Genetic instability in radiation-induced leukaemias: Mouse models

International Journal of Radiation Biology

Volumn 74, Issue 6, 1998, Pages 711-720

  Plumb, M ^a   Cleary, H ^a   Wright, E ^a  

^a MRC Radialion Genome Stability U   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME ABERRATION; CONTROLLED STUDY; GENE DELETION; GENE INACTIVATION; GENE MUTATION; GENETIC STABILITY; IONIZING RADIATION; LEUKEMIA; LEUKEMOGENESIS; MICROSATELLITE INSTABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION INJURY; TANDEM REPEAT; TUMOR SUPPRESSOR GENE; Y CHROMOSOME;

ANIMALIA;

EID: 0031704335     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530098140989     Document Type: Article

References (69)

1. ALEXANDER, B. J., RASKO, J. E. J., MORAHAN, G. and COOK, W. D., 1995, Gene deletion explains both in vivo and in vitro generated chromosome 2 aberrations associated with murine myeloid leukaemia. Leukemia, 9, 2009-2015.
2. ALVAREZ, L., EVANS, J. W., WILKS, R., LUCAS, J. N., BROWN, J. M. and GIACCIA, A. J., 1993, Chromosomal radiosensitivity at intrachromosomal telomeric sites. Genes Chromosomes and Cancer, 8, 8-14.
3. BAN, N., KAI, M. and KUSAMA, T., 1997, Chromosome aberrations in bone marrow cells of C3H/He mice at an early stage after whole-body irradiation. Journal of Radiation Research, 38, 219-231.
4. BARLOW, C., HIROTSUNE, S., PAYLOR, R., LIYANAGE, M., ECKHAUS, M., COLLINS, F., SHILOH, Y., CRAWLEY, J. N., RIED, T., TAGLE, D. and WYNSHAW-BORIS, A., 1996, Atm-deficient mice: a paradigm of Ataxia Telangiectasia. Cell, 86, 159-171.
5. BARR, F. G., 1996, The malevolence of matchmaking. Nature Genetics, 12, 113-114.
6. BOIS, P., WILLIAMSON, J., BROWN, J., DUBROVA, Y. E. and JEFFREYS, A. J., 1998, A novel unstable mouse VNTR family expanded frome SINE B1 elements. Genomics, 49, 122-128.
7. BOUFFLER, S. D, BRECKON, G. and COX, R., 1996b, Chromosomal mechanisms in murine radiation acute myeloid leukaemogenesis. Carcinogenesis, 17, 655-659.
8. BOUFFLER, S. D., MEIJNE, E. I. M., HUISKAMP, R. and COX, R., 1996a, Chromosomal abnormalities in neutron-induced acute myeloid leukaemias in CBA/H mice. Radiation Research, 146, 349-352.
9. BOUFFLER, S. D., MEIJNE, E. I. M., MORRIS, D. J. and PAPWORTH, D., 1997, Chromosome 2 hypersensitivity and clonal development in murine radiation acute myeloid leukaemia. International Journal of Radiation Biology, 72, 181-189.
10. BOUFFLER, S., SILVER, A., PAPWORTH D., COATES, J. and COX, R., 1993, Murine radiation myeloid leukameogenesis: relationship between interstitial telomere-like sequences and chromosome 2 fragile sites. Genes Chromosomes and Cancer, 6, 98-106.
11. BRADLEY, W. E. C., BELOUCHI, A. and MESSING, K., 1988, The aprt heterozygote/hemizygote system for screening mutagenic agents allows detection of large deletions. Mutation Research, 199, 131-138.
12. BRECKON, C., PAPWORTH, D. and COX, R., 1991, Murine radiation myeloid leukaemogenesis: a possible role for radiation-sensitive sites on chromosome 2. Genes Chromosomes and Cancer, 3, 367-375.
13. BREIMER, L. H., NALBANTOGLU, J. and MEUTH, M., 1986, Structure and sequence of mutations induced by ionizing radiation at selectable loci in chinese hamster ovary cells. Journal of Molecular Biology, 192, 669-674.
14. BROWN, J. A., TAKAHASHI, S., ALCARAZ, A., BORELL, T. J., ANDERL, K. L., QIAN, J., PERSONS, D. L., BOSTWICK, D. G., LIEBER, B. M. and JENKINS, R. B., 1996, Fluorescence in situ hybridization analysis of renal oncocytoma reveals frequent loss of chromosomes Y and 1. Journal of Urology, 156, 31-35.
