메뉴 건너뛰기




Volumn 23, Issue 7, 1998, Pages 712-717

F-1394. Hypolipidemic, ACAT inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BIS[[1 CYCLOHEPTYL 3 (4 DIMETHYLAMINOPHENYL)UREIDO]METHYL]BENZENE; 1,4 BIS[[1 CYCLOHEXYL 3 (4 DIMETHYLAMINOPHENYL)UREIDO]METHYL]CYCLOHEXANE; 2 [3 (2,2 DIMETHYLPROPYL) 3 NONYLUREIDO]CYCLOHEXANE 1 YL 3 [N (2,2,5,5 TETRAMETHYL 1,3 DIOXANE 4 CARBONYL)AMINO]PROPIONIC ACID; 2,2 DIMETHYL N (2,4,6 TRIMETHOXYPHENYL)DODECANAMIDE; 3 (2,4 DIFLUOROPHENYL) 1 HEPTYL 1 (4 NEOPENTYLBENZYL)UREA; ACA 147; ACB 796; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CLOFIBRATE; EFLUCIMIBE; ELDACIMIBE; EPICOCHIOQUINONE A; FR 186054; KV 2920; KY 455; LECIMIBIDE; MELINAMIDE; N (2,2,5,5 TETRAMETHYL 1,3 DIOXAN 4 YLCARBONYL) BETA ALANINE 2 [N' (2,2 DIMETHYLPROPYL) N'NONYLUREIDO] 1 CYCLOHEXYL ESTER; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; PRAVASTATIN; PROBUCOL; R 755; SKK 58099; SULFAMIC ACID ((2,4,6 TRIS (1 METHYLETHYL) PHENYL)ACETYL) 2,6 BIS(1 METHYLETHYL) PHENYL ESTER; TRIACYLGLYCEROL; TS 962; TYLOXAPOL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 0031694354     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1998.023.07.466747     Document Type: Article
Times cited : (1)

References (31)
  • 4
    • 3543048920 scopus 로고
    • Pharmaco-biochemical properties of F-1394, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor
    • Abst P-625
    • Aragane, K., Kusunoki, J., Kaneshige, M., Yatabe, Y., Yamaura, T., Ohnishi, H. Pharmaco-biochemical properties of F-1394, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. Jpn J Pharmacol 1994, 64(Suppl. 1): Abst P-625.
    • (1994) Jpn J Pharmacol , vol.64 , Issue.1 SUPPL.
    • Aragane, K.1    Kusunoki, J.2    Kaneshige, M.3    Yatabe, Y.4    Yamaura, T.5    Ohnishi, H.6
  • 5
    • 0028967720 scopus 로고
    • Studies on acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory effects and enzyme selectivity of F-1394, a pantothenic acid derivative
    • Kusunoki, J., Aragane, K., Yamaura, T., Ohnishi, H. Studies on acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory effects and enzyme selectivity of F-1394, a pantothenic acid derivative. Jpn J Pharmacol 1995, 67: 195-203.
    • (1995) Jpn J Pharmacol , vol.67 , pp. 195-203
    • Kusunoki, J.1    Aragane, K.2    Yamaura, T.3    Ohnishi, H.4
  • 6
    • 0029133230 scopus 로고
    • Hypocholesterolemic action and prevention of cholesterol absorption via the gut by F-1394, a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in cholesterol diet-fed rats
    • Kusunoki, J., Aragane, K., Kitamine, T., Higashinakagawa, S., Kase, N., Yamaura, T., Ohnishi, H. Hypocholesterolemic action and prevention of cholesterol absorption via the gut by F-1394, a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in cholesterol diet-fed rats. Jpn J Pharmacol 1995, 69: 53-60.
