Age-associated alterations in calcium current and its modulation in cardiac myocytes

Drugs and Aging

Volumn 13, Issue 2, 1998, Pages 159-171

  Zhou, Ying Ying ^a   Lakatta, Edward G ^a   Xiao, Rui Ping ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CALCIUM ION; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ACTION POTENTIAL; AGING; CALCIUM CURRENT; EXCITATION CONTRACTION COUPLING; HEART ARRHYTHMIA; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENESCENCE;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM CHANNELS; CARDIOMEGALY; HEART FAILURE, CONGESTIVE; HUMANS; MIDDLE AGED; MYOCARDIUM; PHOSPHOPROTEIN PHOSPHATASE;

EID: 0031691230     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-199813020-00007     Document Type: Review

References (113)

1. Lakatta EG. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev 1993; 73: 413-67
2. Fabiato A. Simulated calcium current can both cause calcium loading and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. J Gen Physiol 1985; 85: 291-320
3. Walker KE, Lakatta EG, Houser SR. Age associated changes in membrane currents in rat ventricular myocytes. Cardiovasc Res 1943; 27: 1968-77
4. Xiao RP, Spurgeon HA, O'Connor F, et al. Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling. J Clin Invest 1944; 94: 2051-9
5. Cerbai E, Guerra L, Varani K, et al. Beta-adrenoceptor subtypes in young and old rat ventricular myocytes: a combined patch-clamp and binding study. Br J Pharmacol 1995; 116: 1835-42
6. Orchard CH, Lakatta EG. Intracellular calcium transients and developed tension in rat heart muscle: a mechanism for the negative interval-strength relationship. J Gen Physiol 1985; 86: 637-51
7. Wei J Y, Spurgeon HA, Lakatta EG. Excitation-contraction in rat myocardium: alterations with adult aging. Am J Physiol 1984; 246 (6 Pt 2): H784-91
8. Fraticelli A, Josephson R, Danziger R, et al. Morphological and contractile characteristics or rat cardiac myocytes from maturation to senescence. Am J Physiol 1989; 257 (1 Pt 2): H259-65
9. Xiao RP, Lakatta HG. Deterioration of beta-adrenergic modulation of cardiovascular function with aging. Ann N Y Acad Sci 1992; 673: 293-310
10. Xiao RP, Lakatta EG. Mechanism of altered β-adrenergic modulation of the cardiovascular system with aging. Clin Gerontol 1991; 1: 309-22
11. Swynghedauw B, Besse S, Assayag P, et al. Molecular and cellular biology of the senescent hypertrophical and failing heart. Am J Cardiol 1995; 76: 2D-7D
12. Svanborg A. Age-related changes in cardiac physiology: can they be postponed or treated by drugs? Drugs Aging 1997; 10: 463-72
13. Folkow B, Svanborg A. Physiology of cardiovascular aging. Physiol Rev 1993; 73: 725-64
14. Boluyt MO, Lakatta EG. Cardiovascular aging in health. In: Altschuld RA, Haworth RA, editors. Heart metabolism in failure. London: JAI Press Inc. In press
15. Bangalore R, Triggle DJ. Age-dependent changes in voltage-gated calcium channels and ATP-dependent potassium channels in Fischer 344 rats. Gen Pharmacol 1995; 26: 1237-42
16. Kusumoto FM, Capili H, Sniezek MJ, et al. Responses to calcium and binding of 3H-nimodipine in the atrioventricular node, atria, and ventricles of mature and old male Fischer 344 rats. J Cardiovasc Pharmacol 1995; 26: 348-53
17. 2+ current by mechanical stimulation in single rabbit cardiac myocytes. Circ Res 1996; 78: 650-9
18. Zhou YY, Yao JA, Tseng GN. Role of tyrosine kinase activity in cardiac slow delayed rectifier channel modulation by cell swelling. Pflugers Arch 1997; 433: 750-7
19. + pump currents by hypotonic solutions in guinea pig cardiac myocytes. Circ Res 1994; 75: 887-95
