Dietary fish oils modify the assembly of VLDL and expression of the LDL receptor in rabbit liver

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 9, 1998, Pages 1490-1497

  Wilkinson, Jane ^a   Higgins, Joan A ^a   Fitzsimmons, Colin ^b   Bowyer, David E ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apolipoprotein B; Cholesterol; Golgi; Rough endoplasmic reticulum; Smooth endoplasmic reticulum

Indexed keywords

FISH OIL; LOW DENSITY LIPOPROTEIN RECEPTOR; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL TISSUE; ARTICLE; CELL PROTECTION; DIETARY INTAKE; LIPOPROTEIN METABOLISM; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; RECEPTOR DOWN REGULATION; ROUGH ENDOPLASMIC RETICULUM; SMOOTH ENDOPLASMIC RETICULUM;

EID: 0031664806     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.9.1490     Document Type: Article

References (10)

1. Harris WS. Fish-oils and plasma lipid and lipoprotein metabolism in humans: a critical review. J Lipid Res. 1989;30:785-807.
2. Nestel PJ. Effect of n-3 fatty acids on lipid metabolism Annu Rev Nutr. 1990;10:149-167.
3. Wong SH, Fisher EA, Marsh JB. Effect of eicosapentaenoic acid and docosahexaenoic acid on apolipoprotein B mRNA and secretion of very low density lipoproteins in Hep-G2 cells. Atherosclerosis. 1989;9:836-841.
4. Lang CA, Davis RA. Fish oils impair VLDL assembly and/or secretion by cultured rat hepatocytes. J Lipid Res. 1990;31:2079-2086.
5. Wang H, Chen X, Fisher EA. N-3 fatty acids stimulate intracellular degradation of lipoprotein B in rat hepatocytes. J Clin Invest. 1993;91:1380-1389.
6. Brown A-M, Baker PW, Gibbons GF. Changes in fatty acid metabolism in rat hepatocytes in response to dietary n-3 fatty acids are associated with changes in the intracellular metabolism and secretion of apolipoprotein B-48. J Lipid Res. 1997;38:469-481.
7. Hebbachi A-M, Seelaender MCL, Baker PW, Gibbons GF. Decreased secretion of very-low-density lipoprotein triacylglycerol and apolipoprotein B is associated with decreased intracellular triacylglycerol lipolysis in hepatocytes derived from rats fed orotic acid or n-3 fatty acids. Biochem J. 1997;375:711-719.
8. Boren J, Rustaeus M, Olofsson S-O. Studies on the assembly of apolipoprotein B-100 and -B 48 containing very low density lipoproteins in McA RH 7777 cells. J Biol Chem. 1994;269:25879-25888.
9. Bostrom K, Wettesten M, Boren J, Bondjers G, Wiklund O, Olofsson S-O. Pulse chase studies of the synthesis and intracellular transport of apolipoprotein B-100 in Hep-G2 cells. J Biol Chem. 1986;262:13800-13806.
10. Bostrom K, Boren J, Wettesten M, Sjoberg A, Bondjers G, Wiklund O, Carlsson P, Olofsson S-O. Studies on the assembly of apo-B 100 containing lipoproteins in Hep-G2 cells. J Biol Chem. 1988;263:4434-4442.