Raphe magnus serotonergic neurons tonically modulate nociceptive transmission

Pain Forum

Volumn 7, Issue 3, 1998, Pages 143-150

  Mason, P ^a   Gao, K ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Analgesia; Autonomic modulation; Morphine; Nociceptive modulation; Periaqueductal gray; Serotonin

Indexed keywords

ANTINOCICEPTION; HUMAN; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; RAPHE MAGNUS NUCLEUS; REGULATORY MECHANISM; REVIEW; SEROTONINERGIC NERVE;

EID: 0031690017     PISSN: 10589139     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1082-3174(98)70008-x     Document Type: Review

References (79)

1. I A Abois AI Basbaum Afferent connections of the rostral medulla of the cat: a neural substrate for midbrain- medullary interactions in the modulation of pain J Comp Neurol 201 1981 285 297
2. H Akil JC Liebeskind Monoaminergic mechanisms of stimulation-produced analgesia Brain Res 94 1975 279 296
3. H Akil DJ Mayer Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor Brain Res 44 1972 692 697
4. AA Alhaider GL Wilcox Differential roles of 5-hydroxytryptamine1 A and 5-hydroxytryptamine1 B receptor subtypes in modulating spinal nociceptive transmission in mice J Pharm Exp Ther 265 1993 378 385
5. Z Ali G Wu A Kozlov S Barasi The actions of 5-HT1 agonists and antagonists on nociceptive processing in the rat spinal cord: results from behavioural and electrophysiological studies Brain Res 661 1994 83 90
6. S Auerbach C Fornal BL Jacobs Response of serotonin-containing neurons in nucleus raphe magnus to morphine, noxious stimuli, and periaqueductal gray stimulation in freely moving cats Exp Neurol 88 1985 609 628
7. SJ Bacon A Zagon AD Smith Electron microscopic evidence of a monosynaptic pathway between cells in the caudal raphe nuclei and sympathetic preganglionic neurons in the rat spinal cord Exp Brain Res 79 1990 589 602
8. NM Barbaro MM Heinricher HL Fields Putative pain modulating neurons in the rostral ventral medulla: reflexrelated activity predicts effects of morphine Brain Res 366 1986 203 210
9. AI Basbaum CH Clanton HL Fields Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems J Comp Neurol 178 1978 209 224
10. AI Basbaum HL Fields The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation J Comp Neurol 187 1979 513 531
11. JB Bederson HL Fields NM Barbaro Hyperalgesia during naloxone-precipitated withdrawal from morphine is associated with increased on-cell activity in the rostral ventromedial medulla Somat Mot Res 7 1990 185 203
12. G Belcher RW Ryall R Schaffner The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat Brain Res 151 1978 307 321
13. JM Besson JL Oliveras Analgesia induced by electrical stimulation of the brain stem in animals: involvement of serotoninergic mechanisms Act Neurochir (suppl) 30 1980 201 217
14. RJ Bodnar CL Williams SJ Lee GW Pasternak Role of mu 1-opiate receptors in supraspinal opiate analgesia: a microinjection study Brain Res 447 1988 25 34
15. RM Bowker RP Dilts Distribution of mu-opioid receptors in the nucleus raphe magnus and nucleus gigantocellularis: a quantitative autoradiographic study Neurosci Lett 88 1998 247 252
16. MC Bushnell GH Duncan R Dubner Attentional influences on noxious and innocuous cutaneous heat detection in humans and monkeys J Neurosci 5 1985 1103 1110
17. JB Cabot Some principles of the spinal organization of the sympathetic preganglionic outflow Prog Brain Res 107 1996 29 42
18. E Carstens M Fraunhoffer M Zimmermann Serotonergic mediation of descending inhibition from midbrain periaqueductal gray, but not reticular formation, or spinal nociceptive transmission in the cat Pain 10 1981 149 167
19. CY Chiang ZZ Pan Differential responses of serotonergic and non-serotonergic neurons in nucleus raphe magnus to systemic morphine in rats Brain Res 337 1985 146 150
20. CY Chiang XK Xiang Does morphine enhance the release of 5-hydroxytryptamine in the rat spinal cord? An in vivo differential pulse voltammetry study Brain Res 411 1987 259 266
21. RW Clarke J Harris AK Houghton Spinal 5-HT-receptors and tonic modulation of transmission through a withdrawal reflex pathway in the decerebrated rabbit Brit J Pharmacol 119 1996 1167 1176
22. A Dahlstrom K Fuxe Evidence for the existence of monoamine-containing neurons in the central nervous system I. Demonstration of monoamine in the cell bodies of brain stem neurons Acta Physiol Scand 232 1964 1 36