20. Kokubun S, Irisawa H. Effects of various intracellular Ca ion concentrations on the calcium current of guinea-pig single ventricular cells. Jpn J Physiol 1984; 34: 599-611
21. Lee KS, Marban E, Tsien RW. Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium. J Physiol Lond 1985; 364: 395-411
22. Levi AJ, Mitcheson JS, Hancox JC. The effect of internal sodium and caesium on phasic contraction of patch-clamped rabbit ventricular myocytes. J Physiol Lond 1996; 492: 1-19
23. 2+ channels and ryanodine receptors in rat ventricular myocytes. J Gen Physiol 1996; 108: 435-54
24. 2+ channels and ryanodine receptors in cardiac myocytes. Proc Natl Acad Sci U S A 1995; 92: 121-5
25. 2+ influx during the cardiac action potential in guinea pig ventricular myocytes. Circ Res 1996; 79: 194-200
26. Gomez AM, Valdivia HH, Cheng H, et al. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure [see comments]. Science 1997; 276: 800-6
27. Kleiman RB, Houser SR. Calcium currents in normal and hypertrophied isolated feline ventricular myocytes. Am J Physiol 1988; 255 (6 Pt 2): H1434-42
28. Keung EC. Calcium current is increased in isolated adult myocytes from hypertrophied rat myocardium. Circ Res 1989; 64: 753-63
29. 2+ channel function and drug action. Trends Pharmacol Sci 1995; 16: 43-9
30. Birnbaumer L, Campbell KP, Catterall WA, et al. The naming of voltage-gated calcium channels. Neuron 1994; 13: 505-6
31. Welling A, Kwan YW, Bosse E, et al. Subunit-dependent modulation of recombinant L-type calcium channels: molecular basis for dihydropyridine tissue selectivity. Circ Res 1993; 73: 974-80
32. Diebold RJ, Koch WJ, Ellinor PT, et al. Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart. Proc Natl Acad Sci U S A 1992; 89: 1497-501
33. Buttrick P, Malhotra A, Factor S, et al. Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart. Circ Res 1991; 68: 645-52
34. O'Neill L, Holbrook NJ, Fargnoli J, et al. Progressive changes from young adult age to senescence in mRNA for rat cardiac myosin heavy chain genes. Cardioscience 1991; 2: 1-5
35. Cerbai E, Barbieri M, Li Q, et al. Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages. Cardiovasc Res 1994; 28: 1180-7
36. Koban MU, Moorman AF, Holtz J, et al. Expressional analysis of the cardiac Na-Ca exchanger in rat development and senescence. Cardiovasc Res 1998; 37: 405-23
37. Hano O, Bogdanov KY, Sakai M, et al. Reduced threshold for myocardial cell calcium intolerance in the rat heart with aging. Am J Physiol 1995; 269 (5 Pt 2): H1607-12
38. McDonald TF, Pelzer S, Trautwein W, et al. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 1994; 74: 365-507
39. Kawano S, DeHaan RL. Low-threshold current is major calcium current in chick ventricle cells. Am J Physiol 1989; 256 (5 Pt 2): H1505-8
40. Furukawa T, Ito H, Nitta J, et al. Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes. Circ Res 1992; 71: 1242-53
41. 2+ channel kinetics in acutely isolated fetal, neonatal, and adult rabbit cardiac myocytes. Circ Res 1993; 72: 1065-74
42. Brillantes AM, Bezprozvannaya S, Marks AR. Developmental and tissue-specific regulation of rabbit skeletal and cardiac muscle calcium channels involved in excitation-contraction coupling. Circ Res 1994; 75: 503-10
43. Xu X, Best PM. Increase in T-type calcium current in atrial myocytes from adult rats with growth hormone-secreting tumors. Proc Natl Acad Sci U S A 1990; 87: 4655-9
44. 2+ current is expressed in hypertrophied adult feline left ventricular myocytes. Circ Res 1993; 73: 777-82
