Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4

Atherosclerosis

Volumn 121, Issue 1, 1996, Pages 13-21

  Muros, Mercedes ^a   Rodríguez Ferrer, Carmen ^b  

^a HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Apolipoprotein E polymorphism; Canary Islands; Cholesterol; Lipoprotein(a); Lipoproteins; Triglyceride

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; LIPOPROTEIN; LIPOPROTEIN A; TRIACYLGLYCEROL;

ADULT; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ETHNIC DIFFERENCE; FEMALE; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; SPAIN;

EID: 0343832920     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(95)06643-8     Document Type: Article

References (37)

1. Artaud-Wild SM, Connor SL, Sexton G, Connor WE. Differences in coronary mortality can be explained by differences in cholesterol and saturated fat intakes in 40 countries but not in France and Finland. Circulation 1993;88:2771.
2. Manttari M, Koskinen P, Ehnholm C, Huttunen JK, Manninen V. Apolipoprotein E polymorphism influences the serum colesterol response to dietary intervention. Metabolism 1991;40:217.
3. Jones JH, Main BF, Frolich JJ. Response of cholesterol synthesis to cholesterol feeding in men with different apolipoprotein E genotypes. Metabolism 1993;42:1065.
4. Boerwinkle E, Utermann G. Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism. Am J Hum Genet 1988;42:104.
5. Hitoshi S, Nobuhiro Y, Motoya K, Shimada M, Gotoda T, Harada K, Murase T, Fukazawa C, Takaku F, Yazaki Y. Overexpression of apoliprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia. Proc Natl Acad Sci USA 1992;89:1750.
6. Yamada N, Shimano H, Mokuno H, Ishibashi S, Gotoda T, Kawakami M, Watanabe Y, Akanuma Y, Murase T, Takaku F. Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits. Proc Natl Acad Sci USA 1989;86:665.
7. Mahley RW, Weisgraber KH, Hussain MM, Greenman B, Fisher M, Vogel T, Gorecki M. Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits, J Clin Invest 1989;83:2125.
8. Shimano H, Yamada N, Katsuki M, Yamamoto K, Gotoda T, Harada K, Shimada M, Yazaki Y. Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. J Clin Invest 1992;90:2084.
9. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992;258:468.
10. Mahley RW. Apolipoprotein E:cholesterol transport protein with expanding role in cell biology. Science 1988;240:622.
11. Utermann G, Langenbeck U, Beisiegel U, Weber W. Genetics of the apolipoprotein E system in man. Am J Hum Genet 1980;32:339.
12. Weisgraber KH, Innerarity TL, Mahley RW. Abnormal lipoprotein receptor-binding activity of the human apo E apolipoprotein due to cysteine-arginine interchange at a single site. J Biol Chem 1982;257:2518.
13. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 1988;8:1.
14. Sepehrnia B, Kamboh MI, Adams-Capbell LL, Bunker CH, Nwankwo M, Majumder PP, Ferrell RE. Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of lipoproteins in nigerian blacks. Am J Hum Genet 1989;45:586.
15. Kamboh MI, Bhatia KK, Ferrell RE. Genetic studies of human apolipoproteins. XII. Population genetics of apolipoproteins in Papua New Guinea. Am J Hum Biol 1990;2:17.
16. Ehnholm C, Lukka M, Kuusi T, Nikkila E, Utermann G. Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J Lipid Res 1986;27:227.
17. Eggertsen, G, Tegelman R, Ericsson S, Angelin B, Berglund L. Apolipoprotein E polymorphism in a healthy Swedish population: Variation of allele frequency with age and relation to serum lipid concentrations. Clin Chem 1993;39:2125.
18. James RW, Boemi M, Giansanti R, Fumelli P, Pometta D. Underexpression of the apolipoprotein E4 isoform in an Italian population. Arterioscler Thromb 1993;13: 1456.
19. Lorehzo PL, Gil M. Aproximación al estado de salud en Canarias. Consejería de Sanidad, Trabajo y Servicios Sociales del Gobierno de Canarias. Santa Cruz de Tenerife, 1990.
20. Tiret L, de Knijff P, Menzel HJ, Ehnholm Ch, Nicaud V, Havekes L. ApoE polymorphism and predisposition to coronary heart disease in youths of different European populations. The EARS Study. Arterioscl and Thromb 1994;14:1617.
21. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of preparatory ultracentrifugation. Clin Chem 1972;18:499.
22. Levine DM, Sloan B, Donner JE, Lorenz JD, Heinzerling RH. Automated measurement of lipoprotein(a) by immunoturbidimetric analysis. Int J Clin Lab Res 1992;22:173.
23. Havekes LM, De Knijff P, Beisiegel U, Havinga J, Smith M, Klasen E. A rapid micromethod for apolipoprotein E phenotyping directly in serum. J Lipid Res 1987;28:445.
24. Senti M, Nogués X, Pedro-Botet J, Rubiés-Prat J, Vidal-Barraquer F. Lipoprotein profile in men with peripheral vascular disease. Role of intermediate density lipoproteins and apolipoprotein E phenotypes. Circulation 1992;85: 30.
25. Sing CF, Davignon J. Role of the apolipoprotein E polymorphism in determinig normal plasma lipid and lipoprotein variation. Am J Hum Genet 1985;37:268.
26. Lenzen HJ, Assmann G, Buchwalsky R, Schulte H. Association of apolipoprotein E polymorphism, low density lipoprotein cholesterol, and coronary artery disease. Clin Chem 1986;32:778.
27. Kuusi T, Nieminen MS, Ehnholm C, Yki-Jarvinen H, Valle M, Nikkila EA, Taskinen MR. Apolipoprotein E polymorphism and coronary artery disease: increased prevalence of apolipoprotein E-4 in angiographically verified coronary patients. Arteriosclerosis 1989;9:237.
28. Utermann G. Apolipoprotein E polymorphism in health and disease. Am Heart J 1987;113:433.
29. Boerwinkle E, Visvikis S, Welsh D, Steinmetz J, Hanash SM, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphism in determining levels, variability and covariability of cholesterol, betalipoprotein and triglycerides in a sample of unrelated individuals. Am J Hum Genet 1987;27:567.
30. Utermann G, Steinmetz A, Weber W. Genetic control of human apolipoprotein E polymorphism: comparison of one and two-dimensional techniques of isoprotein analysis. Hum Genet 1982;60:344.
31. Hallman DM, Boerwinkle E, Saha N, Sandholzer C, Menzel HJ, Csázár A, Utermann G. The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. Am J Hum Genet 1991;49: 338.
32. Walsh W, Schiff I, Rosner B, Greenberg L, Ravnikar V, Sacks FM. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 1991;35:1196.
33. Schaefer E, Lamon-Fava S, Johnson S, Ordovas JM, Schaefer MM. Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham offspring study. Arterioscler Thromb 1994;14:1105.
34. Austin MA, Plasma triglyceride and coronary heart disease. Arterioscler Thromb 1990;11:2.
35. Dallongeville J, Lussier-Cacan S, Davignon J. Modulation of plasma triglyceride levels by apo E phenotype: a meta-analysis. J Lipid Res 1992;33:447.
36. De Knijff P, Kaptein A, Boomsma D, Princen HMG, Frants RR, Havekes LM. Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a). Atherosclerosis 1991;90:169.
37. Sehayek E, Eisenberg S. Mechanism of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J Biol Chem 1991;266:18259.