23. JF Deakin JO Dostrovsky Involvement of the periaqueductal grey matter and spinal 5-hydroxytryptaminergic pathways in morphine analgesia: effects of lesions and 5-hydroxytryptamine depletion Brit J Pharmacol 63 1978 159 165
24. R Dubner DJ Kenshalo W Maixner The correlation of monkey medullary dorsal horn neuronal activity and the perceived intensity of noxious heat stimuli J Neurophys 62 1989 450 457
25. N el Yassir SM Fleetwood-Walker A 5-HT1-type receptor mediates the antinociceptive effect of nucleus raphe magnus stimulation in the rat Brain Res 523 1990 92 99
26. HL Fields MM Heinricher P Mason Neurotransmitters in nociceptive modulatory circuits Ann Rev Neurosci 14 1991 219 245
27. C Fornal S Auerbach BL Jacobs Activity of serotonincontaining neurons in nucleus raphe magnus in freely moving cats Exp Neurol 88 1985 590 608
28. K Gao DO Chen JR Genzen P Mason Activation of serotonergic neurons in the raphe magnus is not necessary for morphine antinociception J Neurosci 17 1998 3285 3292
29. K Gao YH Kim P Mason Serotonergic pontomedullary neurons are not activated by antinociceptive stimulation in the periaqueductal gray J Neurosci 17 1997 3285 3292
30. K Gao P Mason Somatodendritic morphology and axonal anatomy of intracellularly labeled serotonergic neurons in the rat medulla J Comp Neurol 389 1997 309 328
31. J Gjerstad A Tjolsen K Hole The effect of 5-HT1A receptor stimulation on nociceptive dorsal horn neurones in rats Eur J Pharmacol 318 1996 315 321
32. EJ Glazer AI Basbaum Axons which take up [3H]seroto-nin are presynaptic to enkephalin immunoreactive neurons in cat dorsal horn Brain Res 298 1984 386 391
33. R Hen Mean genes Neuron 16 1996 17 21
34. Y Hori K Endo T Takahashi Long-lasting synaptic facilitation induced by serotonin in superficial dorsal horn neurones of the rat spinal cord J Physiol 492 1996 867 876
35. BL Jacobs EC Azmitia Structure and function of the brain serotonin system Physiol Rev 72 1992 165 229
36. AS Jansen XV Nguyen V Karpitskiy Central command neurons of the sympathetic nervous system: basis of the flight-or-flight response Science 270 1995 644 646
37. H Kaplan HL Fields Hyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla J Neurosci 11 1991 1433 1439
38. H Khachaturian ME Lewis SJ Watson Enkephalin systems in diencephalon and brainstem of the rat J Comp Neurol 220 1983 310 320
39. S Lakos Al Basbaum An ultrastructural study of the projections from the midbrain periaqueductal gray to spinally projecting, serotonin-immunoreactive neurons of the medullary nucleus raphe magnus in the rat Brain Res 443 1998 383 388
40. D LeBars Serotonin and pain NN Osborne M Hamon Neuronal serotonin 1998 Wiley New York 171 226
41. KP Lesch Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1996 1527 1531
42. P Li M Zhuo Facilitatory and inhibitory modulation of synaptic nociceptive transmission in dorsal horn neurons of the spinal cord of the rat Soc Neurosci Abstr 23 1997 1539
43. AR Light AM Kavookjian P Petrusz The ultrastructure and synaptic connections of serotonin-immunoreactive terminals in spinal laminae I and II Somat Mot Res 1 1983 33 50
44. Q Lin YB Peng WD Willis Antinociception and inhibition from the periaqueductal gray are mediated in part by spinal 5-hydroxytryptamine (1A) receptors J Pharm Exp Ther 276 1996 958 967
45. L Marlier F Sandillon P Poulat Serotonergic innervation of the dorsal horn of rat spinal cord: light and electron microscopic immunocytochemical study J Neurocytol 20 1991 310 322
46. P Mason Physiological identification of pontomedullary serotonergic neurons in the rat J Neurophys 77 1997 1087 1098
47. P Mason I Escobedo Nociceptive responsiveness is greater during slow wave sleep than during waking Soc Neurosci Abstr 21 1995 387
48. P Mason A Strassman R Maciewicz Serotonin immunocytochemistry of physiologically characterized raphe magnus neurons Exp Brain Res 73 1988 1 7
49. FF Matos H Rollema JL Brown AI Basbaum Do opioids evoke the release of serotonin in the spinal cord? An in vivo microdialysis study of the regulation of extracellular serotonin in the rat Pain 48 1992 439 447
50. DJ Maxwell C Leranth AA Verhofstad Fine structure of serotonin-containing axons in the marginal zone of the rat spinal cord Brain Res 266 1983 253 259
51. RJ Milne GD Gamble Behavioural modification of bulbospinal serotonergic inhibition and morphine analgesia Brain Res 521 1990 167 174
52. N Mjellem A Lund K Hole Different functions of spinal 5-HT1A and 5-HT2 receptor subtypes in modulating behaviour induced by excitatory amino acid receptor agonists in mice Brain Res 626 1993 78 82
