Mechanisms of nuclear positioning

Journal of Cell Science

Volumn 111, Issue 16, 1998, Pages 2283-2295

  Reinsch, Sigrid ^a   Gönczy, Pierre ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Centrosome nucleus connection; Dynein; Microtubule; MTOC; Nucleus

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE;

CELL NUCLEUS; CENTROSOME; MICROTUBULE; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; REVIEW;

ANIMALS; CELL NUCLEUS; CENTROSOME; DYNEIN ATPASE; FEMALE; HUMANS; MALE; MICROTUBULES; MODELS, BIOLOGICAL; MOVEMENT; SACCHAROMYCES CEREVISIAE;

ANIMALIA;

EID: 0031716602     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (126)

1. Allan, V. (1995a). Membrane traffic motors. FEBS Lett. 369, 101-106.
2. Allan, V. (19956). Protein phosphatase 1 regulates the cytoplasmic dynein-driven formation of endoplasmic reticulum networks in vitro. J. Cell Biol 128, 879-891.
3. Allan, V. (1996). Role of motor proteins in organizing the endoplasmic reticulum and Golgi apparatus. Semin. Cell Dev. Biol. 1. 335-342.
4. Allen, R. D. (1954). Fertilization and activation of sea urchin eggs in glass capillaries. Exp. Cell Res. 6, 403-424.
5. Aronson, J. and Inoue, S. (1970). Reversal by light of the action of N- methyl N-desacetyl colchicine on mitosis. J. Cell Biol. 45, 470-477.
6. Aronson, J. F. (1971). Demonstration of a colcemid-sensitive attractive force acting between the nucleus and a center. J. Cell Biol. 51, 579-583.
7. Baker, J., Theurkauf, W. E. and Schubiger, G. (1993). Dynamic changes in Microtubule configuration correlate with nuclear migration in the preblastoderm Drosophila embrvo. J. Cell Biol, 122, 113-121.
8. Baluska, F., Volkmann, D. and Barlow, P. W. (1997). Nuclear components with microtubule-organizing properties in multicellular eukaryotes: functional and evolutionary considerations. Int. Rev. Cytol. 175, 91-135.
9. Bjerknes, M. (1986). Physical theory of the orientation of astral mitotic spindles. Science 234, 1413-1416.
10. Book, K. J., Howard, R. and Morest, D. K. (1991). Direct observation in vitro of how neuroblasls migrate: medulla and cochleovestibular ganglion of the chick embryo. Exp. Neurol. 111, 228-243.
11. Bornens, M. (1977). Is the centriole bound to the nuclear membrane? Nature 270, 80-82.
12. Boveri, T. (1888). Über partielle Befruchtung. Sitz.-Berg. Ges. Morph. u. Phys. München 4, 2.
13. Bruner, J. M. and Bursztajn, S. (1986). Acetylcholine receptor clusters are associated with nuclei in rat myotubes. Dev. Biol. 115, 35-43.
14. Busson, S., Dujardin, D., Moreau, A., Dompierre, J. and De Mey, J. R. (1998). Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells. Curr. Biol. 8, 541-544.
15. Carminati, J. L. and Stearns, T. (1997). Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex. J. Cell Biol. 138, 629-641.
16. Carre, D. and Sardet, C. (1984). Fertilization and early development in Beroe ovata. Dev. Biol 105, 188-195.
17. Carre, D., Rouviere, C. and Sardet, C. (1991). In vitro fertilization in ctenophores: sperm entry, mitosis, and the establishment of bilateral symmetry in Beroe ovata. Dev. Biol. 147, 381-391.
18. Chambers, E. L. (1939). The movement of the egg nucleus in relation to the sperm aster in the echinoderm egg. J. Exp. Biol. 16, 409-424.
19. Conklin, E. G. (1894). The fertilization of the ovum. Biol. Lect., Marine Biol. Lab., Woods Hole.
20. Conklin, E. G. (1916). Effects of centrifugal force on the polarity of the eggs of Crepidula. Proc. Nat. Acad. Sci. USA 2, 87-90.
