Effects of dexamethasone and SB 209670 on the regional haemodynamic responses to lipopolysaccharide in conscious rats

British Journal of Pharmacology

Volumn 118, Issue 1, 1996, Pages 141-149

  Gardiner, S M ^a   Kemp, P A ^a   March, J E ^a   Bennett, T ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Dexamethasone; Endothelin; Lipopolysaccharide; SB 209670

Indexed keywords

3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; ANGIOTENSIN; DEXAMETHASONE; ENDOTHELIN RECEPTOR ANTAGONIST; GLUCOCORTICOID; LIPOPOLYSACCHARIDE; LOSARTAN; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE; VASOPRESSIN; VASOPRESSIN ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HEMODYNAMICS; HINDLIMB; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY BLOOD VESSEL; MALE; MEAN ARTERIAL PRESSURE; MESENTERY BLOOD VESSEL; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; VASOCONSTRICTION; VASODILATATION;

EID: 0029962321     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15377.x     Document Type: Article

References (31)

1. BATIN, P., GARDINER, S.M., COMPTON, A.M. & BENNETT, T. (1991). Differential regional haemodynamic effects of the non-peptide angiotensin II antagonist, DuP 753, in water-replete and water-deprived Brattleboro rats. Life Sci., 48, 733-739.
2. DOUGLAS, S.A., EDWARDS, R.M., ELLIOTT, J.D. & OHLSTEIN, E.H. (1995a). In vivo pharmacological characterization of the non-peptide endothelin receptor antagonist SB 209670. Br. J. Pharmacol., 114, 405-413.
3. DOUGLAS, S.A., GELLAI, M., EZEKEIL, M., FEUERSTEIN, G.Z., ELLIOTT, J.D. & OHLSTEIN, EH. (1995b). Antihypertensive actions of the novel nonpeptide endothelin receptor antagonist SB 209670. Hypertension, 25, 818-822.
4. DRAYER, J.I.M., WEBER, M.A., PURDY, R.E. & LIPSON, J.L. (1984). The effects of steroid hormones on vascular tissue. J. Cardiovasc. Pharmacol., 6 (Suppl.), S394-S400.
5. GARDINER, S.M., COMPTON, A.M. & BENNETT, T. (1989). Regional hemodynamic changes following hypovolemia in conscious rats. Am. J. Physiol., 256, R1076-R1083.
6. GARDINER, S.M., COMPTON, A.M. & BENNETT, T. (1990a). Regional haemodynamic effects of endothelin-1 and endothelin-3 in conscious Long Evans and Brattleboro rats. Br. J. Pharmacol., 99, 2107-112.
7. G-nitro-L-arginine methyl ester. Br. J. Pharmacol., 101, 632-639.
8. GARDINER, S.M., KEMP, P.A., MARCH, J.E. & BENNETT, T. (1995a). Involvement of angiotensin II and vasopressin in the haemodynamic responses to lipopolysaccharide (LPS) in conscious rats. Br. J. Pharmacol., 114, 243P.
9. GARDINER, S.M., KEMP, P.A., MARCH, J.E. & BENNETT, T. (1995b). Regional haemodynamic effects of human and rat adrenomedullin in conscious rats. Br. J. Pharmacol., 114, 584-591.
10. GARDINER, S.M., KEMP, P.A., MARCH, J.E. & BENNETT, T. (1995c). Cardiac and regional haemodynamics, inducible nitric oxide synthase (NOS) activity, and the effects of NOS inhibitors in conscious, endotoxaemic rats. Br. J. Pharmacol. 116, 2005-2016.
11. GARDINER, S.M., KEMP, P.A., MARCH, J.E. & BENNETT, T. (1995d). Enhancement of the hypotensive and vasodilator effects of endotoxaemia in conscious rats by the endothelin antagonist, SB 209670. Br. J. Pharmacol., 116, 1718-1719.
12. GARDINER, S.M., MARCH, J.E., KEMP, P.A., MULLINS, J.J. & BENNETT, T. (1995e). Haemodynamic effects of losartan and the endothelin antagonist, SB 209670, in conscious, transgenic ((mRen-2)27), hypertensive rats. Br. J. Pharmacol., 116, 2237-2244.
