Nucleotides in infant nutrition

Monatsschrift fur Kinderheilkunde

Volumn 146, Issue 8 SUPPL. 1, 1998, Pages

  Boza, J ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Human milk; Infant nutrition; Nucleotides; Purines; Pyrimidines

Indexed keywords

NUCLEOTIDE; PURINE; PYRIMIDINE; RNA;

ARTIFICIAL MILK; BREAST MILK; CHILD GROWTH; CONFERENCE PAPER; DIGESTION; HUMAN; IMMUNE SYSTEM; INFANT; INFANT NUTRITION; INTESTINE FLORA; INTESTINE INJURY; LIPID METABOLISM; LIVER METABOLISM; LOW BIRTH WEIGHT; NONHUMAN; NUCLEOTIDE METABOLISM; NUTRIENT; STRESS;

EID: 0031709834     PISSN: 00269298     EISSN: None     Source Type: Journal    
DOI: 10.1007/pl00014765     Document Type: Conference Paper

References (68)

1. Carver JD, Walker WA (1995) The role of nucleotides in human nutrition. J Nutr Biochem 6:58-72
2. Rudolph FB (1994) The biochemistry and physiology of nucleotides. J Nutr 124:1245-1275
3. Uauy R (1989) Dietary nucleotides and requirements in early life. Ir., Lebenthal E (ed) Textbook of gastroenterology and nutrition in infancy. Raven, New York, pp 265-280
4. Quan R, Barness LA, Uauy R (1990) Do infants need nucleotide supplemented formula for optimal nutrition? J Pediatr Gastroenterol Nutr 11:429-437
5. Uauy R, Quan R, Gil A (1994) Role of nucleotides in intestinal development and repair: implications for infant nutrition. J Nutr 124:1436S-1441S
6. Jarvis SM (1989) Characterisation of sodium-dependent nucleoside transport in rabbit intestinal brush-border membrane vesides. Biochim Biophys Acta 979:132-133
7. Savaiano DA, Clifford AJ (1978) Absorption, tissue incorporation and excretion of free purine bases in rats. Nutr Reports Intern 17:551-556
8. Sonoda T, Tatibana M (1978) Metabolic fate of pyrimidines and purines ingested by mice. Biochim Biophys Acta 521:55-66
9. Savaiano DA, Ho CY, Chu V, Gifford AJ (1980) Metabolism of orally and intravenously administered purine in rats. J Nutr 110:1793-1804
10. Simmonds AH, Hatfield PJ, Cameron SJ, Jones AS, Cadenhead A (1973) Metabolic studies of purine metabolism in the pig during the oral administration of guanine and allopurinol. Biochem Pharmacol 22:2537-2552
11. Simmonds AH, Rising TJ, Cadenhead A, Hatfield PJ, Jones AS, Cameron SJ (1973) Radioisotope studies of purine metabolism during administration of guanine and allopurinol in the pig. Biochem Pharmacol 22:2553-2563
12. Gil A, Uauy R (1990) Dietary nucleotides and infant nutrition. J Clin Nutr Gastroenterol 4:145-153
13. Uauy R, Quan R, Gil A (1996) Nucleotides in infant nutrition. In. Gil A, Uauy R (eds) Nutritional and biological significance of dietary nucleotides and nucleic acids. Abbott Laboratories, Granada, Spain, pp 169-180
14. He Y, Sanderson IR, Walker WA (1994) Uptake, transport and metabolism of exogenous nucleosides in intestinal epithelial cell cultures. J Nutr 124:1942-1949
15. Berthold HK, Crain PF, Goun I, Reeds PJ, Klein PD (1995) Evidence for incorporation of intact dietary pyrimidine (but not purine) nucleosides into hepatic RNA. Proc Nat Acad Sci USA 92 10123-10127
16. Boza JJ, Jahoor F, Reeds PJ (1996) Ribonucleic acid nucleotides in maternal and fetal tissues derive almost exclusively from synthesis de novo in pregnant mice. J Nutr 126:1749-1758
17. Grimble GK (1993) Essential and conditionally essential nutrients in clinical nutrition. Nutr Res Rev 6:97-119