15. BRYNDORF, T., KIRCHHOFF, M., ROSE, H., MAAHR, J., GERDES, T., KARHU, R., KALLIONIEMI, A., CHRISTENSEN, B., LUNDSTEEN, C. and PHILIP, J., 1995, Comparative genomic hybridization and clinical cytogenetics. American Journal of Human Genetics, 57, 1211-1220.
16. CAHILL, D. P., LENGAUER, C., YU, J., RIGGINS, G. J., WILLISON, J. K. V., MARKOWITZ, S. D., KINZLER, K. W. and VOGELSTEIN, B., 1998, Mutations of mitotic checkpoint genes in human cancers. Nature, 392, 300-303.
17. CASARETT, G. W., 1964, Similarities and contrasts between radiation and time pathology. Advances in Gerontological Research, 1, 109-123.
18. CATTANACH, B. M. and JONES, J., 1994, Genetic impriniting in the mouse: implications for gene regulation. Journal of Inherited Metababolic Diseases, 17, 403-420.
19. CLARK, D. J., MEIJNE, E. I. M., BOUFFLER, S. D., HUISKAMP, R., SKIDMORE, C. J., COX, R. and SILVER, A. R. J., 1996, Microsatellite analysis of recurrent chromosome 2 deletions in acute myeloid leukaemia induced by radiation in F1 hybrid mice. Genes Chromosomes and Cancer, 16, 238-246.
20. DE WIND, N., DEKKER, M., BERNS, A., RADMAN, M. and TE RIELE, H., 1995, Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination and predisposition to cancer. Cell, 82, 321-330.
21. DIGWEED, M. and SPERLING, K., 1996, Molecular analysis of Fanconi anaemia. Bioessays, 18, 579-585.
22. DUBROVA, Y. E., NESTEROV, V. N., KROUCHINSKY, N. G., OSTAPENKO, V. A., NEUMANN, R., NEIL, D. L. and JEFFREYS, A. J., 1996, Human minisatellite mutation rate after the Chernobyl accident. Nature, 380, 683-686.
23. DUBROVA, Y. E., PLUMB, M., BROWN, J., FENNELLY, J., BOIS, P., GOODHEAD, D., and JEFFREYS, A. J., 1998, Stage specificity, dose response and doubling dose for mouse minisatellite germline mutation induced by acute radiation. Proceeds of the National Academy of Sciences USA, 95, 6251-6255.
24. ESHLEMAN, J. R. and MARKOWITZ, S. D., 1996, Mismatch repair defects in human carcinogenesis. Human Molecular Genetics, 5, 1489-1494.
25. FENNELLY, J., CRABTREE, G., MACDONALD, D., LORIMORE, S., LAVAL, S., PROFFITT, J., BOYD, Y., WRIGHT, E. and PLUMB, M., 1995, Complex Y chromosome aberrations are a recurrent secondary event in radiation-induced murine acute myeloid leukaemia. Leukemia, 9, 506-512.
26. FENNELLY, J., WRIGHT, E. and PLUMB, M., 1997, Mini- und micro-satellite mutations in radiation-induced acute myeloid leukaemia in the CBA/H mouse. Leukemia, 11, 807-810.
27. GIBBS, M., COLLICK, A., KELLY, R. G. and JEFFREYS, A. J., 1993, A tetranucleotide repeat mouse minisatellite displaying substantial somatic instability during early preimplantation development. Genomics, 17, 121-128.
28. HAYATA, I., SEKI, M., YOSHIDA, K., HIRASHIMA, K., SADO, T., YAMAGIWA, J. and ISHIHARA, T., 1983, Chromosomal aberrations observed in 52 mouse myeloid leukaemias. Cancer Research, 43, 367-373.
29. INK4B) in childhood acute lymphoblastic leukemia. Oncogene, 15, 2609-2614.
30. JEFFREYS, A. J., ROYLE, N. J., WILSON, V. and WONG, Z., 1988, Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA. Nature, 332, 278-281.
31. JEFFREYS, A. J., TAMAKI, K., MACLEOD, A., MONCKTON, D. G., NEIL, D. L. and ARMOUR, J. A. L., 1994, Complex gene conversion events in germline mutation at human minisatellites. Nature Genetics, 6, 136-145.
32. JHAPPAN, C., MORSE, H. C., FLEISCHMANN, R. D., GOTTESMAN, M. M. and MERLINO, G., 1997, DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nature Genetics, 17, 483-486.
33. JOHANSSON, B., MERTENS, F. and MITELMAN, F., 1994, Secondary chromosomal abnormalities in acute leukemias. Leukemia, 8, 953-962.