45. Qin D, Jain P, Boutjdir M, et al. Expression of T-type calcium current in remodeled hypertrophied left ventricle from adult rat following myocardial infarction [abstract]. Circ Res 1995; 92: 1-547
46. White M, Roden R, Minobe W, et al. Age-related changes in beta-adrenergic neuroeffector systems in the human heart. Circulation 1994; 90: 1225-38
47. 2+ current. Circ Res 1989; 64: 977-90
48. 2+ channel agonist Bay K 8644. Circ Res 1988; 62: 563-71
49. 2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. J Clin Invest 1998; 101: 1273-82
50. Lakatta EG, Gerstenblith G, Angell CS, et al. Diminished inotropic response of aged myocardium to catecholamines. Circ Res 1975; 36: 262-9
51. Haase H, Karczewski P, Beckert R, et al. Phosphorylation of the L-type calcium channel beta subunit is involved in beta-adrenergic signal transduction in canine myocardium. FEBS Lett 1993; 335: 217-22
52. Brum G, Osterrieder W, Trautwein W. β-Adrenergic increase in the calcium conductance of cardiac myocytes studied with the patch clamp. Pflugers Arch 1984; 401: 111-8
53. Charnet P, Lory P, Bourinet E, et al. cAMP-dependent phosphorylation of the cardiac L-type Ca channel: a missing link? Biochimie 1995; 77: 957-62
54. Yatani A, Brown AM. Rapid β-adrenergic modulation of cardiac calcium channel currents by a fast G protein pathway. Science 1989; 245: 71-4
55. Welling A, Felbel J, Peper K, et al. Hormonal regulation of calcium current in freshly isolated airway smooth muscle cells. Am J Physiol 1992; 262 (3 Pt 1): L351-9
56. 2+ current of rat ventricular myocytes in neonatal compared to adult. Eur J Pharmacol 1996; 317: 391-400
57. Xiao RP, Ji X, Lakatta EG. Functional coupling of the beta2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol 1995; 47: 322-9
58. Zhou YY, Cheng H, Bogdanov KY, et al. Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling. Am J Physiol 1997; 273 (3 Pt 2): H1611-8
59. Ferrara N, Bohm M, Zolk O, et al. The role of Gi-proteins and beta-adrenoceptors in the age-related decline of contraction in guinea-pig ventricular myocytes. J Mol Cell Cardiol 1997; 29: 439-48
60. Brodde OE, Zerkowski HR, Schranz D, et al. Age-dependent changes in the beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium. J Cardiovasc Pharmacol 1995; 26: 20-6
61. Bohm M, Dorner H, Htun P, et al. Effects of exercise on myocardial adenylate cyclase and Gi alpha expression in senescence. Am J Physiol 1993; 264 (3 Pt 2): H805-14
62. Bazan A, Van de Velde E, Fraeyman N. Effect of age on beta-receptors. Gs alpha- and Gi alpha-proteins in rat heart. Biochem Pharmacol 1994; 48: 479-86
63. Scarpace PJ. Forskolin activation of adenylate cyclase in rat myocardium with age: effects of guanine nucleotide analogs. Mech Ageing Dev 1990; 52: 169-78
64. Rosenthal MJ, Morley JE, Flood JF, et al. Relationship between behavioral and motor responses of mature and old mice and cerebellar beta-adrenergic receptor density. Mech Ageing Dev 1988; 45: 231-7
65. Scarpace PJ, Abrass IB. Beta-adrenergic agonist-mediated desensitization in senescent rats. Mech Ageing Dev 1986; 35: 255-64
66. Narayanan N, Derby JA. Alterations in the properties of beta-adrenergic receptors of myocardial membranes in aging: impairments in agonist-receptor interactions and guanine nucleotide regulation accompany diminished catecholamine-responsiveness of adenylate cyclase. Mech Ageing Dev 1982; 19: 127-39
67. Miyamotu A, Kawana S, Kimura H, et al. Impaired expression of Gs alpha protein mRNA in rat ventricular myocardium with aging. Eur J Pharmacol 1994; 266: 147-54
68. Hardouin S, Bourgeois F, Besse S, et al. Decreased accumulation of beta 1-adrenergic receptor. G alpha s and total myosin heavy chain messenger RNAs in the left ventricle of senescent rat heart. Mech Ageing Dev 1993; 71: 169-88
