Specific K-ras2 mutations in human sporadic colorectal adenomas are associated with DNA near-diploid aneuploidy and inhibition of proliferation

American Journal of Pathology

Volumn 153, Issue 4, 1998, Pages 1201-1209

  Giaretti, Walter ^a,c   Rapallo, Anna ^a   Geido, Elio ^a   Sciutto, Andrea ^a   Merlo, Franco ^a   Risio, Mauro ^b   Rossini, Francesco P ^b  

^a CANDIOLO CANCER INSTITUTE   (Italy)

^b Ospedale S Giovanni Vecchio   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; RAS PROTEIN;

ADULT; AGED; ANEUPLOIDY; ARTICLE; CELL PROLIFERATION; COLON ADENOMA; FEMALE; FLOW CYTOMETRY; GENETIC STABILITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN INTERACTION; REGRESSION ANALYSIS;

EID: 0031715339     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65664-7     Document Type: Article

References (74)

1. Bos JL, Fearon EL, Hamilton SR, Verlaan de Vries M, van Boom JH, Van der Eb AJ, Vogelstein B: Prevalence of ras gene mutations in human colorectal cancers. Nature 1987, 327:293-297
2. Barbacid M: ras genes. Annu Rev Biochem 1987, 56:779-827
3. Bollag G, McCormick F: Regulators and effectors of ras proteins. Annu Rev Cell Biol 1991, 7:601-632
4. Aktas H, Cai H, Cooper GM: Ras links growth factor signaling to cell cycle machinery via regulation of cyclin D1 and the CdK inhibitor p27 KIP1. Mol Cell Biol 1997, 17:3850-3857
5. Arber N, Hibshoosh H, Moss SF, Sutter T, Zhang Y, Begg M, Wang S, Weinstein B, Holt PR: Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology 1996, 110:669-674
6. INK4. Science 1995, 267:249-252
7. Khosravi-Far R, Campbell S, Rossman KL, Der CJ: Increasing complexity of Ras signal transduction: involvement of Rho family proteins. Adv Cancer Res 1998, 72:57-107
8. Bedi A, Pasricha PJ, Akhtar AJ, Barber JP, Bedi GC, Giardiello FM, Zehnbauer BA, Hamilton SR, Jones RJ: Inhibition of apoptosis during development of colorectal cancer. Cancer Res 1995, 55:1811-1816
9. Jimenez B, Arends M, Esteve P, Perona R, Sanchez R, Ramon y Cajal S, Wyllie A, Lacal JC: Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of rho-p21, a GTPase protein of the ras superfamily. Oncogene 1995, 10:811-816
10. Ward RL, Todd AV, Santiago F, O'Connor T, Hawkins N: Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis. Cancer 1997, 79:1106-1113
11. Chen CY, Faller DV: Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene 1995, 11:1487-1498
12. Hall A: Small GTP-binding proteins, and the regulation of the actin cytoskeleton. Annu Rev Cell Biol 1994, 10:31-54
13. Nobes CD, Hall A: Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995, 81:53-62
14. Hagag N, Diamond L, Palermo R, Lyubsky S: High expression of ras p21 correlates with increased rate of abnormal mitosis in NIH3T3 cells. Oncogene 1990, 5:1481-1489
15. Nigro S, Geido E, Infusini E, Orecchia R, Giaretti W: Transfection of human mutated K-ras in mouse NIH-3T3 cells is associated with increased cloning efficiency and DNA aneupioidization. Int J Cancer 1996, 67:871-875
16. Mello MLS, Lin TY, Russo J: Scanning microphotometry image analysis of Ha-ras-transformed human breast epithelial cells. Anal Cell Pathol 1994, 7:301-319
17. Aldaz CM, Conti CJ, Klein-Szanto AJP, Slaga TJ: Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy. Proc Natl Acad Sci USA 1987, 84:2029-2032
18. Quintanilla M, Brown K, Ramsden M, Balmain A: Carcinogen specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 1986, 322:78-80
19. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767
20. Vogelstein B, Fearon ER, Hamilton SR, Kern, Preisinger AC, Leppert BAM, Nakamura Y, White R, Smits AMM, Bos JL: Genetic alterations during colorectal-tumor development. New Engl J Med 1988, 319: 525-532
21. Hasegawa H, Ueda M, Watanabe M, Teramoto T, Mukai M, Kitajima M: K-ras gene mutations in early colorectal cancer: flat elevated vs polyp-forming cancer. Oncogene 1995, 10:1413-1416