    • (1995) Jpn J Pharmacol , vol.69 , pp. 53-60
    • Kusunoki, J.1    Aragane, K.2    Kitamine, T.3    Higashinakagawa, S.4    Kase, N.5    Yamaura, T.6    Ohnishi, H.7
  • 7
    • 0031948269 scopus 로고    scopus 로고
    • Effects of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on ACAT activity in HepG2 cells and on hepatic secretion of lipids in Triton WR-1339-induced hyperlipidemic rats: Possible role of hepatic ACAT in very low density lipoprotein secretion
    • Aragane, K., Kusunoki, J., Kitamine, T., Yamaura, T., Ohnishi, H. Effects of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on ACAT activity in HepG2 cells and on hepatic secretion of lipids in Triton WR-1339-induced hyperlipidemic rats: Possible role of hepatic ACAT in very low density lipoprotein secretion. Jpn J Pharmacol 1998, 76: 309-12.
    • (1998) Jpn J Pharmacol , vol.76 , pp. 309-312
    • Aragane, K.1    Kusunoki, J.2    Kitamine, T.3    Yamaura, T.4    Ohnishi, H.5
  • 8
    • 3543133033 scopus 로고    scopus 로고
    • Effect of F-1394, an ACAT inhibitor, on the postprandial hyperlipidemia induced in streptozotocin-diabetic rats
    • May 30-June 3, Florence
    • Kusunoki, J., Aragane, K., Kitamine, T., Kozono, H., Sekine, Y. Effect of F-1394, an ACAT inhibitor, on the postprandial hyperlipidemia induced in streptozotocin-diabetic rats. 13th Int Symp Drugs Affect Lipid Metab (May 30-June 3, Florence) 1998, 49.
    • (1998) 13th Int Symp Drugs Affect Lipid Metab , pp. 49
    • Kusunoki, J.1    Aragane, K.2    Kitamine, T.3    Kozono, H.4    Sekine, Y.5
  • 10
    • 0030965284 scopus 로고    scopus 로고
    • Hypolipidemic action of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in high-fat diet fed beagle dogs
    • Kusuno, J., Aragane, K., Kitamine, T., Yamaura, T., Ohnishi, H. Hypolipidemic action of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in high-fat diet fed beagle dogs. Yakugaku Zasshi 1997, 117: 233-41.
    • (1997) Yakugaku Zasshi , vol.117 , pp. 233-241
    • Kusuno, J.1    Aragane, K.2    Kitamine, T.3    Yamaura, T.4    Ohnishi, H.5
  • 11
    • 0031455483 scopus 로고    scopus 로고
    • Effect of F-1394, a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), on esterification of cholesterol and basolateral secretion of cholesteryl ester in Caco-2 cells
    • Kusunoki, J., Aragane, K., Kitamine, T., Yamaura, T., Ohnishi, H. Effect of F-1394, a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), on esterification of cholesterol and basolateral secretion of cholesteryl ester in Caco-2 cells. Folia Pharmacol Jpn 1997, 110: 357-65.
    • (1997) Folia Pharmacol Jpn , vol.110 , pp. 357-365
    • Kusunoki, J.1    Aragane, K.2    Kitamine, T.3    Yamaura, T.4    Ohnishi, H.5
  • 15
    • 0030715610 scopus 로고    scopus 로고
    • Inhibitory effect of a new ureidophenol derivative T-2591 on LDL oxidation and ACAT activity
    • Yasuhara, M., Saito, K., Kubota, H., Ohmizu, H., Suzuki, T. Inhibitory effect of a new ureidophenol derivative T-2591 on LDL oxidation and ACAT activity. Biol Pharm Bull 1997, 20: 1056-60.
    • (1997) Biol Pharm Bull , vol.20 , pp. 1056-1060
    • Yasuhara, M.1    Saito, K.2    Kubota, H.3    Ohmizu, H.4    Suzuki, T.5
  • 16
    • 0029000473 scopus 로고
    • Effect of E5324, a novel inhibitor of acyl-CoA:cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages
    • Kogushi, M., Tanaka, H., Kobayashi, H., Yamada, T., Ohtsuka, I., Kimura, T., Saito, I. Effect of E5324, a novel inhibitor of acyl-CoA:cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages. Jpn J Pharmacol 1995, 68: 191-9.