21. Conklin, E. G. (1917). Effects of centrifugal force on the structure and development of the eggs of Crepidula. J. Exp. Zool. 22, 311-419.
22. Cottingham, F. R. and Hoyt, M. A. (1997). Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J. Cell Biol. 138, 1041-1053.
23. Dan, K. (1979). Studies on unequal cleavage in sea urchins 1. Migration of the nuclei to the vegetal pole. Dev. Growth Differ. 21, 527-535.
24. Dan, K., Endo, S. and Uemura, I. (1983). Studies on unequal cleavage in sea urchins II. Surface differentiation and the direction of nuclear migration. Dev. Growth Differ. 25, 227-237.
25. Dan, K. (1984). The cause and consequence of unequal cleavage in sea urchins. Zool. Science 1, 151-160.
26. Dan, K. and Ito, S. (1984). Studies of unequal cleavage in molluscs: I. Nuclear behavior and anchorage of a spindle pole to cortex as revealed by isolation technique. Dev. Growth Differ. 26, 249-262.
27. Desai, A. and Mitchison, T. J. (1997). Microtubule polymerization dynamics. Annu. Rev. Cell Dev. Biol. 13, 83-117.
28. DeZwaan, T. M., Ellingson, E., Pellman, D. and Roof, D. M. (1997). Kinesin-related KIP3 of Saccharomyces cerevisiae is required for a distinct step in nuclear migration. J. Cell Biol. 138. 1023-1040.
29. Dogterom, M. and Yurke, B. (1997). Measurement of the force-velocity relation for growing microtubules. Science 278, 856-860.
30. Echeverri, C. J., Paschal, B. M., Vaughan, K. T. and Vallee, R. B. (1996). Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J. Cell Biol. 132, 617-633.
31. Endow, S. A., Kang, S. J., Satterwhite, L. L., Rose, M. D., Skeen, V. P. and Salmon, E. D. (1994). Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends. EMBO J. 13. 2708-2713.
32. Englander, L. L. and Rubin, L. L. (1987). Acetylcholine receptor clustering and nuclear movement in muscle fibers in culture. J. Cell Biol. 104, 87-95.
33. Eshel, D., Urrestarazu, L. A., Vissers, S., Jauniaux, J. C., van, V., Reedijk, J. C., Planta, R. J. and Gibbons, I. R. (1993). Cytoplasmic dynein is required for normal nuclear segregation in yeast. Proc. Nat. Acad. Sci. USA 90, 1172-11176.
34. Euteneuer, U. and Schliwa, M. (1992). Mechanism of centrosome positioning during the wound response in BSC-1 cells. J. Cell Biol. 116, 1157-1166.
35. Farkasovsky, M. and Kuntzel, H. (1995). Yeast Numlp associates with the mother cell cortex during S/G2 phase and affects microtubular functions. J. Cell Biol. 131, 1003-1014.
36. Fischer, R. and Timberlake, W. E. (1995). Aspergillus nidulans apsA (anucleate primary sterigmata) encodes a coiled-coil protein required for nuclear positioning and completion of asexual development. J. Cell Biol. 128, 485-498.
37. Foe, V. E. and Alberts, B. M. (1983). Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis. J. Cell Sci. 61, 31-70.
38. Fontaine, B., Sassoon, D., Buckingham, M. and Changeux, J. P. (1988). Detection of the nicotinic acetylcholine receptor alpha-subunit mRNA by in situ hybridization at neuromuscular junctions of 15-day-old chick striated muscles. EMBO J. 7, 603-609.
39. Gard, D. L. (1993). Ectopic spindle assembly during maturation of Xenopus oocytes: evidence for functional polarization of the oocyte cortex. Dev. Biol. 159, 298-310.
40. Geiser, J. R., Schott, E. J., Kingsbury, T. J., Cole, N. B., Totis, L. J., Bhattacharyya, G., He, L. and Hoyt, M. A. (1997). Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Mol. Biol. Cell 8, 1035-1050.
41. Gill, S. R., Schroer, T. A., Szilak, I., Steuer, E. R., Sheetz, M. P. and Cleveland, D. W. (1991). Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J. Cell Biol. 115, 1639-1650.
