Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans

Molecular Microbiology

Volumn 19, Issue 5, 1996, Pages 1019-1024

  Arst Jr , Herbert N ^a   Sheerins, Alan ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ARTICLE; ASPERGILLUS NIDULANS; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; TRANSLATION INITIATION;

EID: 0029983040     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1996.470976.x     Document Type: Article

References (18)

1. Arst, Jr, H.N., and Cove, D.J. (1973) Nitrogen metabolite repression in Aspergillus nidulans. Mol Gen Genet 126: 111-141.
2. Arst, Jr, H.N., Tollervey, D.W., and Sealy-Lewis, H.M. (1982) A possible regulatory gene for the molybdenum-containing cofactor in Aspergillus nidulans. J Gen Microbiol 128: 1083-1093.
3. Caddick, M.X., Peters, D., and Platt, A. (1994) Nitrogen regulation in fungi. Anton v Leeuwenhoek 65: 169-177.
4. Clutterbuck, A.J. (1993) Aspergillus nidulans. In Genetic Maps. Locus Maps of Complex Genomes. Vol. 3. 6th edn. O'Brien, S.J. (ed.). Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, pp. 3.71-3.84.
5. Cove, D.J. (1966) The induction and repression of nitrate reductase in the fungus Aspergillus nidulans. Biochim Biophys Acta 113: 51-56.
6. Crawford, N.M., and Arst, Jr, H.N. (1993) The molecular genetics of nitrate assimilation in fungi and plants. Annu Rev Genet 27: 115-146.
7. Grant, C.M., Miller, P.F., and Hinnebusch, A.G. (1994) Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron. Mol Cell Biol 14: 2616-2628.
8. Kozak, M. (1991) An analysis of vertebrate mRNA sequences: intimations of translational control. J Cell Biol 115: 887-903.
9. Kozak, M. (1992) Regulation of translation in eukaryotic systems. Annu Rev Cell Biol 8: 197-225.
10. Kozak, M. (1995) Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. Proc Natl Acad Sci USA 92: 2662-2666.
11. Kudla, B., Caddick, M.X., Langdon, T., Martinez-Rossi, N.M., Bennett, C.F., Sibley, S., Davies, R.W., and Arst, Jr, H.N. (1990) The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger. EMBO J 9: 1355-1364.
12. Langdon, T., Sheerins, A., Ravagnani, A., Gielkens, M., Caddick, M.X., and Arst, Jr, H.N. (1995) Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression. Mol Microbiol 17: 877-888.
13. Rand, K.N. (1978) Aspects of the control of nitrogen metabolism in Aspergillus nidulans. PhD Thesis, University of Cambridge, Cambridge, England.
14. Slusher, L.B., Gillman, E.C., Martin, N.C., and Hopper, A.K. (1991) mRNA leader length and initiation codon context determine alternative AUG selection for the yeast gene MOD5. Proc Natl Acad Sci USA 88: 9789-9793.
15. Stankovich, M., Platt, A., Caddick, M.X., Langdon, T., Shaffer, P.M., and Arst, Jr, H.N. (1993) C-terminal truncation of the transcriptional activator encoded by areA in Aspergillus nidulans results in both loss-of-function and gain-of-function phenotypes. Mol Microbiol 7: 81-87.
16. Tilburn, J., Sarkar, S., Widdick, D.A., Espeso, E.A., Orejas, M., Mungroo, J., Peñalva, M.A., and Arst, Jr, H.N. (1995) The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH. EMBO J 14: 779-790.
17. Wolfe, C.L., Lu, Y.-c., Hopper, A.K., and Martin, N.C. (1994) Interplay of heterogeneous transcriptional start sites and translation selection of AUGs dictate the production of mitochondrial and cytosolic/nuclear tRNA nucleotidyltransferase from the same gene in yeast. J Biol Chem 269: 13361-13366.
18. Yun, D.-F., and Sherman, F. (1995) Initiation of translation can occur only in a restricted region of the CYC1 mRNA of Saccharomyces cerevisiae. Mol Cell Biol 15: 1021-1033.