    • (1995) Jpn J Pharmacol , vol.68 , pp. 191-199
    • Kogushi, M.1    Tanaka, H.2    Kobayashi, H.3    Yamada, T.4    Ohtsuka, I.5    Kimura, T.6    Saito, I.7
  • 17
    • 0026668238 scopus 로고
    • Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents
    • Roth, B.D., Blankley, C.J., Hoefle, M.L., Holmes, A., Roark, W.H., Trivedi, B.K., Essenburg, A.D., Kieft, K.A., Krause, B.R., Stanfield, R.L. Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem 1992, 35: 1609-17.
    • (1992) J Med Chem , vol.35 , pp. 1609-1617
    • Roth, B.D.1    Blankley, C.J.2    Hoefle, M.L.3    Holmes, A.4    Roark, W.H.5    Trivedi, B.K.6    Essenburg, A.D.7    Kieft, K.A.8    Krause, B.R.9    Stanfield, R.L.10
  • 18
    • 0030472785 scopus 로고    scopus 로고
    • Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents. Cl-1011: An acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets
    • Lee, H.T., Sliskovic, D.R., Picard, J.A. et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents. Cl-1011: An acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J Med Chem 1996, 39: 5031-4.
    • (1996) J Med Chem , vol.39 , pp. 5031-5034
    • Lee, H.T.1    Sliskovic, D.R.2    Picard, J.A.3
  • 20
    • 0032543617 scopus 로고    scopus 로고
    • Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N′-arylureas
    • Tanaka, A., Terasawa, T., Hagihara, H., Sakuma, Y., Ishibe, N., Sawada, M., Takasugi, H., Tanaka, H. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N′-arylureas. J Med Chem 1998, 41: 2390-410.
    • (1998) J Med Chem , vol.41 , pp. 2390-2410
    • Tanaka, A.1    Terasawa, T.2    Hagihara, H.3    Sakuma, Y.4    Ishibe, N.5    Sawada, M.6    Takasugi, H.7    Tanaka, H.8
  • 21
    • 0027985805 scopus 로고
    • Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: Synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles
    • Higley, C.A., Wilde, R.G., Maduskuie, T.P., Johnson, A.L., Pennev, P., Billheimer, J.T., Robinson, C.S., Gillies, P.J., Wexler, R.R. Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: Synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles. J Med Chem 1994, 37: 3511-22.
    • (1994) J Med Chem , vol.37 , pp. 3511-3522
    • Higley, C.A.1    Wilde, R.G.2    Maduskuie, T.P.3    Johnson, A.L.4    Pennev, P.5    Billheimer, J.T.6    Robinson, C.S.7    Gillies, P.J.8    Wexler, R.R.9
  • 23
    • 3543113211 scopus 로고    scopus 로고
    • KY-455, a new bioavailable ACAT inhibitor with anti-peroxidative activity
    • Abst 2.P.49
    • Kamiya, S., Shirahase, H., Yomishi, S., Kanda, M., Murase, K., Kurahashi, K. KY-455, a new bioavailable ACAT inhibitor with anti-peroxidative activity. Atherosclerosis 1997, 134(1-2): Abst 2.P.49.
    • (1997) Atherosclerosis , vol.134 , Issue.1-2
    • Kamiya, S.1    Shirahase, H.2    Yomishi, S.3    Kanda, M.4    Murase, K.5    Kurahashi, K.6
  • 24
    • 3543083968 scopus 로고    scopus 로고
    • Effects of NTE-122, a new ACAT inhibitor, on cholesterol ester secretion in hepatic cells, and foam cell formation from macrophages
    • Abst P-565
    • Azuma, Y., Ikemoto, K., Obata, K., Mikami, H., Sajiki, N., Ohno, K., Yamada, T., Yamasaki, M., Nobuhara, Y. Effects of NTE-122, a new ACAT inhibitor, on cholesterol ester secretion in hepatic cells, and foam cell formation from macrophages. Jpn J Pharmacol 1997, 73(Suppl. 1): Abst P-565.
    • (1997) Jpn J Pharmacol , vol.73 , Issue.1 SUPPL.