69. Rockman HA, Choi DJ, Rahman NU, et al. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc Natl Acad Sci U S A 1996; 93: 9954-9
70. Hausdorff WP, Caron MG, Lefkowitz RJ. Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J 1990; 4: 2881-9
71. 2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx. Proc Natl Acad Sci U S A 1994; 91: 9659-63
72. 2+-calmodulin-dependent protein kinase II on cardiac excitation-contraction coupling in ferret ventricular myocytes. J Physiol Lond 1997; 501: 17-31
73. Yuan W, Bers DM. Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase. Am J Physiol 1994; 267 (3 Pt 2): H982-93
74. Bassani RA, Mattiazzi A, Bers DM. CaMKII is responsible for activity-dependent acceleration of relaxation in rat ventricular myocytes. Am J Physiol 1995; 268 (2 Pt 2): H703-12
75. 2+-cycling proteins and their phosphorylation in rat myocardium. Am J Physiol. In press
76. Jiang MT, Narayanan N. Effects of aging on phospholamban phosphorylation and calcium transport in rat cardiac sarcoplasmic reticulum. Mech Ageing Dev 1990; 54: 87-101
77. Narayanan N. Differential alterations in ATP-supported calcium transport activities of sarcoplasmic reticulum and sarcolemma of aging myocardium. Biochim Biophys Acta 1981; 678: 442-59
78. Hunter T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 1995; 80: 225-36
79. Hartzell HC, Mery PF, Fischmeister R, et al. Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation. Nature 1991; 351: 573-6
80. Kameyama M, Hescheler J, Hofmann F, et al. Modulation of Ca current during the phosphorylation cycle in the guinea pig heart. Pflugers Arch 1986; 407: 123-8
81. 2+ channels. J Physiol Lond 1995; 484: 583-92
82. Hescheler J, Mieskes G, Ruegg JC, et al. Effects of a protein phosphatase inhihitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes. Pflugers Arch 1988; 412: 248-52
83. Hescheler J, Kameyama M, Trautwein W, et al. Regulation of the cardiac calcium channel by protein phosphatases. Eur J Biochem 1987; 165: 261-6
84. Lu C, Kumar R, Akita T, et al. Developmental changes in the actions of phosphatase inhibitors on calcium current of rabbit heart cells. [Pflugers Arch 1994; 427: 389-98
85. 2+, pHi, and contractility during ischemia and reperfusion. Circulation 1992; 86 (5 Suppl.): 11371-6
86. Snoeckx LH, van der Vusse GJ, Coumans WA, et al. Differences in ischaemia tolerance between hypertrophied hearts of adult and aged spontaneously hypertensive rats. Cardiovasc Res 1993; 27: 874-81
87. McKee PA, Castelli WP, McNamara PM, et al. The natural history of congestive heart failure: the Framingham study. N Engl J Med 1971; 285: 1441-6
88. Brookshy P, Levi AJ, Jones JV. Investigation of the mechanisms underlying the increased contraction of hypertrophied ventricular myocytes isolated from the spontaneously hypertensive rat. Cardiovasc Res 1993; 27: 1268-77
89. Brooksby P, Levi AJ, Jones JV. The electrophysiological characteristics of hypertrophied ventricular myocytes from the spontaneously hypertensive rat. J Hypertens 1993; 11: 611-22
90. Scamps F, Mayoux E, Charlemagne D, et al. Calcium current in single cells isolated from normal and hypertrophied rat heart: effects of beta-adrenergic simulation. Circ Res 1990; 67: 199-208
91. Momtaz A, Coulombe A, Richer P, et al. Action potential and plateau ionic currents in moderately and severely DOCA-salt hypertrophied rat hearts. J Mol Cell Cardiol 1996; 28: 2511-22