34. KADHIM, M. A., MACDONALD, D. A., GOODHEAD, D. T., LORIMORE, S. A., MARSDEN, S. J. and WRIGHT, E. G., 1992, Transmission of chromosomal instability after plutonium α-particle irradiation. Nature, 355, 738-740.
35. KANEKO, H., HORIIKE, S., TANIWAKI, M. and MISAWA, S., 1996, Microsatellite instability is an early genetic event in myelodysplastic syndrome but is infrequent and not associated with TGF-β receptor type II gene mutation. Leukemia, 10, 1696-1699.
36. KELLY, R., BULFIELD, G., COLLICK, A., GIBBS, M. and JEFFREYS, A. J., 1989, Characterization of a highly unstable mouse minisatellite locus: evidence for somatic mutation during early development. Genomics, 5, 844-856.
37. KEMP, C. J., WHELDON, T. and BALMAIN, A., 1994, p53-deficient mice are extremely susceptible to radiation-induced tumourigenesis. Nature Genetics, 8, 66-69.
38. KINZLER, K. W. and VOGELSTEIN, B., 1996, Lessons from hereditary colorectal cancer. Cell, 87, 159-170.
39. KIRK, J. A., VANDEVANTER, D. R., BIBERMAN, J. and BRYANT, E. M., 1994, Y chromosome loss in chronic myeloid leukemia detected in both normal and malignant cells by interphase FISH. Genes Chromosomes and Cancer, 11, 141-145.
40. KRONENBERG, A., 1994, Radiation-induced gcnomic instability. International Journal of Radiation Biology, 66, 603-609.
41. LANE, D. P., 1992, p53, guardian of the genome. Nature, 358, 15-16.
42. MAJOR, I. R., 1979, Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to X-rays. British Journal of Cancer, 40, 903-913.
43. MAJOR, I. R. and MOLE, R. H., 1978, Myeloid leukaemia in X-ray irradiated CBA mice. Nature, 272, 455-456.
44. INK4a alterations in murine primary T-cell lymphomas. Oncogene, 14, 1361-1370.
45. MATSUMOTO, Y., KOSUGI, S., SHINBO, T., CHOU, D., OHASHI, M., WAKABAYASHI, Y., SAKAI, K., OKUMOTO, M., MORI, N., AIZAWA, S., NIWA, O. and KOMINAMI, R., 1998. Allelic loss analysis of γ-ray-induced mouse thymic lymphomas: two candidate tumour suppressor gene loci on chromosomes 12 and 16. Oncogene, 16, 2747-2754.
46. MCMORROW, L. E., NEWCOMB, E. W. and PELLICER, A., 1988, Identification of a specific marker chromosome early in tumor development in α-irradiated C57BL/6J mice. Leukemia, 2, 115-119.
47. MEUTH, M., 1989, Illegitimate recombination in mammalian cells. In 'Mobile DNA', eds. Berg, D. E. and Howe, M. M., (American Society of Microbiology), pp. 833-860.
48. MORGAN, W. F., DAY, J. P., KAPLAN, M. I., MCGHEE, E. M. and LIMOLI, C. L., 1996, Genomic instability induced by ionizing radiation. Radiation Research, 146, 247-258.
49. MOSLEIN, G., TESTER, D. J., LINDOR, N. M., HONCHEL, R., CUNNINGHAM, J. M., FRENCH, A. J., HALLING, K. C., SCHWAB, M., GORETZKI, P. and THIBODEAU, S. N., 1996, Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. Human Molecular Genetics, 5, 1245-1252.
50. NIWA, O., KAMIYA, K., FURIHATA, C., NITTA, Y., WANG, Z., FAN, Y.-J., NINOMIYA, Y., KOTOMURA, N., NUMOTO, M. and KOMINAMI, R., 1995, Association of minisatellite instability with c-myc amplification and K-ras mutation in methylcholanthrene-induced mouse sarcomas. Cancer Research, 55, 5670-5676.
51. ORR-WEAVER, T. L. AND WEINBERG, R. A., 1998, A checkpoint on the road to cancer. Nature, 392, 223-224.
52. PAQUETTE, B. and LITTLE, J. B., 1994, In vivo enhancement of gcnomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays. Cancer Research, 54, 3173-3178.
53. PEDERSEN-BJERGAARD, J., PHILIP, P., LARSEN, S. O., JENSEN, G. and BYRSTING, K., 1990, Chromosome aberrations and prognostic factors in therapy-related myelodysplasia and acute nonlymphocytic leukemia. Blood, 76, 1083-1091.