22. Giaretti W, Pujic N, Rapallo A, Nigro S, Di Vinci A, Geido E, Risio M: K-ras2 G-C, and G-T transversions correlate with DNA aneuploidy in colorectal adenomas. Gastroenterology 1995, 108:1040-1047
23. Burmer GC, Loeb LA: Mutations in the K-ras2 oncogene during progressive stages of human colon carcinoma. Proc Natl Acad Sci USA 1989, 86:2403-2407
24. Van den Ingh HF, Griffioen G, Cornelisse CJ: Flow cytometric detection of aneuploidy in colorectal adenomas. Cancer Res 1985, 45: 3392-3397
25. Giaretti W, Sciallero S, Bruno S, Geido E, Aste H, Di Vinci A: DNA flow cytometry of endoscopically examined colorectal adenomas and adenocarcinomas. Cytometry 1988, 9:238-244
26. Giaretti W, Santi L: Tumor progression by DNA flow cytometry in human colorectal cancer. Int J Cancer 1990, 45:597-603
27. Giaretti W: A model of DNA aneuploidization and evolution in colorectal cancer. Lab Invest 1994, 71:904-910
28. Yamashita N, Minamoto T, Ochiai A, Onda M, Esumi H: Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon. Gastroenterology 1995, 108:434-440
29. Otori K, Sugijama K, Hasebe T, Fukushima S, Esumi H: Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation. Cancer Res 1995, 55:4743-4746
30. Pretlow PT: Aberrant crypt foci and K-ras mutations: early recognized players or innocent bystanders in colorectal carcinogenesis? Gastroenterology 1995, 108:600-603
31. Jass JR, Sobin LH: Histological typing of intestinal tumors. WHO International Histological Classification of Tumors. Berlin, Springer-Verlag, 1989
32. Santos E, Martin-Zanca D, Reddy EP, Pierotti MA, Della Porta G, Barbacid M: Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science 1984, 223:661-664
33. Verlaan-de-Vries M, Bogaard ME, van del Elst H, van Boom JH, van der Eb AJ, Bos JL: A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides. Gene 1986, 50: 313-320
34. Current Protocols in Molecular Biology. New York, John Wiley & Sons, 1988
35. Burmer GC, Rabinovitch PS, Haggit RC, Crispin DA, Brentnall TA, Kolli VR, Stevens AC, Rubin CE: Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele. Gastroenterology 1992, 103:1602-1610
36. Fleiss JL: Statistical Methods for Rates and Proportions, ed 2. New York, John Wiley & Sons, 1981
37. Kleinbaum DG: Logistic Regression. New York, Springer-Verlag, 1994
38. SPSS Professional Statistics, version 7.5. Chicago, SPSS Inc., 1997
39. Hartwell L, Kastan MB: Cell cycle control and cancer. Science 1994, 266:1821-1828
40. Rubio CA: Atypical mitosis in colorectal adenomas. Pathol Res Pract 1991, 187:508-513
41. Giaretti W, Monaco R, Pujic N, Rapallo A, Nigro S, Geido E: Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas. Am J Pathol 1996, 149:237-245
42. Barton NR, Goldstein LSB: Going mobile: microtubule motors and chromosome segregation. Proc Natl Acad Sci USA 1996, 93:1735-1742
43. Marra G, Boland CR: Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J Natl Cancer Inst 1995, 87:114-1125
44. Lengauer C, Kinzler KW, Vogelstein B: Genetic instability in colorectal cancer. Nature 1992, 386:623-626
45. Di Vinci A, Infusini E, Peveri C, Risio M, Rossini FP, Giaretti W: Deletions at chromosome 1p by fluorescence in situ hybridization are an early event in human colorectal tumorigenesis. Gastroenterology 1996, 111:102-107
46. Di Vinci A, Infusini E, Peveri C, Sciutto A, Geido E, Risio M, Rossini FP, Giaretti W: Correlation between 1p deletions and aneusomy in human colorectal adenomas. Int J Cancer 1998, 75:45-50
47. Ried T, Knutzen R, Steinbeck R, Biegen H, Schrock E, Heselmeyer K, du Manoir S, Auer G: Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosomes Cancer 1996, 15:1-5
48. Houldsworth J, Chaganti RSK: Comparative genomic hybridization: an overview. Am J Pathol 1994, 145:1253-1260
49. Bardi G, Pandis N, Fenger C, Kronborg O, Bomme L, Heim S: Deletion of 1p36 as a primary chromosomal aberration in intestinal tumorigenesis. Cancer Res 1993, 53:1895-1898
