Potent anti-inflammatory/analgesic effects of lornoxicam in comparison to other NSAIDS: A c-Fos study in the rat

Inflammopharmacology

Volumn 5, Issue 4, 1997, Pages 331-341

  Buritova, J ^a   Besson, J M ^a  

^a INSERM   (France)

Author keywords

C Fos; Carrageenan; Dorsal horn; Lornoxicam; Nociception; Rat

Indexed keywords

CARRAGEENAN; LORNOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANKLE EDEMA; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NOCICEPTION; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL;

EID: 0030825960     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-997-0030-9     Document Type: Article

References (42)

1. 1. JA Balfour A Fitton LB Barradell 1996 Lornoxicam: A review of its pharmacology and therapeutic potential in the management of painful and inflammatory conditions Drugs 51 639 57 8706598 1:CAS:528:DyaK28XislKntrk%3D Balfour JA Fitton A, Barradell LB. Lornoxicam: A review of its pharmacology and therapeutic potential in the management of painful and inflammatory conditions. Drugs. 1996;51:639–57.
2. 2. TP Pruss H Stroissnig S Radhofer-Welte 1990 Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam Postgrad Med J 66 Suppl.4 S18 21 2284216 1:CAS:528:DyaK3MXktVSjsL0%3D Pruss TP, Stroissnig H, Radhofer-Welte S et al. Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam. Postgrad Med J. 1990;66(Suppl.4): S18–21.
3. 3. A Patel AM Skelly H Kohn HW Preiskel 1991 Double-blind placebo-controlled comparison of the analgesic effects of single doses of lornoxicam and aspirin in patients with post-operative dental pain Br Dent J 170 295 9 2036277 1:STN:280:DyaK3M3kt1aitw%3D%3D Patel A, Skelly AM, Kohn H, Preiskel HW. Double-blind placebo-controlled comparison of the analgesic effects of single doses of lornoxicam and aspirin in patients with post-operative dental pain. Br Dent J. 1991;170:295–9.
4. 4. H Berry HA Bird C Black 1992 A double blind, multicentre, placebo controlled trial of lornoxicam in patients with osteoarthritis of the hip and knee Ann Rheum Dis 51 238 42 1550410 1:STN:280:DyaK387pvVWitg%3D%3D 10.1136/ard.51.2.238 Berry H, Bird HA, Black C et al. A double blind, multicentre, placebo controlled trial of lornoxicam in patients with osteoarthritis of the hip and knee. Ann Rheum Dis. 1992;51:238–42.
5. 5. B Kidd A Frenzel 1996 A multicenter, randomized, double blind study comparing lornoxicam with diclofenac in osteoarthritis J Rheumatol 23 1605 11 8877932 1:CAS:528:DyaK28XlvVCru7s%3D Kidd B, Frenzel A. A multicenter, randomized, double blind study comparing lornoxicam with diclofenac in osteoarthritis. J Rheumatol. 1996;23:1605–11.
6. 6. SE Norholt S Sindet-Pedersen C Bugge PA Branebjerg BK Ersboll LH Bastian 1995 A randomized, double-blind, placebo-controlled, dose-response study of analgesic effect of lornoxicam after surgical removal of mandibular third molars J Clin Pharmacol 35 606 14 7665721 1:STN:280:DyaK2MzpsFSrtg%3D%3D Norholt SE, Sindet-Pedersen S, Bugge C, Branebjerg PA, Ersboll BK, Bastian LH. A randomized, double-blind, placebo-controlled, dose-response study of analgesic effect of lornoxicam after surgical removal of mandibular third molars. J Clin Pharmacol. 1995;35:606–14.
7. 7. F Rainer G Klein F Mayrhofer F Singer H Uray FW Kursen 1996 A prospective, multi-centre, openlabel, uncontrolled Phase II study of the local tolerability, safety and efficacy of intramuscular chlortenoxicam in patients with acute low back pain Eur J Clin Res 8 1 13 Rainer F, Klein G, Mayrhofer F, Singer F, Uray H, Kursen FW. A prospective, multi-centre, openlabel, uncontrolled Phase II study of the local tolerability, safety and efficacy of intramuscular chlortenoxicam in patients with acute low back pain. Eur J Clin Res 1996;8:1–13.
8. 8. JI Morgan 1991 Proto-oncogene Expression in the Nervous System. Discussions in Neuroscience Elsevier Amsterdam Morgan JI. Proto-oncogene Expression in the Nervous System. Discussions in Neuroscience. Amsterdam, Elsevier; 1991.