18. Uauy R, Stringel G, Thomas R, Quan R (1990) Effect of dietary nucleosides on growth and maturation of the developing gut in the rat J Pediatr Gastroenterol Nutr 10:497-503
19. Ortega MA, Gil A, Sanchez-Pozo A (1995) Maturation status of smalll intestine epithelium in rats deprived of dietary nucleotides. Life Sci 56:1623-1630
20. Quan R, Gil A, Uauy R (1991) Effect of dietary nucleosides on intestinal growth and maturation after injury from radiation. Pediatr Res 29:111
21. Nuñez MC, Ayudarte MV, Morales D, Suerez MD, Gil A (1990) Effect of dietary nucleotides on intestinal repair in rats with experimental chronic diarrhoea. J Parenter Enteral Nutr 14:598-604
22. Ortega MC, Nuñez MC, Gil A, Sanchez-Pozo A (1995) Dietary nucleotides accelerate intestinal recovery after food deprivation in old rats. J Nutr 125:1413-1418
23. Iijima S, Tsujinaka T, Kido Y, Hayashida Y, Ishida H, Homma T, Yokoyama H, Mon S (1993) Intravenous administration of nucleosides and a nucleotide mixture diminishes intestinal mucosal athrophy induced by total parenteral nutrition. J Parenter Enteral Nutr 17:265-270
24. Tsujinaka T, Iijima S, Kido Y, Homma T, Ebisui C, Kan K, Imamura I, Fukui H, Mori T (1993) Role of nucleosides and nucleotide mixture in intestinal mucosal growth under total parenteral nutrition. Nutrition 9:532-525
25. Gil A, Corral E, Martinez-Valverde A, Molina JA (1986) Effects of the addition of nucleotides to an adapted milk formula on the microbial pattern of feces in at term newborn infants. J Clin Nutr Gastroenterol 1:127-132
26. Balmer SE, Hanvey LS, Wharton BA (1994) Diet and faecal flora in the newborn: nucleotides. Arch Dis Child 70:137-140
27. Novak DA, Carver JD, Barness LA (1994) Dietary nucleotides affect hepatic growth and composition in the weanling mouse. J Parenter Enteral Nutr 18:62-66
28. Lopez-Navarro AT, Onega MA, Peragon J, Gil A, Sanchez-Pozo A (1996) Deprivation of dietary nucleotides decreases protein synthesis in the liver and the small intestine in rats. Gastroenterology 110:1760-1769
29. Ogoshi S, Iwasa M, Kitagawa S, Ohmori Y, Mizobuchi S, Iwasa Y, Tamiya T (1988) Effects of total parenteral nutrition with nucleoside and nucleotide mixture on D-galactosamine-induced liver injury in rats. J Parenter Enteral Nutr 12:53-57
30. Ogoshi S, Iwasa M, Yonezawa T, Tamiya T (1985) Effect of nucleotide and nucleoside mixture on rats given total parenteral nutrition after 70% hepatectomy. J Parenter Enteral Nutr 9:339-342
31. Boza J, Jimenez J, Faus MJ, Gil A (1992) Influences of postnatal age and dietary nucleotides on plasma fatty acids in the weanling rat. J Parenter Enteral Nutr 16-322-326
32. Nuñez MC, Ayudarte MV, Gil A, Suarez MD (1993) Effect of dietary nucleotides on the fatty acid composition of rat liver microsomes. Arch Int Physiol Biochim Biophys 101:123-128
33. Pita ML, Fernandez MR, DeLucchi C, Medina A, Martinez-Valverde A, Uauy R, Gil A (1988) Changes in the fatty acids pattern of red blood cell phospholipids induced by type of milk, dietary nucleotide supplementation, and postnatal age in preterm infants. J Pediatr Gastroenterol Nutr 7:740-747
