-
2
-
-
3543149541
-
-
EP 421441, JP 91218350, JP 91218366, JP 91218340, US 5120738
-
Ikawa, H., Matsumoto, H., Kobayashi, N., Kusunoki, J. (Fujirebio, Inc.). Pantothenic acid derivs. EP 421441, JP 91218350, JP 91218366, JP 91218340, US 5120738.
-
Pantothenic Acid Derivs
-
-
Ikawa, H.1
Matsumoto, H.2
Kobayashi, N.3
Kusunoki, J.4
-
3
-
-
3543127163
-
Synthesis of ACAT inhibitors
-
March 29-31, Osaka Abst 29PB 15-02
-
Ikawa, H., Matsumoto, H., Kobayashi, N., Kusunoki, J., Yamaura, T. Synthesis of ACAT inhibitors. 115th Annu Meet Pharmaceut Soc Jpn (March 29-31, Osaka) 1993, Abst 29PB 15-02.
-
(1993)
115th Annu Meet Pharmaceut Soc Jpn
-
-
Ikawa, H.1
Matsumoto, H.2
Kobayashi, N.3
Kusunoki, J.4
Yamaura, T.5
-
4
-
-
3543048920
-
Pharmaco-biochemical properties of F-1394, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor
-
Abst P-625
-
Aragane, K., Kusunoki, J., Kaneshige, M., Yatabe, Y., Yamaura, T., Ohnishi, H. Pharmaco-biochemical properties of F-1394, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. Jpn J Pharmacol 1994, 64(Suppl. 1): Abst P-625.
-
(1994)
Jpn J Pharmacol
, vol.64
, Issue.1 SUPPL.
-
-
Aragane, K.1
Kusunoki, J.2
Kaneshige, M.3
Yatabe, Y.4
Yamaura, T.5
Ohnishi, H.6
-
5
-
-
0028967720
-
Studies on acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory effects and enzyme selectivity of F-1394, a pantothenic acid derivative
-
Kusunoki, J., Aragane, K., Yamaura, T., Ohnishi, H. Studies on acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory effects and enzyme selectivity of F-1394, a pantothenic acid derivative. Jpn J Pharmacol 1995, 67: 195-203.
-
(1995)
Jpn J Pharmacol
, vol.67
, pp. 195-203
-
-
Kusunoki, J.1
Aragane, K.2
Yamaura, T.3
Ohnishi, H.4
-
6
-
-
0029133230
-
Hypocholesterolemic action and prevention of cholesterol absorption via the gut by F-1394, a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in cholesterol diet-fed rats
-
Kusunoki, J., Aragane, K., Kitamine, T., Higashinakagawa, S., Kase, N., Yamaura, T., Ohnishi, H. Hypocholesterolemic action and prevention of cholesterol absorption via the gut by F-1394, a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in cholesterol diet-fed rats. Jpn J Pharmacol 1995, 69: 53-60.
-
(1995)
Jpn J Pharmacol
, vol.69
, pp. 53-60
-
-
Kusunoki, J.1
Aragane, K.2
Kitamine, T.3
Higashinakagawa, S.4
Kase, N.5
Yamaura, T.6
Ohnishi, H.7
-
7
-
-
0031948269
-
Effects of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on ACAT activity in HepG2 cells and on hepatic secretion of lipids in Triton WR-1339-induced hyperlipidemic rats: Possible role of hepatic ACAT in very low density lipoprotein secretion
-
Aragane, K., Kusunoki, J., Kitamine, T., Yamaura, T., Ohnishi, H. Effects of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on ACAT activity in HepG2 cells and on hepatic secretion of lipids in Triton WR-1339-induced hyperlipidemic rats: Possible role of hepatic ACAT in very low density lipoprotein secretion. Jpn J Pharmacol 1998, 76: 309-12.