    • Azuma, Y.1    Ikemoto, K.2    Obata, K.3    Mikami, H.4    Sajiki, N.5    Ohno, K.6    Yamada, T.7    Yamasaki, M.8    Nobuhara, Y.9
  • 25
    • 3543130706 scopus 로고    scopus 로고
    • Pharmaco-biochemical properties of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor
    • Abst P-764
    • Kawasaki, T., Azuma, Y., Ikemoto, K., Mikami, H., Yamada, T., Nobuhara, Y. Pharmaco-biochemical properties of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. Jpn J Pharmacol 1996, 71(Suppl. 1): Abst P-764.
    • (1996) Jpn J Pharmacol , vol.71 , Issue.1 SUPPL.
    • Kawasaki, T.1    Azuma, Y.2    Ikemoto, K.3    Mikami, H.4    Yamada, T.5    Nobuhara, Y.6
  • 26
    • 0030049343 scopus 로고    scopus 로고
    • RP 64477: A potent inhibitor of acyl-coenzyme A. Cholesterol O-acyltransferase with low systemic bioavailability
    • Bello, A.A., Bright, C., Burton, B.J. et al. RP 64477: A potent inhibitor of acyl-coenzyme A. Cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol 1996, 51: 413-21.
    • (1996) Biochem Pharmacol , vol.51 , pp. 413-421
    • Bello, A.A.1    Bright, C.2    Burton, B.J.3
  • 28
    • 3543110836 scopus 로고    scopus 로고
    • Effects of a novel ACAT inhibitor HL-004 on cholesterol absorption in cholesterol-fed models
    • Abst P-362
    • Asami, Y., Ohta, Y., Yamagishi, I., Murakami, S., Araki, H., Higuchi, S. Effects of a novel ACAT inhibitor HL-004 on cholesterol absorption in cholesterol-fed models. Jpn J Pharmacol 1996, 71(Suppl. 1): Abst P-362.
    • (1996) Jpn J Pharmacol , vol.71 , Issue.1 SUPPL.
    • Asami, Y.1    Ohta, Y.2    Yamagishi, I.3    Murakami, S.4    Araki, H.5    Higuchi, S.6
  • 29
    • 3543052290 scopus 로고
    • Hypolipidemic effects of HL-004, a novel ACAT inhibitor, in hamsters fed normal chow
    • Abst 204
    • Murakami, S., Ohta, Y., Asami, Y., Yamagishi, I., Toda, Y., Araki, H., Otomo, S. Hypolipidemic effects of HL-004, a novel ACAT inhibitor, in hamsters fed normal chow. Atherosclerosis 1994, 109(1-2): Abst 204.
    • (1994) Atherosclerosis , vol.109 , Issue.1-2
    • Murakami, S.1    Ohta, Y.2    Asami, Y.3    Yamagishi, I.4    Toda, Y.5    Araki, H.6    Otomo, S.7
  • 30
    • 3543146029 scopus 로고
    • Synthesis and hypolipidemic activity of tricyclic-arylmethyl substituted ureas: Potent ACAT inhibitors
    • Sept 13-17, Basel Abst P-093.B
    • Matsuda, K., Ito, N., Iwaoka, K., Miyauchi, H., Iizumi, Y. Synthesis and hypolipidemic activity of tricyclic-arylmethyl substituted ureas: Potent ACAT inhibitors. 12th Int Symp Med Chem (Sept 13-17, Basel) 1992, Abst P-093.B.
    • (1992) 12th Int Symp Med Chem
    • Matsuda, K.1    Ito, N.2    Iwaoka, K.3    Miyauchi, H.4    Iizumi, Y.5
  • 31
    • 15144356732 scopus 로고    scopus 로고
    • Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs
    • Kashiwa, M., Masuyama, Y., Miyauchi, H. et al. Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol 1997, 73: 41-50.
    • (1997) Jpn J Pharmacol , vol.73 , pp. 41-50
    • Kashiwa, M.1    Masuyama, Y.2    Miyauchi, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.