I.6 Tamoxifen metabolism and activation: The reason for interspecies differences

European Journal of Cancer

Volumn 34, Issue SUPPL. 4, 1998, Pages

  Phillips, D H ^a   Davis, W ^a   Venitt, S ^a   Glatt, H ^b  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; HYDROXYSTEROID; SULFOTRANSFERASE; SULFUR; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BINDING AFFINITY; CONFERENCE PAPER; DNA BINDING; DRUG ACTIVATION; DRUG METABOLISM; GENOTOXICITY; HYDROXYLATION; LIVER TUMOR; MAMMAL; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENTIATION;

EID: 0031695123     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(98)00089-6     Document Type: Conference Paper

References (8)

1. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 66, Some Pharmaceutical Drugs. Lyon, International Agency for Research on Cancer, 1996, 253-365.
2. Phillips DH, Carmichael PL, Hewer A, et al. Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes. Carcinogenesis 1996, 17, 88-94.
3. Phillips DH, Carmichael PL, Hewer A, Cole KJ, Poon GK. α-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Res 1994, 54, 5518-5522.
4. Osborne MR, Hewer A, Hardcastle IR, Carmichael PL, Phillips DH. Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen. Cancer Res 1996, 56, 66-71.
5. Osborne MR, Hardcastle IR, Phillips DH. Minor products of reaction with DNA of α-acetoxytamoxifen. Carcinogenesis 1997, 18, 539-543.
6. Carmichael PL, Ugwumadu AHN, Neven P, Hewer A, Poon GK, Phillips DH. Lack of genotoxicity of tamoxifen in human endometrium. Cancer Res 1996, 56, 1475-1479.
7. Hemminki K, Rajaniemi H, Lindahl B, Moberger B. Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients. Cancer Res 1996, 56, 4374-4377.
8. Davis W, Venitt S, Phillips DH. The metabolic activation of tamoxifen and α-hydroxytamoxifen to DNA binding species in rat hepatocytes proceeds via sulphation. Carcinogenesis 1998, in press.