Peripheral and/or central effects of racemic-, S(+)- and R(-)-flurbiprofen on inflammatory nociceptive processes: A c-Fos protein study in the rat spinal cord

British Journal of Pharmacology

Volumn 125, Issue 1, 1998, Pages 87-101

  Buritova, Jaroslava ^a   Besson, Jean Marie ^a  

^a PSL RESEARCH UNIVERSITY   (France)

Author keywords

c Fos; Carrageenan inflammation; Dorsal horn; Nociception; NSAIDs; R( ) flurbiprofen; Racemic flurbiprofen S(+) flurbiprofen; Rat

Indexed keywords

CARRAGEENAN; FLURBIPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANKLE; ARTICLE; CONTROLLED STUDY; INFLAMMATION; LUMBAR SPINE; MALE; NERVE CELL; NOCICEPTION; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; EDEMA; FLURBIPROFEN; INJECTIONS, INTRAVENOUS; LUMBOSACRAL REGION; MALE; PAIN MEASUREMENT; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 0031686095     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702053     Document Type: Article

References (73)

1. ALHAVA, E. (1994). Reported adverse drug reactions and consumption of non-steroidal anti-inflammatory drugs. Pharmacol. Toxicol., 75(Suppl. 11), 37-43.
2. ATTAL, N., KAYSER, V., ESCHALIER, A., BENOIST, J.M. & GUILBAUD, G. (1988). Behavioural and electrophysiological evidence for an analgesic effect of non-steroidal anti-inflammatory agent, sodium diclofenac. Pain, 35, 341-348.
3. BESSON, J.M. & CHAOUCH, A. (1987). Peripheral and spinal mechanisms of nociception. Physiol. Rev., 67, 67-186.
4. BIELA, G. & GROPPETTI, A. (1993). Correlation between the antinociceptive effect of aspirin and central transmiters. In Progress in Pharmacology and Clinical Pharmacology, ed. Jurna, I. & Yaksh, T.L., pp. 1-9, Stuttgard: Fischer Verlag.
5. BRUNE, K., BECK, W.S., GEISSLINGER, G., MENZEL-SOGLOWEK, S., PESKAR, B.M. & PESKAR, B.A. (1991). Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition. Experimentia, 47, 257-261.
6. BRUNE, K., BUCHER, K. & WALZ, D. (1974). The avian microcrystal inflammation. II. Central versus peripheral effects of sodium salicylate, acetaminophen and colchicine. Agents Actions, 4, 27-33.
7. BRUNE, K., GEISSLINGER, G. & MENZEL-SOGLOWEK, S. (1992a). Pure enantiomers of 2-arylpropionic acids: Tools in pain research and improved drugs in rheumatology. J. Clin. Pharmacol., 32, 944-952.
8. BRUNE, K., MENZEL-SOGLOWEK, S. & ZEILHOFER, H.U. (1992b). Differential analgesic effects of aspirin-like drugs. Drugs, 44, 52-59.
9. BURITOVA, J. & BESSON, J.M. (1997a). Potent anti-inflammatory/ analgesic effects of lornoxicam in comparison to other NSAIDs: A spinal c-Fos study in the rat. Inflammopharmacology, 5, 331-341.
10. BURITOVA, J. & BESSON, J.M. (1997b). Peripheral versus central effects of flurbiprofen enantiomers on carrageenan inflammation: A spinal c-Fos protein study. 27th Annual Meeting of Society for Neuroscience in New Orleans, Soc. Neurosci. Abstr., Vol. 23, Part 1, p. 167 (Abstract 71.18).
11. BURITOVA, J. & BESSON, J.M. (1998). Dose-related anti-inflammatory/analgesic effects of lornoxicam: A spinal c-Fos protein study in the rat. Inflamm. Res., 47, 18-25.
12. BURITOVA, J., BESSON, J.M. & BERNARD, J.F. (1998). Involvement of the spinoparabrachial pathway in inflammatory nociceptive processes: A c-fos protein study in the awake rat. J. Comp. Neurol., 397, 10-28.