-
(1998)
Jpn J Pharmacol
, vol.76
, pp. 309-312
-
-
Aragane, K.1
Kusunoki, J.2
Kitamine, T.3
Yamaura, T.4
Ohnishi, H.5
-
8
-
-
3543133033
-
Effect of F-1394, an ACAT inhibitor, on the postprandial hyperlipidemia induced in streptozotocin-diabetic rats
-
May 30-June 3, Florence
-
Kusunoki, J., Aragane, K., Kitamine, T., Kozono, H., Sekine, Y. Effect of F-1394, an ACAT inhibitor, on the postprandial hyperlipidemia induced in streptozotocin-diabetic rats. 13th Int Symp Drugs Affect Lipid Metab (May 30-June 3, Florence) 1998, 49.
-
(1998)
13th Int Symp Drugs Affect Lipid Metab
, pp. 49
-
-
Kusunoki, J.1
Aragane, K.2
Kitamine, T.3
Kozono, H.4
Sekine, Y.5
-
9
-
-
3543051200
-
Effects of a novel ACAT inhibitor F-1394 on the progression and regression of atherosclerotic lesions in the aorta of cholesterol-fed rabbits
-
Nov 7-10, Houston
-
Yamashita, S., Islam, A., Ishigami, M., Nakamura, T., Kusunoki, J., Aragane, K., Kitamine, T., Yamaura, T., Ohnishi, H., Matsuzawa, Y. Effects of a novel ACAT inhibitor F-1394 on the progression and regression of atherosclerotic lesions in the aorta of cholesterol-fed rabbits. 12th Int Symp Drugs Affect Lipid Metab (Nov 7-10, Houston) 1995, 49.
-
(1995)
12th Int Symp Drugs Affect Lipid Metab
, pp. 49
-
-
Yamashita, S.1
Islam, A.2
Ishigami, M.3
Nakamura, T.4
Kusunoki, J.5
Aragane, K.6
Kitamine, T.7
Yamaura, T.8
Ohnishi, H.9
Matsuzawa, Y.10
-
10
-
-
0030965284
-
Hypolipidemic action of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in high-fat diet fed beagle dogs
-
Kusuno, J., Aragane, K., Kitamine, T., Yamaura, T., Ohnishi, H. Hypolipidemic action of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in high-fat diet fed beagle dogs. Yakugaku Zasshi 1997, 117: 233-41.
-
(1997)
Yakugaku Zasshi
, vol.117
, pp. 233-241
-
-
Kusuno, J.1
Aragane, K.2
Kitamine, T.3
Yamaura, T.4
Ohnishi, H.5
-
11
-
-
0031455483
-
Effect of F-1394, a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), on esterification of cholesterol and basolateral secretion of cholesteryl ester in Caco-2 cells
-
Kusunoki, J., Aragane, K., Kitamine, T., Yamaura, T., Ohnishi, H. Effect of F-1394, a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), on esterification of cholesterol and basolateral secretion of cholesteryl ester in Caco-2 cells. Folia Pharmacol Jpn 1997, 110: 357-65.
-
(1997)
Folia Pharmacol Jpn
, vol.110
, pp. 357-365
-
-
Kusunoki, J.1
Aragane, K.2
Kitamine, T.3
Yamaura, T.4
Ohnishi, H.5
-
12
-
-
15844430993
-
Inhibitors of acyl CoA:cholesterol acyltransferase
-
Vaccaro, W., Amore, C., Berger, J., Burner, R., Clader, J., Davis, H., Domalski, M., Fevig, T., Salisbury, B., Sher, R. Inhibitors of acyl CoA:cholesterol acyltransferase. J Med Chem 1996, 39: 1704-19.
-
(1996)
J Med Chem
, vol.39
, pp. 1704-1719
-
-
Vaccaro, W.1
Amore, C.2
Berger, J.3
Burner, R.4
Clader, J.5
Davis, H.6
Domalski, M.7
Fevig, T.8
Salisbury, B.9
Sher, R.10
-
13
-
-
84965990462
-
ACA-147: An inhibitor of ACAT and the oxidative modification of LDL
-
Adelman, S.J., McKean, M.L., Prozialeck, D.H., Clark, D.E., Fobare, W.F. ACA-147: An inhibitor of ACAT and the oxidative modification of LDL. Atherosclerosis 1994, 109(1-2): 89.