50. Bomme L, Bardi G, Pandis N, Fenger C, Kronborg O, Heim S: Clonal karyotypic abnormalities in colorectal adenomas: clues to the early genetic events in the adenoma-carcinoma sequence. Genes Chromosomes Cancer 1994, 10:190-196
51. Glenny RW, Robertson HT: Fractal modeling of pulmonary blood flow heterogeneity. J Appl Physiol 1991, 70:1024-1030
52. Hammarberg C, Tribukait B, Rubio C, Slezak P: Application clinique de la citométrie de flux de l'ADN à la caractérisation des polypes colorectaux. Acta Endoscopica 1985, 15:265-274
53. Bauer KD, Bagwell CB, Giaretti W, Melamed M, Zarbo RJ, Witzig TE, Rabinovitch PS: Consensus review of the clinical utility of DNA flow cytometry in colorectal cancer. Cytometry 1993, 14:486-491
54. Rabinovitch PS, Reid BJ, Haggit RC, Norwood TH, Rubin CE: Progression to cancer in Barrett's esophagus is associated with genomic instability. Lab Invest 1988, 60:65-71
55. Reid BJ, Sanchez CA, Blount PL, Levine DS: Barrett's esophagus: cell cycle abnormalities in advancing stages of neoplastic progression. Gastroenterology 1993, 105:119-129
56. Giaretti W: Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus: is there a role for K-ras and p53 mutations? Anal Cell Pathol 1997, 15:99-117
57. Shackney SE, Smith CA, Miller BW, Burholt DR, Murtha K, Giles HR, Ketter, DM, Pollice AA: Model for the genetic evolution of human solid tumors. Cancer Res 1989, 49:3344-3354
58. Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL, Raskind WH, Reid BJ: A p53-dependent mouse spindle check-point. Science 1995, 267:1353-1356
59. Fukasawa K, Taesaeng C, Kuriyama R, Rulong S, Vande Woude GF: Abnormal centrosome amplification in the absence of p53. Science 1996, 271:1744-1747
60. Baker SJ, Preisinger AC, Jessup JM, Paraskeva C, Markowitz S, Willson JK, Hamilton S, Vogelstein B: p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 1990, 50:7717-7722
61. McCormick F: ras GTPase activating protein: signal transmitter and signal terminator. Cell 1989, 56:5-8
62. Krengel U, Schlichting I, Scherer A, Schumann R, Frech M, John J, Kabsch W, Pai EF, Wittinghofer A: Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell 1990, 62:539-548
63. Bos JL: p21ras: an oncoprotein functioning in growth factor-induced signal transduction. Eur J Cancer 1995, 31A:1051-1054
64. Loeb LA: Endogenous carcinogenesis: molecular oncology into the twenty-first century (presidential address). Cancer Res 1989, 49: 5489-5496
65. Bos JL: Ras oncogenes in human cancer: a review. Cancer Res 1989, 49:4682-4689
66. Topal MD: DNA repair, oncogenes, and carcinogenesis. Carcinogenesis 1988, 9:691-696
67. Capella G, Cronauer-Mitra S, Peinado MA, Perucho M: Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect 1991, 93:125-131
68. Vousden KH, Bos JL, Marshall CJ, Phillips DH: Mutations activating human c-Ha-ras1 proto-oncogene (Hras1) induced by chemical carcinogens and depurination. Proc Natl Acad Sci USA 1986, 83:1222-1226
69. Brown K, Buchmann A, Balmain A: Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression. Proc Natl Acad Sci USA 1990, 87:538-542
70. Urosevic N, Krtolica K, Skaro-Milic A, Knezevic-Usaj S, Dujic A: Prevalence of G-to-T transversions among K-ras oncogene mutations in human colorectal tumors in Yugoslavia. Int J Cancer 1993, 54:249-254
71. Kinzler WK, Vogelstein B: Lessons from hereditary colorectal cancer. Cell 1996, 87:159-170
72. Tsao JI, Shibata D: Further evidence that one of the earliest alterations in colorectal carcinogenesis involves APC. Am J Pathol 1994, 145:531-534
73. Kouri M, Laasonen A, Mecklin JP, Järvinen H, Franssila K, Pyrhönen S: Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry. Cancer 1990, 65:1825-1829
74. DuBois RN: Nonsteroidal anti-inflammatory drug use and sporadic colorectal adenomas. Gastroenterology 1995, 108:1310-1314