9. 9. JI Morgan T Curran 1995 Immediate-early genes: ten years on Trends Neurosci 18 66 7 7537412 10.1016/0166-2236(95)93874-W 1:CAS:528:DyaK2MXjtlGiurg%3D Morgan JI, Curran T. Immediate-early genes: ten years on. Trends Neurosci. 1995;18:66–7.
10. 10. P Hughes M Dragunow 1995 Induction of immediate-early genes and the control of neurotransmitterregulated expression within the nervous system Pharmacol Rev 47 133 78 7784478 1:CAS:528:DyaK2MXkvF2hsbk%3D Hughes, P, Dragunow M. Induction of immediate-early genes and the control of neurotransmitterregulated expression within the nervous system. Pharmacol Rev. 1995;47:133–78.
11. 11. R Munglani SP Hunt 1995 Molecular biology of pain Br J Anaesth 75 186 92 7577252 1:STN:280:DyaK28%2FptV2ltg%3D%3D Munglani R, Hunt SP. Molecular biology of pain. Br J Anaesth. 1995;75:186–92.
12. 12. W Zieglgänsberger TR Tölle 1993 The pharmacology of pain signalling Curr. Opin Neurobiol 3 611 18 8219729 10.1016/0959-4388(93)90063-5 Zieglgänsberger W, Tölle TR. The pharmacology of pain signalling. Curr. Opin Neurobiol. 1993;3: 611–18.
13. 13. C Abbadie P Honoré J-M Besson 1994 Postsynaptic changes during sustained primary afferent fibre stimulation as revealed by c-Fos immunohistochemistry in the rat spinal cord L Urban A Dray S Jeftinifa P Reeh CJ Woolf The Cellular Mechanisms of Sensory Processing Laszlo Urban Berlin 449 71 Abbadie C, Honoré P, Besson J-M. Postsynaptic changes during sustained primary afferent fibre stimulation as revealed by c-Fos immunohistochemistry in the rat spinal cord. In: Urban L, Dray A, Jeftinifa S, Reeh P, Woolf CJ, eds. The Cellular Mechanisms of Sensory Processing. Berlin: Laszlo Urban; 1994:449–71.
14. 14. C Abbadie J-M Besson 1994 Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis with fos-like immunoreactivity in rat lumbar spinal cord Pain 57 45 54 8065795 10.1016/0304-3959(94)90106-6 1:CAS:528:DyaK2cXlsVymtL8%3D Abbadie C, Besson J-M. Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis with fos-like immunoreactivity in rat lumbar spinal cord. Pain. 1994;57:45–54.
15. 15. P Honoré J Buritova J-M Besson 1995 Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenan inflammation Pain 63 365 75 8719538 10.1016/0304-3959(95)00065-8 Honoré P, Buritova J, Besson J-M. Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenan inflammation. Pain. 1995;63:365–75.
16. 16. P Honoré J Buritova J-M Besson 1995 Carrageenan-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacin Eur J Pharmacol 272 249 59 7713169 10.1016/0014-2999(94)00656-R Honoré P, Buritova J, Besson J-M. Carrageenan-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacin. Eur J Pharmacol. 1995;272:249–59.
17. 17. J Buritova P Honoré V Chapman J-M Besson 1995 Concurrent reduction of inflammation and spinal Fos-LI neurons by systemic diclofenac in the rat Neurosci Lett 188 175 8 7609902 10.1016/0304-3940(95)11426-W 1:CAS:528:DyaK2MXkvVaks7g%3D Buritova J, Honoré P, Chapman V, Besson J-M. Concurrent reduction of inflammation and spinal Fos-LI neurons by systemic diclofenac in the rat. Neurosci Lett. 1995;188:175–8.
18. 18. J Buritova P Honoré V Chapman J-M Besson 1995 Carrageenan oedema and spinal Fos-LI neurons are reduced by piroxicam in the rat Neuroreport 6 1257 60 10.1097/00001756-199507100-00006 Buritova, J, Honoré P, Chapman V, Besson J-M. Carrageenan oedema and spinal Fos-LI neurons are reduced by piroxicam in the rat. Neuroreport. 1995;6:1257–60.
19. 19. J Buritova P Honoré J-M Besson 1996 Ketoprofen produces profound inhibition of spinal c-Fos protein expression resulting from an inflammatory stimulus but not from noxious heat Pain 67 379 89 8951933 10.1016/0304-3959(96)03138-7 1:CAS:528:DyaK28XnsVCqsro%3D Buritova J, Honoré P, Besson J-M. Ketoprofen produces profound inhibition of spinal c-Fos protein expression resulting from an inflammatory stimulus but not from noxious heat. Pain. 1996;67:379–89.
