Mechanisms by which vegetable consumption reduces genetic damage in humans

Cancer Epidemiology Biomarkers and Prevention

Volumn 7, Issue 10, 1998, Pages 891-899

  Pool Zobel, Beatrice L ^a,b   Bub, Achim ^a   Liegibel, Ute M ^a   Treptow van Lishaut, Silvia ^a   Rechkemmer, Gerhard ^a  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CAROTENE; BETA CAROTENE; DNA; DNA BASE; GLUTATHIONE TRANSFERASE; LYCOPENE; PROTEIN; PYRIMIDINE; XANTHOPHYLL;

ADULT; ALLELE; ARTICLE; CARROT; COLORIMETRY; DNA DAMAGE; DNA REPAIR; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SPINACH; TOMATO; VEGETABLE;

ADULT; ANTIOXIDANTS; BEVERAGES; CAROTENOIDS; DIET; DNA DAMAGE; DNA REPAIR; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; LYMPHOCYTES; MALE; MUTAGENICITY TESTS; OXIDATIVE STRESS; POLYMORPHISM, GENETIC; VEGETABLES;

EID: 0031663162     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Machlin, L J. Critical assessment of the epidemiological data concerning the impact of antioxidant nutrients on cancer and cardiovascular disease. Crit. Rev. Food Sci. Nutr., 35 41-50, 1995.
2. Pool-Zobel, B. L., Bub, A., Muller, H., Wollowski, I., and Rechkemmer, G. Consumption of vegetables reduces genetic damage in humans: first results of an intervention trial with carotenoid-rich foods Carcinogenesis (Lond.), 18: 1847-1850, 1997.
3. Muller, H, Bub, A, and Rechkemmer, G. Plasmagehalte an Carotinoiden, antioxidativen vitamenen und ubichinonen nach Verzehr carotinoidreicher Gemuseprodukte. Eur. J Nutr, 37, 80, 1997
4. Wattenberg, L. W. Inhibition of carcinogenesis by minor dietary constituents. Cancer Res., 52 (Suppl. 7): 2085s-2091s, 1992.
5. Wasserman, W. W., and Fahl, W. E. Functional antioxidant responsive elements Proc. Natl. Acad. Sci. USA, 94: 5361-5366, 1997.
6. Hayes, J. D, and Strange, R C. Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress Free Radic. Res., 22: 193-207, 1995.
7. Bogaards, J. J. P., Vertragen, H., Willems, M. I., van Poppel, G., and van Bladeren, P. J. Consumption of Brussels sprouts results in elevated a class glutathiune S-transferase levels in human blood plasma. Carcinogenesis (Lond.), 15, 1073-1075, 1994.
8. Nijhoff, W. A., Mulder, T P. J., Verhagen, H., van Poppel, G., and Peters, W H. M. Effects of consumption of Brussels sprouts on plasma and urinary glutathione S-transferase class-α and -π in humans. Carcinogenesis (Lond.), 16 955-957, 1995
9. Prochaska, H. J, and Fernandes, C. L. Elevation of serum Phase II enzymes by anticarcinogenic enzyme inducers, markers for a chemoprotected state? Carcinogenesis (Lond.), 14, 2441-2445, 1993.
10. Peters, W. H. M., Roelofs, H. M. J., Nagengast, F. M., and van Tongeren, J. H. M. Human intestinal glutathione S-transferases Biochem. J., 257: 471-476, 1989.
11. Peters, W. H. M., Boon, C. E. W., Roelofs, H. M. J., and Wobbes, T. Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa. Gastroenterology, 103: 448-455, 1992
12. Smith, G., Stanley, L. A., Sim, E., Strange, R C., and Wolf, C. R. Metabolic polymorphisms and cancer susceptibility. In: H Ponder and A. J. Bruce (eds), Genetics and Cancer, A Second Look, pp. 27-65. New York: Cold Spring Harbor Laboratory Press, 1995.
13. Bartsch, H, and Hietanen, E. The role of individual susceptibility in cancer burden related to environmental exposure Environ Health Perspect, 104 569-577, 1996.
14. Singh, N P., McCoy, M. T, Tice, R R, and Schneider, E. L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res., 175: 184-191, 1988