42. Gittes, F., Mickey, B., Nettleton, J. and Howard, J. (1993). Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape. J. Cell Biol. 120, 923-934.
43. Goldstein, B. (1995). Cell contacts orient some cell division axes in the Caenorhabditis elegans embryo. J. Cell Biol. 129, 1071-10780.
44. Grolig, F. (1998). Nuclear centering in Spirogyra: force integration by microfilaments along microtubules. Planta 204, 54-63.
45. Guild, G. M., Connelly, P. S., Shaw, M. K. and Tilney, L. G. (1997). Actin filament cables in Drosophila nurse cells are composed of modules that slide passively past one another during dumping. J. Cell Biol. 138, 783-797.
46. Hager, G., Dodt, H. U., Zieglgansberger, W. and Liesi, P. (1995). Novel forms of neuronal migration in the rat cerebellum. J. Neurosci Res. 40, 207-219.
47. Hamaguchi, M. S. and Hiramoto, Y. (1980). Fertilization process in the heart urchin (Clypeaster japonicus) observed with differential interference microscopy. Dev. Growth Differ. 22, 517-530.
48. Hamaguchi, M. S. and Hiramoto, Y. (1986). Analysis of the role of astral rays in pronuclear migration by the colcemid-UV method. Dev. Growth Differ. 28. 143-156.
49. Hattori, M., Adachi, H., Tsujimoto, M., Arai, H. and Inoue, K. (1994). Miller-Dicker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase. Nature 370, 216-218.
50. Hausen, P. and Riebessell, M. (1991). The early development of Xenopus laevis. pp. 142. Springer-Verlag, Berlin.
51. Heidemann, S. R. and Kirschner, M. W. (1975). Aster formation in eggs of Xenopus laevis. Induction by isolated basal bodies. J. Cell Biol. 67, 105-117.
52. Hill, T. L. and Kirschner, M. W. (1982). Bioenergetics and kinetics of microtubule and actin filament assembly-disassembly. Int. Rev. Cytol. 78, 1- 125.
53. Hiramoto, Y. (1970). Rheological properties of sea urchin eggs. Biorheology 6, 201-234.
54. Holleran, E. A., Karki, S. and Holzbaur, E. L. (1998). The role of the dynactin complex in intracellular motility. Int. Rev. Cytol. 182, 69-109.
55. Holy, J. and Schatten, G. (1991). Differential behavior of centrosomes in unequally dividing blastomeres during fourth cleavage of sea urchin embryos. J. Cell Sci. 98, 423-431.
56. Holy, T. E., Dogterom, M., Yurke, B. and Leibler, S. (1997). Assembly and positioning of microtubule asters in microfabricated chambers. Proc. Nat. Acad. Sci. USA 94, 6228-6231.
57. Hörstadius, S. (1928). Ueber die Determination des Keimes bei Echinodermen. Acta Zool. 9, 3-177.
58. Hyman, A. A. and White, J. G. (1987). Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans. J. Cell Biol. 105, 2123-2135.
59. Hyman, A. A. (1989). Centrosome movement in the early divisions of Caenorhabditis elegans: a cortical site determining centrosome position. J. Cell Biol. 109, 1185-1193.
60. Inoue, S. and Salmon, E. D. (1995). Force generation by microtubule assembly/disassembly in mitosis and related movements. Mol. Biol. Cell 6, 1619-1640.
61. Ishii, R. and Shimizu, T. (1997). Equalization of unequal first cleavage in the Tubifex egg by introduction of an additional centrosome: implications for the absence of cortical mechanisms for mitotic spindle asymmetry. Dev. Biol 189, 49-56.
62. Jennings, C. G. and Burden, S. J. (1993). Development of the neuromuscular synapse. Curr. Opin. Neurobiol. 3, 75-81.
63. Kachar, B. and Reese, T. S. (1988). The mechanism of cytoplasmic streaming in characean algal cells: sliding of endoplasmic reticulum along actin filaments. J. Cell Biol. 106, 1545-1552.
