In vitro and in vivo stimulation of the murine immune system by AGM-1470, a potent angiogenesis inhibitor

American Journal of Pathology

Volumn 148, Issue 2, 1996, Pages 393-398

  Antoine, Nadine ^a   Daukandt, Marc ^a   Heinen, Ernst ^a   Simar, Léon J ^a   Castronovo, Vincent ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; FREUND ADJUVANT; FUMAGILLOL CHLOROACETYLCARBAMATE; PHYTOHEMAGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AXILLARY LYMPH NODE; B LYMPHOCYTE; CANCER INHIBITION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; FEMALE; GERMINAL CENTER; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INTRAPERITONEAL DRUG ADMINISTRATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; NUDE MOUSE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; B-LYMPHOCYTES; CELL DIVISION; CYCLOHEXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GERMINAL CENTER; IMMUNOHISTOCHEMISTRY; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; SESQUITERPENES; T-LYMPHOCYTES; THYMIDINE;

EID: 0030039870     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Brem H Folkman J Analysis of experimental antiangiogenic therapy. J Pediatr Surg 1993, 28:445-451
2. Kusaka M, Sudo K, Fujita T, Marui S, Itoh F, Ingber D, Folkman J Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent. Biochem Biophys Res Commun 1993, 174:1070-1076
3. Ingber D, Fujita T, Kishimoto S, Sudo K, Kamaru T, Brem H, Folkman J: Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature 1990, 348:555-557
4. Antoine N, Greimers R, De Roanne C, Kusaka M, Heinen E, Simar LJ, Castronovo V AGM-1470, a potent angiogenesis inhibitor, prevents the entry of normal but not transformed endothelial cells into the G1 phase of the cell cycle Cancer Res 1994, 54:2073-2076
5. Yanase T, Tamaru M, Fujita K, Kodama S, Tanaka K: Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res 1993, 53:2566-2569
6. Berger AE, Dortch KA, Staite ND, Mitchell MA, Evans BR, Holm MS: Modulation of T lymphocyte function by the angiogenesis inhibitor AGM-1470 Agents Actions 1993, 39:86-88
7. Schoof DD, Obando JA, Cusack JC Jr, Goedegebuure PS, Brem H, Eberlein TJ. The influence of angiogenesis inhibitor AGM-1470 on immune system status and tumor growth in vitro Int J Cancer 1993, 55:630-635
8. Antoine N, Bours V, Heinen E, Simar LJ, Castronovo V: Stimulation of human B lymphocyte proliferation by AGM-1470, a potent inhibitor of angiogenesis. J Natl Cancer Inst 1995, 87 136-139
9. Antoine N, Heinen E, Marcoty C, Bosseloir A, Simar LJ: DRC1 expression on normal and pathological lymphoid cells Adv Exp Med Biol 1993, 329:365-369
10. Hsu S, Raine L, Fanger H Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase technique: a comparison between ABC and unlabeled antibody PAP procedures. J Histochem Cytochem 1981, 29: 577-580
11. Placidi L, Cretton-Scott E, de Sousa G, Rahmani R Placidi M, Sommadossi J-P Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissues microsomes Cancer Res 1995, 55:3036-3042