13. BURITOVA, J., HONORÉ, P. & BESSON, J.M. (1996a). Ketoprofen produces profound inhibition of spinal c-Fos protein expression resulting from an inflammatory stimulus but not from noxious heat. Pain, 67, 379-389.
14. BURITOVA, J., HONORÉ, P., CHAPMAN, V. & BESSON, J.M. (1996b). Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and spinal c-Fos expression in the rat: Synergistic mechanisms. Pain, 64, 559-568.
15. BURITOVA, J., CHAPMAN, V., HONORÉ, P. & BESSON, J.M. (1996c). Selective cyclooxygenase-2 inhibition reduces carrageenan oedema and spinal c-Fos expression in the rat. Brain Res., 715, 217-220.
16. CARABAZA, A., CABRÉ, K., ROTLLAN, E., GOMEZ, M., GUTIÉRREZ, M., GARCIA, L. & MAULEON, D. (1996). Stereoselective inhibition of inducible cyclooxygenase by chiral nonsteroidal antiinflammatory drugs. J. Clin. Pharmacol., 36, 505-512.
17. CARLSSON, K.H., MONZEL, W. & JURNA, I. (1988). Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents. Pain, 32, 313-326.
18. CHAPMAN, V. & BESSON, J.M. (1997). Pharmacological studies of nociceptive systems using the c-Fos immunohistochemical technique: An indicator of noxiously activated spinal neurones. In The Pharmacology of Pain, ed. Dickenson, A. & Besson, J.-M., pp. 235-279. Berlin Heidelberg: Springer-Verlag.
19. CHAPMAN, V., BURITOVA, J., HONORÉ, P. & BESSON, J.M. (1996). Physiological contribution of neurokinin 1 receptor activation, and interaction with NMDA receptors, to inflammatory-evoked spinal c-Fos expression. J. Neurophysiol., 76, 1817-1827.
20. CHAPMAN, V. & DICKENSON, A.H. (1992). The spinal and peripheral roles of bradykinin and prostaglandins in nociceptive processing in the rat. Eur. J. Pharmacol., 219, 427-433.
21. DAVIES, N.M., WRIGHT, M.R., RUSSELL, A.S. & JAMALI, F. (1996) Effect of the enantiomers of Flurbiprofen. Ibuprofen, and Ketoprofen on intestinal permeability. J. Pharm. Sci., 85(11), 1170-1173.
22. DI ROSA, M., GIROUD, J.P. & WILLOUGHBY, D.A. (1971). Studies of the mediators of the acute inflammatory-response induced in rats in different sites by carrageenin and turpentine. J. Pathol., 104, 15-29.
23. DRAISCI, G. & IADAROLA, M. J. (1989). Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord. Mol. Br. Res., 6, 31-37.
24. ELLIOTT, G., PURMALIS, A., VANDERMEER, D.A. & DENLINGER, H. (1988). The propionic acids. Gastrointestinal toxicity in various species. Toxicol. Pathol., 16, 245-250.
25. EVANS, A.M. (1996). Pharmacodynamics and pharmacokinetics of the profens: Enantioselectivity, clinical implication, and special reference to S(+)-Ibuprofen. J. Clin. Pharmacol., 36, 7S-15S.
26. FERREIRA, S.H. (1972). Prostaglandins, aspirin-like drugs and analgesia. Nature, 240, 200-203.
27. FLOWER, R.J. & VANE J.R. (1974). Inhibition of prostaglandin biosynthesis. Biochem. Pharmacol., 23, 1439-1450.
28. GEISSLINGER, G., FERREIRA, S.H., MENZEL, S., SCHLOTT, D. & BRUNE, K. (1994). Antinociceptive actions of R( )-flurbiprofen a non-cyclooxygenase inhibiting 2-arylpropionic acid in rats. Life Sciences, 54, 173-177.
29. GEISSLINGER, G. & SHAIBLE, H.G. (1996). New insights into the site and mode of antinociceptive action of Flurbiprofen enantiomers. J. Clin. Pharmacol., 36, 513-520.
30. GROSSMAN, C.J., WISEMAN, J., LUCAS, F.S., TREVETHICK, M.A. & BIRCH, P.J. (1995). Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and COX-2 inhibitors. Inflamm. Res., 4, 253-257.