-
(1994)
Atherosclerosis
, vol.109
, Issue.1-2
, pp. 89
-
-
Adelman, S.J.1
McKean, M.L.2
Prozialeck, D.H.3
Clark, D.E.4
Fobare, W.F.5
-
15
-
-
0030715610
-
Inhibitory effect of a new ureidophenol derivative T-2591 on LDL oxidation and ACAT activity
-
Yasuhara, M., Saito, K., Kubota, H., Ohmizu, H., Suzuki, T. Inhibitory effect of a new ureidophenol derivative T-2591 on LDL oxidation and ACAT activity. Biol Pharm Bull 1997, 20: 1056-60.
-
(1997)
Biol Pharm Bull
, vol.20
, pp. 1056-1060
-
-
Yasuhara, M.1
Saito, K.2
Kubota, H.3
Ohmizu, H.4
Suzuki, T.5
-
16
-
-
0029000473
-
Effect of E5324, a novel inhibitor of acyl-CoA:cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages
-
Kogushi, M., Tanaka, H., Kobayashi, H., Yamada, T., Ohtsuka, I., Kimura, T., Saito, I. Effect of E5324, a novel inhibitor of acyl-CoA:cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages. Jpn J Pharmacol 1995, 68: 191-9.
-
(1995)
Jpn J Pharmacol
, vol.68
, pp. 191-199
-
-
Kogushi, M.1
Tanaka, H.2
Kobayashi, H.3
Yamada, T.4
Ohtsuka, I.5
Kimura, T.6
Saito, I.7
-
17
-
-
0026668238
-
Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents
-
Roth, B.D., Blankley, C.J., Hoefle, M.L., Holmes, A., Roark, W.H., Trivedi, B.K., Essenburg, A.D., Kieft, K.A., Krause, B.R., Stanfield, R.L. Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem 1992, 35: 1609-17.
-
(1992)
J Med Chem
, vol.35
, pp. 1609-1617
-
-
Roth, B.D.1
Blankley, C.J.2
Hoefle, M.L.3
Holmes, A.4
Roark, W.H.5
Trivedi, B.K.6
Essenburg, A.D.7
Kieft, K.A.8
Krause, B.R.9
Stanfield, R.L.10
-
18
-
-
0030472785
-
Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents. Cl-1011: An acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets
-
Lee, H.T., Sliskovic, D.R., Picard, J.A. et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents. Cl-1011: An acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J Med Chem 1996, 39: 5031-4.
-
(1996)
J Med Chem
, vol.39
, pp. 5031-5034
-
-
Lee, H.T.1
Sliskovic, D.R.2
Picard, J.A.3
-
19
-
-
0345469432
-
Cl-1011: A novel cholesterol-lowering compound in both chow-fed and cholesterol-fed rodent and nonrodent species
-
Nov 7-10, Houston
-
Krause, B.R., Pape, M., Rea, T., Bousley, R., Stanfield, R., Kieft, K., Anderson, M.K., Lee, H., Homan, R. Cl-1011: A novel cholesterol-lowering compound in both chow-fed and cholesterol-fed rodent and nonrodent species. 12th Int Symp Drugs Affect Lipid Metab (Nov 7-10, Houston) 1995, 136.
-
(1995)
12th Int Symp Drugs Affect Lipid Metab
, pp. 136
-
-
Krause, B.R.1
Pape, M.2
Rea, T.3
Bousley, R.4
Stanfield, R.5
Kieft, K.6
Anderson, M.K.7
Lee, H.8
Homan, R.9
-
20
-
-
0032543617
-
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N′-arylureas
-
Tanaka, A., Terasawa, T., Hagihara, H., Sakuma, Y., Ishibe, N., Sawada, M., Takasugi, H., Tanaka, H. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N′-arylureas. J Med Chem 1998, 41: 2390-410.