54. PLUMB, M., HARPER, K., MACDONALD, D., FENNELLY, J., LORIMORE, S. and WRIGHT, E., 1997, Ongoing Y chromosome instability defines sub-clonal variants in radiation-induced leukaemias in the mouse. International Journal of Radiation Biology, 72, 1-9.
55. PRESTON, D. L., KUSUMI, S., TOMONAGA, M., IZUMI, S., RON, E., KURAMOTO, A., KAMADA, N., DOHY, H., MATSUI, T., NONAKA, H., THOMPSON, D. E., SODA, M. and MABUCHI, K., 1994, Cancer incidence in atomic bomb survivors. Part III: Leukemia, lymphoma and multiple myeloma, 1950-1987. Radialion Research, 137, S68-S97.
56. PROLLA, T. A., BAKER, S. M., HARRIS, A. C., TSAO, J-L., YAO, X., BRONNER, C. E., ZHENG, B., GORDON, M., RENEKER, J., ARNHELM, N., SHIBATA, D., BRADLEY, A. and LISKAY, R. M., 1998, Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 mismatch repair. Nature Genetics, 18, 276-279.
57. REITMAIR, A. H., SCHMITS, R., EWEL, A., BAPAT, B., REDSTON, M., MITRI, A., WATERHOUSE, P., MITTRUCKER, H.-W., WAKEHAM, A., LIU, B., THOMASON, A., GRIESSER, H., GALLINGER, S., BALLHAUSEN, W. G., FISHEL, R. and MAK, T. W., 1995, MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nature Genetics, 11, 64-70.
58. RITHIDECH, K., BOND, V. P., CRONKITE, E. P., THOMPSON, M. H. and BULLIS, J. E., 1995, Hypermutability of mouse chromosome 2 during the development of x-ray-induced murine myeloid leukemia. Proceeds of the National Academy of Sciences USA, 92, 1152-1156.
59. ROBELDO, M., MARTINEZ, B., ARRANZ, E., TRUJILLO, M. J., AGEITOS, A. G., RIVAS, C. and BENITEZ, J., 1995, Genetic instability of microsatellites in hematological neoplasms. Leukemia, 9, 960-964.
60. SAKURAI, M. and SANDBERG, A. A., 1976, The chromosomes and causation of human cancer and leukemia. The missing Y in acute myeloblastic leukemia (AML) and ph-positive chronic myelocytic leukemia (CLL). Cancer, 38, 762-769.
61. SANTOS, J., PEREZ DE CASTRO, I., HERRANZ, M., PELLICER, A. and FERNANDEZ-PIQUERAS, J., 1996, Allelic losses on chromosome 4 suggest the existence of a candidate tumour suppressor gene region of about 0.6 cM in γ-radiation-induced mouse primary thymic lymphomas. Oncogene, 12, 669-676.
62. SAUTER, G., MOCH, H., WAGNER, U., NOVOTNA, H., GASSER, T. C., MATTARELLI, G., MIHATSCH, M. J. and WALDMAN, F. M., 1995, Y chromosome loss detected by FISH in bladder cancer. Cancer Genetics and Cytogenetics, 82, 163-169.
63. SHILOH, Y., 1997, Ataxia-teangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annual Review of Genetics, 31, 635-662.
64. SILLY, H., CHASE, A., MILLS, K. I., APFELBECK, U., SORMANN, S., GOLDMAN, J. M. and CROSS, N. C. P., 1994, No evidence for microsalellite instability or consistent loss of heterozygosity at selected loci in chronic mycloid leukaemia blast crisis. Leukemia, 8, 1923-1928.
65. TRAKHTENBROT, L., KRAUTHGAMER, R., RESNITZKY, P. and HARAN-GHERA, N., 1988, Deletion of chromosome 2 is an early event in the development of radiation-induced myeloid leukaemia in SJL/J mice. Leukemia, 2, 545-550.
66. UNITED KINGDOM CANCER CYTOGENETICS GROUP (UKCCG), 1992, Loss of the Y chromosome from normal and neoplastic bone marrows. Genes Chromosomes and Cancer, 5, 83-88.
67. VOGELSTEIN, B. and KINZLER, K. W., 1992, p53 function and dysfunction. Cell, 70, 523-526.
68. WRIGHT, E. G., 1997, Radiation-induced Genomic instability in haemopoietic cells: implications for radiation pathology. Radiation Oncolgy Investigation, 5, 115-118.
69. INK4b genes in 2′,3′-dideoxycytidine- and 1,3-butadiene-induced murine lymphomas. Oncogene, 16, 803-808.