15. Pool-Zobel, B. L., and Leucht, U. Induction of DNA damage in human colon cells derived from biopsies by suggested risk factors of colon cancer. Mutat Res., 375: 105-116, 1997.
16. Pool-Zobel, B. L., Lotzmann, N., Knoll, M., Kuchenmeister, F., Lambertz, R., Leucht, U., Schröder, H. G., and Schmezer, P. Detection of genotoxic effects in human gastric and nasal mucosa cells isolated from biopsy samples Environ. Mol. Mutagen., 24: 23-45, 1994.
17. Duthie, S., Ma, A., Ross, M. A., and Collins, A. R. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res, 56: 1291-1295, 1996
18. Penible, S., Schroeder, K. R., Spencer, S. R., Meyer, D. J., Hallier, E., Bolt, H. M., Ketterer, B., and Taylor, J. B. Human glutathione S-transferase θ (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J., 300: 271-276, 1994
19. Bell, D A., Taylor, J A, Paulson, D. F., Robertson, C. N., Mohler, J L, and Lucier, G. W. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst., 85: 1159-1164, 1993.
20. Harries, L W, Stubbins, M. J, Forman, D., Howard, G. C. W., and Wolf, C R. Identification of genetic polymorphisms at the glutathione S-transferase π locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis (Lond.), 18: 641-644, 1997.
21. Bradford, M. M A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem, 72: 248-254, 1976.
22. Nalimov, N. N. The Application of Mathematical Statistics to Chemical Analyses. Oxford, London, Paris, Frankfurt: Pergamon Press, 1963.
23. Negri, E., La Vecchia, C, Francheschi, S., D'Avanzo, B., and Parazzini, F. Vegetable and fruit consumption and cancer risk Int. J. Cancer, 48: 350-354, 1991
24. Steinmetz, K. A, and Potter, J. D. Vegetables, fruit, and cancer I. Epidemiology Cancer Causes Control, 2, 325-357, 1991.
25. Hill, M. J Diet and cancer: a review of scientific evidence. Eur. J Cancer Prev., 4 (Suppl. 2): 3-42, 1995.
26. Johnson, I. T., Williamson, G, and Musk, S. R. R. Anticarcinogemc factors in plant foods: a new class of nutrients? Nutr. Res. Rev., 7: 175-204, 1994.
27. Howe, G. R., Benito, E., Castelleto, R., Cornee, J, Esteve, J., Gallagher, R. P., Iscovich, J M., Deng-ao, J., Kaaks, R, Kune, G A, Kune, S., L'Abbe, K. A., Lee, H. P., Lee, M., Miller, A B, Peters, R K., Potter, J. D, Riboli, E., Slatttery, M. L., Trichopoulos, D., Tuyns, A., Tzonou, A., Whittemore, A. S., Wu-Williams, H, and Shu, Z Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies. J. Natl Cancer Inst, 84: 1887-1896, 1992.
28. Klurfeld, D. M. Dietary fiber-mediated mechanisms in carcinogenesis. Cancer Res., 52 (Suppl. 7): 2055s-2059s, 1992.
29. Tinkler, J. H., and Truscott, T. G Carotenoids protect against cell membrane damage by the nitrogen dioxide radical. Nat. Med, 1: 98-99, 1995.
30. Rousseau, E. J., Davison, A J., and Dunn, B Protection by -carotene, and related compounds against oxygen-mediated cytotoxicity and genotoxicity: implications for carcinogenesis and anticarcinogenesis. Free Radic. Biol. Med., 13: 407-433, 1995.
31. Bendich, A., and Olson, J. A. Biological actions of carotenoids. FASEB J., 3: 1927-1932, 1989.
32. Albanes, D, Heinonen, O. P., Taylor, P R, Virtamo, J, Edwards, B. K., Rautalahti, M., Hartman, A. M., Palmgren, J., Freedman, L. S., Haapakoski, J., Barrett, M. J., Pietinen, P., Malila, N, Tala, E., Liippo, K., Salomaa, E. R., Tangrea, J A., Teppo, L., Askin, F. B., Taskinen, E., Erozan, Y, Greenwald, P, and Huttunen, J. K. α-Tocopherol, and β-carotene supplements and lung cancer incidence in the α-tocopherol, β-carotene cancer prevention study: effects of base-line characteristics and study compliance J. Natl Cancer Inst., 88: 1560-1570, 1996