-
(1998)
J Med Chem
, vol.41
, pp. 2390-2410
-
-
Tanaka, A.1
Terasawa, T.2
Hagihara, H.3
Sakuma, Y.4
Ishibe, N.5
Sawada, M.6
Takasugi, H.7
Tanaka, H.8
-
21
-
-
0027985805
-
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: Synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles
-
Higley, C.A., Wilde, R.G., Maduskuie, T.P., Johnson, A.L., Pennev, P., Billheimer, J.T., Robinson, C.S., Gillies, P.J., Wexler, R.R. Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: Synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles. J Med Chem 1994, 37: 3511-22.
-
(1994)
J Med Chem
, vol.37
, pp. 3511-3522
-
-
Higley, C.A.1
Wilde, R.G.2
Maduskuie, T.P.3
Johnson, A.L.4
Pennev, P.5
Billheimer, J.T.6
Robinson, C.S.7
Gillies, P.J.8
Wexler, R.R.9
-
22
-
-
3543058181
-
F 12511: A potent inhibitor of cholesterol esterification in cultured cells
-
Oct 5-9, Paris Abst 385
-
Junquéro, D., Puech, L., Béneteau, N., Barthes, V., Patoiseau, J.-F., Autin, J.-M., Donate, S., Colpaert, F.C., Delhon, A. F 12511: A potent inhibitor of cholesterol esterification in cultured cells. 11th Int Symp Atheroscler (Oct 5-9, Paris) 1997, Abst 385.
-
(1997)
11th Int Symp Atheroscler
-
-
Junquéro, D.1
Puech, L.2
Béneteau, N.3
Barthes, V.4
Patoiseau, J.-F.5
Autin, J.-M.6
Donate, S.7
Colpaert, F.C.8
Delhon, A.9
-
23
-
-
3543113211
-
KY-455, a new bioavailable ACAT inhibitor with anti-peroxidative activity
-
Abst 2.P.49
-
Kamiya, S., Shirahase, H., Yomishi, S., Kanda, M., Murase, K., Kurahashi, K. KY-455, a new bioavailable ACAT inhibitor with anti-peroxidative activity. Atherosclerosis 1997, 134(1-2): Abst 2.P.49.
-
(1997)
Atherosclerosis
, vol.134
, Issue.1-2
-
-
Kamiya, S.1
Shirahase, H.2
Yomishi, S.3
Kanda, M.4
Murase, K.5
Kurahashi, K.6
-
24
-
-
3543083968
-
Effects of NTE-122, a new ACAT inhibitor, on cholesterol ester secretion in hepatic cells, and foam cell formation from macrophages
-
Abst P-565
-
Azuma, Y., Ikemoto, K., Obata, K., Mikami, H., Sajiki, N., Ohno, K., Yamada, T., Yamasaki, M., Nobuhara, Y. Effects of NTE-122, a new ACAT inhibitor, on cholesterol ester secretion in hepatic cells, and foam cell formation from macrophages. Jpn J Pharmacol 1997, 73(Suppl. 1): Abst P-565.
-
(1997)
Jpn J Pharmacol
, vol.73
, Issue.1 SUPPL.
-
-
Azuma, Y.1
Ikemoto, K.2
Obata, K.3
Mikami, H.4
Sajiki, N.5
Ohno, K.6
Yamada, T.7
Yamasaki, M.8
Nobuhara, Y.9
-
25
-
-
3543130706
-
Pharmaco-biochemical properties of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor
-
Abst P-764
-
Kawasaki, T., Azuma, Y., Ikemoto, K., Mikami, H., Yamada, T., Nobuhara, Y. Pharmaco-biochemical properties of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. Jpn J Pharmacol 1996, 71(Suppl. 1): Abst P-764.
-
(1996)
Jpn J Pharmacol
, vol.71
, Issue.1 SUPPL.