31. HARGREAVES, K., DUBNER, R., BROWN, F., FLORES, C. & JORIS, J. (1988). A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain, 32, 77-88.
32. HONORÉ, P., BURITOVA, J. & BESSON, J.M. (1995). Carrageenin-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacin. Eur. J. Pharmacol., 272, 249-259.
33. HSU, S., RAINE, L. & FANGER, H. (1981). Use of avidin-biotin-peroxydase complex (ABC) in immunoperoxydase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures. J. Histochem. Cytochem., 29, 577-580.
34. HUGHES, P. & DRAGUNOW, M. (1995). Induction of immediate-early genes and the control of neurotransmitter-regulated expression within the nervous system. Pharmacol. Reviews, 47, 133-178.
35. IADAROLA, M.J., BRADY, L.S., DRAISCI, G. & DUBNER, R. (1988). Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding. Pain, 35, 313-326.
36. INSEL, P.A. (1991) Analgesic-antipyretics and antiinflammatory agens; drugs employed in treatment of rheumatoid arthritis and gout. In The pharmacological basis of therapeutics, ed. Goodman Gilman, A., Rall, T.W., Nies, A.S. & Taylor, P., 638-681, Singapore: McGraw-Hill Inc.
37. JAMALI, F., BERRY, B.W., TEHRANI, M.R. & RUSSELL, A.S. (1988). Stereoselective pharmacokinetics of flurbiprofen in humans and rats. J. Pharm. Sci., 77, 666-669.
38. JORIS, J., COSTELLO, A., DUBNER, R. & HARGREAVES, K. (1990). Opiates supress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia. Pain, 43, 95-103.
39. JURNA, I. (1997). Opioid and nonopioid analgesis agents: some aspects of central (spinal) and peripheral actions. Pain Reviews, 4, 205-229.
40. JURNA, I. & BRUNE, K. (1990). Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C-fibre-evoked activity in single neurones of the rat thalamus. Pain, 41, 71-80.
41. JURNA, I., SPOHRER, B. & BOCK, R. (1992). Intrathecal injection of acetylsalicylic acid, salicylic acid and indometacin depresses C fibre-evoked activity in the rat thalamus and spinal cord. Pain, 49, 249-256.
42. KAYSER, V. & GUILBAUD, G. (1987). Local and remote modifications of nociceptive sensitivity during carrageenin-induced inflammation in the rat. Pain, 28, 99-107.
43. KRESS, M., VYKLICKY, L. & REEH, P.W. (1996). The capsaicin receptor - target for a novel action of aspirin-like drugs? 26th Annual Meeting of Society for Neuroscience in Washington D.C., Soc. Neurosci. Abstr., Vol. 22, p. 1028 (Abstract 409.1).
44. LANEUVILLE, O., BREUER, D.K., DEWITT, D.L., HLA, T., FUNK, C.D. & SMITH, W.L. (1994). Differential inhibition of human prostaglandin endoparoxide H synthase-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther., 271, 927-934.
45. MALMBERG, A.B. & YAKSH, T.L. (1992a). Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther., 263, 136-146.
46. MALMBERG, A.B. & YAKSH, T.L. (1992b). Hyperalgesia mediated by spinal glutamate or substance P receptor bloced by spinal cyclooxygenase inhibition. Science, 257, 1276-1279.
47. 2 release in spinal cord slices: relative effect of cyclooxygenase inhibitors. Eur. J. Pharmacol., 271, 293-299.
48. MALMBERG, A.B. & YAKSH, T.L. (1994b). Antinociception produced by spinal delivery of S and R enantiomers of flurbiprofen in the formalin test in rats. Eur. J. Pharmacol., 256, 205-209.
49. 2 and amino acids evoked by paw formalin injection: A microdialysis study in unanesthetized rats. J. Neurosci., 15, 2768-2776.
50. MCCORMACK, K. (1994). Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain, 59, 9-43.