64. Kellogg, D. R., Moritz, M. and Alberts, B. M. (1994). The centrosome and cellular organization. Annu. Rev. Biochem. 63, 639-674.
65. Kelly, A. M. and Zacks, S. I. (1969). The fine structure of motor endplate morphogenesis. J. Cell Biol. 42, 154-169.
66. Klotz, C., Dabauvalle, M. C., Paintrand, M., Weber, T., Bornens, M. and Karsenti, E. (1990). Parthenogenesis in Xenopus eggs requires centrosomal integrity. J. Cell Biol. 110, 405-415.
67. Li, Y. Y., Yeh, E., Hays, T. and Bloom, K. (1993). Disruption of mitotic spindle orientation in a yeast dynein mutant. Proc. Nat. Acad. Sci. USA 90, 10096-10100.
68. Liesi, P. (1992). Neuronal migration on laminin involves neuronal contact formation followed by nuclear movement inside a preformed process. Exp. Neurol. 117, 103-113.
69. Lillie, F. R. (1909). Polarity and bilaterality of the annelid egg. Experiments with centrifugal force. Biol. Bull. 16, 54-79.
70. Lloyd, C. W., Pearce, K. J., Rawlins, D. J., Ridge, R. W. and Shaw, P. J. (1987). Endoplasmic microtubules connect the advancing nucleus to the tip of legume root hairs, but F-actin is involved in basipetal migration. Cell Motil. Cytoskel. 8, 27-36.
71. Lombillo, V. A., Stewart, R. J. and McIntosh, J. R. (1995). Minus-end-directed motion of kinesin-coated microspheres driven by microtubule depolymerization. Nature 373, 161-164.
72. Lutz, D. A., Hamaguchi, Y. and Inoue, S. (1988). Micromanipulation studies of the asymmetric positioning of the maturation spindle in Chaetopterus sp. oocytes: I. Anchorage of the spindle to the cortex and migration of a displaced spindle. Cell. Motil. Cytoskel. 11, 83-96.
73. MacRae, T. H. (1992). Microtubule organization by cross-linking and bundling proteins. Biochim. Biophys. Acta 1160, 145-155.
74. Mandelkow, E. and Mandelkow, E. M. (1995). Microtubules and microtubule-associated proteins. Curr. Opin. Cell Biol. 1, 72-81.
75. Manes, M. M. and Barbieri, F. D. (1977). On the possibility of sperm aster involvement in dorso-ventral polarization and pronuclear migration in the amphibian egg. J., Embryol. Exp. Morphol. 40, 187-197.
76. Maniotis, A. J., Chen, C. S. and Ingber, D. E. (1997). Demonstration of mechanical connections between integrins. cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc. Nat. Acad. Sci. USA 94. 849-854.
77. McGrail, M. and Hays, T. S. (1997). The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila. Development 124, 2409-2419.
78. MeIntosh, J. R. and Porter, M. E. (1989). Enzymes for microtubule- dependent motility. J. Biol. Chem. 264, 6001-6004.
79. McMillan, J. N. and Tatchell, K. (1994). The JNM1 gene in the yeast Saccharomyces cerevisiae is required for nuclear migration and spindle orientation during the mitotic cell cycle. J. Cell Biol. 125, 143-158.
80. Meindl, U., Zhang, D. and Hepler, P. K. (1994). Actin microfilaments are associated with the migrating nucleus and the cell cortex in the green alga Micrasterias. Studies on living cells. J. Cell Sci. 107, 1929-1934.
81. Micklem, D. K., Dasgupta, R., Elliott, H., Gergely, F., Davidson, C., Brand, A., Gonzalez, R. A. and St, J. D. (1997). The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila. Curr. Biol. 7, 468-478.
82. Miller, R. K. and Rose, M. D. (1998). Kar9p is a novel conical protein required for cytoplasmic microtubule orientation in yeast. J. Cell Biol. 140, 377-390.
83. Muhua, L., Karpova, T. S. and Cooper, J. A. (1994). A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration. Cell 78, 669-679.
84. Murray, A. W., Desai, A. B. and Salmon, E. D. (1996). Real time observation of anaphase in vitro. Proc. Nat. Acad. Sci. USA 93, 12327-12332.
