Role of the regulatory gene areA of Aspergillus oryzae in nitrogen metabolism

Applied and Environmental Microbiology

Volumn 64, Issue 9, 1998, Pages 3232-3237

  Christénsen, Tove ^a   Hynes, Michael J ^b   Davis, Meryl A ^b  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; GENE PRODUCT; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITROGEN;

ARTICLE; ASPERGILLUS ORYZAE; BACTERIAL GROWTH; BACTERIUM MUTANT; GENE DELETION; GENE FUNCTION; GENE STRUCTURE; MOLECULAR CLONING; NITROGEN METABOLISM; NONHUMAN; REGULATOR GENE;

ASPERGILLUS ORYZAE; BACTERIA (MICROORGANISMS); EMERICELLA NIDULANS; FUNGI; MYXOGASTRIA;

EID: 0031665468     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/aem.64.9.3232-3237.1998     Document Type: Article

References (33)

1. Andrianopoulos, A., and M. J. Hynes. 1988. Cloning and analysis of the positively acting regulatory gene amdR from Aspergillus nidulans. Mol. Cell. Biol. 8:3532-3541.
2. Arst, H. N., Jr., and D. J. Cove. 1973. Nitrogen metabolite repression in Aspergillus nidulans. Mol. Gen. Genet. 126:111-141.
3. Arst, H. N., Jr., and A. Sheerin. 1996. Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans. Mol. Microbiol. 19:1019-1024.
4. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248-254.
5. Burger, G., J. Strauss, C. Scazzochio, and B. F. Lang. 1991. nirA, the pathway specific regulatory gene ot nitrate assimilation in Aspergillus nidutans, encodes a putative GAL4-type zinc finger protein and contains four introns in highly conserved regions. Mol. Cell. Biol. 11:5746-5755.
6. Caddick, M. X., H. N. Arst, L. H. Taylor, R. I. Johnson, and A. G. Brownlee. 1986. Cloning of the regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. EMBO J. 5:1087-1090.
7. Clutterbuck, A. J. 1914. Aspergillus nidulans genetics, p. 447-510. In R. C. King (ed.), Handbook of genetics, vol. 1. Plenum Press, New York, N.Y.
8. Cohen, B. L. 1972. Ammonium repression of extracellular protease in As pergillus nidulans. J. Gen. Microbiol. 71:293-299.
9. Cook, R. J., and C. Anthony. 1978. Regulation by glutamine of ammonium transport in Aspergillus nidulans. J. Gen. Microbiol. 109:275-286.
10. Cove, D. J. 1966. The induction and repression of nitrate reductase in the fungus Aspergillus nidulans. Biochim. Biophys. Acta 133:51-56.
11. Dantzig, A. H., F. L. Weigmann, Jr., and A. Nason. 1979. Regulation of glutamate dehydrogenase in nit-2 and am mutants of Neurospora crassa. J. Bacteriol. 137:1333-1339.
12. Davis, M. A., and M. J. Hynes. Unpublished data.
13. Dunn-Coleman, N. S-, M. D. Nassiff, and R. H. Garrett. 1984. Isolation and characterisation of a methylammonium resistant mutant of Neurospora crassa. Curr. Genet. 8:423-427.
14. Feng, B., X. Xiao, and G. A. Marzluf. 1993. Recognition of specific nucleotide bases and cooperative binding by the frans-acting nitrogen regulatory protein NIT2 of Neurospora crassa. Nucleic Acids Res. 21:3989-3996.
15. Frederick, G. D., and J. A. Kinsey. 1990. Nucleotide sequence and nuclear protein binding of the two regulatory sequences upstream of the am (GDH) gene in Neurospora. Mol. Gen. Genet. 221:148-154.
16. Fu, Y.-H., and G. A. Marzluf. 1990. nit-2, the major nitrogen regulatory gene of Neurospora crassa, encodes a protein with a putative zinc finger DNA-binding domain. Mol. Cell. Biol. 10:1056-1065.
17. Fu, Y.-H., and G. A. Marzluf. 1990. nit-2, the major nitrogen regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. Proc. Natl. Acad. Sci. USA 87:5331-5335.
18. Haas, H., B. Bauer, B. Redl, G. Stuffler, and G. A. Marzluf. 1995. Molecular cloning and analysis of nre, the major nitrogen regulatory gene of Penicillium chrysogenum. Curr. Genet. 27:150-158.
19. Hawkins, A. R., S. J. Gurr, P. Montague, and J. R. Kinghorn. 1989. Nucleotide sequence and regulation of expression of the Aspergillus nidulans gdhA gene encoding NADP-dependent glutamate dehydrogenase. Mol. Gen. Genet. 218:105-111.
20. Hynes, M. J., and J. A. Pateman. 1970. The genetic analysis of regulation of amidase synthesis in Aspergillus nidulans. I. Mutants able to utilize acrylamide. Mol. Gen. Genet. 108:97-106.
21. Hynes, M. J. 1975. Studies on the role of the areA gene in the regulation of nitrogen catabolism in Aspergillus nidulans. Aust. J. Biol. Sci. 28:301-313.
22. Kudla, B., M. X. Caddick, T. Langdon, N. Martinez-Rossi, C. F. Bennett, S. Sibley, R. W. Davies, and H. N. Arst. 1990. The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger. EMBO J. 9:1355-1364.
23. Langdon, T., A. Sheerins, A. Ravagnani, M. Gielkens, M. X. Caddick, and H. N. Arst, Jr. 1995. Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression. Mol. Microbiol. 17:877-888.
24. Merika, M., and S. H. Orkin. 1993. DNA binding specificity of GATA family transcription factors. Mol. Cell. Biol. 13:3999-4010.
25. Oakley, C. E., C. F. Weil, P. L. Ktrez, and B. R. Oakley. 1987. Cloning of the riboB locus oi Aspergillus nidulans. Gene 53:293-298.
26. Parsons, L. M., M. A. Davis, and M. J. Hynes. 1992. Identification of functional regions of the positively acting regulatory gene amdR from Aspergillus nidulans. Mol. Microbiol. 6:2999-3007.
27. Pateman, J. A. 1969. Regulation of synthesis of glutamate dehydrogenase and glutamine synthetase in micro-organisms. Biochem. J. 115:769-775.
28. Pateman, J. A., E. Dunn, J. A. Kinghorn, and E. C. Forbes. 1974. The transport of ammonium and methylammonium in wild-type and mutant cells of Aspergillus nidulans. Mol. Gen. Genet. 133:225-236.
29. Perrine, K. G., and G. A. Marzluf. 1986. Amber nonsense mutations in regulatory and structural genes of the nitrogen control circuit of Neurospora crassa. Curr. Genet. 10:677-684.
30. Peters, D. G., and M. X. Caddick. 1994. Direct analysis of native and chimeric GATA specific DNA binding proteins from Aspergillus nidulans. Nucleic Acids Res. 22:5164-5172.
31. Platt, A., T. Langdon, H. N. Arst, Jr., D. Kirk, D. Tollervey, J. M. Mates Sanchez, and M. X. Caddick. 1996. Nitrogen metabolite signalling involves the C-terminus and the GATA domain of the Aspergillus transcription factor AREA and the 3′ untranslated region of its mRNA. EMBO J. 15:2791-2801.
32. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
33. Xiao, X., Y.-H. Fu, and G. A. Marzluf. 1995. The negative-acting NMR regulatory protein of Neurospora crassa binds to and inhibits the DNA-binding activity of the positive-acting nitrogen regulatory protein NIT2. Biochemistry 34:8861-8868.