Gly166 in the NK1 receptor regulates tachykinin selectivity and receptor conformation

FEBS Letters

Volumn 416, Issue 3, 1997, Pages 335-338

  Ciucci, Alessandra ^a   Palma, Carla ^a   Riitano, Daniela ^b   Manzini, Stefano ^a   Werge, Thomas M ^b,c  

^a Menarini Ricerche SpA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Affinity; Neurokinin A; NK1 receptor; Receptor conformation; Selectivity; Substance P

Indexed keywords

N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ A; NEUROKININ B; NEUROKININ B [7 METHYLPHENYLALANINE]; NOLPITANTIUM; SEPTIDE; SUBSTANCE P; SUBSTANCE P DERIVATIVE; SUBSTANCE P METHYL ESTER; TACHYKININ; CYSTEINE; DITHIOTHREITOL; GLYCINE; N ETHYLMALEIMIDE; RECOMBINANT PROTEIN; TACHYKININ RECEPTOR;

AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN COS1; COMPUTER PROGRAM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; LIGAND BINDING; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CHEMISTRY; CHO CELL; HAMSTER; KINETICS; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; RAT; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CHO CELLS; COS CELLS; CRICETINAE; CYSTEINE; DITHIOTHREITOL; ETHYLMALEIMIDE; GLYCINE; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; NEUROKININ A; NEUROKININ B; PROTEIN CONFORMATION; RATS; RECEPTORS, NEUROKININ-1; RECEPTORS, TACHYKININ; RECOMBINANT PROTEINS; SUBSTANCE P;

EID: 0030613786     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)01236-2     Document Type: Article

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