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Volumn 12, Issue 2, 1998, Pages 191-211

The pharmacology of the cytochrome P450 enzyme system

Author keywords

CYP; Cytochrome P450; Drug response; Drug toxicity; Idiosyncratic toxicity; Interindividual variation

Indexed keywords

CYTOCHROME P450; OXYGEN;

EID: 0031660126     PISSN: 09503501     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0950-3501(98)80028-7     Document Type: Article
Times cited : (9)

References (98)
  • 2
    • 0028358565 scopus 로고
    • The cytochrome P450 CYP2D6 allelic variant CYP2D6J and related polymorphisms in a European population
    • Armstrong M Fairbrother K Idle Jr Daly AK The cytochrome P450 CYP2D6 allelic variant CYP2D6J and related polymorphisms in a European population Pharmacogenetics 4 1994 73 81
    • (1994) Pharmacogenetics , vol.4 , pp. 73-81
    • Armstrong, M1    Fairbrother, K2    Idle3    Daly, AK4
  • 3
    • 0003069620 scopus 로고
    • Drug interactions
    • Back DJ Orme ML'E Drug interactions Goldzieher JW Pharmacology of the Contraceptive Steroids 1994 Raven Press New York 407 425
    • (1994) , pp. 407-425
    • Back, DJ1    Orme, ML'E2
  • 4
    • 0028153858 scopus 로고
    • Grapefruit juice and drugs: how significant is the interaction?
    • Bailey DG Arnold JMO Spence JD Grapefruit juice and drugs: how significant is the interaction? Clinical Pharmacokinetics 26 1994 91 98
    • (1994) Clinical Pharmacokinetics , vol.26 , pp. 91-98
    • Bailey, DG1    Arnold, JMO2    Spence, JD3
  • 6
    • 0030935086 scopus 로고    scopus 로고
    • Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions
    • Bertz RJ Granneman GR Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions Clinical Pharmacokinetics 32 1997 210 258
    • (1997) Clinical Pharmacokinetics , vol.32 , pp. 210-258
    • Bertz, RJ1    Granneman, GR2
  • 7
    • 0027097496 scopus 로고
    • Liver failure induced by paracetamol
    • Bray GP Liver failure induced by paracetamol British Medical Journal 306 1993 157 158
    • (1993) British Medical Journal , vol.306 , pp. 157-158
    • Bray, GP1
  • 8
    • 0026734346 scopus 로고
    • Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic-failure
    • Bray GP Harrison PM O'Grady JG Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic-failure Human and Experimental Toxicology 11 1992 265 270
    • (1992) Human and Experimental Toxicology , vol.11 , pp. 265-270
    • Bray, GP1    Harrison, PM2    O'Grady, JG3
  • 9
    • 0024359574 scopus 로고
    • Clinical significance of the sparteine-debrisoquine oxidation polymorphism
    • Brosen K Gram LF Clinical significance of the sparteine-debrisoquine oxidation polymorphism European Journal of Clinical Pharmacology 36 1989 537 547
    • (1989) European Journal of Clinical Pharmacology , vol.36 , pp. 537-547
    • Brosen, K1    Gram, LF2
  • 10
    • 0026496950 scopus 로고
    • The role of individual human cytochromes P450 in drug metabolism and clinical response
    • Cholerton S Daly AK Idle JR The role of individual human cytochromes P450 in drug metabolism and clinical response Trends in Pharmacological Science 13 1992 434 439
    • (1992) Trends in Pharmacological Science , vol.13 , pp. 434-439
    • Cholerton, S1    Daly, AK2    Idle, JR3
  • 12
    • 0028856846 scopus 로고
    • Molecular basis of polymorphic drug metabolism
    • Daly AK Molecular basis of polymorphic drug metabolism Journal of Molecular Medicine 73 1995 539 553
    • (1995) Journal of Molecular Medicine , vol.73 , pp. 539-553
    • Daly, AK1
  • 13
    • 0028807577 scopus 로고
    • Structural domains of P450-containing monooxygenase systems