13. GRÜNFELD, J-P. & ELOY, R (1987). Glucocorticoids modulate vascular reactivity in the rat. Hypertension, 10, 608-618.
14. HAUSER, G.J., DAYAO, E.K. & ZUKOWSKA-GROJEC, Z. (1995). Effect of neuropeptide Y on endotoxin-induced suppression of the response to various agonists in conscious rats. Life Sci., 57, 235-244.
15. KUJUBU, D.A. & HERSCHMAN, H.R. (1992). Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene. J. Biol. Chem., 267, 7991-7994.
16. MASFERRER, J.L. & SEIBERT, K. (1994). Regulation of prostaglandin synthesis by glucocorticoids. Receptors, 4, 25-30.
17. MINAMINO, N., SHOJI, H., SUGO, S., KANGAWA, K. & MATSUO, H. (1995). Adrenocortical steroids, thyroid hormones and retinoic acid augment the production of adrenomedullin in vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 211, 686-693.
18. OHLSTEIN, E.H., NAMBI, P., DOUGLAS, S.A., EDWARDS, R.M., GELLAI, M., LAGO, A., LEBER, J.D., COUSINS, R.D., GAO, A., FRAZEE, J.S., PEISHOFF, C.E., BEAN, J.W., EGGLESTON, D.S., ELSHOURBAGY, N.A., KUMAR, C., LEE, J.A., YUE, T-L., LOUDEN, C., BROOKS, D.P., WEINSTOCK, J., FEUERSTEIN, G., POSTE, G., RUFFOLO, R.R., GLEASON, J.G. & ELLIOTT, J.D. (1994). SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Proc. Natl. Acad. Sci. U.S.A., 91, 8052-8056.
19. PAYA, D., GRAY, G.A., FLEMING, I. & STOCLET, J.C. (1993). Effect of dexamethasone on the onset and persistence of vascular hyporeactivity induced by E.coli lipopolysaccharide in rats. Circ. Shock, 41, 103-112.
20. RADOMSKI, M.W., PALMER, R.M.J. & MONCADA, S. (1990). Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. U.S.A., 87, 10043-10047.
21. RAFF, H. (1987). Glucocorticoid inhibition of neurohypophysial vasopressin secretion. Am. J. Physiol., 252, R635-R644.
22. RUBANYI, G.M. & POLOKOFF, M.A. (1994). Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev., 46, 325-415.
23. SCHALLER, M.D., WAEBER, B., NUSSBERGER, J. & BRUNNER, H.R. (1985). Angiotensin II, vasopressin, and sympathetic activity in conscious rats with endotoxaemia. Am. J. Physiol., 249, H1086-H1092.
24. SUGIRUA, M., INAGAMI, T. & KON, V. (1989). Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay. Biochem. Biophys. Res. Commun., 161, 1220-1227.
25. SUGO, S., MINAMINO, N., SHOJI, H., KANGAWA, K., KITAMURA, K., ETO, T. & MATSUO, H. (1995). Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 207, 25-32.
26. SZABO, C., MITCHELL, J.A., THIEMERMANN, C & VANE, J.R. (1993). Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br. J. Pharmacol., 108, 786-792.
27. VEMULAPALLI, S., CHIU, P.J.S., RIVELLI, M., FOSTER, C.J. & SYBERTZ, E.J. (1991). Modulation of circulating endotoxin levels in hypertension and endotoxaemia in rats. J. Cardiovasc. Pharmacol., 18, 895-903.
28. WALKER, B.R. & WILLIAMS, B.C. (1992). Corticosteroids and vascular tone: mapping the messenger maze. Clin. Sci., 82, 597-605.
29. WALLER, J., GARDINER, S.M. & BENNETT, T. (1994). Regional haemodynamic responses to acetylcholine, methoxamine, salbutamol and bradykinin during lipopolysaccaride infusion in conscious rats. Br. J. Pharmacol., 112, 1057-1064.
30. WRIGHT, C.E., REES, D.D. & MONCADA, S. (1992). Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc. Res., 26, 48-57.
31. WU, C-C., CROXTALL, J.D., PERRETTI, M., BRYANT, C.E., THIEMERMANN, C., FLOWER, R.J. & VANE, J.R. (1995). Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proc. Natl. Acad. Sci. U.S.A., 92, 3473-3477.