33. Mayne, S. T., Hanelman, G. J., and Beecher, G. β-Carotene and lung cancer promotion in heavy smokers - a plausible relationship? J. Natl. Cancer Inst., 88: 1513-1515, 1996.
34. Holzman, D. Whatever happened to β carotene? J. Natl. Cancer Inst., 87: 1739-1741, 1995.
35. Mayne, S. T. β-carotene, carotenoids, and disease prevention in humans FASEB J., 10: 690-701, 1996.
36. Clevidence, B. A., Khachik, F., Brown, E. D., Nair, P. P., Wiley, E. R., Prior, R. L., Cao, G., Morel, D. W., Stone, W., Gross, M, and Kramer, T. R Human consumption of carotenoid-rich vegetables. In: O. I. Aruoma and S. L. Cuppett (eds.), Antioxidant Methodology, in Vivo and in Vitro Concepts, pp 53-63. Champaign, IL: AOCS Press, 1997
37. Seidegard, J., Vorachek, W. R., Pero, R. W, and Pearson, W R Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl. Acad. Sci. USA, 85: 7293-7297, 1988.
38. Board, P. G. Gene deletion and partial deficiency of the glutathione S-transferase (Ligandin) system in man. FEBS Lett., 135: 12-14, 1981.
39. Deakin, M., Elder, J., Hendrickse, C., Peckham, D., Baldwin, D., Pantin, C., Wild, N., Leopard, P, Bell, D A., Jones, P., Duncan, H., Brannigan, K., Alldersea, J., Fryer, A. A., and Strange, R. C. Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis (Lond), 17, 881-884, 1996.
40. Nelson, H. H, Wiencke, J K., Christiani, D. C., Cheng, T. J., Zuo, Z. F., Schwarz, B. S., Lee, B. K., Spitz, M. R., Wang, M, Xu, X., and Kelsey, K T. Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase θ. Carcinogenesis (Lond.), 16: 1243-1245, 1995.
41. Elexpuru-Camiruaga, J., Buxton, N., Kandula, V., Dias, P. S., Campbell, D. McIntosh, J, Broome, J., Jones, P, Inskip, A., Alldersea, J., Fryer, A. A., and Strange, R C. Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome p-450 (CP2D6) loci. Cancer Res, 55: 4237-4239, 1995.
42. Chenevix-Trench, G., Young, J., Coggan, M., and Board, P. Glutathione S-transferase M1, and T1 polymorphisms. Susceptibility to colon cancer and age of onset Carcinogenesis (Lond.), 16: 1655-1657, 1995.
43. Katoh, T., Nagata, N, Kuroda, Y., Itoh, H., Kawahara, A., Kuroki, N., Ookuma, R., and Bell, D. A Glutathione S-transferase M1 (GSTM1), and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis (Lond.), 17: 1855-1859, 1996.
44. Brockmoeller, J., Cascorbi, I., Kerb, R., and Roots, I. Combined analysis of inherited polymorphisms in arylamme N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolases, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res., 56: 3915-3925, 1996.
45. Ali-Osman, F., Akande, O., Antoun, G., Mao, J. X., and Buolamwini, J Molecular cloning characterization and expression in Escherichia coli of full length cDNAs of three human glutathione S-transferase π gene variants. J. Biol Chem, 272 10004-10021, 1997.
46. Ali-Osman, F., Akande, N., and Mao, J. Molecular cloning, characterisation and expression of novel functionally different human glutathione S-transferase P1 gene variants. In: Proceedings of the ISSX Workshop on Glutathione S-transferases. London. Taylor and Francis, 1995.
47. Hayes, J. D., and Strange, R C. Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress Free Radic. Res, 22: 193-207, 1995.
48. Berhane, K., Widersten, M., Engstrom, A., Kozarich, J. W, and Mannervik, B Detoxication of base propenals and other α, β-unsaturated aldehyde products of radical reactions and lipid peroxidation by humane glutathione transferases. Proc. Natl Acad. Sci USA, 91: 1480-1484, 1994.
49. Compton, S. J. Mechanism of dye response and interference in the Bradford protein assay. Anal. Biochem., 151: 369-374, 1985.