53. JS Mohrland GF Gebhart Effect of selective destruction of serotonergic neurons in nucleus raphe magnus on morphine-induced antinociception Life Sci 27 1980 2627 2632
54. K Murase M Randic T Shirasaki Serotonin suppresses N-methyl-D-aspartate responses in acutely isolated spinal dorsal horn neurons of the rat Brain Res 525 1990 84 91
55. JL Oliveras S Bourgoin F Hery JM Besson M Hamon The topographical distribution of serotoninergic terminals in the spinal cord of the cat: biochemical mapping by the combined use of microdissection and microassay procedures Brain Res 138 1977 393 406
56. YB Peng Q Lin WD Willis The role of 5-HT3 receptors in periaqueductal gray-induced inhibition of nociceptive dorsal horn neurons in rats J Pharm Exp Ther 276 1996 116 124
57. SB Potrebic HL Fields P Mason Serotonin immunoreactivity is contained in one physiological cell class in the rat rostral ventromedial medulla J Neurosci 14 1994 1655 1665
58. JL Ridet M Geffard A Privat Light and electron microscopic studies of the effects of p-chloroamphetamine on the monoaminergic innervation of the rat spinal cord J Comp Neurol 343 1994 281 296
59. A Riehle S Grun M Diesmann A Aertsen Spike synchronization and rate modulation differentially involved in motor cortical function Science 278 1997 1950 1953
60. JP Rivot B Calvino JM Besson Is there a serotonergic tonic descending inhibition on the responses of dorsal horn convergent neurons to C-fibre inputs? Brain Res 403 1987 142 146
61. Y Saito JG Collins H Iwasaki Tonic 5-HT modulation of spinal dorsal horn neuron activity evoked by both noxious and non-noxious stimuli: a source of neuronal plasticity Pain 40 1990 205 219
62. M Satoh A Kubota T Iwama Comparison of analgesic potencies of mu, delta and kappa agonists locally applied to various CNS regions relevant to analgesia in rats Life Sci 1 1983 689 692
63. H Shiomi H Murakami H Takagi Morphine analgesia and the bulbospinal serotonergic system: increase in concentration of 5-hydroxyindoleacetic acid in the rat spinal cord with analgesics Eur J Pharmacol 52 1978 335 344
64. LS Sorkin DJ McAdoo WD Willis Raphe magnus stimulation-induced antinociception in the cat is associated with release of amino acids as well as serotonin in the lumbar dorsal horn Brain Res 618 1993 95 108
65. SS Tenen Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor Psychopharm 12 1968 278 285
66. AJ Todd J Millar Receptive fields and responses to ionophoretically applied noradrenaline and 5-hydroxytryptamine of units recorded in laminae I-III of cat dorsal horn Brain Res 288 1983 159 167
67. H Vanegas NM Barbaro HL Fields Midbrain stimulation inhibits tail-flick only at currents sufficient to excite rostral medullary neurons Brain Res 321 1984 127 133
68. MR Vasko IH Pang M Vogt Involvement of 5-hydroxytryptamine-containing neurons in antinociception produced by injection of morphine into nucleus raphe magnus or onto spinal cord Brain Res 306 1984 341 348
69. LR Watkins EP Wiertelak LE Goehler Neurocircuitry of illness-induced hyperalgesia Brain Res 639 1994 283 299
70. MW Wessendorf EG Anderson Single unit studies of identified bulbospinal serotonergic units Brain Res 279 1983 93 103
71. S Wigdor GL Wilcox Central and systemic morphineinduced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways J Pharmacol Exp Ther 242 1987 90 95
72. RG Williams GJ Dockray Distribution of enkephalinrelated peptides in rat brain: immunohistochemical studies using antisera to met-enkephalin and met-enkephalin Arg6Phe7 J Neurosci 9 1983 563 586
73. W Xu XC Qiu JS Han Serotonin receptor subtypes in spinal antinociception in the rat J Pharm Exp Ther 269 1994 1182 1189
74. TL Yaksh GM Tyce Microinjection of morphine into the periaqueductal gray evokes the release of serotonin from spinal cord Brain Res 171 1979 176 181
75. TL Yaksh PR Wilson Spinal serotonin terminal system mediates antinociception J Pharm Exp Ther 208 1979 446 453
76. FP Zemlan AZ Murphy MM Behbehani 5-HT1A receptors mediate the effect of the bulbospinal serotonin system on spinal dorsal horn nociceptive neurons Pharmacol 48 1994 1 10
77. M Zhuo GF Gebhart Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat Brain Res 550 1991 35 48
78. M Zhuo GF Gebhart Characterization of descending facilitation and inhibition of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat J Neurophysiol 67 1992 1599 1614
79. M Zhuo GF Gebhart Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat J Neurophysiol 78 1997 746 758