34. Woltil HA, van Busekom CM, Siemensma AD, Polman HA, Muskiet, F, Okken A (1995) Erythrocyte and plasma cholesterol ester long-chain polyunsaturated fatty acids of low birth-weight babies fed preterm formula with and without ribonucleotides: comparison with human milk. Am J Clin Nutr 62:943-949
35. Henderson TR, Hamosh M, Mehta NR, Angelus PA, Hamosh P (1994) Red blood cell (RBS) phospholipid (PL) docosahexaenoic acid (DHA) and arachidonic acid (AA) concentrations in very low birth weight (VLBW) infants are not affected by nucleotide supplementation (NS) of PREEMIE formula (F) and are lower than in mother's own milk (MOM) fed infants. Pediatr Res 35:313A
36. Axeisson I, Flodmark CE, Raiha N, Tacconi M, Visentin M, Minoli I, Moro G, Warm A (1997) The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants. Acta Paediatr 86:539-544
37. De Lucch C, Pita ML, Faus MJ, Uauy R, Gil A (1987) Effects of dietary nucleotides on the fatty acid composition of erythrocyte membrane lipids interm infants. J Pediatr Gastroenterol Nutr 6:568-574
38. Gil A, Lozano E, De Lucchi C, Maldonado J, Molina JA, Pita ML (1988) Changes in the fatty acid profiles of plasma lipid fractions induced by dietary nucleotides in infants born at term. Eur J Clin Nutr 42:473-481
39. Barankiewicz J, Cohen A (1987) Purine nucleotide metabolism in phytohemag-glutinin-induced human T lymphocytes. Arch Biochem Biophys 258:167-175
40. Rudolph FB, Kulkarni AD, Fanslow WC, Pizzini RP, Kumar S, Van Buren CT (1990) Role of RNA as a dietary source of pyrimidines and purines in immune function. Nutrition 6:45-52
41. Van Buren CT, Kulkarni Ad, Schandle CV (1983) The influence of dietary nucleotides on cell mediated immunity. Transplantation 36:350-352
42. Van Buren CT, Kulkarni AD, Fanslow WC (1985) Dietary nucleotides, a requirement for helper/inducer T lymphocytes. Transplantation 40:694-597
43. Pizzini RP, Kumar S, Kulkarni AD, Rudolph FB, Van Buren CT (1990) Dietary nucleotides reverse malnutrition and starvation-induced immunosuppresion. Arch Surg 125:86-90
44. Kulkarni AD, Fanslow WC, Rudolph FB, Van Buren CT (1987) Modulation of delayed hypersensitivity in mice by dietary nucleotide restriction. Transplantation 44:847-849
45. Yamauchi Y, Adjei AA, Ameho CK, Chan YC, Kulkarni AD, Sato S, Okamoto K, Yamamoto S (1996) A nucleotide-nucleoside mixture and its components increase lymphoproliferative and delayed hypersensitivity responses in mice. J Nutr 126:1571-1517
46. Carver JD, Cox WI, Barness LA (1990) Dietary nucleotide effects upon murine natural killer cell activity and macrophage activation. J Parenter Enteral Nutr 14:18-22
47. Pengnon JL, Bories DM, Houilier AM, Thuillier L, Cartier PH (1987) Metabolism of pyrimidine bases and nucleosides by pyrimidine-nucleoside phosphorylases in cultured human lymphoid cells. Biochim Biophys Acta 928:130-136
48. Fanslow WC, Kulkarni AD, Van Buren CT, Rudolph FB (1988) Effect of nucleotide restriction and supplementation on resistance to experimental candidiasis. J Parenter Enteral Nutr 12:49-52
49. Adjei AA, Takamne F, Yokoyama H, Shiokawa K, Matsumoto Y, Asato L, Shmjo S, Imamura T, Yamamoto S (1993) The effects of oral RNA and intraperitoneal nucleoside-nucleotide administration on methicillin-resistant Staphylococcus aureus infection in mice. J Parenter Enteral Nutr 17:148-152
