effects of ACE inhibitors in low-renin hypertension. Am J Physiol 272(Heart Cir Physiol 41):H679-H687, 1997
13. FENOY FJ, SCICLI G, CARRETERO O, ROMAN RJ: Effect of an angiotensin II and a kinin receptor antagonist on the renal hemodynamic response to captopril. Hypertension (Dallas) 17:1038-1044, 1991
14. SCHNACKENBERG C, PATEL AR, KIRCHNER KA, GRANGER JP: Nitric oxide, the kidney and hypertension. Clin Exp Pharmacol Physiol 24:600-606, 1997
15. HIGASHI Y, OSHIMA T, OZONO R, MATSUURA H, KAJIYAMA G: Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans. Hypertension 30:252-258, 1997
16. 2 release in normotensive and hypertensive rats. Hypertension 30:934-941, 1997
17. SANTOS RAS, SIMOES E SILVA AC, MAGALDI AJ, KHOSLA MC, CESAR KR, PASSAGLIO KT, BARACHO NCV: Evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance. Hypertension 27:875-884, 1996
18. BOTELHO LM, BLOCK CH, KHOSLA MC, SANTOS RAS: Plasma angiotensin-(1-7) levels is increased by water deprivation, salt load and hemorrhage. Peptides 15:723-729, 1994
19. HEYNE N, BEER W, MUHLBAUER B, OSSWALD H: Renal response to angiotensin-(1-7) in anesthetized rats. Kidney Int 47:975-976, 1995
20. MILETICH DJ, MINSHALL RD, ALBRECHT RF: The influence of chronic hypokalemia on myocardial adrenergic receptor densities: Enhanced sensitivity to epinephrine-induced arrhythmias. Anesth Analg 84:734-739, 1997
21. GURLEK A, EROL C, BASESME E: Antiarrhythmic effect of converting enzyme inhibitors in congestive heart failure. Int J Cardiol 43:315-318, 1994
22. MASCHIO G, ALBERTI D, JANIN G, LOCATELLI F, MANN JFE, MOTOLESE M, PONTICELLI C, RITZ E, ZUCCHELLI P: ACE Inhibition In Progressive Renal Insufficiency study group: Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. N Engl J Med 334:939-945, 1996
23. SUZUKI T, OBOSHI S, SATO R: Periarteritis nodosa in spontaneously hypertensive rats-incidence and distribution. Acta Pathol Jpn 29:697-703, 1979
24. RICHER C, FORNES P, VACHER E, BRUNEVAL P, GIUDICELLI J-F: Trandolapril's protective effects in stroke-prone spontaneously hypertensive rats persist long after treatment withdrawal. Am J Cardiol 73:26C-35C, 1994
25. MÜNTER K, HERGENRÖDER S, JOCHIMS K, KIRCHENGAST M: Individual and combined effects of verapamil or trandolapril on attenuating hypertensive glomerulopathic changes in the stroke-prone rat. J Am Soc Nephrol 7:681-686, 1996
26. BÜNNING P: Inhibition of angiotensin converting enzyme by 2-[N-[(S)-1Carboxy-3-phenylpropyl]-L-alanyl]-(IS, 3S, 5S)-2azabicyclo [3.3.0]octane-3-carboxylic Acid (HOE 498 Diacid). Arzneim Forsch/Drug Res 34:1406-1410, 1984