    • Degtyarenko KN Structural domains of P450-containing monooxygenase systems Protein Engineering 8 1995 737 747
    • (1995) Protein Engineering , vol.8 , pp. 737-747
    • Degtyarenko, KN1
  • 15
    • 0025305464 scopus 로고
    • The genetic polymorphism of debrisoquine/sparteine metabolism—clinical aspects
    • Eichelbaum M Gross AS The genetic polymorphism of debrisoquine/sparteine metabolism—clinical aspects Pharmacology and Therapeutics 46 1990 377 394
    • (1990) Pharmacology and Therapeutics , vol.46 , pp. 377-394
    • Eichelbaum, M1    Gross, AS2
  • 16
    • 0024828720 scopus 로고
    • In vitro production of IL-1-beta, IL-1-alpha, TNF and IL-2 in healthy-subjects—distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation
    • Endres S Cannon JG Ghorbani R In vitro production of IL-1-beta, IL-1-alpha, TNF and IL-2 in healthy-subjects—distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation European Journal of Immunology 19 1989 2327 2333
    • (1989) European Journal of Immunology , vol.19 , pp. 2327-2333
    • Endres, S1    Cannon, JG2    Ghorbani, R3
  • 17
    • 0029048772 scopus 로고
    • The CYP2A gene subfamily—species differences, regulation, catalytic activities and role in chemical carcinogenesis
    • Fernandez-Salguero P Gonzalez FJ The CYP2A gene subfamily—species differences, regulation, catalytic activities and role in chemical carcinogenesis Pharmacogenetics 5 1995 S123 S128
    • (1995) Pharmacogenetics , vol.5 , pp. S123-S128
    • Fernandez-Salguero, P1    Gonzalez, FJ2
  • 18
    • 0029099107 scopus 로고
    • A genetic polymorphism in coumarin 7-hydroxylation—sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
    • Fernandez-Salguero P Hoffman SMG Cholerton S A genetic polymorphism in coumarin 7-hydroxylation—sequence of the human CYP2A genes and identification of variant CYP2A6 alleles American Journal of Human Genetics 57 1995 651 660
    • (1995) American Journal of Human Genetics , vol.57 , pp. 651-660
    • Fernandez-Salguero, P1    Hoffman, SMG2    Cholerton, S3
  • 19
    • 0026096515 scopus 로고
    • Cyclosporine dose reduction by ketoconazole administration in renal transplant recipients
    • First MR Schroeder TJ Alexander JW Cyclosporine dose reduction by ketoconazole administration in renal transplant recipients Transplantation 51 1991 365 370
    • (1991) Transplantation , vol.51 , pp. 365-370
    • First, MR1    Schroeder, TJ2    Alexander, JW3
  • 20
    • 0028789701 scopus 로고
    • The hepatic effects of sevoflurane
    • Frink EJ The hepatic effects of sevoflurane Anesthesia and Analgesia 81 1995 S46 S50
    • (1995) Anesthesia and Analgesia , vol.81 , pp. S46-S50
    • Frink, EJ1
  • 21
    • 0029564238 scopus 로고
    • Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy
    • Furuya H Fernandez-Salguero P Gregory W Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy Pharmacogenetics 5 1995 389 392
    • (1995) Pharmacogenetics , vol.5 , pp. 389-392
    • Furuya, H1    Fernandez-Salguero, P2    Gregory, W3
  • 22
    • 0028590127 scopus 로고
    • Biochemistry and molecular biology of the human CYP2C subfamily
    • Goldstein JA de Morais SMF Biochemistry and molecular biology of the human CYP2C subfamily Pharmacogenetics 4 1994 285 300
    • (1994) Pharmacogenetics , vol.4 , pp. 285-300
    • Goldstein, JA1    de Morais, SMF2
  • 23
    • 0028279041 scopus 로고
    • Evidence that CYP2C19 is the major (s)-mephenytoin 4′-hydroxylase in humans
    • Goldstein JA Faletto MB Romkes-Sparks M Evidence that CYP2C19 is the major (s)-mephenytoin 4′-hydroxylase in humans Biochemistry 33 1994 1743 1752