85. Nothnagel, E. A. and Webb, W. W. (1982). Hydrodynamic models of viscous coupling between motile myosin and endoplasm in characean algae. J. Cell Biol. 94, 444-454.
86. Oakley, B. R. and Morris, N. R. (1980). Nuclear movement is beta-tubulin- dependent in Aspergillus nidulans. Cell 19, 255-262.
87. Palmer, R. E., Sullivan, D. S., Huffaker, T. and Koshland, D. (1992). Role of astral microtubules and actin in spindle orientation and migration in the budding yeast. Saccharomyces cerevisiae. J. Cell Biol. 119, 583-593.
88. Paschal, B. M. and Vallee, R. B. (1993). Microtubule and axoneme gliding assays for force production by microtubule motor proteins. Meth. Cell Biol. 39, 65-74.
89. Raff, J. W. and Glover, D. M. (1988). Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin. J. Cell Biol. 107, 2009-2019.
90. Reiner, O., Carrozzo, R., Shen, Y., Wehnert, M., Faustinella, F., Dobyns, W. B., Caskey, C. T. and Ledbettcr, D. H. (1993). Isolation of a Miller-Dicker lissencephaly gene containing G protein beta-subunit-like repeats. Nature 364, 717-721.
91. Reinsch, S. and Karsenti, E. (1994). Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells. J. Cell Biol. 126, 1509-1526.
92. Reinsch, S. and Karsenti, E. (1997). Movement of nuclei along microtubules in Xenopus egg extracts. Curr. Biol. 7, 211-214.
93. Rose, M. D. (1996). Nuclear fusion in the yeast Saccharomyces cerevisiae. Annu. Rev. Cell Dev. Biol. 12, 663-695.
94. Roth, S., Neu man, S. F., Barcelo, G. and Schupbach, T. (1995). cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila. Cell 81, 967- 978.
95. Rouviere, C., Houliston, E., Carre, D., Chang, P. and Sardet, C. (1994). Characteristics of pronuclear migration in Beroe ovata. Cell Motil. Cytoskel, 29, 301-311.
96. Sapir, T., Elbaum, M. and Reiner, O. (1997). Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. EMBO J. 16, 6977-6984.
97. Saunders, W., Hornack, D., Lengyel, V. and Deng, C. (1997). The Saccharomyces cerevisiae kinesin-related motor Kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules, J. Cell Biol. 137, 417-431.
98. Schatten, G. (1981). The movements and fusion of the pronuclei at fertilization of the sea urchin Lytechinus variegatus: time-lapse video microscopy. J. Morphol. 167, 231-247.
99. Schatten, G. and Schatten, H. (1981). Effects of motility inhibitors during sea urchin fertilization: microfilament inhibitors prevent sperm incorporation and restructuring of fertilized egg cortex, whereas microtubule inhibitors prevent pronuclear migrations. Exp. Cell Res. 135, 311-330.
100. Schatten, G. (1982). Motility during fertilization. Int. Rev. Cytol 79, 59-163.
101. Schatten, G. (1994). The centrosome and its mode of inheritance: the reduction of the centrosome during gametogenesis and its restoration during fertilization. Dev. Biol. 165, 299-335.
102. Shaw, S. L., Yen, E., Maddox, P., Salmon, E. D. and Bloom, K. (1997). Astral microtubule dynamics in yeast: a microtubule-based searching mechanism for spindle orientation and nuclear migration into the bud. J. Cell Biol 139, 985-994.
103. Singal, P. K. and Sanders, E. J. (1974). Cytomembranes in first cleavage Xenopus embryos. Interrelationship between Golgi bodies, endoplasmic reticulum and lipid droplets. Cell Tissue Res. 154, 189-209.
104. Snyder, M. (1994). The spindle pole body of yeast. Chromosoma 103, 369- 380.
105. Stearns, T. (1997). Motoring to the finish: kinesin and dynein work together to orient the yeast mitotic spindle. J. Cell Biol. 138, 957-960.