92. Meszaros J, Coutinho JJ, Bryant SM, et al. L-type calcium current in catecholamine-induced cardiac hypertrophy in the rat. Exp Physiol 1997; 82: 71-83
93. Nuss HB, Houser SR. Voltage dependence of contraction and calcium current in severely hypertrophied feline ventricular myocytes. J Mol Cell Cardiol 1991; 23: 717-26
94. Chouabe C, Espinosa L, Megas P, et al. Reduction of I(Ca.L) and I(to 1) density in hypertrophied right ventricular cells by simulated high altitude in adult rats. J Mol Cell Cardiol 1997; 29: 193-206
95. Santos PE, Barcellos LC, Mill JG, et al. Ventricular action potenlial and L-type calcium channel in infarct-induced hypertrophy in rats. J Cardiovasc Electrophysiol 1995; 6: 1004-14
96. Mukherjee R, Hewett KW, Spinale FG. Myocyte electrophysiological properties following the development of supraventricular tachycardia-induced cardiomyopathy. J Mol Cell Cardiol 1995; 27: 1333-48
97. Tanaka R, Fulbright BM, Mukherjee R, et al. The cellular basis for the blunted response to beta-adrenergic stimulalion in supraventricular tachycardia-induced cardiomyopathy. J Mol Cell Cardiol 1993; 25: 1215-33
98. Ming Z, Nordin C, Siri F, et al. Reduced calcium current density in single myocytes isolated from hypertrophied failing guinea pig hearts. J Mol Cell Cardiol 1994; 26: 1133-43
99. Pinto JM, Yuan F, Wasserlauf BJ, et al. Regional gradation of L-type calcium currents in the feline heart with a healed myocardial infarct. J Cardiovasc Electrophysiol 1997; 8: 548-60
100. Thuringer D, Deroubaix E, Coulombe A, et al. Ionic basis of the action potential prolongation in ventricular myocytes from Syrian hamsters with dilated cardiomyopathy. Cardiovasc Res 1996; 31: 747-57
101. Rossner KL. Calcium current in congestive heart failure of hamster cardiomyopathy. Am J Physiol 1991; 260 (4 Pt 2): H1179-86
102. Ouadid H, Albat B, Nargeot J. Calcium currents in diseased human cardiac cells. J Cardiovasc Pharmacol 1995; 25: 282-91
103. 2+ current in ventricular myocytes between spontaneously hypertensive rats and normotensive rats. Clin Exp Pharmacol Physiol 1995; 22 Suppl. 1: S230-1
104. Gidh-Jain M, Huang B, Jain P, et al. Reemergence of the fetal pattern of L-type calcium channel gene expression in non-infarcted myocardium during left ventricular remodeling. Biochem Biophys Res Commun 1995; 216: 892-7
105. 1c subunit [abstract]. Circulation 1997; 96: 1-54
106. Pende A, Tremmel KD, DeMaria CT, et al. Regulation of the mRNA-binding protein AUF1 by activation of the beta-adrenergic receptor signal transduction pathway. J Biol Chem 1996; 271: 8493-501
107. White M, Yanowitz F, Gilbert EM, et al. Role of beta-adrenergic receptor downregulation in the peak exercise response in patients with heart failure due to idiopathic dilated cardiomyopathy. Am J Cardiol 1995; 76: 1271-6
108. Fowler MB, Laser JA, Hopkins GL, et al. Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response. Circulation 1986; 74: 1290-302
109. Bristow MR, Ginsburg R, Umans V, et al. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ Res 1986; 59: 297-309
110. Ungerer M, Kessebohm K, Kronsbein K, et al. Activation of beta-adrenergic receptor kinase during myocardial ischemia. Circ Res 1996; 79: 455-60
111. Ungerer M, Bohm M, Elce JS, et al. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation 1993; 87: 454-63
112. Feldman AM, Ray PE, Bristow MR. Expression of alpha-subunits of G proteins in failing human heart: a reappraisal utilizing quantitative polymerase chain reaction. J Mol Cell Cardiol 1991; 23: 1355-8
113. Feldman AM, Jackson DG, Bristow MR, et al. Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate. J Mol Cell Cardiol 1991; 23: 439-52