    • (1994) Biochemistry , vol.33 , pp. 1743-1752
    • Goldstein, JA1    Faletto, MB2    Romkes-Sparks, M3
  • 24
    • 0024236331 scopus 로고
    • The molecular biology of cytochrome P450s
    • Gonzalez FJ The molecular biology of cytochrome P450s Pharmacological Reviews 40 1989 243 288
    • (1989) Pharmacological Reviews , vol.40 , pp. 243-288
    • Gonzalez, FJ1
  • 25
    • 0026651273 scopus 로고
    • Human cytochromes P450: problems and prospects
    • Gonzalez FJ Human cytochromes P450: problems and prospects Trends in Pharmacological Sciences 13 1992 346 352
    • (1992) Trends in Pharmacological Sciences , vol.13 , pp. 346-352
    • Gonzalez, FJ1
  • 26
    • 0028272001 scopus 로고
    • Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins
    • Gonzalez FJ Gelboin HV Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins Drug Metabolism Reviews 26 1994 165 183
    • (1994) Drug Metabolism Reviews , vol.26 , pp. 165-183
    • Gonzalez, FJ1    Gelboin, HV2
  • 27
    • 0025940815 scopus 로고
    • Molecular genetics of the debrisoquin-sparteine polymorphism
    • Gonzalez F Meyer UA Molecular genetics of the debrisoquin-sparteine polymorphism Clinical Pharmacology and Therapeutics 50 1991 233 238
    • (1991) Clinical Pharmacology and Therapeutics , vol.50 , pp. 233-238
    • Gonzalez, F1    Meyer, UA2
  • 28
    • 0027409436 scopus 로고
    • Regulation of cytochrome P-450 genes: molecular mechanisms
    • Gonzalez FJ Liu SY Yano M Regulation of cytochrome P-450 genes: molecular mechanisms Pharmacogenetics 3 1993 51 57
    • (1993) Pharmacogenetics , vol.3 , pp. 51-57
    • Gonzalez, FJ1    Liu, SY2    Yano, M3
  • 29
    • 0026536551 scopus 로고
    • Characterization of human cytochrome P450 enzymes
    • Guengerich FP Characterization of human cytochrome P450 enzymes FASEB Journal 6 1992 745 748
    • (1992) FASEB Journal , vol.6 , pp. 745-748
    • Guengerich, FP1
  • 32
    • 0026062622 scopus 로고
    • Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene
    • (Tokyo) Hayashi S Watanabe J Kawajiri K Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene Journal of Biochemistry 110 1991 559 565
    • (1991) Journal of Biochemistry , vol.110 , pp. 559-565
    • Hayashi, S1    Watanabe, J2    Kawajiri, K3
  • 34
    • 0028030973 scopus 로고
    • Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane
    • Ilyin GP Rissel M Malledant Y Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane Biochemical Pharmacology 48 1994 561 567
    • (1994) Biochemical Pharmacology , vol.48 , pp. 561-567
    • Ilyin, GP1    Rissel, M2    Malledant, Y3
  • 36
    • 0027731547 scopus 로고
    • Ethanol-inducible cytochrome P4502E1—genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liverdisease
    • Ingelman-Sundberg M Johansson I Yin H Ethanol-inducible cytochrome P4502E1—genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liverdisease Alcohol 10 1993 447 452
    • (1993) Alcohol , vol.10 , pp. 447-452
    • Ingelman-Sundberg, M1    Johansson, I2    Yin, H3
  • 37
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome-P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I Lundqvist E Bertilsson L Inherited amplification of an active gene in the cytochrome-P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine Proceedings of the National Academy of Sciences of the USA 90 1993 11825 11829
    • (1993) , pp. 11825-11829
    • Johansson, I1    Lundqvist, E2    Bertilsson, L3
  • 39
    • 0029078019 scopus 로고
    • Genetic polymorphisms of drug-metabolizing-enzymes and lung-cancer susceptibility