106. Stewart-Savage, J. and Grey, R. D. (1982). The temporal and spatial relationships between cortical contraction, sperm trail formation, and pronuclear migration in fertilized Xenopus eggs. Wilhelm Roux's Archives 191, 241-245.
107. Strome, S. and Hill, D. P. (1988). Early embryogenesis in Caenorhabditis elegans: the cytoskeleton and spatial organization of the zygote. BioEssays 8, 145-149.
108. Subtelny, S. and Bradt, C. (1963). Cytological observations on the early developmental stages of activated Rana pipens eggs receiving a transplanted blastula nucleus. J. Morphol. 112, 45-59.
109. Swope, R. E. and Kropf, D. L. (1993). Pronuclear positioning and migration during fertilization in Pelvetia. Dev. Biol. 157, 269-276.
110. Tassin, A. M., Maro, B. and Bornens, M. (1985). Fate of microtubule- organizing centers during myogenesis in vitro. J. Cell Biol. 100, 35-46.
111. Terasaki, M. and Jaffe, L. A. (1991). Organization of the sea urchin egg endoplasmic reticulum and its reorganization at fertilization. J. Cell Biol. 114, 929-940.
112. Theurkauf, W. E., Smiley, S., Wong, M. L. and Alberts, B. M. (1992). Reorganization of the cytoskeleton during Drosophila oogenesis: implications for axis specification and intercellular transport. Development 115, 923-936.
113. Theurkauf, W. E., Alberts, B. M., Jan, Y. N. and Jongens, T. A. (1993). A central role for microtubules in the differentiation of Drosophila oocytes. Development 118, 1169-1180.
114. Theurkauf, W. E. (1994). Microtubules and cytoplasm organization during Drosophila oogenesis. Dev. Biol. 165, 352-360.
115. Thorpe, C. J., Schlesinger, A., Carter, J. C. and Bowerman, B. (1997). Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm. Cell 90, 695-705.
116. Tournebize, R., Andersen, S. S., Verde, F., Doree, M., Karsenti, E. and Hyman, A. A. (1997). Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis. EMBO J. 16, 5537-5549.
117. von Dassow, G. and Schubiger, G. (1994). How an actin network might cause fountain streaming and nuclear migration in the syncytial Drosophila embryo. J. Cell Biol. 127, 1637-1653.
118. Waddle, J. A., Cooper, J. A. and Waterston, R. H. (1994). Transient localized accumulation of actin in Caenorhabditis elegans blastomeres with oriented asymmetric divisions. Development 120, 2317-2328.
119. Walczak, C. E., Mitchison, T. J. and Desai, A. (1996). XKCM1 : a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell 84, 37-47.
120. Waters, J. C., Cole, R. W. and Rieder, C. L. (1993). The force-producing mechanism for centrosome separation during spindle formation in vertebrates is intrinsic to each aster. J. Cell Biol. 122, 361-372.
121. Willins, D. A., Liu, B., Xiang, X. and Morris, N. R. (1997). Mutations in the heavy chain of cytoplasmic dynein suppress the nudF nuclear migration mutation of Aspergillus nidulans. Mol. Gen. Genet. 255, 194-200.
122. Wilson, E. B. (1901). Some phenomena of fertilization and cell-division in etherized eggs. Arch. EntwMech. Org. 13, 353-373.
123. Wilson, E. B. (1928). The Cell in Development and Heredity, pp. 377. MacMillan Publishing Co.
124. Xiang, X., Osmani, A. H., Osmani, S. A., Roghi, C. H., Willins, D. A., Beckwith, S., Goldman, G., Chiu, Y., Xin, M., Liu, B., et al. (1995a). Analysis of nuclear migration in Aspergillus nidulans. Cold Spring Harbor Symp. Quant. Biol. 60, 813-819.
125. Xiang, X., Osmani, A. H., Osmani, S. A., Xin, M. and Morris, N. R. (1995b). NudF. a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration. Mol. Biol. Cell. 6, 297-310.
126. Yeh, E., Skibbens, R. V., Cheng, J. W., Salmon, E. D. and Bloom, K. (1995). Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomvces cerevisiae. J. Cell Biol. 130, 687-700.