50. Adjei AA, Yamauchi K, Chan YC, Konishi M, Yamamoto S (1996) Comparative effects of dietary nucleoside-nucleotide mixture and its components on endotoxin induced bacterial translocation and small intestinal injury in protein deficient mice. Gut 38 531-537
51. Adjei AA, Monoka T, Ameho CK, Yamauchi K, Kulkarni AD, AL-Mansouri HMSH, Kawajiri A, Yamamoto S (1996) Nucleoside-nucleotide free diet protects rat colonic mucosa from damage induced by trinitrobenzene sulphonic acid. Gut 39 428-433
52. Jyonouchi H, Sun S (1996) An orally supplemented mononucleotide mixture prevents the decrease in T-cell-dependent humoral immunity in C57BL/6 mice fed a nucleotide-free diet. J Nutr 126:1586-1593
53. Jyonouchi H, Hill RJ, Voss RM, Ishit E (1993) Immunomodulating actions of RNA and nucleotides on murine lymphocytes in vitro: augmentation of antibody production to T-dependent antigens on expansion of T-helper cells. J Nutr Immunol 2:5-24
54. Jyonouchi H, Zhang-Shanbhag L, Georgieff M, Tomita Y (1993) Immunomodulating actions of nucleotides: enhancement of immunoglobulin production by human cord blood lymphocytes. Pediatr Res 34:565-571
55. Carver JD, Pimentel B, Cox WI, Barness LA (1991) Dietary nucleotide effects upon immune function in infants. Pediatrics 88:359-363
56. Pickering LK, Granoff DM, Erickson J, Masor ML, Hilly MD (1995) Dietary modulation of the immune system by human milk and infant formula containing human milk levels of nucleotides. Pediatr Res 37:131A
57. Martinez-Augustin O, Boza JJ, Del Pino JI, Lucena J, Martinez-Valverde A, Gil A (1997) Dietary nucleotides might influence the humoral immune response against cow's milk proteins in preterm neonates. Biol Nieonate 71:215-223
58. Martinez-Augustin O, Boza JJ, Navarro J, Martinez-Valverde A, Araya M, Gil A (1997) Dietary nucleotides may influence the humoral immunity in immunocompromised children. Nutrition 13:465-469
59. Gil A, Sanchez de Medina F (1981) Acid-soluble nucleotides of human milk at different stages of lactation. J Dairy Res 49:301-307
60. Janas LM, Picciano MF (1982) The nucleotide profile of human milk. Pediatr Res 16 559-662
61. Durschlag RP, Robinson JL (1980) Species specificity in the metabolic consequences of orotic acid consumption. J Nutr 110.822-828
62. Harden KK, Robinson JL (1984) Hypocholerestemia induced by orotic acid: dietary effects and spedes specificity. J Nutr 114:411-421
63. Donovan, Lonnerdal B (1989) Non-protein nitrogen and true protein in infant formulas. Acta Paediatr Scand 78:497-504
64. Carlson SE (1985) Human milk non-protein nitrogen: occurrence and possible functions. Adv Pediatr 32:43-70
65. Hamosh M (1997) Introduction: should infant formulas be supplemented with bioactive components and conditionally essential nutrients present in human milk? J Nutr 127:971S-974S
66. Leach JL, Baxter JH, Molitor BE, Ramstack MB, Masor ML (1995) Total potentially available nucleosides of human milk by stage of lactation. Am J Clin Nutr 61:1224-1230
67. Thorell L, Sjoberg LB, Hernell O (1996) Nucleotides in human milk: sources and metabolism by the newborn infant. Pediatr Res 40 84S-852
68. Reecs PJ, Berthoid HK, Boza JJ, Burrin DG, Jahoor F, Jaksic T, Klein PD, Keshen T, Miller R, Stoll B, Wykes U (1997) Integration of amino acid and carbon intermediary metabolism: studies with uniformly labelled tracers and mass isotopomer analysis. Eur J Pediatr 156:S50-S58