    • Kawajiri K Watanabe J Eguchi H Hayashi S Genetic polymorphisms of drug-metabolizing-enzymes and lung-cancer susceptibility Pharmacogenetics 5 1995 S70 S73
    • (1995) Pharmacogenetics , vol.5 , pp. S70-S73
    • Kawajiri, K1    Watanabe, J2    Eguchi, H3    Hayashi, S4
  • 41
    • 0023898070 scopus 로고
    • Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane
    • Kenna JG Satoh H Christ DD Pohl LR Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane Journal of Pharmacology and Experimental Therapeutics 245 1988 1103 1109
    • (1988) Journal of Pharmacology and Experimental Therapeutics , vol.245 , pp. 1103-1109
    • Kenna, JG1    Satoh, H2    Christ, DD3    Pohl, LR4
  • 42
    • 0027515708 scopus 로고
    • Identification of cytochrome P450 2E1 as the predominant enzyme catalysing human liver microsomal defluorination of sevoflurane, isoflurane and methoxyflurane
    • Kharasch ED Thummel KE Identification of cytochrome P450 2E1 as the predominant enzyme catalysing human liver microsomal defluorination of sevoflurane, isoflurane and methoxyflurane Anesthesiology 79 1993 795 807
    • (1993) Anesthesiology , vol.79 , pp. 795-807
    • Kharasch, ED1    Thummel, KE2
  • 43
    • 0028925110 scopus 로고
    • Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity
    • Kharasch ED Hankins DC Thummel KE Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity Anesthesiology 82 1995 689 699
    • (1995) Anesthesiology , vol.82 , pp. 689-699
    • Kharasch, ED1    Hankins, DC2    Thummel, KE3
  • 44
    • 0029984604 scopus 로고    scopus 로고
    • Identification of the enzyme responsible for oxidative halothane metabolism—implications for prevention of halothane hepatitis
    • Kharasch ED Hankins D Mautz D Thummel KE Identification of the enzyme responsible for oxidative halothane metabolism—implications for prevention of halothane hepatitis Lancet 347 1996 1367 1371
    • (1996) Lancet , vol.347 , pp. 1367-1371
    • Kharasch, ED1    Hankins, D2    Mautz, D3    Thummel, KE4
  • 47
    • 0030430035 scopus 로고    scopus 로고
    • Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
    • Kumar GN Rodrigues AD Buko AM Denissen JF Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes Journal of Pharmacology and Experimental Therapeutics 277 1996 423 431
    • (1996) Journal of Pharmacology and Experimental Therapeutics , vol.277 , pp. 423-431
    • Kumar, GN1    Rodrigues, AD2    Buko, AM3    Denissen, JF4
  • 48
    • 0030896337 scopus 로고    scopus 로고
    • The site of general anesthesia and cytochrome P450 oxygenases: similarities defined by straight chain and cyclic alcohols
    • LaBella FS Chen Q-M Stein D Queen G The site of general anesthesia and cytochrome P450 oxygenases: similarities defined by straight chain and cyclic alcohols British Journal of Pharmacology 120 1997 1158 1164
    • (1997) British Journal of Pharmacology , vol.120 , pp. 1158-1164
    • LaBella, FS1    Chen, Q-M2    Stein, D3    Queen, G4
  • 49
    • 0025790577 scopus 로고
    • Localization of cypla1 and cypla2 messenger-RNA in normal human liver and in hepatocellular-carcinoma by in situ hybridization
    • McKinnon RA Hall PD Quattrochi LC Localization of cypla1 and cypla2 messenger-RNA in normal human liver and in hepatocellular-carcinoma by in situ hybridization Hepatology 14 1991 848 856
    • (1991) Hepatology , vol.14 , pp. 848-856
    • McKinnon, RA1    Hall, PD2    Quattrochi, LC3
  • 50
    • 0029825327 scopus 로고    scopus 로고
    • Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system
    • Makita K Falck JR Capdevila JH Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system FASEB Journal 10 1996 1456 1463