-
-
Kawasaki, T.1
Azuma, Y.2
Ikemoto, K.3
Mikami, H.4
Yamada, T.5
Nobuhara, Y.6
-
26
-
-
0030049343
-
RP 64477: A potent inhibitor of acyl-coenzyme A. Cholesterol O-acyltransferase with low systemic bioavailability
-
Bello, A.A., Bright, C., Burton, B.J. et al. RP 64477: A potent inhibitor of acyl-coenzyme A. Cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol 1996, 51: 413-21.
-
(1996)
Biochem Pharmacol
, vol.51
, pp. 413-421
-
-
Bello, A.A.1
Bright, C.2
Burton, B.J.3
-
27
-
-
0026714607
-
RP 70676: A potent systemically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT)
-
Ashton, M.J., Bridge, A.W., Bush, R.C., Dron, D.I., Harris, N.V., Jones, G.D., Lythgoe, D.J., Riddell, D., Smith, C. RP 70676: A potent systemically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT). Bioorg Med Chem Lett 1992, 2: 375-80.
-
(1992)
Bioorg Med Chem Lett
, vol.2
, pp. 375-380
-
-
Ashton, M.J.1
Bridge, A.W.2
Bush, R.C.3
Dron, D.I.4
Harris, N.V.5
Jones, G.D.6
Lythgoe, D.J.7
Riddell, D.8
Smith, C.9
-
28
-
-
3543110836
-
Effects of a novel ACAT inhibitor HL-004 on cholesterol absorption in cholesterol-fed models
-
Abst P-362
-
Asami, Y., Ohta, Y., Yamagishi, I., Murakami, S., Araki, H., Higuchi, S. Effects of a novel ACAT inhibitor HL-004 on cholesterol absorption in cholesterol-fed models. Jpn J Pharmacol 1996, 71(Suppl. 1): Abst P-362.
-
(1996)
Jpn J Pharmacol
, vol.71
, Issue.1 SUPPL.
-
-
Asami, Y.1
Ohta, Y.2
Yamagishi, I.3
Murakami, S.4
Araki, H.5
Higuchi, S.6
-
29
-
-
3543052290
-
Hypolipidemic effects of HL-004, a novel ACAT inhibitor, in hamsters fed normal chow
-
Abst 204
-
Murakami, S., Ohta, Y., Asami, Y., Yamagishi, I., Toda, Y., Araki, H., Otomo, S. Hypolipidemic effects of HL-004, a novel ACAT inhibitor, in hamsters fed normal chow. Atherosclerosis 1994, 109(1-2): Abst 204.
-
(1994)
Atherosclerosis
, vol.109
, Issue.1-2
-
-
Murakami, S.1
Ohta, Y.2
Asami, Y.3
Yamagishi, I.4
Toda, Y.5
Araki, H.6
Otomo, S.7
-
30
-
-
3543146029
-
Synthesis and hypolipidemic activity of tricyclic-arylmethyl substituted ureas: Potent ACAT inhibitors
-
Sept 13-17, Basel Abst P-093.B
-
Matsuda, K., Ito, N., Iwaoka, K., Miyauchi, H., Iizumi, Y. Synthesis and hypolipidemic activity of tricyclic-arylmethyl substituted ureas: Potent ACAT inhibitors. 12th Int Symp Med Chem (Sept 13-17, Basel) 1992, Abst P-093.B.
-
(1992)
12th Int Symp Med Chem
-
-
Matsuda, K.1
Ito, N.2
Iwaoka, K.3
Miyauchi, H.4
Iizumi, Y.5
-
31
-
-
15144356732
-
Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs
-
Kashiwa, M., Masuyama, Y., Miyauchi, H. et al. Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol 1997, 73: 41-50.
-
(1997)
Jpn J Pharmacol
, vol.73
, pp. 41-50
-
-
Kashiwa, M.1
Masuyama, Y.2
Miyauchi, H.3
|