20. 20. J Buritova V Chapman P Honoré J-M Besson 1996 Interactions between NMDA and prostaglandin receptor mediated events in model of inflammatory nociception Eur J Pharmacol 303 91 100 8804916 10.1016/0014-2999(96)00074-X 1:CAS:528:DyaK28XjtlSktLk%3D Buritova J, Chapman, V, Honoré P, Besson J-M. Interactions between NMDA and prostaglandin receptor mediated events in model of inflammatory nociception. Eur J Pharmacol. 1996;303:91–100.
21. 21. CA Winter EA Risley GW Nuss 1962 Carrageenan-induced edema in hind paw of the rat as an assay for antiinflammatory drugs Proc Soc Exp Biol Med 111 544 7 14001233 1:CAS:528:DyaF3sXkvV2itA%3D%3D Winter CA, Risley EA, Nuss GW. Carrageenan-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc Soc Exp Biol Med. 1962;111:544–7.
22. 22. M Rosa Di JP Giroud DA Willoughby 1971 Studies of the mediators of the acute inflammatory-response induced in rats in different sites by carrageenan and turpentine J Pathol. 104 15 29 4398139 10.1002/path.1711040103 Di Rosa M, Giroud JP, Willoughby DA. Studies of the mediators of the acute inflammatory-response induced in rats in different sites by carrageenan and turpentine. J Pathol. 1971;104:15–29.
23. 23. V Kayser G Guilbaud 1987 Local and remote modifications of nociceptive sensivity during carrageenaninduced inflammation in the rat Pain 28 99 107 3822499 10.1016/0304-3959(87)91064-5 1:STN:280:DyaL2s7ksFOrsw%3D%3D Kayser V, Guilbaud G. Local and remote modifications of nociceptive sensivity during carrageenaninduced inflammation in the rat. Pain. 1987;28:99–107.
24. 24. K Hargreaves R Dubner F Brown C Flores J Joris 1988 A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia Pain 32 77 88 3340425 10.1016/0304-3959(88)90026-7 1:STN:280:DyaL1c7itlOntw%3D%3D Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 1988;32:77–88.
25. 25. MJ Iadarola LS Brady G Draisci R Dubner 1988 Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding Pain 35 313 26 2906426 10.1016/0304-3959(88)90141-8 1:CAS:528:DyaL1MXhtleju7c%3D Iadarola MJ, Brady LS, Draisci G, Dubner R. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding. Pain. 1988;35:313–26.
26. 26. J Joris A Costello R Dubner K Hargreaves 1990 Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia Pain 43 95 103 2277720 10.1016/0304-3959(90)90054-H 1:CAS:528:DyaK3MXktVSmtb8%3D Joris J, Costello A, Dubner R, Hargreaves K. Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia. Pain. 1990;43:95–103.
27. 27. G Draisci MJ Iadarola 1989 Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord Mol Brain Res 6 31 7 2570339 10.1016/0169-328X(89)90025-9 1:CAS:528:DyaL1MXkvFCqs7k%3D Draisci G, Iadarola MJ. Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord. Mol Brain Res. 1989;6:31–7.
28. 28. K Noguchi K Kowalski R Traub A Solodkin MJ Iadarola MA Ruda 1991 Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons Mol Brain Res 10 227 33 1679515 10.1016/0169-328X(91)90065-6 1:CAS:528:DyaK3MXltFaisLw%3D Noguchi K, Kowalski K, Traub R, Solodkin A, Iadarola MJ, Ruda MA. Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons. Mol Brain Res. 1991;10:227–33.
29. 29. K Noguchi R Dubner MA Ruda 1992 Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos-related proteins Neuroscience 46 561 70 1545910 10.1016/0306-4522(92)90144-Q 1:CAS:528:DyaK38XhsVChtL8%3D Noguchi K, Dubner R, Ruda MA. Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos-related proteins. Neuroscience. 1992;46:561–70.
30. 30. M Zimmermann 1983 Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 109 10 6877845 10.1016/0304-3959(83)90201-4 1:STN:280:DyaL3s3nt1GqsQ%3D%3D Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109–10.
31. 31. J Buritova P Honoré V Chapman J-M Besson 1996 Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and spinal c-Fos expression in the rat: Synergistic mechanisms Pain 64 559 68 8783322 10.1016/0304-3959(95)00167-0 1:CAS:528:DyaK28Xkt1ekurw%3D Buritova J, Honoré P, Chapman V, Besson J-M. Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and spinal c-Fos expression in the rat: Synergistic mechanisms. Pain. 1996;64:559–68.