    • (1996) FASEB Journal , vol.10 , pp. 1456-1463
    • Makita, K1    Falck, JR2    Capdevila, JH3
  • 51
    • 0025745523 scopus 로고
    • Cytochrome P450 enzymes as human autoantigens
    • Manns MP Cytochrome P450 enzymes as human autoantigens Immunological Research 10 1991 503 507
    • (1991) Immunological Research , vol.10 , pp. 503-507
    • Manns, MP1
  • 52
    • 0015546496 scopus 로고
    • Renal toxicity of anaesthetics: with specific reference to the nephrotoxicity of methoxyflurane
    • Mazze RI Cousins MJ Renal toxicity of anaesthetics: with specific reference to the nephrotoxicity of methoxyflurane Canadian Anesthetists Society Journal 20 1973 64 80
    • (1973) Canadian Anesthetists Society Journal , vol.20 , pp. 64-80
    • Mazze, RI1    Cousins, MJ2
  • 53
    • 0016252246 scopus 로고
    • Renal effects and metabolism of isoflurane in man
    • Mazze RI Cousins MJ Barr GA Renal effects and metabolism of isoflurane in man Anesthesiology 40 1974 536 542
    • (1974) Anesthesiology , vol.40 , pp. 536-542
    • Mazze, RI1    Cousins, MJ2    Barr, GA3
  • 54
    • 0017579637 scopus 로고
    • Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anaesthesia in volunteers
    • Mazze RI Calverley RK Smith NT Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anaesthesia in volunteers Anesthesiology 46 1977 265 271
    • (1977) Anesthesiology , vol.46 , pp. 265-271
    • Mazze, RI1    Calverley, RK2    Smith, NT3
  • 55
    • 0031032476 scopus 로고    scopus 로고
    • Saquinavir interaction with midazolam: pharmacokinetic considerations when prescribing protease inhibitors for patients with HIV disease
    • Merry C Mulcahy F Barry M Saquinavir interaction with midazolam: pharmacokinetic considerations when prescribing protease inhibitors for patients with HIV disease AIDS 11 1997 268 269
    • (1997) AIDS , vol.11 , pp. 268-269
    • Merry, C1    Mulcahy, F2    Barry, M3
  • 56
    • 0023689026 scopus 로고
    • Endotoxin-stimulated human monocyte secretion of interleukin-1, tumor necrosis factor-alpha, and prostaglandin-e2 shows stable interindividual differences
    • Molvig J Baek L Christensen P Endotoxin-stimulated human monocyte secretion of interleukin-1, tumor necrosis factor-alpha, and prostaglandin-e2 shows stable interindividual differences Scandinavian Journal of Immunology 27 1988 705 716
    • (1988) Scandinavian Journal of Immunology , vol.27 , pp. 705-716
    • Molvig, J1    Baek, L2    Christensen, P3
  • 57
    • 0021146282 scopus 로고
    • Impaired oxidation of debrisoquine in patients with perhexilene liver injury
    • Morgan MY Reshef R Shah RR Impaired oxidation of debrisoquine in patients with perhexilene liver injury Gut 10 1984 1057 1064
    • (1984) Gut , vol.10 , pp. 1057-1064
    • Morgan, MY1    Reshef, R2    Shah, RR3
  • 59
    • 0028007371 scopus 로고
    • Cytochrome P450: evolution and functional diversity
    • Nebert DW McKinnon RA Cytochrome P450: evolution and functional diversity Progress in Liver Disease 12 1994 63 97
    • (1994) Progress in Liver Disease , vol.12 , pp. 63-97
    • Nebert, DW1    McKinnon, RA2
  • 60
    • 0023122517 scopus 로고
    • The P450 gene superfamily. Recommended nomenclature
    • Nebert DW Adesnik M Coon MJ The P450 gene superfamily. Recommended nomenclature DNA 6 1987 1 11
    • (1987) DNA , vol.6 , pp. 1-11
    • Nebert, DW1    Adesnik, M2    Coon, MJ3
  • 61
    • 0024550760 scopus 로고
    • The P450 gene superfamily. Update on the naming of new genes and nomenclature of chromosomal loci
