Therapeutic effect of interferon-γ gene transfer in experimental visceral leishmaniasis

Journal of Infectious Diseases

Volumn 178, Issue 3, 1998, Pages 908-911

  Taylor, Alice P ^a   Murray, Henry W ^a,b  

^a Department of Obstetrics Gynecology   (United States)

^b Box 130 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE TRANSFER; HOST RESISTANCE; IMMUNOMODULATION; INFECTION RESISTANCE; LEISHMANIA DONOVANI; MOUSE; NONHUMAN; PRIORITY JOURNAL; VISCERAL LEISHMANIASIS;

EID: 0031660027     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515354     Document Type: Article

References (15)

1. Murray HW. Gamma interferon, cytokine-induced macrophage activation, and antimicrobial host defense: in vitro, in animal models, and in humans. Diagn Microbiol Infect Dis 1990;13:411-21.
2. Miralles GD, Stoeckle MY, McDermott DF, Finkelman FD, Murray HW. Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis. Infect Immun 1994;62:1058-63.
3. Squires KE, Schreiber RD, McElrath MJ, Rubin BY, Anderson SL, Murray HW. Experimental visceral leishmaniasis: role of endogenous IFN-γ in host defense and tissue granulomatous response. J Immunol 1989;143:4244-9.
4. Murray HW, Cervia JS, Hariprashad J, Taylor AP, Stoeckle MY, Hockman H. Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasis. J Clin Invest 1995;95:1183-92.
5. Murray HW, Stern JJ, Weite K, Rubin BY, Carriero SM, Nathan CF. Experimental visceral leishmaniasis: production of interleukin 2 and interferon-γ, tissue immune reaction, and response to treatment with interleukin 2 and interferon-γ. J Immunol 1987;138:2290-7.
6. Murray HW. Effect of continuous administration of interferon-γ in experimental visceral leishmaniasis. J Infect Dis 1990;161:992-4.
7. Murray HW, Berman JD, Wright SD. Immunochemotherapy for intracellular Leishmania donovani infection: γ-interferon plus pentavalent antimony. J Infect Dis 1988;157:973-8.
8. Taylor AP, Murray HW. Intracellular antimicrobial activity in the absence of interferon-γ: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-γ gene-disrupted mice. J Exp Med 1997;185:1231-9.
9. Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 1993;159:1739-42.
10. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
11. Murray HW, Spitalny GL, Nathan CF. Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-γ. J Immunol 1985;134:1619-22.
12. Zhu N, Liggit D, Liu Y, Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science 1993;261:209-11.
13. Feigner PL, Gadek TR, Holm M, et al. Lipofectin: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987;84:7413-7.
14. Stoeckle MY, Falk-Pedersen E, Rubin BY, Anderson SL, Murray HW. Delivery of human interferon-gamma via gene transfer in vitro: prolonged expression and induction of macrophage antimicrobial activity. J Interferon Cytokine Res 1996;16:1015-9.
15. Dinghua L, Lancaster JR Jr, Joshi MS, et al. Activation of alveolar macrophages and lung host defenses using transfer of the interferon-γ gene. Am J Physiol 1997;272:L852-9.