32. 32. S Hsu L Raine H Fanger 1981 Use of avidin-biotin-peroxydase complex (ABC) in immunoperoxydase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures J Histochem Cytochem 29 577 80 6166661 1:STN:280:DyaL3M3ktVKrug%3D%3D Hsu S, Raine L, Fanger H. Use of avidin-biotin-peroxydase complex (ABC) in immunoperoxydase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem. 1981;29:577–80.
33. 33. D Menétrey J Pommery de KG Baimbridge M Thomasset 1992 Calbindin-D28K (CaBP28k)-like immunoreactivity in ascending projections. I. Trigemial nucleus caudalis and dorsal vagal complex projections Eur J Neurosci 4 61 9 12106442 10.1111/j.1460-9568.1992.tb00109.x Menétrey D, de Pommery J, Baimbridge KG, Thomasset M. Calbindin-D28K (CaBP28k)-like immunoreactivity in ascending projections. I. Trigemial nucleus caudalis and dorsal vagal complex projections. Eur J Neurosci. 1992;4:61–9.
34. 34. C Molander Q Xu G Grant 1984 The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord J Comp Neurol 230 133 41 6512014 10.1002/cne.902300112 1:STN:280:DyaL2M%2FotVOlsA%3D%3D Molander C, Xu Q, Grant G. The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J Comp Neurol. 1984;230:133–41.
35. 35. C Molander G Grant 1986 Laminar distribution and somatotropic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat Neuroscience 19 297 312 3785668 10.1016/0306-4522(86)90023-0 1:STN:280:DyaL2s%2FmsFKhsg%3D%3D Molander C, Grant G. Laminar distribution and somatotropic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat. Neuroscience. 1986;19:297–312.
36. 36. J-M Besson A Chaouch 1987 Peripheral and spinal mechanisms of nociception Physiol Rev 67 67 186 3543978 1:STN:280:DyaL2s7hvVGjsQ%3D%3D Besson J-M, Chaouch A. Peripheral and spinal mechanisms of nociception. Physiol Rev. 1987;67:67–186.
37. 37. AB Malmberg TL Yaksh 1994 Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat Neurosci Lett 173 193 6 7936413 10.1016/0304-3940(94)90181-3 1:CAS:528:DyaK2cXkt1Oksrc%3D Malmberg AB, Yaksh TL. Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. Neurosci Lett. 1994;173:193–6.
38. 38. AB Malmberg TL Yaksh 1992 Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat J Pharmacol Exp Ther 263 136 46 1403779 1:CAS:528:DyaK38XmsVGmsLk%3D Malmberg AB, Yaksh TL. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J Pharmacol Exp Ther. 1992;263:136–46.
39. 39. AB Malmberg TL Yaksh 1994 Antinociception produced by spinal delivery of S and R enantiomers of flurbiprofen in the formalin test in rats Eur J Pharmacol 256 205 9 8050472 10.1016/0014-2999(94)90247-X 1:CAS:528:DyaK2cXjtFGiu7k%3D Malmberg AB, Yaksh TL. Antinociception produced by spinal delivery of S and R enantiomers of flurbiprofen in the formalin test in rats. Eur J Pharmacol. 1994;256:205–9.
40. 40. I Jurna K Bruna 1990 Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C-fibre-evoked activity in single neurones of the rat thalamus Pain 41 71 80 2352767 10.1016/0304-3959(90)91111-U 1:CAS:528:DyaK3cXlsVGjsLs%3D Jurna I, Bruna K. Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C-fibre-evoked activity in single neurones of the rat thalamus. Pain. 1990;41:71–80.
41. 41. I Jurna B Spohrer R Bock 1992 Intrathecal injection of acetylsalicylic acid, salicylic acid and indomethacin depresses C fibre-evoked activity in the rat thalamus and spinal cord Pain 49 249 56 1608648 10.1016/0304-3959(92)90149-6 1:CAS:528:DyaK38XltVCjt7k%3D Jurna I, Spohrer B, Bock R. Intrathecal injection of acetylsalicylic acid, salicylic acid and indomethacin depresses C fibre-evoked activity in the rat thalamus and spinal cord. Pain. 1992;49:249–56.
42. 42. E Alhava 1994 Reported adverse drug reactions and consumption of non-steroidal anti-inflammatory drugs Pharmacol Toxicol 75 Suppl.11 37 43 7816778 1:CAS:528:DyaK2MXhtVKgu74%3D 10.1111/j.1600-0773.1994.tb01994.x Alhava E. Reported adverse drug reactions and consumption of non-steroidal anti-inflammatory drugs. Pharmacol Toxicol. 1994;75(Suppl.11):37–43.