    • Nebert DW Nelson DR Adesnik M The P450 gene superfamily. Update on the naming of new genes and nomenclature of chromosomal loci DNA 8 1989 1 13
    • (1989) DNA , vol.8 , pp. 1-13
    • Nebert, DW1    Nelson, DR2    Adesnik, M3
  • 62
    • 0025981925 scopus 로고
    • The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature
    • Nebert DW Nelson DR Coon MJ The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature DNA and Cell Biology 10 1991 1 14
    • (1991) DNA and Cell Biology , vol.10 , pp. 1-14
    • Nebert, DW1    Nelson, DR2    Coon, MJ3
  • 63
    • 0027922810 scopus 로고
    • Role of the ah receptor and the dioxin-inducible [ah]gene battery in toxicity, cancer, and signal-transduction
    • Nebert DW Puga A Vasiliou V Role of the ah receptor and the dioxin-inducible [ah]gene battery in toxicity, cancer, and signal-transduction Annals of the New York Academy of Sciences 685 1993 624 640
    • (1993) Annals of the New York Academy of Sciences , vol.685 , pp. 624-640
    • Nebert, DW1    Puga, A2    Vasiliou, V3
  • 64
    • 0027446505 scopus 로고
    • The P450 superfamily—update on new sequences, gene-mapping, accession numbers, early trivial names of enzymes, and nomenclature
    • Nelson DR Kamataki T Waxman DJ The P450 superfamily—update on new sequences, gene-mapping, accession numbers, early trivial names of enzymes, and nomenclature DNA and Cell Biology 12 1993 1 51
    • (1993) DNA and Cell Biology , vol.12 , pp. 1-51
    • Nelson, DR1    Kamataki, T2    Waxman, DJ3
  • 65
    • 9044254525 scopus 로고    scopus 로고
    • P450 superfamily: update of new sequences, gene mapping, accession numbers and nomenclature
    • Nelson DR Koymans L Kamataki T P450 superfamily: update of new sequences, gene mapping, accession numbers and nomenclature Pharmacogenetics 6 1996 1 42
    • (1996) Pharmacogenetics , vol.6 , pp. 1-42
    • Nelson, DR1    Koymans, L2    Kamataki, T3
  • 66
    • 78651165715 scopus 로고
    • The carbon monoxide binding pigment of liver microsomes
    • Omura T Sato R The carbon monoxide binding pigment of liver microsomes Journal of Biological Chemistry 239 1964 2370 2378
    • (1964) Journal of Biological Chemistry , vol.239 , pp. 2370-2378
    • Omura, T1    Sato, R2
  • 68
    • 0028074997 scopus 로고
    • Effects of fluorine substitution on drug-metabolism—pharmacological and toxicological implications
    • Park BK Kitteringham NR Effects of fluorine substitution on drug-metabolism—pharmacological and toxicological implications Drug Metabolism Reviews 26 1994 605 643
    • (1994) Drug Metabolism Reviews , vol.26 , pp. 605-643
    • Park, BK1    Kitteringham, NR2
  • 70
    • 0029885913 scopus 로고    scopus 로고
    • Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications
    • Park BK Kitteringham NR Pirmohamed M Tucker GT Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications British Journal of Clinical Pharmacology 41 1996 477 491
    • (1996) British Journal of Clinical Pharmacology , vol.41 , pp. 477-491
    • Park, BK1    Kitteringham, NR2    Pirmohamed, M3    Tucker, GT4
  • 72
    • 19144367776 scopus 로고
    • Enzyme inhibition-mediated toxic effects of drugs
    • Pirmohamed M Park BK Enzyme inhibition-mediated toxic effects of drugs Sandler M Smith J Design of Enzyme Inhibitors as Drugs 1994 OUP Oxford 800 818
    • (1994) , pp. 800-818
    • Pirmohamed, M1    Park, BK2
  • 73
    • 0028074402 scopus 로고
    • The role of active metabolites in drug toxicity
    • Pirmohamed M Kitteringham NR Park BK The role of active metabolites in drug toxicity Drug Safety 11 1994 114 144
    • (1994) Drug Safety , vol.11 , pp. 114-144
    • Pirmohamed, M1    Kitteringham, NR2    Park, BK3