51. MÉNETREY, D., DE POMMERY, J., BAIMBRIDGE, K.G. & THOMASSET, M. (1992). Calbindin-D28K (CaBP28k)-like immunoreactivity in ascending projections. I. Trigemial nucleus caudalis and dorsal vagal complex projections. Europ. J. Neurosci., 4, 61-69.
52. MEADE, E.A., SMITH, W.L. & DE WITT, D.L. (1993). Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem., 268, 6610-6614.
53. MENZEL-SOGLOWEK, S., GEISSLINGER, G., BECK, W.S. & BRUNE, K. (1992). Variability of inversion of (R)-flurbiprofen in different species. J. Pharm. Sci., 81, 888-891.
54. MITCHELL, J.A., AKARASEREENONT, P., THIEMERMANN, C., FLOWER, R.J. & Vane, J.R. (1993). Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A., 90, 11693-11697.
55. MOLANDER, C. & GRANT, G. (1986). Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat. Neuroscience, 19, 297-312.
56. MOLANDER, C., XU, Q. & GRANT, G. (1984). The cytoarchitectonic organization of the spinal cord in the rat: I. The lower thoracic and lumbosacral cord. J. Comp. Neurol., 230, 133-141.
57. MORGAN, J.I. (1991). Proto-oncongene expression in the nervous system. Discussions in Neuroscience. Amsterdam, Elsevier Science Publishers B.V., pp. 10-50.
58. MORGAN, J.I. & CURRAN, T. (1995). Immediate-early genes: ten years on. Trends Neurosci., 18, 66-67.
59. MUNGLANI, R. & HUNT, S.P. (1995). Molecular biology of pain. Br. J. Anaesthesia, 75, 186-192.
60. NEUGEBAUER, V., GEISSLINGER, G., RÜMENAPP, P., WEIRETTER, F., SZELENYI, I., BRUNE, K. & SHAIBLE, H.G. (1995). Anti-nociceptive effects of R(-)- and S(+)-Flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation. J. Pharmacol. Exp. Ther., 275, 618-628.
61. NEUGEBAUER, SHAIBLE, H.G., HE, X., LÜCKE, T., GÜNDLING, P & SCHMIDT, R.F. (1994). Electrophysiological evidence for a spinal antinociceptive action of dipyrone. Agents Actions, 41, 62-70.
62. NOGUCHI, K., DUBNER, R. & RUDA, M. A. (1992). Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins. Neuroscience., 46, 561-570.
63. NOGUCHI, K., KOWALSKI, K., TRAUB, R., SOLODKIN, A., IADAROLA, M. J. & RUDA, M. A. (1991). Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons. Molec. Brain Res., 10, 227-233.
64. PESKAR, B.M., KLUGE, S., PESKAR, B.A., MENZEL-SOGLOWEK, S. & BRUNE, K. (1991). Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo. Prostaglandins, 42, 515-531.
65. REXED, B. (1952). The cytoarchitectonic organization of the spinal cord in the cat. J. Comp. Neurol., 96, 415-495.
66. 2α. Brain Res., 373, 81-84.
67. VANE, J.R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature, 231, 232-235.
68. WILLIAMS, K.M. (1990). Enantiomers in arthritic disorders. Pharmacol. Ther., 46, 273-295.
69. WILLIS, W.D. & COGGESHALL, R.E. (1991). Sensory mechanisms of the spinal cord, pp. 79-151, New York: Plenum Press.
70. WINTER, C.A., RISLEY E.A. & NUSS G.W. (1962). Carrageenan-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol. Med., 111, 544-547.
71. WECHTER, W.J. (1994). Drug chirality: On the mechanism of R-aryl propionic acid class NSAIDs. Epimerization in humans and the clinical implication for use of Racemates. J. Clin. Pharmacol., 34, 1036-1042.
72. ZIEGLGANSBERGER, W. & TÖLLE, T.R. (1993). The pharmacology of pain signalling. Curr. Opin. Neurobiol., 3, 611-618.
73. ZIMMERMANN, M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain, 16, 109-110.