On the catalase-peroxidase gene, katG, of Mycobacterium leprae and the implications for treatment of leprosy with isoniazid

FEMS Microbiology Letters

Volumn 149, Issue 2, 1997, Pages 273-278

  Eiglmeier, Karin ^a   Fsihi, Hafida ^a   Heym, Beate ^a,b   Cole, Stewart T ^a  

^a INSTITUT PASTEUR   (France)

^b HÔPITAL AMBROISE PARÉ   (France)

Author keywords

Catalase peroxidase; Isoniazid; katG; Mycobacterium leprae

Indexed keywords

CATALASE; ISONIAZID; PEROXIDASE;

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFICACY; DRUG TOXICITY; LEPROSY; MYCOBACTERIUM LEPRAE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSEUDOGENE;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CLONING, MOLECULAR; COSMIDS; GENES, BACTERIAL; ISONIAZID; LEPROSY; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM LEPRAE; PEROXIDASES; PSEUDOGENES; SEQUENCE HOMOLOGY, AMINO ACID;

MYCOBACTERIUM LEPRAE; MYCOBACTERIUM SMEGMATIS;

EID: 0030891597     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00087-6     Document Type: Article

References (28)

1. Cole S.T. Mycobacterium tuberculosis: Drug resistance mechanisms. Trends Microbiol. 2:1994;411-415.
2. Johnsson K., King D.S., Schultz P.G. Studies on the mechanism of action of isoniazid and ethionamide in the chemotherapy of tuberculosis. J. Am. Chem. Soc. 117:1995;5009-5010.
3. Heym B., Zhang Y., Poulet S., Young D., Cole S.T. Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis. J. Bacteriol. 175:1993;4255-4259.
4. Banerjee A., Dubnau E., Quémard A., Balasubramanian V., Um K.S., Wilson T., Collins D., de Lisle G., Jacobs W.R. Jr. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science. 263:1994;227-230.
5. Mdluli K., Sherman D.R., Hickey M.J., Kreiswirth B.N., Morris S., Stover C.K., Barry I., C.E. Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis. J. Infect. Dis. 174:1996;1085-1090.
6. Dhandayuthapani S., Zhang Y., Mudd M.H., Deretic V. Oxidative stress response and its role in sensitivity to isoniazid in Mycobacteria: Characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis. J. Bacteriol. 178:1996;3641-3649.
7. Zhang Y., Dhandayuthapaani S., Deretic V. Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid. Proc. Natl. Acad. Sci. USA. 93:1996;13212-13216.
8. Heym B., Alzari P., Honoré N., Cole S.T. Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid-resistance in Mycobacterium tuberculosis. Mol. Microbiol. 15:1995;235-245.
9. Morris S., Bai G., Suffys P., Portillo-Gomez L., Fairchok M., Rouse D. Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis. J. Infect. Dis. 171:1995;954-960.
10. Freerksen E., Rosenfeld M. Leprosy eradication project of Malta. First published report after 5 years. Chemotherapy. 23:1977;356-386.
11. Heym B., Cole S.T. Isolation and characterization of isoniazid-resistant mutants of Mycobacterium smegmatis and M. aurum. Res. Microbiol. 143:1992;721-730.
12. Fsihi H., Cole S.T. The Mycobacterium leprae genome: systematic sequence analysis identifies key catabolic enzymes, ATP-dependent transport systems and a novel polA locus associated with genomic variability. Mol. Microbiol. 16:1995;909-919.
13. Woods S.A., Cole S.T. A rapid method for the detection of potentially viable Mycobacterium leprae in human biopsies: a novel application of PCR. FEMS Microbiol. Lett. 65:1989;305-310.
14. Eiglmeier K., Honoré N., Woods S.A., Caudron B., Cole S.T. Use of an ordered cosmid library to deduce the genomic organisation of Mycobacterium leprae. Mol. Microbiol. 7:1993;197-206.
15. Zhang Y., Heym B., Allen B., Young D., Cole S. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature. 358:1992;591-593.
16. Rouse D.A., deVito J.A., Li Z., Byer H., Morris S.L. Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis: effects on catalase-peroxidase activities and isoniazid resistance. Mol. Microbiol. 22:1996;583-592.
17. Morris S.L., Nair J., Rouse D.J. The catalase-peroxidase of Mycobacterium intracellulare: nucleotide sequence analysis and expression in Escherichia coli. J. Gen. Microbiol. 138:1992;2363-2370.
18. Fsihi H., De Ross E., Salazar L., Cantoni R., Labò M., Riccardi G., Takiff H.E., Eiglmeier K., Bergh S., Cole S.T. Gene arrangement and organisation in a ~76 kilobase fragment encompassing the oriC region of the chromosome of Mycobacterium leprae. Microbiology. 142:1996;3147-3161.
19. Wheeler P.R., Gregory D. Superoxide dismutase, peroxidatic activity and catalase in Mycobacterium leprae purified from armadillo liver. J. Gen. Microbiol. 121:1980;457-464.
20. Katoch V.M., Wayne L.G., Diaz G.A. Serological approaches for the characterization of catalase in tissue-derived mycobacteria. Ann. Microbiol. Inst. Pasteur. 133B:1982;407-414.
21. Franzblau S.G., Hastings R.C. Rapid in vitro metabolic screen for antileprosy compounds. Antimicrob. Agents Chemother. 31:1987;780-783.
22. Pattyn S.R., Portaels F., Van Loo G., Van den Breen L. Activity of the combination of isoniazid, protionamide and dapsone against Mycobacterium leprae and some other mycobacteria. Arzneim. Forsch. 31:1981;2155-2157.
23. Wilson T.M., de Lisle G.W., Collins D.M. Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis. Mol. Microbiol. 15:1995;1009-1015.
24. Deretic V., Philipp W., Dhandayuthapani S., Mudd M.H., Curcic R., Garbe T., Heym B., Via L.E., Cole S.T. Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid. Mol. Microbiol. 17:1995;889-900.
25. Sherman D.R., Sabo P.J., Hickey M.J., Arain T.M., Mahairas G.G., Yuan Y., Barry I., C.E., Stover C.K. Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria. Proc. Natl. Acad. Sci. USA. 92:1995;6625-6629.
26. Sherman D.R., Mdluli K., Hickey M.J., Arain T.M., Morris S.L., Barry II C.E., Stover C.K. Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis. Science. 272:1996;1641-1643.
27. Pessolani M.C.V., Brennan P. Molecular definition and identification of new proteins of Mycobacterium leprae. Infect. Immun. 64:1996;5425-5427.
28. Devereux J., Haeberli P., Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:1984;387-395.