  • 75
    • 10144260620 scopus 로고    scopus 로고
    • Idiosyncratic drug reactions: metabolic bioactivation as a pathogenic mechanism
    • Pirmohamed M Madden S Park BK Idiosyncratic drug reactions: metabolic bioactivation as a pathogenic mechanism Clinical Pharmacokinetics 31 1996 215 230
    • (1996) Clinical Pharmacokinetics , vol.31 , pp. 215-230
    • Pirmohamed, M1    Madden, S2    Park, BK3
  • 77
    • 0029884033 scopus 로고    scopus 로고
    • Introduction: basal and inducible expression of cytochromes P450 and related enzymes
    • Prough RA Introduction: basal and inducible expression of cytochromes P450 and related enzymes FASEB Journal 10 1996 807 808
    • (1996) FASEB Journal , vol.10 , pp. 807-808
    • Prough, RA1
  • 78
    • 0029621945 scopus 로고
    • Risk assessment—toxicity from chemical-exposure resulting from enhanced expression of cyp2e1
    • Raucy JL Risk assessment—toxicity from chemical-exposure resulting from enhanced expression of cyp2e1 Toxicology 105 1995 217 224
    • (1995) Toxicology , vol.105 , pp. 217-224
    • Raucy, JL1
  • 79
    • 0014107416 scopus 로고
    • Halothane biotransformation in man: a quantitative study
    • Rehder K Forbes J Alter H Halothane biotransformation in man: a quantitative study Anesthesiology 28 1967 711 715
    • (1967) Anesthesiology , vol.28 , pp. 711-715
    • Rehder, K1    Forbes, J2    Alter, H3
  • 80
    • 0017580220 scopus 로고
    • Renal tubular site of action of fluoride in Fischer 344 rats
    • Roman RJ Carter JR North WC Kauker ML Renal tubular site of action of fluoride in Fischer 344 rats Anesthesiology 46 1977 260 264
    • (1977) Anesthesiology , vol.46 , pp. 260-264
    • Roman, RJ1    Carter, JR2    North, WC3    Kauker, ML4
  • 81
    • 0020075333 scopus 로고
    • Impaired oxidation of debrisoquine in patients with perhexilene neuropathy
    • Shah RR Oates NS Idle JR Impaired oxidation of debrisoquine in patients with perhexilene neuropathy British Medical Journal 284 1982 295 298
    • (1982) British Medical Journal , vol.284 , pp. 295-298
    • Shah, RR1    Oates, NS2    Idle, JR3
  • 82
    • 0026747176 scopus 로고
    • Debrisoquine hydroxylation gene polymorphism and susceptibility to Parkinson's disease
    • Smith CAD Gough AC Leigh PN Debrisoquine hydroxylation gene polymorphism and susceptibility to Parkinson's disease Lancet i 1992 1375 1377
    • (1992) Lancet , vol.i , pp. 1375-1377
    • Smith, CAD1    Gough, AC2    Leigh, PN3
  • 83
    • 0028131808 scopus 로고
    • Genetic polymorphisms in xenobiotic metabolism
    • Smith CAD Smith G Wolf CR Genetic polymorphisms in xenobiotic metabolism European Journal of Cancer 30A 1994 1921 1935
    • (1994) European Journal of Cancer , vol.30A , pp. 1921-1935
    • Smith, CAD1    Smith, G2    Wolf, CR3
  • 84
    • 0027342798 scopus 로고
    • Fluvoxamine-induced alterations in plasma concentrations of imipramine and desipramine in depressed patients
    • Spina E Pollicino AM Avenoso A Fluvoxamine-induced alterations in plasma concentrations of imipramine and desipramine in depressed patients International Journal of Clinical Pharmacology Research 13 1993 167 171
    • (1993) International Journal of Clinical Pharmacology Research , vol.13 , pp. 167-171
    • Spina, E1    Pollicino, AM2    Avenoso, A3
  • 85
    • 0027442014 scopus 로고
    • Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes—P450
    • Stevens JC Wrighton SA Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes—P450 Journal of Pharmacology and Experimental Therapeutics 266 1993 964 971
    • (1993) Journal of Pharmacology and Experimental Therapeutics , vol.266 , pp. 964-971
    • Stevens, JC1    Wrighton, SA2
  • 86
    • 0025284207 scopus 로고
    • UDP-glucuronyl transferases: a family of detoxifying enzymes
    • Tephly TR Burchell B UDP-glucuronyl transferases: a family of detoxifying enzymes Trends in Pharmacological Sciences 11 1990 276 279
    • (1990) Trends in Pharmacological Sciences , vol.11 , pp. 276-279
    • Tephly, TR1    Burchell, B2
  • 88
    • 0024378451 scopus 로고
    • The intralobular distribution of ethanol-inducible-P450iie1 in rat and human-liver
    • Tsutsumi M Lasker JM Shimizu M The intralobular distribution of ethanol-inducible-P450iie1 in rat and human-liver Hepatology 10 1989 437 446
    • (1989) Hepatology , vol.10 , pp. 437-446
    • Tsutsumi, M1    Lasker, JM2    Shimizu, M3
  • 89
    • 0025779409 scopus 로고
    • Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (−)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6
    • Tyndale RF Sunahara T Inaba T Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (−)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6 Molecular Pharmacology 40 1991 63 68
    • (1991) Molecular Pharmacology , vol.40 , pp. 63-68
    • Tyndale, RF1    Sunahara, T2    Inaba, T3
  • 90
    • 0027320344 scopus 로고
    • Type II autoimmune hepatitis. What is the role of the hepatitis C virus?
    • Vergani D Mieli-Vergani G Type II autoimmune hepatitis. What is the role of the hepatitis C virus? Gastroenterology 104 1993 1870 1873
    • (1993) Gastroenterology , vol.104 , pp. 1870-1873
    • Vergani, D1    Mieli-Vergani, G2
  • 91
    • 0002979167 scopus 로고    scopus 로고
    • Role of metabolism in chemical toxicity
    • Vermeulen NPE Role of metabolism in chemical toxicity Ioannides C Cytochromes P450: Metabolic and Toxicological Aspects 1996 CRC Press Boca Raton 29 54
    • (1996) , pp. 29-54
    • Vermeulen, NPE1
  • 93
    • 0026512675 scopus 로고
    • Phenobarbital induction of cytochrome P-450 gene expression
    • Waxman DJ Azaroff L Phenobarbital induction of cytochrome P-450 gene expression Biochemical Journal 281 1992 577 592
    • (1992) Biochemical Journal , vol.281 , pp. 577-592
    • Waxman, DJ1    Azaroff, L2
  • 95
    • 5244238307 scopus 로고
    • The metabolism of drugs and toxic substances
    • Williams RT The metabolism of drugs and toxic substances Annual Review of Biochemistry 20 1951 441 464
    • (1951) Annual Review of Biochemistry , vol.20 , pp. 441-464
    • Williams, RT1
  • 96
    • 0027984719 scopus 로고
    • Metabolic polymorphisms in carcinogen metabolising enzymes and cancer susceptibility
    • Wolf CR Smith CAD Forman D Metabolic polymorphisms in carcinogen metabolising enzymes and cancer susceptibility British Medical Bulletin 50 1994 718 731
    • (1994) British Medical Bulletin , vol.50 , pp. 718-731
    • Wolf, CR1    Smith, CAD2    Forman, D3
  • 97
    • 0028805889 scopus 로고
    • Designing safer chemicals—predicting the rates of metabolism of halogenated alkanes
    • Yin HQ Anders MW Korzekwa KR Designing safer chemicals—predicting the rates of metabolism of halogenated alkanes Proceedings of the National Academy of Sciences of the USA 92 1995 11 076 11 080
    • (1995) , pp. 11 076-11 080
    • Yin, HQ1    Anders, MW2    Korzekwa, KR3
  • 98
    • 0029083319 scopus 로고
    • Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure
    • Zimmerman HJ Maddrey WC Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure Hepatology 22 1995 767 773
    • (1995) Hepatology , vol.22 , pp. 767-773
    • Zimmerman, HJ1    Maddrey, WC2


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